{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T05:30:00Z","timestamp":1787808600099,"version":"build-2784847793"},"reference-count":73,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T00:00:00Z","timestamp":1742947200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T00:00:00Z","timestamp":1742947200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Hospital capability enhancement project of Xiyuan Hospital, CACMS.","award":["NO. XYZX0405-05"],"award-info":[{"award-number":["NO. XYZX0405-05"]}]},{"name":"the National Natural Science Foundation of China Youth Science Foundation","award":["82104677"],"award-info":[{"award-number":["82104677"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-95021-x","type":"journal-article","created":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T04:03:56Z","timestamp":1742961836000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Risk assessment of the top 50 drugs associated with drug-induced orthostatic hypotension: a disproportionality analysis of the FAERS and JADER databases"],"prefix":"10.1038","volume":"15","author":[{"given":"Gaocan","family":"Ren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiansu","family":"Chi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingping","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqiu","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghua","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochang","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,26]]},"reference":[{"key":"95021_CR1","first-page":"154","volume":"26","author":"JA Palma","year":"2020","unstructured":"Palma, J. A. & Kaufmann, H. Management of orthostatic hypotension. Continuum (Minneap Minn). 26, 154\u2013177 (2020).","journal-title":"Continuum (Minneap Minn)"},{"key":"95021_CR2","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1016\/S1474-4422(22)00169-7","volume":"21","author":"W Wieling","year":"2022","unstructured":"Wieling, W. et al. Diagnosis and treatment of orthostatic hypotension. Lancet Neurol. 21, 735\u2013746 (2022).","journal-title":"Lancet Neurol."},{"key":"95021_CR3","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1111\/jch.13521","volume":"21","author":"N Magkas","year":"2019","unstructured":"Magkas, N. et al. Orthostatic hypotension: from pathophysiology to clinical applications and therapeutic considerations. J. Clin. Hypertens. (Greenwich) 21, 546\u2013554 (2019).","journal-title":"J. Clin. Hypertens. (Greenwich)"},{"key":"95021_CR4","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1001\/jama.2023.18497","volume":"330","author":"SP Juraschek","year":"2023","unstructured":"Juraschek, S. P. et al. Orthostatic hypotension, hypertension treatment, and cardiovascular disease: an individual participant Meta-Analysis. JAMA 330, 1459\u20131471 (2023).","journal-title":"JAMA"},{"key":"95021_CR5","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1093\/gerona\/gly188","volume":"75","author":"NI Saedon","year":"2020","unstructured":"Saedon, N. I., Pin Tan, M. & Frith, J. The prevalence of orthostatic hypotension: A systematic review and Meta-Analysis. J. Gerontol. Biol. Sci. Med. Sci. 75, 117\u2013122 (2020).","journal-title":"J. Gerontol. Biol. Sci. Med. Sci."},{"key":"95021_CR6","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.puhe.2024.04.011","volume":"233","author":"DA Alsayed Hassan","year":"2024","unstructured":"Alsayed Hassan, D. A., Chivese, T., Syed, M. A. & Alhussaini, N. W. Z. Prevalence and factors associated with falls in older adults in a middle Eastern population: a retrospective cross-sectional study. Public. Health 233, 54\u201359 (2024).","journal-title":"Public. Health"},{"key":"95021_CR7","doi-asserted-by":"publisher","first-page":"2468","DOI":"10.1016\/j.jamda.2021.08.014","volume":"22","author":"EM Christopoulos","year":"2021","unstructured":"Christopoulos, E. M., Reijnierse, E. M., Lange, P. W., Meskers, C. G. M. & Maier, A. B. Orthostatic hypotension and orthostatic intolerance symptoms in geriatric rehabilitation inpatients, RESORT. J. Am. Med. Dir. Assoc. 