{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:58:53Z","timestamp":1792155533506,"version":"4.4.0"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T00:00:00Z","timestamp":1744243200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T00:00:00Z","timestamp":1744243200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-96853-3","type":"journal-article","created":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T23:32:36Z","timestamp":1744241556000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Plates made from magnesium alloy with a long period stacking ordered structure promote bone formation in a rabbit fracture model"],"prefix":"10.1038","volume":"15","author":[{"given":"Kosei","family":"Takata","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Yugami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soichiro","family":"Karata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuki","family":"Karasugi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Uehara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuro","family":"Masuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Tokunaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Hisanaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuki","family":"Sugimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuji","family":"Yonemitsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsumasa","family":"Ideo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Fukuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaru","family":"Uragami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Arima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyunki","family":"Kawakami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuya","family":"Maeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoto","family":"Yoshimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideto","family":"Matsunaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Kai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuntaro","family":"Tanimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Shimada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuto","family":"Shibata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Tateyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Takata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hikaru","family":"Goshogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mizuho","family":"Yumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Takashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syotaro","family":"Ueno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuta","family":"Kubo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Tajiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuka","family":"Honma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihito","family":"Kawamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Miyamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,10]]},"reference":[{"issue":"Suppl 2","key":"96853_CR1","doi-asserted-by":"publisher","first-page":"S21","DOI":"10.1016\/S0020-1383(16)47004-X","volume":"47","author":"WH Cheung","year":"2016","unstructured":"Cheung, W. H., Miclau, T., Chow, S. K., Yang, F. F. & Alt, V. Fracture healing in osteoporotic bone. Injury 47(Suppl 2), S21-26 (2016).","journal-title":"Injury"},{"key":"96853_CR2","doi-asserted-by":"publisher","first-page":"1294","DOI":"10.1097\/SCS.0000000000008612","volume":"33","author":"Z Irgebay","year":"2022","unstructured":"Irgebay, Z., Kahan, E. H., Park, K. E., Choi, J. & Zellner, E. G. Characteristics and patterns of facial fractures in the elderly population in the united states based on Trauma quality improvement project data. J. Craniofac. Surg. 33, 1294\u20131298 (2022).","journal-title":"J. Craniofac. Surg."