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Full factorial design was used for rapid optimization of the proposed method. Chromatographic separation was reached using isocratic elution on C18 column. The mobile phase was a mixture of methanol: acetonitrile: 0.05\u00a0M potassium dihydrogen phosphate buffer at pH 5, adjusted using phosphoric acid and\/or NaOH when needed. The flow rate was 1 mL\/min and the injection volume was 20 \u00b5L. The detection wavelength was 230\u00a0nm. The working ranges of the method were 5.0-100.0 and 10.0\u2013100.0\u00a0\u00b5g\/mL, LOD values were 0.8 and 1.8\u00a0\u00b5g\/mL and LOQ values were 2.6 and 5.5\u00a0\u00b5g\/mL for meloxicam and esomeprazole, respectively. The proposed method was successfully applied to their combined tablet dosage forms with acceptable % recoveries (100.4 \u2212\u2009100.7%) obtained. Four methods were used to evaluate the greenness of the proposed method, suggesting the acceptability of the greenness of the proposed method. <\/jats:p>","DOI":"10.1038\/s41598-025-95706-3","type":"journal-article","created":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T09:50:08Z","timestamp":1744710608000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Deduction of full factorial design of HPLC technique for the simultaneous analysis of meloxicam and esomeprazole in their laboratory prepared tablets"],"prefix":"10.1038","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6532-5373","authenticated-orcid":false,"given":"Hesham Sameh","family":"Ramadan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fathalla","family":"Belal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aya","family":"Roshdy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4429-6504","authenticated-orcid":false,"given":"Mohamed M.","family":"Salim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,15]]},"reference":[{"key":"95706_CR1","doi-asserted-by":"publisher","first-page":"450","DOI":"10.4103\/joacp.JOACP_133_18","volume":"34","author":"A 1 Bekker","year":"2018","unstructured":"1 Bekker, A., Kloepping, C. & Collingwood, S. 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