22, 2468\u20132477 (2021).","journal-title":"J. Am. Med. Dir. Assoc."},{"key":"95021_CR8","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1111\/jch.13613","volume":"21","author":"M Min","year":"2019","unstructured":"Min, M. et al. Orthostatic hypotension and the risk of atrial fibrillation and other cardiovascular diseases: an updated meta-analysis of prospective cohort studies. J. Clin. Hypertens. (Greenwich) 21, 1221\u20131227 (2019).","journal-title":"J. Clin. Hypertens. (Greenwich)"},{"key":"95021_CR9","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1016\/j.eprac.2024.06.008","volume":"30","author":"I D\u2019Ippolito","year":"2024","unstructured":"D\u2019Ippolito, I., Carlucci, M. A., D\u2019Amato, C., Lauro, D. & Spallone, V. Determinants of orthostatic hypotension in type 2 diabetes: is cardiac autonomic neuropathy the main factor?? Endocr. Pract. 30, 802\u2013809 (2024).","journal-title":"Endocr. Pract."},{"key":"95021_CR10","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1080\/08037051.2019.1689808","volume":"29","author":"M Min","year":"2020","unstructured":"Min, M. et al. The association between orthostatic hypotension and cognition and stroke: a meta-analysis of prospective cohort studies. Blood Press. 29, 3\u201312 (2020).","journal-title":"Blood Press."},{"key":"95021_CR11","first-page":"271678X24128322","volume":"16","author":"JH Wiersinga","year":"2024","unstructured":"Wiersinga, J. H. et al. Orthostatic hypotension and cerebral small vessel disease: A systematic review. J. Cereb. Blood Flow. Metab. 16, 271678X241283226 (2024).","journal-title":"J. Cereb. Blood Flow. Metab."},{"key":"95021_CR12","doi-asserted-by":"publisher","first-page":"glae087","DOI":"10.1093\/gerona\/glae087","volume":"79","author":"J Liang","year":"2024","unstructured":"Liang, J. et al. Associations between onset age of orthostatic hypotension and incident myocardial infarction, stroke, and dementia: A prospective cohort study. J. Gerontol. Biol. Sci. Med. Sci. 79, glae087 (2024).","journal-title":"J. Gerontol. Biol. Sci. Med. Sci."},{"key":"95021_CR13","first-page":"338","volume":"28","author":"MG Kaye","year":"2023","unstructured":"Kaye, M. G. et al. Screening for orthostatic hypotension in the geriatric population in a real-world primary care setting reduces prescribed antihypertensive drugs. Blood Press. Monit. 28, 338\u2013342 (2023).","journal-title":"Blood Press. Monit."},{"key":"95021_CR14","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/s10286-011-0119-5","volume":"21","author":"R Freeman","year":"2011","unstructured":"Freeman, R. et al. Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome. Clin. Auton. Res. 21, 69\u201372 (2011).","journal-title":"Clin. Auton. Res."},{"key":"95021_CR15","doi-asserted-by":"publisher","first-page":"e010573","DOI":"10.1161\/CIRCEP.121.010573","volume":"15","author":"A Fedorowski","year":"2022","unstructured":"Fedorowski, A. et al. Orthostatic hypotension: management of a complex, but common, medical problem. Circ. Arrhythm. Electrophysiol. 15, e010573 (2022).","journal-title":"Circ. Arrhythm. Electrophysiol."},{"key":"95021_CR16","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1298\/ptr.E10298","volume":"27","author":"K Kominami","year":"2024","unstructured":"Kominami, K., Akino, M. & Kanai, M. Efficacy of Neuro-muscular electrical stimulation for orthostatic hypotension associated with Long-term disuse and diabetic autonomic neuropathy: A case report. Phys. Ther. Res. 27, 180\u2013185 (2024).","journal-title":"Phys. Ther. Res."