{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:47:19Z","timestamp":1790794039015,"version":"4.1.0"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-95852-8","type":"journal-article","created":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T15:56:30Z","timestamp":1743522990000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Association of the digital clock drawing test with amyloid and tau PET biomarkers in low age risk adults"],"prefix":"10.1038","volume":"15","author":[{"given":"Huitong","family":"Ding","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenglin","family":"Lyu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cody","family":"Karjadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preeti","family":"Sunderaraman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina B.","family":"Young","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth C.","family":"Mormino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spencer","family":"Low","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherral","family":"Devine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Gifford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhoda","family":"Au","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honghuang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,1]]},"reference":[{"key":"95852_CR1","doi-asserted-by":"publisher","first-page":"5541","DOI":"10.2147\/IJN.S200490","volume":"66","author":"S Tiwari","year":"2019","unstructured":"Tiwari, S. et al. Alzheimer\u2019s disease: pathogenesis, diagnostics, and therapeutics. Int. J. Nanomed. 66, 5541\u20135554 (2019).","journal-title":"Int. J. Nanomed."},{"issue":"4","key":"95852_CR2","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1016\/j.pneurobio.2011.11.008","volume":"95","author":"H Hampel","year":"2011","unstructured":"Hampel, H. et al. The future of Alzheimer\u2019s disease: The next 10 years. Prog. Neurobiol. 95(4), 718\u2013728 (2011).","journal-title":"Prog. Neurobiol."},{"issue":"5","key":"95852_CR3","doi-asserted-by":"publisher","first-page":"1752","DOI":"10.1002\/alz.12802","volume":"19","author":"N Swaddiwudhipong","year":"2023","unstructured":"Swaddiwudhipong, N. et al. Pre-diagnostic cognitive and functional impairment in multiple sporadic neurodegenerative diseases. Alzheimers Dement. 19(5), 1752\u20131763 (2023).","journal-title":"Alzheimers Dement."},{"key":"95852_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13024-020-00391-7","volume":"15","author":"T Guo","year":"2020","unstructured":"Guo, T. et al. Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer\u2019s disease. Mol. Neurodegener. 15, 1\u201337 (2020).","journal-title":"Mol. Neurodegener."},{"issue":"3","key":"95852_CR5","doi-asserted-by":"publisher","first-page":"138","DOI":"10.3390\/jpm10030138","volume":"10","author":"WJ Lukiw","year":"2020","unstructured":"Lukiw, W. J. et al. Biomarkers for Alzheimer\u2019s disease (AD) and the application of precision medicine. J. Pers. Med. 10(3), 138 (2020).","journal-title":"J. Pers. Med."},{"issue":"12","key":"95852_CR6","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1056\/NEJMoa2305032","volume":"389","author":"RA Sperling","year":"2023","unstructured":"Sperling, R. A. et al. Trial of solanezumab in preclinical Alzheimer\u2019s disease. N. Engl. J. Med. 389(12), 1096\u20131107 (2023).","journal-title":"N. Engl. J. Med."},{"issue":"8","key":"95852_CR7","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1016\/S1474-4422(22)00168-5","volume":"21","author":"R Ossenkoppele","year":"2022","unstructured":"Ossenkoppele, R., van der Kant, R. & Hansson, O. Tau biomarkers in Alzheimer\u2019s disease: Towards implementation in clinical practice and trials. Lancet Neurol. 21(8), 726\u2013734 (2022).","journal-title":"Lancet Neurol."},{"issue":"4","key":"95852_CR8","first-page":"412","volume":"1","author":"N Mattsson","year":"2015","unstructured":"Mattsson, N. et al. Revolutionizing Alzheimer\u2019s disease and clinical trials through biomarkers. Alzheimer\u2019s Dementia Diagn. Assess. Dis. Monit. 1(4), 412\u2013419 (2015).","journal-title":"Alzheimer\u2019s Dementia Diagn. Assess. Dis. Monit."