{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T02:52:04Z","timestamp":1793242324084,"version":"4.5.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T00:00:00Z","timestamp":1744416000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T00:00:00Z","timestamp":1744416000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Jiangxi Province Graduate Innovation Special Fund Project","award":["YC2024-B237"],"award-info":[{"award-number":["YC2024-B237"]}]},{"DOI":"10.13039\/501100004479","name":"Natural Science Foundation of Jiangxi Province","doi-asserted-by":"publisher","award":["20232BAB216116"],"award-info":[{"award-number":["20232BAB216116"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-97217-7","type":"journal-article","created":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T20:47:37Z","timestamp":1744490857000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Naringin promotes osteoblast differentiation and ameliorates osteoporosis in ovariectomized mice"],"prefix":"10.1038","volume":"15","author":[{"given":"Yubo","family":"Cui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guisong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihui","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenlong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengyun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,12]]},"reference":[{"key":"97217_CR1","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1097\/OGX.0000000000001181","volume":"78","author":"E Rentzeperi","year":"2023","unstructured":"Rentzeperi, E. et al. Diagnosis and management of osteoporosis: A comprehensive review of guidelines. Obstet. Gynecol. Surv. 78, 657\u2013681 (2023).","journal-title":"Obstet. Gynecol. Surv."},{"key":"97217_CR2","unstructured":"National Bureau of Statistics, Office of the State Council\u2019s Seventh National Population Census Leading Group. Announcement of the Results of the Seventh National Population Census (No. 5)\u2014Demographic Age Structure [EB\/OL].  05\u201311 http:\/\/www.stats.gov.cn\/tjsj\/tjgb\/rkpcgb\/qgrkpcgb\/202 (2021)."},{"key":"97217_CR3","unstructured":"The Center for Chronic Non-communicable Disease Control. Chinese Center for Disease Control and Prevention, and the Subcommittee on Osteoporosis and Bone Mineral Metabolic Diseases, Chinese Medical Association. Epidemiological Survey Report on Osteoporosis in China (2018)[M] (People\u2019s Health, 2021)."},{"issue":"2","key":"97217_CR4","doi-asserted-by":"publisher","first-page":"S107","DOI":"10.1016\/S1297-319X(10)70004-X","volume":"77","author":"A Leboime","year":"2010","unstructured":"Leboime, A. et al. Osteoporosis and mortality. Joint Bone Spine 77 (2), S107\u2013112 (2010).","journal-title":"Joint Bone Spine"},{"key":"97217_CR5","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1097\/BOR.0000000000000300","volume":"28","author":"D Bliuc","year":"2016","unstructured":"Bliuc, D. & Center, J. R. Determinants of mortality risk following osteoporotic fractures. Curr. Opin. Rheumatol. 28, 413\u2013419 (2016).","journal-title":"Curr. Opin. Rheumatol."},{"key":"97217_CR6","doi-asserted-by":"publisher","first-page":"101782","DOI":"10.1016\/j.beem.2023.101782","volume":"38","author":"TJ de Villiers","year":"2024","unstructured":"de Villiers, T. J. Bone health and menopause: osteoporosis prevention and treatment. Best Pract. Res. Clin. Endocrinol. Metab. 38, 101782 (2024).","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"97217_CR7","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1016\/j.beem.2008.07.004","volume":"22","author":"PD Miller","year":"2008","unstructured":"Miller, P. D. Anti-resorptives in the management of osteoporosis. Best Pract. Res. Clin. Endocrinol. Metab. 22, 849\u2013868 (2008).","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"97217_CR8","first-page":"335","volume":"10","author":"F Chen","year":"2022","unstructured":"Chen, F. et al. Synergy effects of asperosaponin VI and bioactive factor BMP-2 on osteogenesis and anti-osteoclastogenesis. Bioact. Mater. 10, 335\u2013344 (2022).","journal-title":"Bioact Mater."