},{"key":"95021_CR17","doi-asserted-by":"publisher","first-page":"630","DOI":"10.3390\/jcm14020630","volume":"14","author":"C Grosu","year":"2025","unstructured":"Grosu, C., Noea, O., Ma\u0219taleru, A., Ignat, E. B. & Leon, M. M. Neurogenic orthostatic hypotension in Parkinson Disease-A narrative review of diagnosis and management. J. Clin. Med. 14, 630 (2025).","journal-title":"J. Clin. Med."},{"key":"95021_CR18","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1007\/s00415-025-12919-2","volume":"272","author":"J Zhao","year":"2025","unstructured":"Zhao, J. et al. Sustained therapeutic effect of spinal cord stimulation on improving severe neurogenic orthostatic hypotension in a patient with pure autonomic failure converting to multiple system atrophy. J. Neurol. 272, 177 (2025).","journal-title":"J. Neurol."},{"key":"95021_CR19","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1093\/ajh\/hpaa131","volume":"34","author":"JF Idiaquez","year":"2021","unstructured":"Idiaquez, J. F., Idiaquez, J., Casar, J. C. & Biaggioni, I. Neurogenic orthostatic hypotension. Lessons from synucleinopathies. Am. J. Hypertens. 34, 125\u2013133 (2021).","journal-title":"Am. J. Hypertens."},{"key":"95021_CR20","doi-asserted-by":"publisher","first-page":"1294","DOI":"10.1016\/j.jacc.2018.05.079","volume":"72","author":"R Freeman","year":"2018","unstructured":"Freeman, R. et al. Orthostatic hypotension: JACC State-of-the-Art review. J. Am. Coll. Cardiol. 72, 1294\u20131309 (2018).","journal-title":"J. Am. Coll. Cardiol."},{"key":"95021_CR21","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1136\/dtb.2020.000056","volume":"58","author":"JR Gibbon","year":"2020","unstructured":"Gibbon, J. R. & Frith, J. Orthostatic hypotension: a pragmatic guide to diagnosis and treatment. Drug Ther. Bull. 58, 166\u2013171 (2020).","journal-title":"Drug Ther. Bull."},{"key":"95021_CR22","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1007\/s40266-020-00796-5","volume":"37","author":"G Rivasi","year":"2020","unstructured":"Rivasi, G., Rafanelli, M., Mossello, E., Brignole, M. & Ungar, A. Drug-Related orthostatic hypotension: beyond Anti-Hypertensive drugs. Drugs Aging 37, 725\u2013738 (2020).","journal-title":"Drugs Aging"},{"key":"95021_CR23","doi-asserted-by":"publisher","first-page":"107","DOI":"10.2143\/ACB.3215","volume":"68","author":"T Pepersack","year":"2013","unstructured":"Pepersack, T. et al. Prevalence of orthostatic hypotension and relationship with drug use amongst older patients. Acta Clin. Belg. 68, 107\u2013112 (2013).","journal-title":"Acta Clin. Belg."},{"key":"95021_CR24","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1038\/s41531-023-00589-8","volume":"9","author":"W Sako","year":"2023","unstructured":"Sako, W. et al. Comparative efficacy and safety of adjunctive drugs to Levodopa for fluctuating Parkinson\u2019s disease - network meta-analysis. NPJ Parkinsons Dis. 9, 143 (2023).","journal-title":"NPJ Parkinsons Dis."},{"key":"95021_CR25","doi-asserted-by":"crossref","unstructured":"Juraschek, S. P. et al. Orthostatic Hypotension in Adults With Hypertension: A Scientific Statement From the American Heart Association. Hypertension 81, e16-e30 (2024).","DOI":"10.1161\/HYP.0000000000000236"},{"key":"95021_CR26","doi-asserted-by":"publisher","first-page":"e5730","DOI":"10.1002\/pds.5730","volume":"33","author":"C Bhanu","year":"2024","unstructured":"Bhanu, C. et al. Drug-induced orthostatic hypotension: cluster analysis of co-prescription patterns in older people in UK primary care. Pharmacoepidemiol Drug Saf. 33, e5730 (2024).","journal-title":"Pharmacoepidemiol Drug Saf."