{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T04:07:32Z","timestamp":1744862852951,"version":"3.40.4"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T00:00:00Z","timestamp":1744761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T00:00:00Z","timestamp":1744761600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"crossref","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"crossref","award":["406840\/2022-9"],"award-info":[{"award-number":["406840\/2022-9"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"crossref","award":["APQ-02105-18","RED00204-23"],"award-info":[{"award-number":["APQ-02105-18","RED00204-23"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-97601-3","type":"journal-article","created":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T08:43:24Z","timestamp":1744793004000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synergistic effect of secondhand smoke and apical periodontitis on lung tissue damage in rats"],"prefix":"10.1038","volume":"15","author":[{"given":"Danilo Cassiano","family":"Ferraz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e1vio Gabriel Silva","family":"Rende","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anahi de Paula","family":"Melo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo C\u00e9sar","family":"Rosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"San\u00edvia Aparecida de Lima","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camilla Christian Gomes","family":"Moura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priscilla Barbosa Ferreira","family":"Soares","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,4,16]]},"reference":[{"key":"97601_CR1","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1227\/neu.0000000000002412","volume":"93","author":"MD Gruber","year":"2023","unstructured":"Gruber, M. D. et al. The effects of nicotine- and cigarette-related products on osteogenesis, bone formation, and bone mineralization: A systematic review. Neurosurgery 93, 247\u2013256. https:\/\/doi.org\/10.1227\/neu.0000000000002412 (2023).","journal-title":"Neurosurgery"},{"key":"97601_CR2","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.jot.2024.04.003","volume":"46","author":"G Xie","year":"2024","unstructured":"Xie, G. et al. Smoking and osteoimmunology: Understanding the interplay between bone metabolism and immune homeostasis. J. Orthop. Transl. 46, 33\u201345. https:\/\/doi.org\/10.1016\/j.jot.2024.04.003 (2024).","journal-title":"J. Orthop. Translat"},{"key":"97601_CR3","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1007\/s00784-019-03094-6","volume":"24","author":"A Aminoshariae","year":"2020","unstructured":"Aminoshariae, A., Kulild, J. & Gutmann, J. The association between smoking and periapical periodontitis: a systematic review. Clin. Oral Investig.  24, 533\u2013545. https:\/\/doi.org\/10.1007\/s00784-019-03094-6 (2020).","journal-title":"Clin. Oral Investig"},{"key":"97601_CR4","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1055\/s-0043-1761451","volume":"18","author":"E Paljevic","year":"2024","unstructured":"Paljevic, E., Brekalo Prso, I., Hrstic, J. V. & Pezelj-Ribaric, S. Persic Bukmir, R. Impact of smoking on the healing of apical periodontitis after nonsurgical endodontic treatment. Eur. J. Dent. 18, 124\u2013130. https:\/\/doi.org\/10.1055\/s-0043-1761451 (2024).","journal-title":"Eur. J. Dent."},{"key":"97601_CR5","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.1111\/iej.13344","volume":"53","author":"KP Pinto","year":"2020","unstructured":"Pinto, K. P. et al. Effects of alcohol and nicotine consumption on the development of apical periodontitis in rats: a correlative micro-computed tomographic, histological and immunohistochemical study. Int. Endod J. 53, 1238\u20131252. https:\/\/doi.org\/10.1111\/iej.13344 (2020).","journal-title":"Int. Endod J."},{"key":"97601_CR6","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1016\/j.joen.2012.02.011","volume":"38","author":"J Lopez-Lopez","year":"2012","unstructured":"Lopez-Lopez, J. et al. Tobacco smoking and radiographic periapical status: a retrospective case-control study. J. Endod  38, 584\u2013588. https:\/\/doi.org\/10.1016\/j.joen.2012.02.011 (2012).","journal-title":"J. Endod"},{"key":"97601_CR7","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/j.joen.2024.01.005","volume":"50","author":"AMV Vasques","year":"2024","unstructured":"Vasques, A. M. V. et al. Bone resorption in apical periodontitis enhanced by cigarette smoke inhalation: histometric, immunohistochemical, and microtomographic analysis in rats. J. Endod  50, 493\u2013498. https:\/\/doi.org\/10.1016\/j.joen.2024.01.005 (2024).","journal-title":"J. Endod"},{"key":"97601_CR8","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1111\/iej.13883","volume":"56","author":"AMV Vasques","year":"2023","unstructured":"Vasques, A. M. V. et al. Inflammatory profile of apical periodontitis exacerbated by cigarette smoke inhalation: histological and immunohistochemical analysis in rats. Int. Endod J. 56, 465\u2013474. https:\/\/doi.org\/10.1111\/iej.13883 (2023).","journal-title":"Int. Endod J."