},{"key":"97217_CR9","doi-asserted-by":"publisher","first-page":"1451445","DOI":"10.3389\/fphar.2024.1451445","volume":"15","author":"Y Lu","year":"2024","unstructured":"Lu, Y., Li, D. H., Xu, J. M. & Zhou, S. Role of naringin in the treatment of atherosclerosis. Front. Pharmacol. 15, 1451445 (2024).","journal-title":"Front. Pharmacol."},{"key":"97217_CR10","doi-asserted-by":"publisher","first-page":"1235081","DOI":"10.3389\/fmed.2023.1235081","volume":"10","author":"C Zhou","year":"2023","unstructured":"Zhou, C. et al. Mechanisms of action and synergetic formulas of plant-based natural compounds from traditional Chinese medicine for managing osteoporosis: a literature review. Front. Med. (Lausanne). 10, 1235081 (2023).","journal-title":"Front. Med. (Lausanne)"},{"key":"97217_CR11","doi-asserted-by":"publisher","first-page":"5623","DOI":"10.3390\/molecules28155623","volume":"28","author":"VS Shilpa","year":"2023","unstructured":"Shilpa, V. S. et al. Phytochemical properties, extraction, and pharmacological benefits of naringin: A review. Molecules 28, 5623 (2023).","journal-title":"Molecules"},{"key":"97217_CR12","doi-asserted-by":"publisher","first-page":"1686","DOI":"10.3390\/biomedicines10071686","volume":"10","author":"J Stabrauskiene","year":"2022","unstructured":"Stabrauskiene, J., Kopustinskiene, D. M., Lazauskas, R. & Bernatoniene, J. Naringin and naringenin: their mechanisms of action and the potential anticancer activities. Biomedicines 10, 1686 (2022).","journal-title":"Biomedicines"},{"key":"97217_CR13","doi-asserted-by":"publisher","first-page":"2755","DOI":"10.1016\/j.febslet.2011.07.046","volume":"585","author":"ESM Ang","year":"2011","unstructured":"Ang, E. S. M. et al. Naringin abrogates osteoclastogenesis and bone resorption via the Inhibition of RANKL-induced NF-\u03baB and ERK activation. FEBS Lett. 585, 2755\u20132762 (2011).","journal-title":"FEBS Lett."},{"key":"97217_CR14","doi-asserted-by":"crossref","unstructured":"Yang, X. et al. Naringin alleviates H2O2-inhibited osteogenic differentiation of human adipose-derived stromal cells via Wnt\/\u03b2-catenin signaling. Evid. Based Complement. Alternat. Med. 3126094 (2022).","DOI":"10.1155\/2022\/3126094"},{"key":"97217_CR15","first-page":"6330","volume":"13","author":"X Ge","year":"2021","unstructured":"Ge, X. & Zhou, G. Protective effects of naringin on glucocorticoid-induced osteoporosis through regulating the PI3K\/Akt\/mTOR signaling pathway. Am. J. Transl Res. 13, 6330\u20136341 (2021).","journal-title":"Am. J. Transl Res."},{"key":"97217_CR16","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1186\/s10020-024-00957-x","volume":"30","author":"X Wang","year":"2024","unstructured":"Wang, X., Qu, Z., Zhao, S., Luo, L. & Yan, L. Wnt\/\u03b2-catenin signaling pathway: proteins\u2019 roles in osteoporosis and cancer diseases and the regulatory effects of natural compounds on osteoporosis. Mol. Med. 30, 193 (2024).","journal-title":"Mol. Med."},{"key":"97217_CR17","doi-asserted-by":"publisher","first-page":"e22653","DOI":"10.1002\/jbt.22653","volume":"35","author":"J Liu","year":"2021","unstructured":"Liu, J., Deng, X., Liang, X. & Li, L. The phytoestrogen glabrene prevents osteoporosis in ovariectomized rats through upregulation of the canonical Wnt\/\u03b2-catenin signaling pathway. J. Biochem. Mol. Toxicol. 35, e22653 (2021).","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"97217_CR18","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1007\/s11596-024-2921-z","volume":"44","author":"J Lu","year":"2024","unstructured":"Lu, J. et al. Naringin and naringenin: potential multi-target agents for Alzheimer\u2019s disease. Curr. Med. Sci. 44, 867\u2013882 (2024).","journal-title":"Curr. Med. Sci."