},{"key":"95021_CR27","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s40360-023-00657-y","volume":"24","author":"HS Ahdi","year":"2023","unstructured":"Ahdi, H. S., Wichelmann, T. A., Pandravada, S. & Ehrenpreis, E. D. Medication-induced osteonecrosis of the jaw: a review of cases from the food and drug administration adverse event reporting system (FAERS). BMC Pharmacol. Toxicol. 24, 15 (2023).","journal-title":"BMC Pharmacol. Toxicol."},{"key":"95021_CR28","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1186\/s40360-023-00702-w","volume":"24","author":"SP Zou","year":"2023","unstructured":"Zou, S. P. et al. A disproportionality analysis of adverse events associated to Pertuzumab in the FDA adverse event reporting system (FAERS). BMC Pharmacol. Toxicol. 24, 62 (2023).","journal-title":"BMC Pharmacol. Toxicol."},{"key":"95021_CR29","doi-asserted-by":"publisher","first-page":"796","DOI":"10.7150\/ijms.6048","volume":"10","author":"T Sakaeda","year":"2013","unstructured":"Sakaeda, T., Tamon, A., Kadoyama, K. & Okuno, Y. Data mining of the public version of the FDA adverse event reporting system. Int. J. Med. Sci. 10, 796\u2013803 (2013).","journal-title":"Int. J. Med. Sci."},{"key":"95021_CR30","first-page":"9945051","volume":"27","author":"M Yang","year":"2024","unstructured":"Yang, M. et al. Epidemiology and risk factors for orthostatic hypotension and its severity in residents aged\u2009>\u200960 years: A Cross-Sectional study. Int. J. Hypertens. 27, 9945051 (2024).","journal-title":"Int. J. Hypertens."},{"key":"95021_CR31","doi-asserted-by":"publisher","first-page":"571","DOI":"10.3988\/jcn.2024.0092","volume":"20","author":"KT Kim","year":"2024","unstructured":"Kim, K. T. et al. Blood pressure variability and ocular Vestibular-Evoked myogenic potentials are independently associated with orthostatic hypotension. J. Clin. Neurol. 20, 571\u2013579 (2024).","journal-title":"J. Clin. Neurol."},{"key":"95021_CR32","doi-asserted-by":"publisher","first-page":"1609","DOI":"10.1093\/eurheartj\/ehv093","volume":"36","author":"F Ricci","year":"2015","unstructured":"Ricci, F. et al. Cardiovascular morbidity and mortality related to orthostatic hypotension: a meta-analysis of prospective observational studies. Eur. Heart J. 36, 1609\u20131617. https:\/\/doi.org\/10.1093\/eurheartj\/ehv093 (2015).","journal-title":"Eur. Heart J."},{"key":"95021_CR33","first-page":"165","volume":"14","author":"M Safarpour","year":"2019","unstructured":"Safarpour, M., Fotouhi, A., Hosseini, S. R., Mohamadzade, M. & Bijani, A. Predictors of orthostatic hypotension in the elderly: results from the Amirkola health and ageing project (AHAP) study. J. Tehran Heart Cent. 14, 165\u2013170 (2019).","journal-title":"J. Tehran Heart Cent."},{"key":"95021_CR34","doi-asserted-by":"publisher","first-page":"2611","DOI":"10.1152\/jappl.2001.91.6.2611","volume":"91","author":"JM Evans","year":"2001","unstructured":"Evans, J. M. et al. Gender differences in autonomic cardiovascular regulation: spectral, hormonal, and hemodynamic indexes. J. Appl. Physiol. 91, 2611\u20132618 (2001).","journal-title":"J. Appl. Physiol."},{"key":"95021_CR35","doi-asserted-by":"publisher","first-page":"H2028","DOI":"10.1152\/ajpheart.2001.281.5.H2028","volume":"281","author":"JK Shoemaker","year":"2001","unstructured":"Shoemaker, J. K., Hogeman, C. S., Khan, M., Kimmerly, D. S. & Sinoway, L. I. Gender affects sympathetic and hemodynamic response to postural stress. Am. J. Physiol. Heart Circ. Physiol. 281, H2028\u2013H2035 (2001).","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"95021_CR36","doi-asserted-by":"publisher","first-page":"1164519","DOI":"10.3389\/fphys.2023.1164519","volume":"14","author":"A Saz-Lara","year":"2023","unstructured":"Saz-Lara, A. et al. Association between arterial stiffness and orthostatic hypotension: A systematic review and meta-analysis. Front. Physiol. 