},{"key":"97601_CR9","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1111\/iej.13316","volume":"53","author":"KP Pinto","year":"2020","unstructured":"Pinto, K. P. et al. Does tobacco smoking predispose to apical periodontitis and endodontic treatment need? A systematic review and meta-analysis. Int. Endod J. 53, 1068\u20131083. https:\/\/doi.org\/10.1111\/iej.13316 (2020).","journal-title":"Int. Endod J."},{"key":"97601_CR10","doi-asserted-by":"publisher","first-page":"2047","DOI":"10.1093\/ntr\/ntw105","volume":"18","author":"AA Akinkugbe","year":"2016","unstructured":"Akinkugbe, A. A., Slade, G. D., Divaris, K. & Poole, C. Systematic review and meta-analysis of the association between exposure to environmental tobacco smoke and periodontitis endpoints among nonsmokers. Nicotine Tob. Res. 18, 2047\u20132056. https:\/\/doi.org\/10.1093\/ntr\/ntw105 (2016).","journal-title":"Nicotine Tob. Res."},{"key":"97601_CR11","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1007\/s40368-022-00709-7","volume":"23","author":"LM Oliveira","year":"2022","unstructured":"Oliveira, L. M., Oliveira, M. D. M., Ardenghi, T. M. & Zanatta, F. B. Is secondhand smoke exposure associated with poor periodontal status in children and adolescents? A systematic review and meta-analysis. Eur. Arch. Paediatr. Dent. 23, 513\u2013525. https:\/\/doi.org\/10.1007\/s40368-022-00709-7 (2022).","journal-title":"Eur. Arch. Paediatr. Dent."},{"key":"97601_CR12","doi-asserted-by":"publisher","first-page":"4701","DOI":"10.1007\/s00784-022-04531-9","volume":"26","author":"P Pesce","year":"2022","unstructured":"Pesce, P. et al. Evaluation of periodontal indices among non-smokers, tobacco, and e-cigarette smokers: a systematic review and network meta-analysis. Clin. Oral Investig.  26, 4701\u20134714. https:\/\/doi.org\/10.1007\/s00784-022-04531-9 (2022).","journal-title":"Clin. Oral Investig"},{"key":"97601_CR13","first-page":"185","volume":"86","author":"JD Sutton","year":"2012","unstructured":"Sutton, J. D., Ranney, L. M., Wilder, R. S. & Sanders, A. E. Environmental tobacco smoke and periodontitis in U.S. non-smokers. J. Dent. Hyg. 86, 185\u2013194 (2012).","journal-title":"J. Dent. Hyg."},{"key":"97601_CR14","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1902\/jop.2017.160725","volume":"88","author":"JD Sutton","year":"2017","unstructured":"Sutton, J. D., Martinez, S., & Gerkovich, M. M. Environmental tobacco smoke and periodontitis in United States non-smokers, 2009 to 2012. J. Periodontol.  88, 565\u2013574. https:\/\/doi.org\/10.1902\/jop.2017.160725 (2017).","journal-title":"J. Periodontol"},{"key":"97601_CR15","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1111\/j.1600-0501.2008.01695.x","volume":"20","author":"MG Correa","year":"2009","unstructured":"Correa, M. G. et al. Histometric evaluation of bone around titanium implants with different surface treatments in rats exposed to cigarette smoke inhalation. Clin. Oral Implants Res. 20, 588\u2013593. https:\/\/doi.org\/10.1111\/j.1600-0501.2008.01695.x (2009).","journal-title":"Clin. Oral Implants Res."},{"key":"97601_CR16","first-page":"347","volume":"17","author":"FH Nociti Jr","year":"2002","unstructured":"Nociti, F. H. Jr., Cesar, N. J., Carvalho, M. D. & Sallum, E. A. Bone density around titanium implants May be influenced by intermittent cigarette smoke inhalation: a histometric study in rats. Int. J. Oral Maxillofac. Implants  17, 347\u2013352 (2002).","journal-title":"Int. J. Oral Maxillofac. Implants"},{"key":"97601_CR17","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1111\/iej.13981","volume":"56","author":"ACR da Silva","year":"2023","unstructured":"da Silva, A. C. R. et al. Effects of cigarette smoke inhalation on the immune-inflammatory profile of experimental apical periodontitis in rats. Int. Endod J. 56, 1559\u20131570. https:\/\/doi.org\/10.1111\/iej.13981 (2023).","journal-title":"Int. Endod J."},{"key":"97601_CR18","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1111\/iej.13994","volume":"57","author":"KP Pinto","year":"2024","unstructured":"Pinto, K. P. et al. Chronic alcohol and nicotine consumption as catalyst for systemic inflammatory storm and bone destruction in apical periodontitis. Int. Endod J. 57, 178\u2013194. https:\/\/doi.org\/10.1111\/iej.13994 (2024).","journal-title":"Int. Endod J."