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This study aims to develop and evaluate a spatial\u2013temporal prediction model for malaria incidence in Mozambique for potential use in a malaria early warning system (MEWS). We used monthly data on malaria cases from 2001 to 2018 in Mozambique, the model incorporated lagged climate variables selected through Deviance Information Criterion (DIC), including mean temperature and precipitation (1\u20132\u00a0months), relative humidity (5\u20136\u00a0months), and Normalized Different Vegetation Index (NDVI) (3\u20134\u00a0months). Predictive distributions from monthly cross-validations were employed to calculate threshold exceedance probabilities, with district-specific thresholds set at the 75th percentile of historical monthly malaria incidence. The model\u2019s ability to predict high and low malaria seasons was evaluated using receiver operating characteristic (ROC) analysis. Results indicated that malaria incidence in Mozambique peaks from November to April, offering a predictive lead time of up to 4 months. The model demonstrated high predictive power with an area under the curve (AUC) of 0.897 (0.893\u20130.901), sensitivity of 0.835 (0.827\u20130.843), and specificity of 0.793 (0.787\u20130.798), underscoring its suitability for integration into a MEWS. Thus, incorporating climate information within a multisectoral approach is essential for enhancing malaria prevention interventions effectiveness.<\/jats:p>","DOI":"10.1038\/s41598-025-97072-6","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T12:10:35Z","timestamp":1744114235000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Spatio-temporal modelling and prediction of malaria incidence in Mozambique using climatic indicators from 2001 to 2018"],"prefix":"10.1038","volume":"15","author":[{"given":"Chaibo Jose","family":"Armando","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joacim","family":"Rockl\u00f6v","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohsin","family":"Sidat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yesim","family":"Tozan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto Francisco","family":"Mavume","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maquins Odhiambo","family":"Sewe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,8]]},"reference":[{"key":"97072_CR1","unstructured":"CDC, Malaria is a serious disease (2023)."},{"issue":"1","key":"97072_CR2","doi-asserted-by":"crossref","first-page":"67","DOI":"10.3390\/tropicalmed8010067","volume":"8","author":"L Gao","year":"2023","unstructured":"Gao, L. et al. 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