14, 1164519 (2023).","journal-title":"Front. Physiol."},{"key":"95021_CR37","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1186\/s13287-021-02571-8","volume":"12","author":"S Yuan","year":"2021","unstructured":"Yuan, S. et al. Sympathetic activity is correlated with satellite cell aging and myogenesis via \u03b22-adrenoceptor. Stem Cell. Res. Ther. 12, 505 (2021).","journal-title":"Stem Cell. Res. Ther."},{"key":"95021_CR38","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1111\/jch.14709","volume":"25","author":"JG Wang","year":"2023","unstructured":"Wang, J. G., Palmer, B. F., Vogel Anderson, K. & Sever, P. Amlodipine in the current management of hypertension. J. Clin. Hypertens. (Greenwich) 25, 801\u2013807 (2023).","journal-title":"J. Clin. Hypertens. (Greenwich)"},{"key":"95021_CR39","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1186\/s12877-024-05519-8","volume":"24","author":"W Hailu","year":"2024","unstructured":"Hailu, W., Tesfaye, T., Derseh, L., Hailu, A. & Clarfield, A. M. Prevalence of orthostatic hypotension and associated factors among older people with hypertension in Northern Ethiopia. BMC Geriatr. 24, 928 (2024).","journal-title":"BMC Geriatr."},{"key":"95021_CR40","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1097\/HJH.0000000000000781","volume":"34","author":"Y Press","year":"2016","unstructured":"Press, Y., Punchik, B. & Freud, T. Orthostatic hypotension and drug therapy in patients at an outpatient comprehensive geriatric assessment unit. J. Hypertens. 34, 351\u2013358 (2016).","journal-title":"J. Hypertens."},{"key":"95021_CR41","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/S0140-6736(10)62003-X","volume":"377","author":"MJ Brown","year":"2011","unstructured":"Brown, M. J., McInnes, G. T., Papst, C. C., Zhang, J. & MacDonald, T. M. Aliskiren and the calcium channel blocker amlodipine combination as an initial treatment strategy for hypertension control (ACCELERATE): a randomised, parallel-group trial. Lancet 377, 312\u2013320 (2011).","journal-title":"Lancet"},{"key":"95021_CR42","doi-asserted-by":"publisher","first-page":"124","DOI":"10.3810\/pgm.2013.03.2646","volume":"125","author":"MR Weir","year":"2013","unstructured":"Weir, M. R., Shojaee, A. & Maa, J. F. Efficacy of amlodipine\/olmesartan medoxomil\u2009\u00b1\u2009hydrochlorothiazide in patients aged\u2009\u2265\u200965 or <\u200965 years with uncontrolled hypertension on prior monotherapy. Postgrad. Med. 125, 124\u2013134 (2013).","journal-title":"Postgrad. Med."},{"key":"95021_CR43","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1097\/MCC.0000000000001218","volume":"30","author":"MD Simpson","year":"2024","unstructured":"Simpson, M. D. & Cole, J. B. Developments in the epidemiology of calcium channel blocker poisoning and implications for management. Curr. Opin. Crit. Care 30, 603\u2013610 (2024).","journal-title":"Curr. Opin. Crit. Care"},{"key":"95021_CR44","doi-asserted-by":"publisher","first-page":"26826","DOI":"10.1038\/s41598-024-78145-4","volume":"14","author":"WL Murch","year":"2024","unstructured":"Murch, W. L., Spiridigliozzi, J., Heller, A. & Heller, E. Non-invasive, continuous oral delivery of solid levodopa-carbidopa for management of Parkinson\u2019s disease. Sci. Rep. 14, 26826 (2024).","journal-title":"Sci. Rep."},{"key":"95021_CR45","doi-asserted-by":"publisher","first-page":"105860","DOI":"10.1016\/j.parkreldis.2023.105860","volume":"115","author":"Z Liu","year":"2023","unstructured":"Liu, Z. et al. Acute effect of Levodopa on orthostatic hypotension and its association with motor responsiveness in Parkinson\u2019s disease: results of acute Levodopa challenge test. Parkinsonism Relat. Disord. 