},{"key":"95852_CR9","first-page":"66","volume":"6","author":"MT Ferretti","year":"2023","unstructured":"Ferretti, M. T. et al. Maximizing utility of neuropsychological measures in sex-specific predictive models of incident Alzheimer\u2019s disease in the Framingham Heart Study. Alzheimer\u2019s & Dement. 6, 66 (2023).","journal-title":"Alzheimer\u2019s & Dement."},{"key":"95852_CR10","first-page":"127","volume":"2","author":"H Ding","year":"2024","unstructured":"Ding, H. et al. Prediction of progression from mild cognitive impairment to Alzheimer\u2019s disease with longitudinal and multimodal data. Front. Dement. 2, 127\u20131680 (2024).","journal-title":"Front. Dement."},{"key":"95852_CR11","first-page":"1","volume":"66","author":"H Ding","year":"2023","unstructured":"Ding, H. et al. Multimodal machine learning for 10-year dementia risk prediction: The Framingham Heart Study. J. Alzheimer\u2019s Dis. 66, 1\u201310 (2023).","journal-title":"J. Alzheimer\u2019s Dis."},{"issue":"4","key":"95852_CR12","doi-asserted-by":"publisher","DOI":"10.2196\/15376","volume":"22","author":"H Ding","year":"2020","unstructured":"Ding, H. et al. Exploring the hierarchical influence of cognitive functions for alzheimer disease: The Framingham heart study. J. Med. Internet Res. 22(4), e15376 (2020).","journal-title":"J. Med. Internet Res."},{"key":"95852_CR13","first-page":"264","volume":"5","author":"TFA Ang","year":"2019","unstructured":"Ang, T. F. A. et al. Using data science to diagnose and characterize heterogeneity of Alzheimer\u2019s disease. Alzheimers Dement 5, 264\u2013271 (2019).","journal-title":"Alzheimers Dement"},{"key":"95852_CR14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/alzrt155","volume":"5","author":"DM Rentz","year":"2013","unstructured":"Rentz, D. M. et al. Promising developments in neuropsychological approaches for the detection of preclinical Alzheimer\u2019s disease: a selective review. Alzheimer\u2019s Res. Therapy 5, 1\u201310 (2013).","journal-title":"Alzheimer\u2019s Res. Therapy"},{"key":"95852_CR15","unstructured":"Penney, D., et al. The digital clock drawing test (dcdt)-II: a new computerized quantitative system. In Annual Meeting of The International Neuropsychological Society (2010)."},{"key":"95852_CR16","doi-asserted-by":"crossref","unstructured":"Ding, H., et al. The utility of the digital clock drawing test as an accurate early screening tool for those with preclinical Alzheimer\u2019s disease. In Alzheimer\u2019s Association International Conference (ALZ, 2023).","DOI":"10.1002\/alz.075294"},{"issue":"6","key":"95852_CR17","doi-asserted-by":"publisher","DOI":"10.2196\/27407","volume":"23","author":"J Yuan","year":"2021","unstructured":"Yuan, J. et al. Association between the digital clock drawing test and neuropsychological test performance: Large community-based prospective cohort (Framingham heart study). J. Med. Internet Res. 23(6), e27407 (2021).","journal-title":"J. Med. Internet Res."},{"issue":"4","key":"95852_CR18","doi-asserted-by":"publisher","DOI":"10.2196\/34513","volume":"24","author":"J Yuan","year":"2022","unstructured":"Yuan, J. et al. Associations between the digital clock drawing test and brain volume: Large community-based prospective cohort (Framingham heart study). J. Med. Internet Res. 24(4), e34513 (2022).","journal-title":"J. Med. Internet Res."},{"issue":"14","key":"95852_CR19","doi-asserted-by":"publisher","first-page":"e1844","DOI":"10.1212\/WNL.0000000000011697","volume":"96","author":"DM Rentz","year":"2021","unstructured":"Rentz, D. M. et al. Association of digital clock drawing with PET amyloid and tau pathology in normal older adults. Neurology 96(14), e1844\u2013e1854 (2021).","journal-title":"Neurology"},{"key":"95852_CR20","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1007\/s40846-016-0143-y","volume":"36","author":"N-Y Yu","year":"2016","unstructured":"Yu, N.-Y. & Chang, S.-H. Kinematic analyses of graphomotor functions in individuals with Alzheimer\u2019s disease and amnestic mild cognitive impairment. J. Med. Biol. Eng. 36, 334\u2013343 (2016).","journal-title":"J. Med. Biol. Eng."},{"key":"95852_CR21","doi-asserted-by":"publisher","first-page":"1280593","DOI":"10.3389\/fpsyg.2023.1280593","volume":"14","author":"DJ Libon","year":"2023","unstructured":"Libon, D. J. et al. Using digital assessment technology to detect neuropsychological problems in primary care settings. Front. Psychol. 