{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T10:59:13Z","timestamp":1778497153497,"version":"3.51.4"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T00:00:00Z","timestamp":1742947200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T00:00:00Z","timestamp":1742947200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Technology Project of Tianjin Binhai New Area Health Commission","award":["2019BWKY026"],"award-info":[{"award-number":["2019BWKY026"]}]},{"name":"The Talents Cultivated Project of Department of Urology, the Second Hospital of Tianjin Medical University","award":["MNRC202313"],"award-info":[{"award-number":["MNRC202313"]}]},{"name":"the Youth Fund of Tianjin Medical University Second Hospital","award":["2022ydey15"],"award-info":[{"award-number":["2022ydey15"]}]},{"name":"Scientific Research Project of Tianjin Municipal Education Commission","award":["2022ZD069"],"award-info":[{"award-number":["2022ZD069"]}]},{"name":"Tianjin Municipal Health Industry Key Project","award":["TJWJ2022XK014"],"award-info":[{"award-number":["TJWJ2022XK014"]}]},{"name":"Tianjin Health Science and Technology Project","award":["ZC20119"],"award-info":[{"award-number":["ZC20119"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-95684-6","type":"journal-article","created":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T13:03:13Z","timestamp":1742994193000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Development and validation of a nomogram for predicting prostatic urethral involvement in bladder cancer"],"prefix":"10.1038","volume":"15","author":[{"given":"Hao","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhe","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chong","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhouliang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunkai","family":"Qie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dawei","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shenglai","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hailong","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changli","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,3,26]]},"reference":[{"key":"95684_CR1","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.eururo.2016.06.010","volume":"71","author":"S Antoni","year":"2017","unstructured":"Antoni, S. et al. Bladder cancer incidence and mortality: A global overview and recent trends. Eur. Urol. 71, 96\u2013108. https:\/\/doi.org\/10.1016\/j.eururo.2016.06.010 (2017).","journal-title":"Eur. Urol."},{"key":"95684_CR2","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung, H. et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 71, 209\u2013249. https:\/\/doi.org\/10.3322\/caac.21660 (2021).","journal-title":"CA Cancer J. Clin."},{"key":"95684_CR3","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.eururo.2012.07.033","volume":"63","author":"M Burger","year":"2013","unstructured":"Burger, M. et al. Epidemiology and risk factors of urothelial bladder cancer. Eur. Urol. 63, 234\u2013241. https:\/\/doi.org\/10.1016\/j.eururo.2012.07.033 (2013).","journal-title":"Eur. Urol."},{"key":"95684_CR4","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/s0022-5347(05)67975-x","volume":"163","author":"F Millan-Rodriguez","year":"2000","unstructured":"Millan-Rodriguez, F., Chechile-Toniolo, G., Salvador-Bayarri, J., Palou, J. & Vicente-Rodriguez, J. Multivariate analysis of the prognostic factors of primary superficial bladder cancer. J. Urol. 163, 73\u201378. https:\/\/doi.org\/10.1016\/s0022-5347(05)67975-x (2000).","journal-title":"J. Urol."},{"key":"95684_CR5","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1016\/j.urolonc.2007.12.010","volume":"27","author":"DL Walsh","year":"2009","unstructured":"Walsh, D. L. & Chang, S. S. Dilemmas in the treatment of urothelial cancers of the prostate. Urol. Oncol. 27, 352\u2013357. https:\/\/doi.org\/10.1016\/j.urolonc.2007.12.010 (2009).","journal-title":"Urol. Oncol."},{"key":"95684_CR6","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1111\/bju.12486","volume":"114","author":"JJ Knoedler","year":"2014","unstructured":"Knoedler, J. J. et al. Urothelial carcinoma involving the prostate: The association of revised tumour stage and coexistent bladder cancer with survival after radical cystectomy. BJU Int. 114, 832\u2013836. https:\/\/doi.org\/10.1111\/bju.12486 (2014).","journal-title":"BJU Int."},{"key":"95684_CR7","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1016\/j.humpath.2006.01.027","volume":"37","author":"SS Shen","year":"2006","unstructured":"Shen, S. S. et al. Prostatic involvement by transitional cell carcinoma in patients with bladder cancer and its prognostic significance. Hum. Pathol. 