},{"key":"96853_CR3","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1359\/jbmr.061113","volume":"22","author":"R Burge","year":"2007","unstructured":"Burge, R. et al. Incidence and economic burden of osteoporosis-related fractures in the United States, 2005\u20132025. J. Bone Miner. Res. 22, 465\u2013475 (2007).","journal-title":"J. Bone Miner. Res."},{"key":"96853_CR4","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.maturitas.2016.07.014","volume":"92","author":"BA Foulke","year":"2016","unstructured":"Foulke, B. A., Kendal, A. R., Murray, D. W. & Pandit, H. Fracture healing in the elderly: A review. Maturitas 92, 49\u201355 (2016).","journal-title":"Maturitas"},{"key":"96853_CR5","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1007\/s11914-023-00777-8","volume":"21","author":"E Dent","year":"2023","unstructured":"Dent, E., Daly, R. M., Hoogendijk, E. O. & Scott, D. Exercise to prevent and manage frailty and fragility fractures. Curr. Osteoporos. Rep. 21, 205\u2013215 (2023).","journal-title":"Curr. Osteoporos. Rep."},{"key":"96853_CR6","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1359\/jbmr.090731","volume":"25","author":"P Aspenberg","year":"2010","unstructured":"Aspenberg, P. et al. Teriparatide for acceleration of fracture repair in humans: a prospective, randomized, double-blind study of 102 postmenopausal women with distal radial fractures. J. Bone Miner. Res. 25, 404\u2013414 (2010).","journal-title":"J. Bone Miner. Res."},{"key":"96853_CR7","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/j.foot.2015.08.001","volume":"25","author":"J Yates","year":"2015","unstructured":"Yates, J. et al. Jones fracture of the fifth metatarsal: Is operative intervention justified? A systematic review of the literature and meta-analysis of results. Foot (Edinb). 25, 251\u2013257 (2015).","journal-title":"Foot (Edinb)."},{"key":"96853_CR8","doi-asserted-by":"publisher","first-page":"791","DOI":"10.3390\/medicina57080791","volume":"57","author":"JWA Fletcher","year":"2021","unstructured":"Fletcher, J. W. A. et al. Intracapsular femoral neck fractures-a surgical management algorithm. Medicina (Kaunas) 57, 791 (2021).","journal-title":"Medicina (Kaunas)"},{"key":"96853_CR9","doi-asserted-by":"publisher","first-page":"65","DOI":"10.3109\/17453674.2011.652884","volume":"83","author":"KJ Virtanen","year":"2012","unstructured":"Virtanen, K. J., Malmivaara, A. O., Remes, V. M. & Paavola, M. P. Operative and nonoperative treatment of clavicle fractures in adults. Acta. Orthop. 83, 65\u201373 (2012).","journal-title":"Acta. Orthop."},{"key":"96853_CR10","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1186\/s13018-019-1516-z","volume":"14","author":"SW Tsai","year":"2019","unstructured":"Tsai, S. W. et al. Risk factors for refracture after plate removal for midshaft clavicle fracture after bone union. J. Orthop. Surg. Res. 14, 457 (2019).","journal-title":"J. Orthop. Surg. Res."},{"key":"96853_CR11","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1016\/j.jhsa.2011.03.032","volume":"36","author":"C Gyuricza","year":"2011","unstructured":"Gyuricza, C. et al. Removal of locked volar plates after distal radius fractures. J. Hand. Surg. Am. 36, 982\u2013985 (2011).","journal-title":"J. Hand. Surg. Am."},{"key":"96853_CR12","doi-asserted-by":"publisher","first-page":"113","DOI":"10.5435\/00124635-200602000-00006","volume":"14","author":"ML Busam","year":"2006","unstructured":"Busam, M. L., Esther, R. J. & Obremskey, W. T. Hardware removal: Indications and expectations. J. Am. Acad. Orthop. Surg. 14, 113\u2013120 (2006).","journal-title":"J. Am. Acad. Orthop. Surg."},{"key":"96853_CR13","doi-asserted-by":"crossref","unstructured":"Park, J. B. & Kim, Y. K. Metallic Biomaterials Biomaterials 1\u20131\u20131\u201322 (CRC press, 2007).","DOI":"10.1201\/9780849378898.ch1"},{"key":"96853_CR14","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1007\/s10534-019-00170-y","volume":"32","author":"S Kamrani","year":"2019","unstructured":"Kamrani, S. & Fleck, C. Biodegradable magnesium alloys as temporary orthopaedic implants: A review. Biometals 32, 185\u2013193 (2019).","journal-title":"Biometals"},{"key":"96853_CR15","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/j.jma.2017.08.003","volume":"5","author":"R Radha","year":"2017","unstructured":"Radha, R. & Sreekanth, D. Insight of magnesium alloys and composites for orthopedic implant applications \u2013 a review. J. Magnes. Alloy. 