14, 1280593 (2023).","journal-title":"Front. Psychol."},{"issue":"1","key":"95852_CR22","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.pharmthera.2012.07.001","volume":"136","author":"DS Himmelstein","year":"2012","unstructured":"Himmelstein, D. S. et al. Tau as a therapeutic target in neurodegenerative disease. Pharmacol. Ther. 136(1), 8\u201322 (2012).","journal-title":"Pharmacol. Ther."},{"issue":"6","key":"95852_CR23","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1080\/13554791003730600","volume":"16","author":"KL Possin","year":"2010","unstructured":"Possin, K. L. Visual spatial cognition in neurodegenerative disease. Neurocase 16(6), 466\u2013487 (2010).","journal-title":"Neurocase"},{"key":"95852_CR24","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1007\/s00401-016-1618-1","volume":"132","author":"KA Josephs","year":"2016","unstructured":"Josephs, K. A. et al. [18F] AV-1451 tau-PET uptake does correlate with quantitatively measured 4R-tau burden in autopsy-confirmed corticobasal degeneration. Acta Neuropathol. 132, 931\u2013933 (2016).","journal-title":"Acta Neuropathol."},{"issue":"2","key":"95852_CR25","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1097\/01.wnn.0000119564.08162.46","volume":"17","author":"S Cosentino","year":"2004","unstructured":"Cosentino, S. et al. Clock drawing errors in dementia: neuropsychological and neuroanatomical considerations. Cogn. Behav. Neurol. 17(2), 74\u201384 (2004).","journal-title":"Cogn. Behav. Neurol."},{"key":"95852_CR26","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1109\/RBME.2018.2840679","volume":"12","author":"D Impedovo","year":"2018","unstructured":"Impedovo, D. & Pirlo, G. Dynamic handwriting analysis for the assessment of neurodegenerative diseases: A pattern recognition perspective. IEEE Rev. Biomed. Eng. 12, 209\u2013220 (2018).","journal-title":"IEEE Rev. Biomed. Eng."},{"issue":"9921","key":"95852_CR27","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1016\/S0140-6736(13)61752-3","volume":"383","author":"SS Mahmood","year":"2014","unstructured":"Mahmood, S. S. et al. The Framingham Heart Study and the epidemiology of cardiovascular disease: A historical perspective. The Lancet 383(9921), 999\u20131008 (2014).","journal-title":"The Lancet"},{"issue":"6","key":"95852_CR28","doi-asserted-by":"publisher","first-page":"1800","DOI":"10.1093\/ije\/dyv337","volume":"44","author":"CW Tsao","year":"2015","unstructured":"Tsao, C. W. & Vasan, R. S. Cohort Profile: The Framingham Heart Study (FHS): Overview of milestones in cardiovascular epidemiology. Int. J. Epidemiol. 44(6), 1800\u20131813 (2015).","journal-title":"Int. J. Epidemiol."},{"issue":"5","key":"95852_CR29","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1001\/archneurol.2011.977","volume":"69","author":"PA Wolf","year":"2012","unstructured":"Wolf, P. A. Contributions of the Framingham Heart Study to stroke and dementia epidemiologic research at 60 years. Arch. Neurol. 69(5), 567\u2013571 (2012).","journal-title":"Arch. Neurol."},{"issue":"5","key":"95852_CR30","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1016\/S0022-5347(17)38063-1","volume":"146","author":"KL Burgio","year":"1991","unstructured":"Burgio, K. L., Matthews, K. A. & Engel, B. T. Prevalence, incidence and correlates of urinary incontinence in healthy, middle-aged women. J. Urol. 146(5), 1255\u20131259 (1991).","journal-title":"J. Urol."},{"issue":"8","key":"95852_CR31","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1016\/j.amjcard.2011.11.061","volume":"109","author":"RJ Prineas","year":"2012","unstructured":"Prineas, R. J. et al. United States national prevalence of electrocardiographic abnormalities in black and white middle-age (45- to 64-Year) and older (>\/=65-Year) adults (from the Reasons for Geographic and Racial Differences in Stroke Study). Am. J. Cardiol. 109(8), 1223\u20131228 (2012).","journal-title":"Am. J. Cardiol."},{"issue":"5","key":"95852_CR32","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1007\/s11596-020-2270-5","volume":"40","author":"CH Jiang","year":"2020","unstructured":"Jiang, C. H., Zhu, F. & Qin, T. T. Relationships between chronic diseases and depression among middle-aged and elderly people in China: A prospective study from CHARLS. Curr. Med. Sci. 40(5), 858\u2013870 (2020).","journal-title":"Curr. Med. Sci."