115, 105860 (2023).","journal-title":"Parkinsonism Relat. Disord."},{"key":"95021_CR46","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1007\/s10286-024-01024-5","volume":"34","author":"T Earl","year":"2024","unstructured":"Earl, T. et al. Effect of Levodopa on postural blood pressure changes in Parkinson disease: a randomized crossover study. Clin. Auton. Res. 34, 117\u2013124 (2024).","journal-title":"Clin. Auton. Res."},{"key":"95021_CR47","doi-asserted-by":"publisher","first-page":"e17876","DOI":"10.1016\/j.heliyon.2023.e17876","volume":"9","author":"D Su","year":"2023","unstructured":"Su, D., Zhang, X., Su, Y., Chan, P. & Xu, E. Effects of different Levodopa doses on blood pressure in older patients with early and middle stages of Parkinson\u2019s disease. Heliyon 9, e17876 (2023).","journal-title":"Heliyon"},{"key":"95021_CR48","doi-asserted-by":"publisher","first-page":"e16061","DOI":"10.1111\/ene.16061","volume":"31","author":"I Cani","year":"2024","unstructured":"Cani, I. et al. Levodopa-induced orthostatic hypotension in parkinsonism: A red flag of autonomic failure. Eur. J. Neurol. 31, e16061 (2024).","journal-title":"Eur. J. Neurol."},{"key":"95021_CR49","doi-asserted-by":"crossref","unstructured":"Olivares-Hern\u00e1ndez, A. et al. Dopamine Receptors and the Kidney: An Overview of Health- and Pharmacological-Targeted Implications. Biomolecules 11, 254 (2021).","DOI":"10.3390\/biom11020254"},{"key":"95021_CR50","doi-asserted-by":"publisher","first-page":"866","DOI":"10.1186\/s12877-022-03546-x","volume":"22","author":"Q Zhang","year":"2022","unstructured":"Zhang, Q., Shen, S., Guan, H., Zhang, J. & Chen, X. Orthostatic hypotension is associated with malnutrition diagnosed by GLIM in elderly hypertensive patients. BMC Geriatr. 22, 866 (2022).","journal-title":"BMC Geriatr."},{"key":"95021_CR51","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1111\/j.1365-2710.2005.00629.x","volume":"30","author":"IO oon","year":"2005","unstructured":"oon, I. O. & Braun, U. High prevalence of orthostatic hypotension and its correlation with potentially causative drugs among elderly veterans. J. Clin. Pharm. Ther. 30, 173\u2013178 (2005).","journal-title":"J. Clin. Pharm. Ther."},{"key":"95021_CR52","doi-asserted-by":"publisher","first-page":"ytae566","DOI":"10.1093\/ehjcr\/ytae566","volume":"8","author":"L Ordine","year":"2024","unstructured":"Ordine, L., Losi, M. A., Canciello, G., Borrelli, F. & Esposito, G. Symptomatic orthostatic hypotension due to standing mid-left ventricular obstruction: a case report. Eur. Heart J. Case Rep. 8, ytae566 (2024).","journal-title":"Eur. Heart J. Case Rep."},{"key":"95021_CR53","doi-asserted-by":"publisher","first-page":"1443555","DOI":"10.3389\/fphar.2024.1443555","volume":"15","author":"W Li","year":"2024","unstructured":"Li, W. et al. Exploring the top 30 drugs associated with drug-induced constipation based on the FDA adverse event reporting system. Front. Pharmacol. 15, 1443555 (2024).","journal-title":"Front. Pharmacol."},{"key":"95021_CR54","doi-asserted-by":"publisher","first-page":"479","DOI":"10.23736\/S2724-6051.23.05225-4","volume":"75","author":"A Cicione","year":"2023","unstructured":"Cicione, A. et al. Adverse events related to alpha-blockers: analysis of real-life data from Eudra-Vigilance. Minerva Urol. Nephrol. 75, 479\u2013485 (2023).","journal-title":"Minerva Urol. Nephrol."},{"key":"95021_CR55","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1080\/14656566.2024.2446628","volume":"26","author":"AM Bakr","year":"2025","unstructured":"Bakr, A. M. & El-Sakka, A. I. Effects of alpha-1 adrenergic receptor blockers on erectile function: a systematic review. Expert Opin. Pharmacother. 