{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T22:29:28Z","timestamp":1779920968104,"version":"3.53.1"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T00:00:00Z","timestamp":1746748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T00:00:00Z","timestamp":1746748800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"the Natural Science Foundation of Shandong Province","award":["ZR2024MH024"],"award-info":[{"award-number":["ZR2024MH024"]}]},{"name":"the Natural Science Foundation of Shandong Province","award":["ZR2021MH318"],"award-info":[{"award-number":["ZR2021MH318"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-96892-w","type":"journal-article","created":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T14:49:10Z","timestamp":1746802150000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Bousigonine D from Bousigonia mekongensis inhibits bladder cancer growth and overcomes cisplatin resistance"],"prefix":"10.1038","volume":"15","author":[{"given":"Kai","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benkang","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaofeng","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,9]]},"reference":[{"key":"96892_CR1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung, H. et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 71, 209\u2013249. https:\/\/doi.org\/10.3322\/caac.21660 (2021).","journal-title":"CA Cancer J. Clin."},{"key":"96892_CR2","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1016\/j.eururo.2015.08.037","volume":"69","author":"J Dobruch","year":"2016","unstructured":"Dobruch, J. et al. Gender and bladder cancer: A collaborative review of etiology, biology, and outcomes. Eur. Urol. 69, 300\u2013310. https:\/\/doi.org\/10.1016\/j.eururo.2015.08.037 (2016).","journal-title":"Eur. Urol."},{"key":"96892_CR3","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1038\/s41572-023-00468-9","volume":"9","author":"L Dyrskj\u00f8t","year":"2023","unstructured":"Dyrskj\u00f8t, L. et al. Bladder cancer. Nat. Rev. Dis. Primers 9, 58. https:\/\/doi.org\/10.1038\/s41572-023-00468-9 (2023).","journal-title":"Nat. Rev. Dis. Primers"},{"key":"96892_CR4","doi-asserted-by":"publisher","first-page":"1980","DOI":"10.1001\/jama.2020.17598","volume":"324","author":"AT Lenis","year":"2020","unstructured":"Lenis, A. T., Lec, P. M., Chamie, K. & Mshs, M. D. Bladder cancer: A review. JAMA 324, 1980\u20131991. https:\/\/doi.org\/10.1001\/jama.2020.17598 (2020).","journal-title":"JAMA"},{"key":"96892_CR5","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.eururo.2023.03.029","volume":"84","author":"I Jubber","year":"2023","unstructured":"Jubber, I. et al. Epidemiology of bladder cancer in 2023: A systematic review of risk factors. Eur. Urol. 84, 176\u2013190. https:\/\/doi.org\/10.1016\/j.eururo.2023.03.029 (2023).","journal-title":"Eur. Urol."},{"key":"96892_CR6","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.eururo.2023.08.016","volume":"85","author":"J Alfred Witjes","year":"2024","unstructured":"Alfred Witjes, J. et al. European association of urology guidelines on muscle-invasive and metastatic bladder cancer: Summary of the 2023 guidelines. Eur. Urol. 85, 17\u201331. https:\/\/doi.org\/10.1016\/j.eururo.2023.08.016 (2024).","journal-title":"Eur. Urol."