37, 726\u2013734. https:\/\/doi.org\/10.1016\/j.humpath.2006.01.027 (2006).","journal-title":"Hum. Pathol."},{"key":"95684_CR8","doi-asserted-by":"publisher","first-page":"161","DOI":"10.3233\/BLC-160086","volume":"3","author":"M Moschini","year":"2017","unstructured":"Moschini, M. et al. Impact of the level of urothelial carcinoma involvement of the prostate on survival after radical cystectomy. Bladder Cancer. 3, 161\u2013169. https:\/\/doi.org\/10.3233\/BLC-160086 (2017).","journal-title":"Bladder Cancer"},{"key":"95684_CR9","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1016\/j.eururo.2005.05.021","volume":"48","author":"MU Mungan","year":"2005","unstructured":"Mungan, M. U., Canda, A. E., Tuzel, E., Yorukoglu, K. & Kirkali, Z. Risk factors for mucosal prostatic urethral involvement in superficial transitional cell carcinoma of the bladder. Eur. Urol. 48, 760\u2013763. https:\/\/doi.org\/10.1016\/j.eururo.2005.05.021 (2005).","journal-title":"Eur. Urol."},{"key":"95684_CR10","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1007\/s10147-011-0346-8","volume":"18","author":"K Ichihara","year":"2013","unstructured":"Ichihara, K., Kitamura, H., Masumori, N., Fukuta, F. & Tsukamoto, T. Transurethral prostate biopsy before radical cystectomy remains clinically relevant for decision-making on urethrectomy in patients with bladder cancer. Int. J. Clin. Oncol. 18, 75\u201380. https:\/\/doi.org\/10.1007\/s10147-011-0346-8 (2013).","journal-title":"Int. J. Clin. Oncol."},{"key":"95684_CR11","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1159\/000473591","volume":"19","author":"E Solsona","year":"1991","unstructured":"Solsona, E. et al. Recurrence of superficial bladder tumors in prostatic urethra. Eur. Urol. 19, 89\u201392. https:\/\/doi.org\/10.1159\/000473591 (1991).","journal-title":"Eur. Urol."},{"key":"95684_CR12","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.eururo.2021.08.010","volume":"81","author":"M Babjuk","year":"2022","unstructured":"Babjuk, M. et al. European association of urology guidelines on Non-muscle-invasive bladder cancer (Ta, T1, and carcinoma in Situ). Eur. Urol. 81, 75\u201394. https:\/\/doi.org\/10.1016\/j.eururo.2021.08.010 (2022).","journal-title":"Eur. Urol."},{"key":"95684_CR13","doi-asserted-by":"publisher","first-page":"e173","DOI":"10.1016\/S1470-2045(14)71116-7","volume":"16","author":"VP Balachandran","year":"2015","unstructured":"Balachandran, V. P., Gonen, M., Smith, J. J. & DeMatteo, R. P. Nomograms in oncology: More than Meets the eye. Lancet Oncol. 16, e173\u2013180. https:\/\/doi.org\/10.1016\/S1470-2045(14)71116-7 (2015).","journal-title":"Lancet Oncol."},{"key":"95684_CR14","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.1200\/JCO.2007.12.9791","volume":"26","author":"A Iasonos","year":"2008","unstructured":"Iasonos, A., Schrag, D., Raj, G. V. & Panageas, K. S. How to build and interpret a nomogram for cancer prognosis. J. Clin. Oncol. 26, 1364\u20131370. https:\/\/doi.org\/10.1200\/JCO.2007.12.9791 (2008).","journal-title":"J. Clin. Oncol."},{"key":"95684_CR15","doi-asserted-by":"publisher","unstructured":"Benlier, N. et al. A novel diagnostic tool for the detection of bladder cancer: Measurement of urinary high mobility group box-1. Urol. Oncol. 38 (685 e611-685 e616). https:\/\/doi.org\/10.1016\/j.urolonc.2020.03.025 (2020).","DOI":"10.1016\/j.urolonc.2020.03.025"},{"key":"95684_CR16","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1097\/PAI.0b013e31825f3264","volume":"21","author":"MR Raspollini","year":"2013","unstructured":"Raspollini, M. R. et al. A proposed score for assessing progression in pT1 high-grade urothelial carcinoma of the bladder. Appl. Immunohistochem. Mol. Morphol. 21, 218\u2013227. https:\/\/doi.org\/10.1097\/PAI.0b013e31825f3264 (2013).","journal-title":"Appl. Immunohistochem. Mol. Morphol."},{"key":"95684_CR17","doi-asserted-by":"publisher","first-page":"571","DOI":"10.5858\/arpa.2017-0539-RA","volume":"143","author":"G Wang","year":"2019","unstructured":"Wang, G. & McKenney, J. K. Urinary bladder pathology: World health organization classification and American joint committee on cancer staging update. Arch. Pathol. Lab. Med. 143, 571\u2013577. https:\/\/doi.org\/10.5858\/arpa.2017-0539-RA (2019).","journal-title":"Arch. Pathol. Lab. Med."