26, 219\u2013226 (2025).","journal-title":"Expert Opin. Pharmacother."},{"key":"95021_CR56","unstructured":"Schultz, J. L. et al. A pilot dose-finding study of Terazosin in humans. medRxiv [Preprint] 22, 05.22.24307622 (2024). (2024)."},{"key":"95021_CR57","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1002\/mds.20145","volume":"19","author":"MB Stern","year":"2004","unstructured":"Stern, M. B. et al. Double-blind, randomized, controlled trial of Rasagiline as monotherapy in early Parkinson\u2019s disease patients. Mov. Disord. 19, 916\u2013923 (2004).","journal-title":"Mov. Disord."},{"key":"95021_CR58","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1001\/archneur.62.2.241","volume":"62","author":"Parkinson Study Group","year":"2005","unstructured":"Parkinson Study Group. A randomized Placebo-Controlled trial of Rasagiline in Levodopa-Treated patients with Parkinson disease and motor fluctuations: the PRESTO study. Arch. Neurol. 62, 241\u2013248 (2005).","journal-title":"Arch. Neurol."},{"key":"95021_CR59","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1080\/14740338.2023.2293207","volume":"23","author":"N Hattori","year":"2024","unstructured":"Hattori, N., Kajita, M., Fujimoto, S., Izutsu, M. & Fernandez, J. Safety and effectiveness of Rasagiline in patients with Parkinson\u2019s disease in Japan: a post-marketing surveillance study. Expert Opin. Drug Saf. 23, 79\u201388 (2024).","journal-title":"Expert Opin. Drug Saf."},{"key":"95021_CR60","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/S1474-4422(14)70288-1","volume":"14","author":"W Poewe","year":"2015","unstructured":"Poewe, W. et al. Efficacy of Rasagiline in patients with the parkinsonian variant of multiple system atrophy: a randomised, placebo-controlled trial. Lancet Neurol. 14, 145\u2013152 (2015).","journal-title":"Lancet Neurol."},{"key":"95021_CR61","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.xkme.2020.10.012","volume":"3","author":"M Rouabhi","year":"2021","unstructured":"Rouabhi, M. et al. Orthostatic hypertension and hypotension and outcomes in CKD: the CRIC (Chronic renal insufficiency Cohort) study. Kidney Med. 3, 206\u2013215e1 (2021).","journal-title":"Kidney Med."},{"key":"95021_CR62","doi-asserted-by":"publisher","first-page":"e0146156","DOI":"10.1371\/journal.pone.0146156","volume":"11","author":"M Canney","year":"2016","unstructured":"Canney, M. et al. Single agent antihypertensive therapy and orthostatic blood pressure behaviour in older adults using Beat-to-Beat measurements: the Irish longitudinal study on ageing. PLoS One 11, e0146156 (2016).","journal-title":"PLoS One"},{"key":"95021_CR63","doi-asserted-by":"publisher","first-page":"R3","DOI":"10.1152\/ajpregu.00031.2007","volume":"293","author":"KD Monahan","year":"2007","unstructured":"Monahan, K. D. Effect of aging on baroreflex function in humans. Am. J. Physiol. Regul. Integr. Comp. Physiol. 293, R3\u2013R12 (2007).","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"95021_CR64","doi-asserted-by":"crossref","unstructured":"Rivasi, G. & Ungar, A. Orthostatic hypotension in older adults: the role of drugs. Monaldi Arch. Chest Dis. 90, (2020).","DOI":"10.4081\/monaldi.2020.1254"},{"key":"95021_CR65","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1007\/s41999-023-00910-x","volume":"15","author":"AH Dyer","year":"2024","unstructured":"Dyer, A. H. et al. Long-term antipsychotic use, orthostatic hypotension and falls in older adults with Alzheimer\u2019s disease. Eur. Geriatr. Med. 15, 527\u2013537 (2024).","journal-title":"Eur. Geriatr. Med."},{"key":"95021_CR66","doi-asserted-by":"publisher","first-page":"204512532210929","DOI":"10.1177\/20451253221092931","volume":"12","author":"TD Tanzer","year":"2022","unstructured":"Tanzer, T. D. et al. Treatment strategies for clozapine-induced hypotension: a systematic review. Ther. Adv. Psychopharmacol. 