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To address this need, we developed the Parkinson\u2019s Disease\u2014Functional Movement Battery (PD-FUNC), which includes valid items from existing assessments and evaluates five key areas from the MDS-UPDRS-III: manual dexterity, functional strength, locomotion, static balance, and activities of daily living. This study assessed the PD-FUNC\u2019s ability to distinguish between PWPs and healthy controls based on effect sizes and analyzed differences according to disease progression using years since diagnosis and MDS-UPDRS-III scores, as well as Hoehn &amp; Yahr (H&amp;Y) stages. The test was administered to 81 PD patients (H&amp;Y stages 1\u20133) and 81 age-matched controls. All items, except grip force, discriminated effectively, with dexterity tasks showing the highest sensitivity (effect size r\u2009=\u20090.52\u20130.63). The PD-FUNC distinguished PD stages well, revealing early symptoms through dexterity tests (p\u2009=\u20090.001) and late-stage symptoms via dynamic stability tests. The PD-FUNC could provide a comprehensive assessment within 30\u201340\u00a0min and could be used to evaluate disease progression and medication effectiveness at home and in clinical settings.<\/jats:p>","DOI":"10.1038\/s41598-025-96594-3","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T11:41:43Z","timestamp":1744112503000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Parkinson\u2019s disease functional movement battery a comprehensive test set to evaluate of motor abilities in persons with Parkinson\u2019s disease"],"prefix":"10.1038","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0632-3276","authenticated-orcid":false,"given":"Bouwien","family":"Smits-Engelsman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques","family":"Duysens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,4,8]]},"reference":[{"key":"96594_CR1","doi-asserted-by":"publisher","first-page":"2129","DOI":"10.1002\/mds.22340","volume":"23","author":"CG Goetz","year":"2008","unstructured":"Goetz, C. 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Written informed consent was obtained from all the participants before their enrollment. Approval for this study was obtained from the CMO Radboud University Medical Center (file number 2022\u201315731). Written informed consent for publication of the clinical details and photos in the Appendix 1 was obtained from the patient JD. A copy of the consent form is available for review by the Editor of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"12035"}}