{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T19:58:54Z","timestamp":1793735934088,"version":"4.6.1"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T00:00:00Z","timestamp":1743724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T00:00:00Z","timestamp":1743724800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-96554-x","type":"journal-article","created":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T01:56:56Z","timestamp":1743818216000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Value of lung ultrasound scores in assessing extravascular lung water in septic shock patients"],"prefix":"10.1038","volume":"15","author":[{"given":"Xueyan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhifeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,4]]},"reference":[{"key":"96554_CR1","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1097\/CCM.0000000000002244","volume":"45","author":"SO Kuhn","year":"2017","unstructured":"Kuhn, S. O., Meissner, K. & Rehberg, S. Fluid resuscitation in sepsis: Get the balance right. Crit. Care Med. 45, 555\u2013556 (2017).","journal-title":"Crit. Care Med."},{"key":"96554_CR2","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1177\/0310057X1204000304","volume":"40","author":"E Litton","year":"2012","unstructured":"Litton, E. & Morgan, M. The PiCCO monitor: A review. Anaesth. Intensive Care. 40, 393\u2013408 (2012).","journal-title":"Anaesth. Intensive Care"},{"key":"96554_CR3","first-page":"248","volume":"31","author":"K Yu","year":"2019","unstructured":"Yu, K. et al. Application of critical care ultrasound in hemodynamic monitoring of septic shock. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 31, 248\u2013251 (2019).","journal-title":"Zhonghua Wei Zhong Bing Ji Jiu Yi Xue"},{"key":"96554_CR4","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.3390\/jcm13082334","volume":"13","author":"S Kopp","year":"2024","unstructured":"Kopp, S. et al. Injection site matters: A comparative analysis of transpulmonary thermodilution via simultaneous femoral and jugular indicator injections under veno-venous extracorporeal membrane oxygenation therapy. J. Clin. Med. 13, 2334 (2024).","journal-title":"J. Clin. Med."},{"key":"96554_CR5","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1097\/01.CCM.0000130995.18334.8B","volume":"32","author":"R Katzenelson","year":"2004","unstructured":"Katzenelson, R. et al. Accuracy of transpulmonary thermodilution versus gravimetric measurement of extravascular lung water. Crit. Care Med. 32, 1550\u20131554 (2004).","journal-title":"Crit. Care Med."},{"key":"96554_CR6","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","volume":"315","author":"M Singer","year":"2016","unstructured":"Singer, M. et al. The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA 315, 801\u2013810 (2016).","journal-title":"JAMA"},{"key":"96554_CR7","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1055\/s-0042-120260","volume":"38","author":"S Mongodi","year":"2017","unstructured":"Mongodi, S. et al. Modified lung ultrasound score for assessing and monitoring pulmonary aeration. Ultraschall Med. 38, 530\u2013537 (2017).","journal-title":"Ultraschall Med."},{"key":"96554_CR8","first-page":"3124966","volume":"2022","author":"MS Sayed","year":"2022","unstructured":"Sayed, M. S., Elmeslmany, K. A., Elsawy, A. S. & Mohamed, N. A. The validity of quantifying pulmonary contusion extent by lung ultrasound score for predicting ARDS in blunt thoracic trauma. Crit. Care Res. Pract. 3124966 (2022).","journal-title":"Crit. Care Res. Pract."},{"key":"96554_CR9","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1097\/ALN.0000000000003757","volume":"134","author":"S Mongodi","year":"2021","unstructured":"Mongodi, S. et al. Quantitative lung ultrasound: Technical aspects and clinical applications. Anesthesiology 134, 949\u2013965 (2021).","journal-title":"Anesthesiology"},{"key":"96554_CR10","doi-asserted-by":"crossref","first-page":"33","DOI":"10.2147\/OAEM.S289148","volume":"13","author":"G Devia Jaramillo","year":"2021","unstructured":"Devia Jaramillo, G. & Menendez Ramirez, S. USER protocol as a guide to resuscitation of the patient with septic shock in the emergency department. Open. Access. Emerg. Med. 13, 33\u201343 (2021).","journal-title":"Open. Access. Emerg. Med."},{"key":"96554_CR11","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1056\/NEJMoa1701380","volume":"376","author":"PRISM Investigators","year":"2017","unstructured":"Investigators, P. R. I. S. M. et al. Early, goal-directed therapy for septic shock\u2014A patient-level meta-analysis. N Engl. J. Med. 376, 2223\u20132234 (2017).","journal-title":"N Engl. J. Med."},{"key":"96554_CR12","first-page":"2","volume":"25","author":"D Liu","year":"2013","unstructured":"Liu, D. Shock management: Bridging microcirculation and cellular function (in Chinese). Chin. Crit. Care Med. 25, 2\u20134 (2013).","journal-title":"Chin. Crit. Care Med."