},{"issue":"1","key":"95852_CR33","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1212\/CON.0000000000000700","volume":"25","author":"GD Rabinovici","year":"2019","unstructured":"Rabinovici, G. D. Late-onset Alzheimer disease. Continu. Lifelong Learn. Neurol. 25(1), 14\u201333 (2019).","journal-title":"Continu. Lifelong Learn. Neurol."},{"issue":"1","key":"95852_CR34","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.jalz.2017.04.013","volume":"14","author":"J Li","year":"2018","unstructured":"Li, J. et al. Practical risk score for 5-, 10-, and 20-year prediction of dementia in elderly persons: Framingham Heart Study. Alzheimers Dement. 14(1), 35\u201342 (2018).","journal-title":"Alzheimers Dement."},{"issue":"1","key":"95852_CR35","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1212\/WNL.42.1.115","volume":"42","author":"D Bachman","year":"1992","unstructured":"Bachman, D. et al. Prevalence of dementia and probable senile dementia of the Alzheimer type in the Framingham Study. Neurology 42(1), 115\u2013115 (1992).","journal-title":"Neurology"},{"issue":"6","key":"95852_CR36","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1056\/NEJMoa1504327","volume":"374","author":"CL Satizabal","year":"2016","unstructured":"Satizabal, C. L. et al. Incidence of dementia over three decades in the Framingham Heart Study. N. Engl. J. Med. 374(6), 523\u2013532 (2016).","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"95852_CR37","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1002\/ana.26382","volume":"92","author":"RF Buckley","year":"2022","unstructured":"Buckley, R. F. et al. Menopause status moderates sex differences in tau burden: A Framingham PET study. Ann. Neurol. 92(1), 11\u201322 (2022).","journal-title":"Ann. Neurol."},{"issue":"4","key":"95852_CR38","doi-asserted-by":"publisher","first-page":"1603","DOI":"10.3233\/JAD-215372","volume":"86","author":"HI Jacobs","year":"2022","unstructured":"Jacobs, H. I. et al. Associations between brainstem volume and Alzheimer\u2019s disease pathology in middle-aged individuals of the Framingham Heart Study. J. Alzheimers Dis. 86(4), 1603\u20131609 (2022).","journal-title":"J. Alzheimers Dis."},{"issue":"3","key":"95852_CR39","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.3233\/JAD-215409","volume":"86","author":"G Weinstein","year":"2022","unstructured":"Weinstein, G. et al. Non-alcoholic fatty liver disease, liver fibrosis, and regional amyloid-\u03b2 and tau pathology in middle-aged adults: The Framingham study. J. Alzheimers Dis. 86(3), 1371\u20131383 (2022).","journal-title":"J. Alzheimers Dis."},{"issue":"577","key":"95852_CR40","doi-asserted-by":"publisher","first-page":"eabc0655","DOI":"10.1126\/scitranslmed.abc0655","volume":"13","author":"JS Sanchez","year":"2021","unstructured":"Sanchez, J. S. et al. The cortical origin and initial spread of medial temporal tauopathy in Alzheimer\u2019s disease assessed with positron emission tomography. Sci. Transl. Med. 13(577), eabc0655 (2021).","journal-title":"Sci. Transl. Med."},{"issue":"1","key":"95852_CR41","doi-asserted-by":"publisher","first-page":"249","DOI":"10.3233\/JAD-210232","volume":"82","author":"MM Gonzales","year":"2021","unstructured":"Gonzales, M. M. et al. Association of midlife depressive symptoms with regional amyloid-\u03b2 and tau in the Framingham Heart Study. J. Alzheimers Dis. 82(1), 249\u2013260 (2021).","journal-title":"J. Alzheimers Dis."},{"issue":"7","key":"95852_CR42","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1001\/jamaneurol.2022.1261","volume":"79","author":"LL Cooper","year":"2022","unstructured":"Cooper, L. L. et al. Association of aortic stiffness and pressure pulsatility with global amyloid-\u03b2 and regional tau burden among Framingham Heart Study participants without dementia. JAMA Neurol. 79(7), 710\u2013719 (2022).","journal-title":"JAMA Neurol."},{"key":"95852_CR43","first-page":"66","volume":"6","author":"CB Young","year":"2024","unstructured":"Young, C. B. et al. Speech patterns during memory recall relates to early tau burden across adulthood. Alzheimers Dement. 