},{"key":"95684_CR18","doi-asserted-by":"publisher","first-page":"g7594","DOI":"10.1136\/bmj.g7594","volume":"350","author":"GS Collins","year":"2015","unstructured":"Collins, G. S., Reitsma, J. B., Altman, D. G. & Moons, K. G. Transparent reporting of a multivariable prediction model for individual prognosis or diagnosis (TRIPOD): The TRIPOD statement. BMJ 350, g7594. https:\/\/doi.org\/10.1136\/bmj.g7594 (2015).","journal-title":"BMJ"},{"key":"95684_CR19","doi-asserted-by":"publisher","first-page":"2683","DOI":"10.1007\/s00345-019-02673-2","volume":"37","author":"A Brant","year":"2019","unstructured":"Brant, A. et al. Prognostic implications of prostatic urethral involvement in non-muscle-invasive bladder cancer. World J. Urol. 37, 2683\u20132689. https:\/\/doi.org\/10.1007\/s00345-019-02673-2 (2019).","journal-title":"World J. Urol."},{"key":"95684_CR20","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.juro.2008.03.134","volume":"179","author":"MP Revelo","year":"2008","unstructured":"Revelo, M. P. et al. Incidence and location of prostate and urothelial carcinoma in prostates from cystoprostatectomies: Implications for possible apical sparing surgery. J. Urol. 179, 27\u201332. https:\/\/doi.org\/10.1016\/j.juro.2008.03.134 (2008).","journal-title":"J. Urol."},{"key":"95684_CR21","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1186\/s12894-023-01342-2","volume":"23","author":"H Wan","year":"2023","unstructured":"Wan, H. et al. Assessing the prognostic impact of prostatic urethra involvement and developing a nomogram for T1 stage bladder cancer. BMC Urol. 23, 182. https:\/\/doi.org\/10.1186\/s12894-023-01342-2 (2023).","journal-title":"BMC Urol."},{"key":"95684_CR22","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.juro.2014.07.114","volume":"193","author":"FC von Rundstedt","year":"2015","unstructured":"von Rundstedt, F. C. et al. Usefulness of transurethral biopsy for staging the prostatic urethra before radical cystectomy. J. Urol. 193, 58\u201363. https:\/\/doi.org\/10.1016\/j.juro.2014.07.114 (2015).","journal-title":"J. Urol."},{"key":"95684_CR23","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1016\/S0022-5347(05)66352-5","volume":"165","author":"SM Donat","year":"2001","unstructured":"Donat, S. M., Wei, D. C., McGuire, M. S. & Herr, H. W. The efficacy of transurethral biopsy for predicting the long-term clinical impact of prostatic invasive bladder cancer. J. Urol. 165, 1580\u20131584 (2001).","journal-title":"J. Urol."},{"key":"95684_CR24","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1093\/jjco\/hyr013","volume":"41","author":"K Kiyoshima","year":"2011","unstructured":"Kiyoshima, K., Kuroiwa, K., Uchino, H., Yokomizo, A. & Naito, S. Depth and origin of prostatic involvement by urothelial carcinoma: Prognostic significance and staging interpretation. Jpn J. Clin. Oncol. 41, 642\u2013646. https:\/\/doi.org\/10.1093\/jjco\/hyr013 (2011).","journal-title":"Jpn J. Clin. Oncol."},{"key":"95684_CR25","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1016\/S0022-5347(01)69073-6","volume":"167","author":"RG Nixon","year":"2002","unstructured":"Nixon, R. G., Chang, S. S., Lafleur, B. J., Smith, J. J. & Cookson, M. S. Carcinoma in situ and tumor multifocality predict the risk of prostatic urethral involvement at radical cystectomy in men with transitional cell carcinoma of the bladder. J. Urol. 167, 502\u2013505. https:\/\/doi.org\/10.1016\/S0022-5347(01)69073-6 (2002).","journal-title":"J. Urol."},{"key":"95684_CR26","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1055\/s-2003-42002","volume":"34","author":"F Liedberg","year":"2003","unstructured":"Liedberg, F. et al. [Transitional cell carcinoma of the prostate in cystoprostatectomy specimens]. Aktuelle Urol. 34, 333\u2013336. https:\/\/doi.org\/10.1055\/s-2003-42002 (2003).","journal-title":"Aktuelle Urol."},{"key":"95684_CR27","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.juro.2008.03.037","volume":"180","author":"W Kassouf","year":"2008","unstructured":"Kassouf, W. et al. Prostatic urethral biopsy has limited usefulness in counseling patients regarding final urethral margin status during orthotopic neobladder reconstruction. J. Urol. 180, 164\u2013167. https:\/\/doi.org\/10.1016\/j.juro.2008.03.037 (2008). discussion 167.","journal-title":"J. Urol."},{"key":"95684_CR28","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/j.urology.2009.03.010","volume":"74","author":"R Mazzucchelli","year":"2009","unstructured":"Mazzucchelli, R. et al. Prediction of prostatic involvement by urothelial carcinoma in radical cystoprostatectomy for bladder cancer. Urology 74, 385\u2013390. https:\/\/doi.org\/10.1016\/j.urology.2009.03.010 (2009).","journal-title":"Urology"},{"key":"95684_CR29","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1016\/j.urolonc.2008.03.002","volume":"26","author":"SP Lerner","year":"2008","unstructured":"Lerner, S. P. & Shen, S. Pathologic assessment and clinical significance of prostatic involvement by transitional cell carcinoma and prostate cancer. Urol. Oncol. 