},{"key":"97217_CR19","first-page":"191","volume":"13","author":"CI Chukwuma","year":"2024","unstructured":"Chukwuma, C. I. & Antioxidative Metabolic and vascular medicinal potentials of natural products in the non-edible wastes of fruits belonging to the citrus and Prunus genera: A review. Plants (Basel)  13, 191 (2024).","journal-title":"Plants (Basel)"},{"key":"97217_CR20","doi-asserted-by":"publisher","first-page":"863","DOI":"10.3390\/pharmaceutics15030863","volume":"15","author":"S Ravetti","year":"2023","unstructured":"Ravetti, S. et al. Naringin: Nanotechnological strategies for potential pharmaceutical applications. Pharmaceutics 15, 863 (2023).","journal-title":"Pharmaceutics"},{"key":"97217_CR21","doi-asserted-by":"publisher","first-page":"14047","DOI":"10.1038\/s41598-024-64952-2","volume":"14","author":"H Wang","year":"2024","unstructured":"Wang, H. et al. Exploring the effects of naringin on oxidative stress-impaired osteogenic differentiation via the Wnt\/\u03b2-catenin and PI3K\/Akt pathways. Sci. Rep. 14, 14047 (2024).","journal-title":"Sci. Rep."},{"key":"97217_CR22","doi-asserted-by":"publisher","first-page":"1865","DOI":"10.1080\/09205063.2021.1949098","volume":"32","author":"K Shen","year":"2021","unstructured":"Shen, K. et al. Microstructured titanium functionalized by naringin inserted multilayers for promoting osteogenesis and inhibiting osteoclastogenesis. J. Biomater. Sci. Polym. Ed. 32, 1865\u20131881 (2021).","journal-title":"J. Biomater. Sci. Polym. Ed."},{"key":"97217_CR23","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/j.ejphar.2008.04.030","volume":"588","author":"JB Wu","year":"2008","unstructured":"Wu, J. B. et al. Naringin-induced bone morphogenetic protein-2 expression via PI3K, Akt, c-Fos\/c-Jun and AP-1 pathway in osteoblasts. Eur. J. Pharmacol. 588, 333\u2013341 (2008).","journal-title":"Eur. J. Pharmacol."},{"key":"97217_CR24","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/j.ecl.2024.07.001","volume":"53","author":"EM Lewiecki","year":"2024","unstructured":"Lewiecki, E. M. Utility of trabecular bone score in the management of patients with osteoporosis. Endocrinol. Metab. Clin. North. Am. 53, 547\u2013557 (2024).","journal-title":"Endocrinol. Metab. Clin. North. Am."},{"key":"97217_CR25","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1007\/s00198-018-4405-0","volume":"29","author":"WD Leslie","year":"2018","unstructured":"Leslie, W. D. et al. Risk-equivalent T-score adjustment for using lumbar spine trabecular bone score (TBS): the Manitoba BMD registry. Osteoporos. Int. 29, 751\u2013758 (2018).","journal-title":"Osteoporos. Int."},{"key":"97217_CR26","doi-asserted-by":"publisher","first-page":"e24906","DOI":"10.1016\/j.heliyon.2024.e24906","volume":"10","author":"X Li","year":"2024","unstructured":"Li, X. et al. Study on the mechanism of naringin in promoting bone differentiation: in vitro and in vivo study. Heliyon 10, e24906 (2024).","journal-title":"Heliyon"},{"key":"97217_CR27","doi-asserted-by":"publisher","first-page":"113379","DOI":"10.1016\/j.biopha.2022.113379","volume":"153","author":"H Jin","year":"2022","unstructured":"Jin, H. et al. Effect of flavonoids from rhizoma drynariae on osteoporosis rats and osteocytes. Biomed. Pharmacother.  153, 113379 (2022).","journal-title":"Biomed. Pharmacother"},{"key":"97217_CR28","doi-asserted-by":"publisher","first-page":"100757","DOI":"10.1016\/j.diff.2024.100757","volume":"136","author":"V Selvaraj","year":"2024","unstructured":"Selvaraj, V., Sekaran, S., Dhanasekaran, A. & Warrier, S. Type 1 collagen: synthesis, structure and key functions in bone mineralization. Differentiation 136, 100757 (2024).","journal-title":"Differentiation"},{"key":"97217_CR29","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1359\/jbmr.2001.16.4.758","volume":"16","author":"MA Brown","year":"2001","unstructured":"Brown, M. A. et al. Genetic control of bone density and turnover: role of the collagen 1alpha1, Estrogen receptor, and vitamin D receptor genes. J. Bone Min. Res. 16, 758\u2013764 (2001).","journal-title":"J. Bone Min. Res."},{"key":"97217_CR30","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.bone.2019.04.021","volume":"126","author":"ME Robinson","year":"2019","unstructured":"Robinson, M. E. & Rauch, F. Mendelian bone fragility disorders. Bone 126, 11\u201317 (2019).","journal-title":"Bone"},{"key":"97217_CR31","doi-asserted-by":"publisher","first-page":"5776","DOI":"10.3390\/ijms23105776","volume":"23","author":"T Komori","year":"2022","unstructured":"Komori, T. Whole aspect of Runx2 functions in skeletal development. Int. J. Mol. Sci. 23, 5776 (2022).","journal-title":"Int. J. Mol. Sci."