12, 20451253221092931 (2022).","journal-title":"Ther. Adv. Psychopharmacol."},{"key":"95021_CR67","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1089\/cmb.2019.0386","volume":"27","author":"D Pepe","year":"2020","unstructured":"Pepe, D. & Do, J. H. Analyzing Apomorphine-Mediated effects in a cell model for Parkinson\u2019s disease with partial least squares structure equation modeling. J. Comput. Biol. 27, 1273\u20131282 (2020).","journal-title":"J. Comput. Biol."},{"key":"95021_CR68","doi-asserted-by":"publisher","first-page":"e13796","DOI":"10.1111\/cts.13796","volume":"17","author":"E Thijssen","year":"2024","unstructured":"Thijssen, E. et al. Clinical trial evaluating apomorphine oromucosal solution in Parkinson\u2019s disease patients. Clin. Transl Sci. 17, e13796 (2024).","journal-title":"Clin. Transl Sci."},{"key":"95021_CR69","doi-asserted-by":"publisher","first-page":"519","DOI":"10.2165\/00023210-200822060-00005","volume":"22","author":"RM Trosch","year":"2008","unstructured":"Trosch, R. M., Silver, D. & Bottini, P. B. Intermittent subcutaneous apomorphine therapy for \u2018off\u2019 episodes in Parkinson\u2019s disease: a 6-month open-label study. CNS Drugs 22, 519\u2013527 (2008).","journal-title":"CNS Drugs"},{"key":"95021_CR70","doi-asserted-by":"publisher","first-page":"603","DOI":"10.3233\/JPD-171209","volume":"7","author":"S Bacchi","year":"2017","unstructured":"Bacchi, S., Chim, I., Kramer, P. & Postuma, R. B. Domperidone for hypotension in Parkinson\u2019s disease: A systematic review. J. Parkinsons Dis. 7, 603\u2013617 (2017).","journal-title":"J. Parkinsons Dis."},{"key":"95021_CR71","doi-asserted-by":"publisher","first-page":"45","DOI":"10.3109\/00207454.2011.620193","volume":"121","author":"JJ Chen","year":"2011","unstructured":"Chen, J. J. Pharmacologic safety concerns in Parkinson\u2019s disease: facts and insights. Int. J. Neurosci. 121, 45\u201352 (2011).","journal-title":"Int. J. Neurosci."},{"key":"95021_CR72","doi-asserted-by":"crossref","unstructured":"Whelton, P. K. et al. 2017 ACC\/ASPC\/NMA\/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: Executive Summary: A Report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines. Hypertension 71, 1269\u20131324 (2018).","DOI":"10.1161\/HYP.0000000000000075"},{"key":"95021_CR73","doi-asserted-by":"publisher","first-page":"704281","DOI":"10.3389\/fcvm.2021.704281","volume":"8","author":"A Calvi","year":"2021","unstructured":"Calvi, A. et al. Antidepressant drugs effects on blood pressure. Front. Cardiovasc. Med. 8, 704281 (2021).","journal-title":"Front. Cardiovasc. Med."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-95021-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-95021-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-95021-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T06:42:10Z","timestamp":1743316930000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-95021-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,26]]},"references-count":73,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["95021"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-95021-x","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,26]]},"assertion":[{"value":"11 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The data for this study was directly obtained from publicly available information in the US Food and Drug Administration Adverse Event Reporting System (FAERS), and therefore does not require ethics committee approval, nor does it involve the issue of participant consent.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}}],"article-number":"10359"}}