},{"key":"96892_CR7","doi-asserted-by":"publisher","first-page":"1712","DOI":"10.1016\/s0140-6736(22)01188-6","volume":"400","author":"E Comp\u00e9rat","year":"2022","unstructured":"Comp\u00e9rat, E. et al. Current best practice for bladder cancer: A narrative review of diagnostics and treatments. Lancet 400, 1712\u20131721. https:\/\/doi.org\/10.1016\/s0140-6736(22)01188-6 (2022).","journal-title":"Lancet"},{"key":"96892_CR8","doi-asserted-by":"publisher","unstructured":"Flaig, T. W. et al. NCCN Guidelines\u00ae Insights: Bladder Cancer, Version 3.2024. J. Natl. Compr. Cancer Netw. 22, 216\u2013225. https:\/\/doi.org\/10.6004\/jnccn.2024.0024 (2024).","DOI":"10.6004\/jnccn.2024.0024"},{"key":"96892_CR9","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1038\/s41571-023-00826-2","volume":"21","author":"R Nadal","year":"2024","unstructured":"Nadal, R., Valderrama, B. P. & Bellmunt, J. Progress in systemic therapy for advanced-stage urothelial carcinoma. Nat. Rev. Clin. Oncol. 21, 8\u201327. https:\/\/doi.org\/10.1038\/s41571-023-00826-2 (2024).","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"96892_CR10","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1038\/nrclinonc.2016.188","volume":"14","author":"SA Funt","year":"2017","unstructured":"Funt, S. A. & Rosenberg, J. E. Systemic, perioperative management of muscle-invasive bladder cancer and future horizons. Nat. Rev. Clin. Oncol. 14, 221\u2013234. https:\/\/doi.org\/10.1038\/nrclinonc.2016.188 (2017).","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"96892_CR11","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1038\/s41585-019-0208-0","volume":"16","author":"C Alifrangis","year":"2019","unstructured":"Alifrangis, C., McGovern, U., Freeman, A., Powles, T. & Linch, M. Molecular and histopathology directed therapy for advanced bladder cancer. Nat. Rev. Urol. 16, 465\u2013483. https:\/\/doi.org\/10.1038\/s41585-019-0208-0 (2019).","journal-title":"Nat. Rev. Urol."},{"key":"96892_CR12","doi-asserted-by":"publisher","first-page":"2193","DOI":"10.1038\/s41467-017-02320-7","volume":"8","author":"D Liu","year":"2017","unstructured":"Liu, D. et al. Mutational patterns in chemotherapy resistant muscle-invasive bladder cancer. Nat. Commun. 8, 2193. https:\/\/doi.org\/10.1038\/s41467-017-02320-7 (2017).","journal-title":"Nat. Commun."},{"key":"96892_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2023.100938","volume":"68","author":"F Li","year":"2023","unstructured":"Li, F. et al. Regulation of cisplatin resistance in bladder cancer by epigenetic mechanisms. Drug Resist. Updates 68, 100938. https:\/\/doi.org\/10.1016\/j.drup.2023.100938 (2023).","journal-title":"Drug Resist. Updates"},{"key":"96892_CR14","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/s12943-022-01517-9","volume":"21","author":"ZD Shi","year":"2022","unstructured":"Shi, Z. D. et al. Targeting HNRNPU to overcome cisplatin resistance in bladder cancer. Mol. Cancer 21, 37. https:\/\/doi.org\/10.1186\/s12943-022-01517-9 (2022).","journal-title":"Mol. Cancer"},{"key":"96892_CR15","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1038\/s41585-024-00872-0","volume":"21","author":"G Roviello","year":"2024","unstructured":"Roviello, G., Santoni, M., Sonpavde, G. P. & Catalano, M. The evolving treatment landscape of metastatic urothelial cancer. Nat. Rev. Urol. 21, 580\u2013592. https:\/\/doi.org\/10.1038\/s41585-024-00872-0 (2024).","journal-title":"Nat. Rev. Urol."},{"key":"96892_CR16","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1021\/acs.jnatprod.9b01285","volume":"83","author":"DJ Newman","year":"2020","unstructured":"Newman, D. J. & Cragg, G. M. Natural products as sources of new drugs over the nearly four decades from 01\/1981 to 09\/2019. J. Nat. Prod. 83, 770\u2013803. https:\/\/doi.org\/10.1021\/acs.jnatprod.9b01285 (2020).","journal-title":"J. Nat. Prod."