5, 286\u2013312 (2017).","journal-title":"J. Magnes. Alloy."},{"key":"96853_CR16","doi-asserted-by":"publisher","first-page":"1728","DOI":"10.1016\/j.biomaterials.2005.10.003","volume":"27","author":"MP Staiger","year":"2006","unstructured":"Staiger, M. P., Pietak, A. M., Huadmai, J. & Dias, G. Magnesium and its alloys as orthopedic biomaterials: A review. Biomaterials 27, 1728\u20131734 (2006).","journal-title":"Biomaterials"},{"key":"96853_CR17","doi-asserted-by":"publisher","first-page":"3888","DOI":"10.1016\/j.actbio.2012.06.037","volume":"8","author":"M Niinomi","year":"2012","unstructured":"Niinomi, M., Nakai, M. & Hieda, J. Development of new metallic alloys for biomedical applications. Acta. Biomater. 8, 3888\u20133903 (2012).","journal-title":"Acta. Biomater."},{"key":"96853_CR18","doi-asserted-by":"crossref","unstructured":"Gonz\u00e1lez, S., Pellicer, E., Suri\u00f1ach, S., Bar\u00f3, M. D. & Sort, J. Biodegradation and Mechanical Integrity of Magnesium and Magnesium Alloys Suitable for Implants. In Biodegradation, Ch. 12 (eds, Rolando, C. & Francisca, R.) (IntechOpen, 2013).","DOI":"10.5772\/55584"},{"key":"96853_CR19","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1016\/j.actbio.2011.10.031","volume":"8","author":"L Choudhary","year":"2012","unstructured":"Choudhary, L. & Singh Raman, R. K. Magnesium alloys as body implants: Fracture mechanism under dynamic and static loadings in a physiological environment. Acta. Biomater. 8, 916\u2013923 (2012).","journal-title":"Acta. Biomater."},{"key":"96853_CR20","first-page":"1325","volume":"28","author":"A Lambotte","year":"1932","unstructured":"Lambotte, A. L\u2019utilisation du magnesium comme materiel perdu dans l\u2019osteosynth\u00e8se. Bull. Mem. Soc. Nat. Chir. 28, 1325\u20131334 (1932).","journal-title":"Bull. Mem. Soc. Nat. Chir."},{"key":"96853_CR21","doi-asserted-by":"publisher","first-page":"3557","DOI":"10.1016\/j.biomaterials.2004.09.049","volume":"26","author":"F Witte","year":"2005","unstructured":"Witte, F. et al. In vivo corrosion of four magnesium alloys and the associated bone response. Biomaterials 26, 3557\u20133563 (2005).","journal-title":"Biomaterials"},{"key":"96853_CR22","doi-asserted-by":"publisher","first-page":"959","DOI":"10.2320\/matertrans.47.959","volume":"47","author":"S Yoshimoto","year":"2006","unstructured":"Yoshimoto, S., Yamasaki, M. & Kawamura, Y. Microstructure and mechanical properties of extruded Mg-Zn-Y alloys with 14H Long period ordered structure. Mater. Trans. 47, 959\u2013965 (2006).","journal-title":"Mater. Trans."},{"key":"96853_CR23","unstructured":"Kawamura, Y. & Yoshimoto, S. High strength Mg-Zn-Y alloys with LPSO structure (2005)."},{"key":"96853_CR24","doi-asserted-by":"publisher","first-page":"2986","DOI":"10.2320\/matertrans.MER2007142","volume":"48","author":"Y Kawamura","year":"2007","unstructured":"Kawamura, Y. & Yamasaki, M. Formation and mechanical properties of Mg97Zn1RE2 alloys with long-period stacking ordered structure. Mater. Trans. 48, 2986\u20132992 (2007).","journal-title":"Mater. Trans."},{"key":"96853_CR25","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.2320\/matertrans.42.1172","volume":"42","author":"Y Kawamura","year":"2001","unstructured":"Kawamura, Y., Hayashi, K., Inoue, A. & Masumoto, T. Rapidly solidified powder metallurgy Mg97Zn1Y2 alloys with excellent tensile yield strength above 600 MPa. Mater. Trans. 42, 1172\u20131176 (2001).","journal-title":"Mater. Trans."},{"key":"96853_CR26","doi-asserted-by":"publisher","DOI":"10.1016\/j.matdes.2019.107984","volume":"181","author":"D Drozdenko","year":"2019","unstructured":"Drozdenko, D. et al. Optimization of mechanical properties of dilute Mg-Zn-Y alloys prepared by rapid solidification. Mater. Des. 181, 107984 (2019).","journal-title":"Mater. Des."