6, 66 (2024).","journal-title":"Alzheimers Dement."},{"issue":"1","key":"95852_CR44","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1186\/s13195-021-00836-1","volume":"13","author":"SK Royse","year":"2021","unstructured":"Royse, S. K. et al. Validation of amyloid PET positivity thresholds in centiloids: A multisite PET study approach. Alzheimer\u2019s Res. Therapy 13(1), 99 (2021).","journal-title":"Alzheimer\u2019s Res. Therapy"},{"issue":"10","key":"95852_CR45","doi-asserted-by":"publisher","first-page":"1444","DOI":"10.2967\/jnumed.118.224113","volume":"60","author":"SL Baker","year":"2019","unstructured":"Baker, S. L. et al. Effect of off-target binding on 18F-flortaucipir variability in healthy controls across the life span. J. Nucl. Med. 60(10), 1444\u20131451 (2019).","journal-title":"J. Nucl. Med."},{"key":"95852_CR46","first-page":"66","volume":"6","author":"R Davis","year":"2011","unstructured":"Davis, R. et al. The digital clock drawing test (dCDT) I: Development of a new computerized quantitative system. Int. Neuropsychol. Soc. 6, 66 (2011).","journal-title":"Int. Neuropsychol. Soc."},{"issue":"3","key":"95852_CR47","first-page":"49","volume":"36","author":"R Davis","year":"2015","unstructured":"Davis, R. et al. THink: Inferring cognitive status from subtle behaviors. AI Mag. 36(3), 49\u201360 (2015).","journal-title":"AI Mag."},{"key":"95852_CR48","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1007\/s10994-015-5529-5","volume":"102","author":"W Souillard-Mandar","year":"2016","unstructured":"Souillard-Mandar, W. et al. Learning classification models of cognitive conditions from subtle behaviors in the digital clock drawing test. Mach. Learn. 102, 393\u2013441 (2016).","journal-title":"Mach. Learn."},{"key":"95852_CR49","first-page":"1","volume":"66","author":"LI Thompson","year":"2023","unstructured":"Thompson, L. I. et al. Digital clock drawing as an Alzheimer\u2019s disease susceptibility biomarker: Associations with genetic risk score and APOE in older adults. J. Prev. Alzheimer\u2019s Dis. 66, 1\u20139 (2023).","journal-title":"J. Prev. Alzheimer\u2019s Dis."},{"issue":"4","key":"95852_CR50","doi-asserted-by":"publisher","first-page":"1611","DOI":"10.3233\/JAD-170444","volume":"60","author":"RJ Piers","year":"2017","unstructured":"Piers, R. J. et al. Age and graphomotor decision making assessed with the digital clock drawing test: the Framingham Heart Study. J. Alzheimers Dis. 60(4), 1611\u20131620 (2017).","journal-title":"J. Alzheimers Dis."},{"issue":"8","key":"95852_CR51","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1037\/neu0000411","volume":"31","author":"R Au","year":"2017","unstructured":"Au, R., Piers, R. J. & Devine, S. How technology is reshaping cognitive assessment: Lessons from the Framingham Heart Study. Neuropsychology 31(8), 846 (2017).","journal-title":"Neuropsychology"},{"key":"95852_CR52","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1613\/jair.953","volume":"16","author":"NV Chawla","year":"2002","unstructured":"Chawla, N. V. et al. SMOTE: synthetic minority over-sampling technique. J. Artif. Intell. Res. 16, 321\u2013357 (2002).","journal-title":"J. Artif. Intell. Res."},{"key":"95852_CR53","unstructured":"Framingham Heart Study for Researchers. (2024) [cited 2024 04\/22\/2024]. https:\/\/www.framinghamheartstudy.org\/fhs-for-researchers\/."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-95852-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-95852-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-95852-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T16:39:38Z","timestamp":1743784778000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-95852-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,1]]},"references-count":53,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["95852"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-95852-8","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,1]]},"assertion":[{"value":"5 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"RA is a scientific advisor to Signant Health and NovoNordisk. The other authors state that this study was carried out without any commercial or financial affiliations that might be seen as a possible conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"11104"}}