},{"key":"96892_CR17","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1016\/s1470-2045(20)30588-x","volume":"22","author":"G Faguet","year":"2021","unstructured":"Faguet, G. From periwinkle to an enduring anticancer drug. Lancet Oncol. 22, 308. https:\/\/doi.org\/10.1016\/s1470-2045(20)30588-x (2021).","journal-title":"Lancet Oncol."},{"key":"96892_CR18","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1038\/s41573-020-00114-z","volume":"20","author":"AG Atanasov","year":"2021","unstructured":"Atanasov, A. G., Zotchev, S. B., Dirsch, V. M. & Supuran, C. T. Natural products in drug discovery: Advances and opportunities. Nat. Rev. Drug Discov. 20, 200\u2013216. https:\/\/doi.org\/10.1038\/s41573-020-00114-z (2021).","journal-title":"Nat. Rev. Drug Discov."},{"key":"96892_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.semcancer.2019.12.008","volume":"80","author":"D Tewari","year":"2022","unstructured":"Tewari, D., Patni, P., Bishayee, A., Sah, A. N. & Bishayee, A. Natural products targeting the PI3K-Akt-mTOR signaling pathway in cancer: A novel therapeutic strategy. Semin. Cancer Biol. 80, 1\u201317. https:\/\/doi.org\/10.1016\/j.semcancer.2019.12.008 (2022).","journal-title":"Semin. Cancer Biol."},{"key":"96892_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2024.108752","volume":"264","author":"Y Wang","year":"2024","unstructured":"Wang, Y. et al. New drug discovery and development from natural products: Advances and strategies. Pharmacol. Ther. 264, 108752. https:\/\/doi.org\/10.1016\/j.pharmthera.2024.108752 (2024).","journal-title":"Pharmacol. Ther."},{"key":"96892_CR21","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1186\/s13045-022-01350-z","volume":"15","author":"R Qin","year":"2022","unstructured":"Qin, R. et al. Naturally derived indole alkaloids targeting regulated cell death (RCD) for cancer therapy: From molecular mechanisms to potential therapeutic targets. J. Hematol. Oncol. 15, 133. https:\/\/doi.org\/10.1186\/s13045-022-01350-z (2022).","journal-title":"J. Hematol. Oncol."},{"key":"96892_CR22","doi-asserted-by":"publisher","first-page":"3651","DOI":"10.1038\/s41467-019-11622-x","volume":"10","author":"NP Bondonno","year":"2019","unstructured":"Bondonno, N. P. et al. Flavonoid intake is associated with lower mortality in the Danish Diet Cancer and Health Cohort. Nat. Commun. 10, 3651. https:\/\/doi.org\/10.1038\/s41467-019-11622-x (2019).","journal-title":"Nat. Commun."},{"key":"96892_CR23","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1039\/d0np00023j","volume":"38","author":"Y Kuang","year":"2021","unstructured":"Kuang, Y., Li, B., Wang, Z., Qiao, X. & Ye, M. Terpenoids from the medicinal mushroom Antrodia camphorata: Chemistry and medicinal potential. Nat Prod Rep 38, 83\u2013102. https:\/\/doi.org\/10.1039\/d0np00023j (2021).","journal-title":"Nat Prod Rep"},{"key":"96892_CR24","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.3390\/molecules24071256","volume":"24","author":"Y Zhang","year":"2019","unstructured":"Zhang, Y. et al. Antiproliferative aspidosperma-type monoterpenoid indole alkaloids from Bousigonia mekongensis inhibit tubulin polymerization. Molecules 24, 1256. https:\/\/doi.org\/10.3390\/molecules24071256 (2019).","journal-title":"Molecules"},{"key":"96892_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2021.104964","volume":"153","author":"Z-W Wang","year":"2021","unstructured":"Wang, Z.-W., Wang, Y.-L., Zhang, J.-P., Wei, Q.-H. & Wang, X.