},{"key":"96853_CR27","doi-asserted-by":"publisher","first-page":"767","DOI":"10.4028\/www.scientific.net\/MSF.654-656.767","volume":"654\u2013656","author":"S Izumi","year":"2010","unstructured":"Izumi, S., Yamasaki, M. & Kawamura, Y. Improvement of corrosion resistance of extruded Mg-Zn-Y Mg\/LPSO two-phase alloys by fourth element addition. Mater. Sci. Forum. 654\u2013656, 767\u2013770 (2010).","journal-title":"Mater. Sci. Forum."},{"key":"96853_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/j.corsci.2022.110237","volume":"200","author":"M Yamasaki","year":"2022","unstructured":"Yamasaki, M., Shi, Z., Atrens, A., Furukawa, A. & Kawamura, Y. Influence of crystallographic orientation and Al alloying on the corrosion behaviour of extruded \u03b1-Mg\/LPSO two-phase Mg-Zn-Y alloys with multimodal microstructure. Corros. Sci. 200, 110237 (2022).","journal-title":"Corros. Sci."},{"key":"96853_CR29","doi-asserted-by":"publisher","first-page":"8258","DOI":"10.1016\/j.apsusc.2011.01.046","volume":"257","author":"M Yamasaki","year":"2011","unstructured":"Yamasaki, M., Izumi, S., Kawamura, Y. & Habazaki, H. Corrosion and passivation behavior of Mg\u2013Zn\u2013Y\u2013Al alloys prepared by cooling rate-controlled solidification. Appl. Surf. Sci. 257, 8258\u20138267 (2011).","journal-title":"Appl. Surf. Sci."},{"issue":"Suppl 1","key":"96853_CR30","doi-asserted-by":"publisher","first-page":"S2","DOI":"10.1016\/S0020-1383(18)30294-8","volume":"49","author":"P Augat","year":"2018","unstructured":"Augat, P. & von R\u00fcden, C. Evolution of fracture treatment with bone plates. Injury 49(Suppl 1), S2-s7 (2018).","journal-title":"Injury"},{"key":"96853_CR31","doi-asserted-by":"publisher","first-page":"114","DOI":"10.3390\/ma17010114","volume":"17","author":"E Marin","year":"2023","unstructured":"Marin, E. & Lanzutti, A. Biomedical applications of titanium alloys: A comprehensive review. Materials (Basel) 17, 114 (2023).","journal-title":"Materials (Basel)"},{"key":"96853_CR32","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.1002\/jbm.a.31433","volume":"83","author":"C Eriksson","year":"2007","unstructured":"Eriksson, C. et al. Callus formation and remodeling at titanium implants. J. Biomed. Mater. Res. A. 83, 1062\u20131069 (2007).","journal-title":"J. Biomed. Mater. Res. A."},{"key":"96853_CR33","doi-asserted-by":"publisher","first-page":"473","DOI":"10.2106\/00004623-195133020-00021","volume":"33-a","author":"GS Leventhal","year":"1951","unstructured":"Leventhal, G. S. Titanium, a metal for surgery. J. Bone Joint. Surg. Am. 33-a, 473\u2013474 (1951).","journal-title":"J. Bone Joint. Surg. Am."},{"key":"96853_CR34","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1002\/JPER.20-0162","volume":"92","author":"W He","year":"2021","unstructured":"He, W., Zhang, H. & Qiu, J. Osteogenic effects of bioabsorbable magnesium implant in rat mandibles and in vitro. J. Periodontol. 92, 1181\u20131191 (2021).","journal-title":"J. Periodontol."},{"key":"96853_CR35","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1016\/j.actbio.2016.11.067","volume":"49","author":"Y Yu","year":"2017","unstructured":"Yu, Y. et al. Multifunctions of dual Zn\/Mg ion co-implanted titanium on osteogenesis, angiogenesis and bacteria inhibition for dental implants. Acta. Biomater. 49, 590\u2013603 (2017).","journal-title":"Acta. Biomater."},{"key":"96853_CR36","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1016\/j.bbrc.2020.07.057","volume":"531","author":"S Choi","year":"2020","unstructured":"Choi, S. et al. Biochemical activity of magnesium ions on human osteoblast migration. Biochem. Biophys. Res. Commun. 531, 588\u2013594 (2020).