},{"key":"97217_CR32","doi-asserted-by":"publisher","first-page":"1012508","DOI":"10.3389\/fendo.2022.1012508","volume":"13","author":"RJ Bai","year":"2022","unstructured":"Bai, R. J., Li, Y. S. & Zhang, F. J. Osteopontin, a Bridge links osteoarthritis and osteoporosis. Front. Endocrinol. (Lausanne) 13, 1012508 (2022).","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"97217_CR33","doi-asserted-by":"publisher","first-page":"109890","DOI":"10.1016\/j.abb.2024.109890","volume":"753","author":"J Liu","year":"2024","unstructured":"Liu, J. et al. Naringin-induced M2 macrophage polarization facilitates osteogenesis of BMSCs and improves cranial bone defect healing in rat. Arch. Biochem. Biophys. 753, 109890 (2024).","journal-title":"Arch. Biochem. Biophys."},{"key":"97217_CR34","doi-asserted-by":"publisher","first-page":"13020","DOI":"10.1021\/acs.jafc.1c04353","volume":"69","author":"GJ Wu","year":"2021","unstructured":"Wu, G. J., Chen, K. Y., Yang, J. D., Liu, S. H. & Chen, R. M. Naringin improves osteoblast mineralization and bone healing and strength through regulating estrogen receptor alpha-dependent alkaline phosphatase gene expression. J. Agric. Food Chem. 69, 13020\u201313033 (2021).","journal-title":"J. Agric. Food Chem."},{"key":"97217_CR35","doi-asserted-by":"publisher","DOI":"10.1002\/bies.202400110","author":"H H","year":"2024","unstructured":"H, H. et al. Wnt signalosomes: what we know that we do not know. BioEssays: News Rev. Mol. Cell. Dev. Biology. https:\/\/doi.org\/10.1002\/bies.202400110 (2024).","journal-title":"BioEssays: News Reviews Mol. Cell. Dev. Biology"},{"key":"97217_CR36","doi-asserted-by":"publisher","first-page":"2913","DOI":"10.1039\/D1FO02755G","volume":"13","author":"X Wang","year":"2022","unstructured":"Wang, X. et al. Bergamottin promotes osteoblast differentiation and bone formation via activating the Wnt\/\u03b2-catenin signaling pathway. Food Funct. 13, 2913\u20132924 (2022).","journal-title":"Food Funct."},{"key":"97217_CR37","doi-asserted-by":"publisher","first-page":"116587","DOI":"10.1016\/j.bcp.2024.116587","volume":"230","author":"A Abhishek Shah","year":"2024","unstructured":"Abhishek Shah, A. et al. Therapeutic targeting of Wnt antagonists by small molecules for treatment of osteoporosis. Biochem. Pharmacol. 230, 116587 (2024).","journal-title":"Biochem. Pharmacol."},{"key":"97217_CR38","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1007\/s00223-013-9749-z","volume":"93","author":"M Rossini","year":"2013","unstructured":"Rossini, M., Gatti, D. & Adami, S. Involvement of WNT\/\u03b2-catenin signaling in the treatment of osteoporosis. Calcif Tissue Int. 93, 121\u2013132 (2013).","journal-title":"Calcif Tissue Int."},{"key":"97217_CR39","doi-asserted-by":"publisher","first-page":"675470","DOI":"10.3389\/fphar.2021.675470","volume":"12","author":"S Li","year":"2021","unstructured":"Li, S. et al. Total flavonoids of rhizoma drynariae promotes differentiation of osteoblasts and growth of bone graft in induced membrane partly by activating Wnt\/\u03b2-catenin signaling pathway. Front. Pharmacol. 12, 675470 (2021).","journal-title":"Front. Pharmacol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-97217-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-97217-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-97217-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T20:47:42Z","timestamp":1744490862000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-97217-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,12]]},"references-count":39,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["97217"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-97217-7","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,12]]},"assertion":[{"value":"24 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"12651"}}