-J. Monoterpene indole alkaloids from the roots of Bousigonia mekongensis and their anti-diabetic nephropathy activity. Fitoterapia 153, 104964. https:\/\/doi.org\/10.1016\/j.fitote.2021.104964 (2021).","journal-title":"Fitoterapia"},{"key":"96892_CR26","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1016\/j.annonc.2022.01.075","volume":"33","author":"M Moschini","year":"2022","unstructured":"Moschini, M. et al. Bladder cancer: ESMO clinical practice guideline for diagnosis, treatment and follow-up. Ann. Oncol. 33, 561. https:\/\/doi.org\/10.1016\/j.annonc.2022.01.075 (2022).","journal-title":"Ann. Oncol."},{"key":"96892_CR27","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2023-076743","volume":"384","author":"A Lopez-Beltran","year":"2024","unstructured":"Lopez-Beltran, A., Cookson, M. S., Guercio, B. J. & Cheng, L. Advances in diagnosis and treatment of bladder cancer. BMJ 384, e076743. https:\/\/doi.org\/10.1136\/bmj-2023-076743 (2024).","journal-title":"BMJ"},{"key":"96892_CR28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.semcancer.2016.08.006","volume":"40\u201341","author":"A Bishayee","year":"2016","unstructured":"Bishayee, A. & Sethi, G. Bioactive natural products in cancer prevention and therapy: Progress and promise. Semin. Cancer Biol. 40\u201341, 1\u20133. https:\/\/doi.org\/10.1016\/j.semcancer.2016.08.006 (2016).","journal-title":"Semin. Cancer Biol."},{"key":"96892_CR29","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/s0163-7258(01)00137-1","volume":"90","author":"DF Birt","year":"2001","unstructured":"Birt, D. F., Hendrich, S. & Wang, W. Dietary agents in cancer prevention: flavonoids and isoflavonoids. Pharmacol. Ther. 90, 157\u2013177. https:\/\/doi.org\/10.1016\/s0163-7258(01)00137-1 (2001).","journal-title":"Pharmacol. Ther."},{"key":"96892_CR30","doi-asserted-by":"publisher","first-page":"761","DOI":"10.3390\/nu12030761","volume":"12","author":"P Selvakumar","year":"2020","unstructured":"Selvakumar, P. et al. Flavonoids and other polyphenols act as epigenetic modifiers in breast cancer. Nutrients 12, 761. https:\/\/doi.org\/10.3390\/nu12030761 (2020).","journal-title":"Nutrients"},{"key":"96892_CR31","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2024.107457","volume":"209","author":"P Sitarek","year":"2024","unstructured":"Sitarek, P. et al. Flavonoids and their derivatives as DNA topoisomerase inhibitors with anti-cancer activity in various cell models: Exploring a novel mode of action. Pharmacol Res 209, 107457. https:\/\/doi.org\/10.1016\/j.phrs.2024.107457 (2024).","journal-title":"Pharmacol Res"},{"key":"96892_CR32","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1016\/j.jconrel.2021.06.034","volume":"336","author":"Y Liang","year":"2021","unstructured":"Liang, Y. et al. Nanoplatform-based natural products co-delivery system to surmount cancer multidrug-resistant. J. Control Release 336, 396\u2013409. https:\/\/doi.org\/10.1016\/j.jconrel.2021.06.034 (2021).","journal-title":"J. Control Release"},{"key":"96892_CR33","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/s12915-020-00766-8","volume":"18","author":"C Gu","year":"2020","unstructured":"Gu, C. et al. Identification of berberine as a novel drug for the treatment of multiple myeloma via targeting UHRF1. BMC Biol. 18, 33. https:\/\/doi.org\/10.1186\/s12915-020-00766-8 (2020).","journal-title":"BMC Biol."},{"key":"96892_CR34","doi-asserted-by":"publisher","first-page":"129","DOI":"10.2741\/3919","volume":"17","author":"R Schneider-Stock","year":"2012","unstructured":"Schneider-Stock, R., Ghantous, A., Bajbouj, K., Saikali, M. & Darwiche, N. Epigenetic mechanisms of plant-derived anticancer drugs. Front Biosci. (Landmark Ed.) 17, 129\u2013173. https:\/\/doi.org\/10.2741\/3919 (2012).","journal-title":"Front Biosci. (Landmark Ed.)"