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"96853_CR37","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1590\/1414-431x20165257","volume":"49","author":"LY He","year":"2016","unstructured":"He, L. Y., Zhang, X. M., Liu, B., Tian, Y. & Ma, W. H. Effect of magnesium ion on human osteoblast activity. Braz. J. Med. Biol. Res. 49, 7 (2016).","journal-title":"Braz. J. Med. Biol. Res."},{"key":"96853_CR38","doi-asserted-by":"crossref","unstructured":"Luckey, T. D. &amp; Venugopal, B. Toxicologic significance of the physicochemical properties of metals. In Physiologic and Chemical Basis for Metal Toxicity, (eds, Luckey, T. D. &amp; Venugopal, B.) 103\u2013128 (Springer US, 1977).","DOI":"10.1007\/978-1-4684-2952-7_4"},{"key":"96853_CR39","first-page":"237","volume":"72","author":"HJ Schneider","year":"1979","unstructured":"Schneider, H. J. et al. Effect of drugs used for the prevention of urinary calculi recurrence on the growth and metabolism of young experimental animals. Z. Urol. Nephrol. 72, 237\u2013247 (1979).","journal-title":"Z. Urol. Nephrol."},{"key":"96853_CR40","doi-asserted-by":"publisher","first-page":"8199","DOI":"10.3390\/nu7095388","volume":"7","author":"U Gr\u00f6ber","year":"2015","unstructured":"Gr\u00f6ber, U., Schmidt, J. & Kisters, K. Magnesium in prevention and therapy. Nutrients 7, 8199\u20138226 (2015).","journal-title":"Nutrients"},{"key":"96853_CR41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0009-8981(99)00258-2","volume":"294","author":"N-EL Saris","year":"2000","unstructured":"Saris, N.-E.L., Mervaala, E., Karppanen, H., Khawaja, J. A. & Lewenstam, A. Magnesium: An update on physiological, clinical and analytical aspects. Clin. Chim. Acta 294, 1\u201326 (2000).","journal-title":"Clin. Chim. Acta"},{"key":"96853_CR42","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1016\/S0899-9007(01)00551-2","volume":"17","author":"T Okuma","year":"2001","unstructured":"Okuma, T. Magnesium and bone strength. Nutrition 17, 679\u2013680 (2001).","journal-title":"Nutrition"},{"key":"96853_CR43","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1080\/17843286.2018.1516173","volume":"74","author":"S Van Laecke","year":"2019","unstructured":"Van Laecke, S. Hypomagnesemia and hypermagnesemia. Acta. Clin. Belg. 74, 41\u201347 (2019).","journal-title":"Acta. Clin. Belg."},{"key":"96853_CR44","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1038\/nature01657","volume":"423","author":"HM Kronenberg","year":"2003","unstructured":"Kronenberg, H. M. Developmental regulation of the growth plate. Nature 423, 332\u2013336 (2003).","journal-title":"Nature"},{"key":"96853_CR45","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1002\/jcp.25641","volume":"232","author":"T Wang","year":"2017","unstructured":"Wang, T., Zhang, X. & Bikle, D. D. Osteogenic differentiation of periosteal cells during fracture healing. J. Cell Physiol. 232, 913\u2013921 (2017).","journal-title":"J. Cell Physiol."},{"key":"96853_CR46","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1016\/j.injury.2021.10.025","volume":"53","author":"V Herber","year":"2022","unstructured":"Herber, V. et al. Can hardware removal be avoided using bioresorbable Mg-Zn-Ca screws after medial malleolar fracture fixation? mid-term results of a first-in-human study. Injury 53, 1283\u20131288 (2022).","journal-title":"Injury"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-96853-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-96853-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-96853-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T01:04:00Z","timestamp":1744247040000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-96853-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,10]]},"references-count":46,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["96853"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-96853-3","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,10]]},"assertion":[{"value":"19 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declaration"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"12210"}}