{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T11:48:34Z","timestamp":1791460114242,"version":"4.3.4"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T00:00:00Z","timestamp":1745280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T00:00:00Z","timestamp":1745280000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"the Deanship of Scientific Research at King Khalid University, Saudi Arabia; General Research Project under grant number (GRP\/152\/45).","award":["GRP\/152\/45"],"award-info":[{"award-number":["GRP\/152\/45"]}]},{"name":"the Deanship of Scientific Research at King Khalid University, Saudi Arabia; General Research Project under grant number (GRP\/152\/45).","award":["GRP\/152\/45"],"award-info":[{"award-number":["GRP\/152\/45"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>Idiopathic Intracranial Hypertension (IIH) is a neurological disorder characterized by elevated intracranial pressure without definitive etiology, primarily affecting young, obese women. This study aimed to compare the efficacy of bariatric surgery versus conventional community weight management in treating IIH. We conducted a retrospective cohort study in IIH patients undergoing bariatric procedures versus conventional weight loss interventions. Propensity score matching was employed to balance study groups. Outcomes were assessed at 3, 6, 12, and 24 months, including papilledema, headache, visual symptoms, and therapeutic interventions. Bariatric surgery demonstrated superior outcomes compared to community weight management. Papilledema incidence was consistently lower in the bariatric group (RR\u2009=\u20090.591 at 24 months, <jats:italic>p<\/jats:italic>\u2009=\u20090.0001). Headache prevalence and visual symptoms were also reduced in the surgical group. Acetazolamide dose was lower in bariatric patients, starting at 12 and 24 months. Subgroup analysis of different bariatric procedures showed comparable efficacy. Body mass index reduction was significantly greater in the bariatric group throughout the follow-up period. This study provides evidence supporting the efficacy of bariatric surgery in managing IIH, with superior outcomes across multiple parameters compared to conventional weight management. The sustained improvements in papilledema, headache, and visual symptoms, coupled with for the reduction in pharmacological intervention dose, suggest that bariatric surgery may offer a more definitive solution for IIH patients with concurrent obesity. Further research is needed to develop evidence-based guidelines for patient selection and optimize post-operative care protocols.<\/jats:p>","DOI":"10.1038\/s41598-025-97081-5","type":"journal-article","created":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T16:03:19Z","timestamp":1745337799000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Comparison of bariatric surgery and community weight management for idiopathic intracranial hypertension in a multicenter retrospective cohort study"],"prefix":"10.1038","volume":"15","author":[{"given":"Rasha Tarek","family":"Mirdad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud M.","family":"Morsy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed Y.","family":"Azzam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alsaleem Mohammed","family":"Abadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah A.","family":"Dalboh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasser A.","family":"Alsabaani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waleed A.","family":"Aldhabaan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moutasem S.","family":"Aboonq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammed Amir","family":"Essibayi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed D.","family":"Morsy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Altschul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,22]]},"reference":[{"key":"97081_CR1","doi-asserted-by":"crossref","unstructured":"Mollan, S. 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Lancet Neurol. 15 (1), 78\u201391 (2016).","journal-title":"Lancet Neurol."},{"issue":"2","key":"97081_CR4","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1111\/j.1600-0404.2009.01172.x","volume":"121","author":"S Dhungana","year":"2010","unstructured":"Dhungana, S., Sharrack, B. & Woodroofe, N. Idiopathic intracranial hypertension. Acta Neurol. Scand. 121 (2), 71\u201382 (2010).","journal-title":"Acta Neurol. Scand."},{"key":"97081_CR5","doi-asserted-by":"publisher","first-page":"c2701","DOI":"10.1136\/bmj.c2701","volume":"341","author":"AJ Sinclair","year":"2010","unstructured":"Sinclair, A. J. et al. Low energy diet and intracranial pressure in women with idiopathic intracranial hypertension: prospective cohort study. Bmj 341, c2701 (2010).","journal-title":"Bmj"},{"key":"97081_CR6","doi-asserted-by":"crossref","unstructured":"Wall, M. et al. Effect of Acetazolamide on visual function in patients with idiopathic intracranial hypertension and mild visual loss: the idiopathic intracranial hypertension treatment trial. 311(16): pp. 1641\u20131651. (2014).","DOI":"10.1001\/jama.2014.3312"},{"issue":"16","key":"97081_CR7","doi-asserted-by":"publisher","first-page":"1641","DOI":"10.1001\/jama.2014.3312","volume":"311","author":"M Wall","year":"2014","unstructured":"Wall, M. et al. Effect of Acetazolamide on visual function in patients with idiopathic intracranial hypertension and mild visual loss: the idiopathic intracranial hypertension treatment trial. Jama 311 (16), 1641\u20131651 (2014).","journal-title":"Jama"},{"issue":"5","key":"97081_CR8","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1111\/j.1600-0404.2007.00905.x","volume":"116","author":"N Celebisoy","year":"2007","unstructured":"Celebisoy, N. et al. Treatment of idiopathic intracranial hypertension: topiramate vs Acetazolamide, an open-label study. 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Cerebrospinal fluid shunt placement for pseudotumor cerebri-associated intractable headache: predictors of treatment response and an analysis of long-term outcomes. J. Neurosurg. 101 (4), 627\u2013632 (2004).","journal-title":"J. Neurosurg."},{"issue":"1","key":"97081_CR12","doi-asserted-by":"publisher","first-page":"34","DOI":"10.3171\/2009.12.JNS09953","volume":"114","author":"J Fridley","year":"2011","unstructured":"Fridley, J. et al. Bariatric surgery for the treatment of idiopathic intracranial hypertension. J. Neurosurg. 114 (1), 34\u201339 (2011).","journal-title":"J. Neurosurg."},{"issue":"2","key":"97081_CR13","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1007\/s11695-016-2467-7","volume":"27","author":"JH Manfield","year":"2017","unstructured":"Manfield, J. H. et al. Bariatric surgery or Non-surgical weight loss for idiopathic intracranial hypertension?? A systematic review and comparison of Meta-analyses. Obes. 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This process focused solely on improving the text\u2019s clarity and style, without generating or adding any new information to the content.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"LLM statement"}},{"value":"All the used methods in this retrospective cohort study were carried out in accordance with relevant guidelines and regulations, including the Declaration of Helsinki and Good Clinical Practice guidelines for retrospective database research.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statement of methods compliance"}},{"value":"This retrospective study utilizing de-identified data from the TriNetX Research Network was determined to be exempt from review by the Albert Einstein College of Medicine Institutional Review Board as it does not constitute human subjects research according to 45 CFR 46.104(d)(4).","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Institutional Review Statement"}},{"value":"The requirement for individual informed consent was waived as this study analyzed only de-identified data from the TriNetX Research Network, where all participating healthcare organizations have established data use agreements and appropriate patient privacy protocols in accordance with HIPAA regulations.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent statement"}}],"article-number":"13982"}}