},{"key":"96892_CR35","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201800079","volume":"62","author":"B Abbaoui","year":"2018","unstructured":"Abbaoui, B., Lucas, C. R., Riedl, K. M., Clinton, S. K. & Mortazavi, A. Cruciferous vegetables, isothiocyanates, and bladder cancer prevention. Mol. Nutr. Food Res. 62, e1800079. https:\/\/doi.org\/10.1002\/mnfr.201800079 (2018).","journal-title":"Mol. Nutr. Food Res."},{"key":"96892_CR36","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1097\/ju.0000000000004070","volume":"212","author":"ML Kwan","year":"2024","unstructured":"Kwan, M. L. et al. The influence of dietary isothiocyanates on the effectiveness of mitomycin C and bacillus Calmette-Gu\u00e9rin in treating nonmuscle-invasive bladder cancer. J. Urol. 212, 420\u2013430. https:\/\/doi.org\/10.1097\/ju.0000000000004070 (2024).","journal-title":"J. Urol."},{"key":"96892_CR37","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.foodchem.2018.05.050","volume":"265","author":"V S\u00e1ez","year":"2018","unstructured":"S\u00e1ez, V. et al. Oligostilbenoids in Vitis vinifera L. Pinot Noir grape cane extract: Isolation, characterization, in vitro antioxidant capacity and anti-proliferative effect on cancer cells. Food Chem. 265, 101\u2013110. https:\/\/doi.org\/10.1016\/j.foodchem.2018.05.050 (2018).","journal-title":"Food Chem."},{"key":"96892_CR38","doi-asserted-by":"publisher","first-page":"4682","DOI":"10.3390\/cancers14194682","volume":"14","author":"H Xie","year":"2022","unstructured":"Xie, H. et al. Plant-derived sulforaphane suppresses growth and proliferation of drug-sensitive and drug-resistant bladder cancer cell lines in vitro. Cancers (Basel) 14, 4682. https:\/\/doi.org\/10.3390\/cancers14194682 (2022).","journal-title":"Cancers (Basel)"},{"key":"96892_CR39","doi-asserted-by":"publisher","first-page":"1224","DOI":"10.1016\/s1470-2045(20)30461-7","volume":"21","author":"N Baize","year":"2020","unstructured":"Baize, N. et al. Carboplatin plus etoposide versus topotecan as second-line treatment for patients with sensitive relapsed small-cell lung cancer: an open-label, multicentre, randomised, phase 3 trial. Lancet Oncol. 21, 1224\u20131233. https:\/\/doi.org\/10.1016\/s1470-2045(20)30461-7 (2020).","journal-title":"Lancet Oncol."},{"key":"96892_CR40","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2024-008864","author":"Y Choi","year":"2024","unstructured":"Choi, Y. et al. Novel insights into paclitaxel\u2019s role on tumor-associated macrophages in enhancing PD-1 blockade in breast cancer treatment. J. Immunother. Cancer https:\/\/doi.org\/10.1136\/jitc-2024-008864 (2024).","journal-title":"J. Immunother. Cancer"},{"key":"96892_CR41","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/s1470-2045(23)00587-9","volume":"25","author":"C Pfister","year":"2024","unstructured":"Pfister, C. et al. Perioperative dose-dense methotrexate, vinblastine, doxorubicin, and cisplatin in muscle-invasive bladder cancer (VESPER): survival endpoints at 5 years in an open-label, randomised, phase 3 study. Lancet Oncol. 25, 255\u2013264. https:\/\/doi.org\/10.1016\/s1470-2045(23)00587-9 (2024).","journal-title":"Lancet Oncol."},{"key":"96892_CR42","doi-asserted-by":"publisher","first-page":"2979","DOI":"10.1200\/jco.21.00124","volume":"39","author":"AS Defachelles","year":"2021","unstructured":"Defachelles, A. S. et al. Randomized phase II trial of vincristine-irinotecan with or without temozolomide, in children and adults with relapsed or refractory rhabdomyosarcoma: A European paediatric soft tissue sarcoma study group and innovative therapies for children with cancer trial. J. Clin. Oncol. 