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This double-blinded two parallel armed randomized controlled clinical trial comprised the allocation of 108 patients with traumatically exposed dental pulp during the management of deep carious lesions by undergraduate students after fulfilling inclusion and exclusion criteria. Patients were randomized into two groups (<jats:italic>n<\/jats:italic>\u2009=\u200954 in each group) using computer-generated simple randomization, wherein one group Platelet Rich Fibrin (PRF) was prepared from patients\u2019 blood samples and applied directly over exposed pulp followed by MTA application and in the other group MTA was applied directly over pulp exposure. In both groups, cavities were restored with resin-modified glass ionomer liner and resin composite restoration. The overall success of treatment was calculated at 6 and 12\u00a0months after assessing pulp sensibility, history of pain, tenderness on percussion and the existence of any periapical pathosis using in periapical radiographs. Moreover CBCT was used at 12 months to determine the presence or absence of dentin bridge as a secondary outcome. After 12 months follow-up, there was no statistically significant difference in overall success of pulp capping in both groups. As the both groups showed 92.59% success rate. CBCT evaluation of dentin bridge formation by Platelet Rich Fibrin (PRF) demonstrated a significantly higher percentage than that formed in cases treated with MTA alone (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Direct pulp capping with Platelet Rich Fibrin (PRF) exhibited a clinical and radiographic success rate comparable to that of MTA. Platelet Rich Fibrin (PRF) can be implemented as a direct pulp capping agent in forthcoming clinical applications.<\/jats:p>","DOI":"10.1038\/s41598-025-96056-w","type":"journal-article","created":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T04:57:31Z","timestamp":1744693051000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Clinical and radiographic assessment of mineral trioxide aggregate with platelet rich fibrin as pulp capping biomaterials: a 12-month randomized trial"],"prefix":"10.1038","volume":"15","author":[{"given":"Rahma Ahmed Ibrahem Hafiz","family":"Abuhashema","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona El Saied","family":"Essa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1047-124X","authenticated-orcid":false,"given":"Shereen Hafez","family":"Ibrahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omaima Mohamed","family":"Safwat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,15]]},"reference":[{"issue":"7","key":"96056_CR1","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1111\/iej.13128","volume":"52","author":"L Bj\u00f8rndal","year":"2019","unstructured":"Bj\u00f8rndal, L., Simon, S., Tomson, P. 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All the study logistical and clinical procedures were approved by the research ethics committee of the faculty of dentistry, Cairo University (Approval no. 13.9.20) that was in accordance with the ethical standard of Helsinki. Written informed consent with an easy Arabic language as mother language of participants was signed by the recruited participants to permit the use of the clinical photos and other investigation data.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}},{"value":"The authors certify that they have obtained all appropriate patient consent forms. In the form, the patient(s) has\/ have given his\/ her\/ their consent for his\/ her\/ their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published, and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed. Written informed consent with an easy Arabic language as mother language of participants was signed by the participant to permit the use of the clinical photos and other investigation data. All authors read and approved the submission and publication.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"12874"}}