},{"key":"96554_CR13","doi-asserted-by":"crossref","first-page":"e0241590","DOI":"10.1371\/journal.pone.0241590","volume":"15","author":"P Leiser","year":"2020","unstructured":"Leiser, P. et al. A quantitative CT parameter for the assessment of pulmonary oedema in patients with acute respiratory distress syndrome. PLoS ONE 15, e0241590 (2020).","journal-title":"PLoS ONE"},{"key":"96554_CR14","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1016\/j.ultrasmedbio.2010.09.003","volume":"36","author":"Z Jambrik","year":"2010","unstructured":"Jambrik, Z. et al. B-lines quantify the lung water content: A lung ultrasound versus lung gravimetry study in acute lung injury. Ultrasound Med. Biol. 36, 2004\u20132010 (2010).","journal-title":"Ultrasound Med. Biol."},{"key":"96554_CR15","first-page":"1118","volume":"32","author":"C Zhang","year":"2020","unstructured":"Zhang, C. et al. Clinical significance of bilateral lung asymmetry signs of bedside ultrasound in severe patients. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 32, 1118\u20131120 (2020).","journal-title":"Zhonghua Wei Zhong Bing Ji Jiu Yi Xue"},{"key":"96554_CR16","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.ultrasmedbio.2020.12.021","volume":"47","author":"V Speidel","year":"2021","unstructured":"Speidel, V., Conen, A., Gisler, V., Fux, C. A. & Haubitz, S. Lung assessment with point-of-care ultrasound in respiratory coronavirus disease (COVID-19): A prospective cohort study. Ultrasound Med. Biol. 47, 896\u2013901 (2021).","journal-title":"Ultrasound Med. Biol."},{"key":"96554_CR17","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s13089-017-0068-x","volume":"9","author":"A Anile","year":"2017","unstructured":"Anile, A., Russo, J., Castiglione, G. & Volpicelli, G. A simplified lung ultrasound approach to detect increased extravascular lung water in critically ill patients. Crit. Ultrasound J. 9, 13 (2017).","journal-title":"Crit. Ultrasound J."},{"key":"96554_CR18","first-page":"e9953","volume":"12","author":"F Emperador 4th","year":"2020","unstructured":"Emperador, F. 4th et al. Extravascular lung water and effect on oxygenation assessed by lung ultrasound in adult cardiac surgery. Cureus 12, e9953 (2020).","journal-title":"Cureus"},{"key":"96554_CR19","first-page":"281","volume":"221","author":"JT Macho","year":"2021","unstructured":"Macho, J. T. & S\u00e1nchez, G. G. D. C. The lung, paradigm of point-of-care ultrasound. Rev. Cl\u00edn Esp. (Engl. Ed.). 221, 281\u2013282 (2021).","journal-title":"Rev. Cl\u00edn Esp. (Engl. Ed.)"},{"key":"96554_CR20","doi-asserted-by":"crossref","first-page":"195","DOI":"10.4103\/0972-5229.130569","volume":"18","author":"P Theerawit","year":"2014","unstructured":"Theerawit, P., Touman, N., Sutherasan, Y. & Kiatboonsri, S. Transthoracic ultrasound assessment of B-lines for identifying the increment of extravascular lung water in shock patients requiring fluid resuscitation. Indian J. Crit. Care Med. 18, 195\u2013199 (2014).","journal-title":"Indian J. Crit. Care Med."},{"key":"96554_CR21","doi-asserted-by":"crossref","first-page":"99","DOI":"10.4103\/1817-1737.128856","volume":"9","author":"AA Hasan","year":"2014","unstructured":"Hasan, A. A. & Makhlouf, H. A. B-lines: Transthoracic chest ultrasound signs useful in assessment of interstitial lung diseases. Ann. Thorac. Med. 9, 99\u2013103 (2014).","journal-title":"Ann. Thorac. Med."},{"key":"96554_CR22","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.reumae.2020.10.004","volume":"18","author":"F Romero-Bueno","year":"2022","unstructured":"Romero-Bueno, F., Rodr\u00edguez-Nieto, M. J. & Naredo, E. Education and use of lung ultrasound in rheumatology and pneumology in Spain: A SER-SEPAR survey. Reumatol. Cl\u00edn. (Engl. Ed.). 18, 94\u201399 (2022).","journal-title":"Reumatol. Cl\u00edn. (Engl. Ed.)"},{"key":"96554_CR23","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.chest.2019.02.332","volume":"156","author":"DA Lichtenstein","year":"2019","unstructured":"Lichtenstein, D. A. Current misconceptions in lung ultrasound: A short guide for experts. Chest 156, 21\u201325 (2019).","journal-title":"Chest"},{"key":"96554_CR24","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s13089-024-00368-3","volume":"16","author":"G Volpicelli","year":"2024","unstructured":"Volpicelli, G. & Rovida, S. Clinical research on point-of-care lung ultrasound: Misconceptions and limitations. Ultrasound J. 16, 28 (2024).","journal-title":"Ultrasound J."},{"key":"96554_CR25","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1002\/jum.16088","volume":"42","author":"L Demi","year":"2023","unstructured":"Demi, L. et al. New international guidelines and consensus on the use of lung ultrasound. J. Ultrasound Med. 42, 309\u2013344 (2023).","journal-title":"J. Ultrasound Med."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-96554-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-96554-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-96554-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T01:57:48Z","timestamp":1743818268000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-96554-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,4]]},"references-count":25,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["96554"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-96554-x","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,4]]},"assertion":[{"value":"12 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"All the authors have consented to publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"11551"}}