39, 2979\u20132990. https:\/\/doi.org\/10.1200\/jco.21.00124 (2021).","journal-title":"J. Clin. Oncol."},{"key":"96892_CR43","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1038\/s41573-024-00979-4","volume":"23","author":"C Glorieux","year":"2024","unstructured":"Glorieux, C., Liu, S., Trachootham, D. & Huang, P. Targeting ROS in cancer: Rationale and strategies. Nat. Rev. Drug Discov. 23, 583\u2013606. https:\/\/doi.org\/10.1038\/s41573-024-00979-4 (2024).","journal-title":"Nat. Rev. Drug Discov."},{"key":"96892_CR44","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1016\/j.semcancer.2019.06.011","volume":"59","author":"F Fontana","year":"2019","unstructured":"Fontana, F. et al. Unraveling the molecular mechanisms and the potential chemopreventive\/therapeutic properties of natural compounds in melanoma. Semin. Cancer Biol. 59, 266\u2013282. https:\/\/doi.org\/10.1016\/j.semcancer.2019.06.011 (2019).","journal-title":"Semin. Cancer Biol."},{"key":"96892_CR45","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2019.01.009","volume":"38","author":"T Efferth","year":"2020","unstructured":"Efferth, T. et al. Collateral sensitivity of natural products in drug-resistant cancer cells. Biotechnol. Adv. 38, 107342. https:\/\/doi.org\/10.1016\/j.biotechadv.2019.01.009 (2020).","journal-title":"Biotechnol. Adv."},{"key":"96892_CR46","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1039\/c4np00130c","volume":"32","author":"A AlQathama","year":"2015","unstructured":"AlQathama, A. & Prieto, J. M. Natural products with therapeutic potential in melanoma metastasis. Nat. Prod. Rep. 32, 1170\u20131182. https:\/\/doi.org\/10.1039\/c4np00130c (2015).","journal-title":"Nat. Prod. Rep."},{"key":"96892_CR47","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/j.semcancer.2020.10.010","volume":"73","author":"S Patra","year":"2021","unstructured":"Patra, S. et al. Chemotherapeutic efficacy of curcumin and resveratrol against cancer: Chemoprevention, chemoprotection, drug synergism and clinical pharmacokinetics. Semin. Cancer Biol. 73, 310\u2013320. https:\/\/doi.org\/10.1016\/j.semcancer.2020.10.010 (2021).","journal-title":"Semin. Cancer Biol."},{"key":"96892_CR48","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.semcancer.2020.02.011","volume":"80","author":"W Weng","year":"2022","unstructured":"Weng, W. & Goel, A. Curcumin and colorectal cancer: An update and current perspective on this natural medicine. Semin. Cancer Biol. 80, 73\u201386. https:\/\/doi.org\/10.1016\/j.semcancer.2020.02.011 (2022).","journal-title":"Semin. Cancer Biol."},{"key":"96892_CR49","doi-asserted-by":"publisher","first-page":"3233","DOI":"10.2147\/dddt.S466470","volume":"18","author":"J Cai","year":"2024","unstructured":"Cai, J. et al. Flavonoids and gastric cancer therapy: From signaling pathway to therapeutic significance. Drug Des. Dev. Ther. 18, 3233\u20133253. https:\/\/doi.org\/10.2147\/dddt.S466470 (2024).","journal-title":"Drug Des. Dev. Ther."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-96892-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-96892-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-96892-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T14:49:10Z","timestamp":1746802150000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-96892-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,9]]},"references-count":49,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["96892"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-96892-w","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,9]]},"assertion":[{"value":"17 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"16254"}}