26, 481\u2013485. https:\/\/doi.org\/10.1016\/j.urolonc.2008.03.002 (2008).","journal-title":"Urol. Oncol."},{"key":"95684_CR30","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1016\/j.urology.2009.09.081","volume":"75","author":"KA Richards","year":"2010","unstructured":"Richards, K. A. et al. Developing selection criteria for prostate-sparing cystectomy: A review of cystoprostatectomy specimens. Urology 75, 1116\u20131120. https:\/\/doi.org\/10.1016\/j.urology.2009.09.081 (2010).","journal-title":"Urology"},{"key":"95684_CR31","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.eururo.2011.10.029","volume":"62","author":"J Palou","year":"2012","unstructured":"Palou, J. et al. Female gender and carcinoma in situ in the prostatic urethra are prognostic factors for recurrence, progression, and disease-specific mortality in T1G3 bladder cancer patients treated with Bacillus Calmette-Guerin. Eur. Urol. 62, 118\u2013125. https:\/\/doi.org\/10.1016\/j.eururo.2011.10.029 (2012).","journal-title":"Eur. Urol."},{"key":"95684_CR32","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1111\/j.1442-2042.2012.03089.x","volume":"19","author":"AJ Lightfoot","year":"2012","unstructured":"Lightfoot, A. J., Rosevear, H. M., Nepple, K. G. & O\u2019Donnell, M. A. Role of routine transurethral biopsy and isolated upper tract cytology after intravesical treatment of high-grade non-muscle invasive bladder cancer. Int. J. Urol. 19, 988\u2013993. https:\/\/doi.org\/10.1111\/j.1442-2042.2012.03089.x (2012).","journal-title":"Int. J. Urol."},{"key":"95684_CR33","first-page":"499","volume":"19","author":"DL Lamm","year":"1992","unstructured":"Lamm, D. L. Carcinoma in situ. Urol. Clin. North. Am. 19, 499\u2013508 (1992).","journal-title":"Urol. Clin. North. Am."},{"key":"95684_CR34","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1016\/S0022-5347(05)68826-X","volume":"161","author":"HW Herr","year":"1999","unstructured":"Herr, H. W. & Donat, S. M. Prostatic tumor relapse in patients with superficial bladder tumors: 15-year outcome. J. Urol. 161, 1854\u20131857 (1999).","journal-title":"J. Urol."},{"key":"95684_CR35","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.eururo.2018.04.029","volume":"74","author":"V Panebianco","year":"2018","unstructured":"Panebianco, V. et al. Multiparametric magnetic resonance imaging for bladder cancer: Development of VI-RADS (Vesical imaging-Reporting and data System). Eur. Urol. 74, 294\u2013306. https:\/\/doi.org\/10.1016\/j.eururo.2018.04.029 (2018).","journal-title":"Eur. Urol."},{"key":"95684_CR36","doi-asserted-by":"publisher","first-page":"102530","DOI":"10.1016\/j.ctrv.2023.102530","volume":"115","author":"CM Ascione","year":"2023","unstructured":"Ascione, C. M. et al. Role of FGFR3 in bladder cancer: Treatment landscape and future challenges. Cancer Treat. Rev. 115, 102530. https:\/\/doi.org\/10.1016\/j.ctrv.2023.102530 (2023).","journal-title":"Cancer Treat. Rev."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-95684-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-95684-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-95684-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T13:03:27Z","timestamp":1742994207000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-95684-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,26]]},"references-count":36,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["95684"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-95684-6","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,26]]},"assertion":[{"value":"9 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"In accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments, the present study was approved by the Medical Ethics Committee of the Second Hospital of Tianjin Medical University (Office Address: Third floor of the Comprehensive Building, The Second Hospital of Tianjin Medical University, Tianjin, China) (ethics approval number: KY2024K207, date of approval: April 15, 2024). All patients\u2019 records were analyzed anonymously in the retrospective study, which did not affect the clinical course of any patient. Due to the retrospective nature of the study, Medical Ethics Committee of the Second Hospital of Tianjin Medical University waived the need of obtaining informed consent.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics statement"}}],"article-number":"10431"}}