},{"key":"97601_CR19","doi-asserted-by":"publisher","first-page":"1472","DOI":"10.1016\/j.joen.2023.08.012","volume":"49","author":"J Lamba","year":"2023","unstructured":"Lamba, J. et al. Association of apical periodontitis with different stages of chronic kidney disease measured by glomerular filtration rate and systemic markers: an observational study. J. Endod  49, 1472\u20131479. https:\/\/doi.org\/10.1016\/j.joen.2023.08.012 (2023).","journal-title":"J. Endod"},{"key":"97601_CR20","doi-asserted-by":"publisher","first-page":"104849","DOI":"10.1016\/j.archoralbio.2020.104849","volume":"118","author":"RCS Barcelos","year":"2020","unstructured":"Barcelos, R. C. S. et al. Apical periodontitis induces changes on oxidative stress parameters and increases Na(+)\/K(+)-ATPase activity in adult rats. Arch. Oral Biol. 118, 104849. https:\/\/doi.org\/10.1016\/j.archoralbio.2020.104849 (2020).","journal-title":"Arch. Oral Biol."},{"key":"97601_CR21","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1111\/iej.13907","volume":"56","author":"S Xiao","year":"2023","unstructured":"Xiao, S. et al. Is oxidative stress involved in the hepatic inflammatory response to apical periodontitis? A comparative study in normal and hyperlipidaemic rat. Int. Endod J. 56, 722\u2013733. https:\/\/doi.org\/10.1111\/iej.13907 (2023).","journal-title":"Int. Endod J."},{"key":"97601_CR22","doi-asserted-by":"publisher","first-page":"1281685","DOI":"10.3389\/fimmu.2023.1281685","volume":"14","author":"TC Brembach","year":"2023","unstructured":"Brembach, T. C., Sabat, R., Witte, K., Schwerdtle, T. & Wolk, K. Molecular and functional changes in neutrophilic granulocytes induced by nicotine: a systematic review and critical evaluation. Front. Immunol. 14, 1281685. https:\/\/doi.org\/10.3389\/fimmu.2023.1281685 (2023).","journal-title":"Front. Immunol."},{"key":"97601_CR23","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1080\/08958378.2020.1805052","volume":"32","author":"AK Pham","year":"2020","unstructured":"Pham, A. K. et al. Differential lung inflammation and injury with tobacco smoke exposure in Wistar Kyoto and spontaneously hypertensive rats. Inhal. Toxicol. 32, 328\u2013341. https:\/\/doi.org\/10.1080\/08958378.2020.1805052 (2020).","journal-title":"Inhal Toxicol."},{"key":"97601_CR24","doi-asserted-by":"publisher","first-page":"2465","DOI":"10.1097\/CM9.0000000000000469","volume":"132","author":"GB Liang","year":"2019","unstructured":"Liang, G. B. & He, Z. H. Animal models of emphysema. Chin. Med. J. (Engl.)  132, 2465\u20132475. https:\/\/doi.org\/10.1097\/CM9.0000000000000469 (2019).","journal-title":"Chin. Med. J. (Engl)"},{"key":"97601_CR25","doi-asserted-by":"publisher","first-page":"1486","DOI":"10.1002\/fsn3.3188","volume":"11","author":"H Anwar","year":"2023","unstructured":"Anwar, H. et al. Analyzing cross-talk of EPO and EGF genes along with evaluating therapeutic potential of cinnamomum verum in cigarette-smoke-induced lung pathophysiology in rat model. Food Sci. Nutr. 11, 1486\u20131498. https:\/\/doi.org\/10.1002\/fsn3.3188 (2023).","journal-title":"Food Sci. Nutr."},{"key":"97601_CR26","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1111\/aej.12888","volume":"50","author":"NS Macedo Signorelli","year":"2024","unstructured":"Macedo Signorelli, N. S. et al. Identification of oxidative stress biomarkers in apical periodontitis: A scoping review with bibliometric analysis. Aust Endod J. 50, 742\u2013760. https:\/\/doi.org\/10.1111\/aej.12888 (2024).","journal-title":"Aust Endod J."},{"key":"97601_CR27","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1016\/j.joen.2016.01.022","volume":"42","author":"LT Cintra","year":"2016","unstructured":"Cintra, L. T. et al. Multiple apical periodontitis influences serum levels of cytokines and nitric oxide. J. Endod  42, 747\u2013751. https:\/\/doi.org\/10.1016\/j.joen.2016.01.022 (2016).","journal-title":"J. Endod"},{"key":"97601_CR28","doi-asserted-by":"publisher","first-page":"869","DOI":"10.3389\/fphys.2017.00869","volume":"8","author":"P Hernandez-Rios","year":"2017","unstructured":"Hernandez-Rios, P., Pussinen, P. J., Vernal, R. & Hernandez, M. Oxidative stress in the local and systemic events of apical periodontitis. Front. Physiol. 8, 869. https:\/\/doi.org\/10.3389\/fphys.2017.00869 (2017).","journal-title":"Front. Physiol."},{"key":"97601_CR29","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1007\/s11999-016-5184-6","volume":"475","author":"HA Santiago","year":"2017","unstructured":"Santiago, H. A., Zamarioli, A., Sousa Neto, M. D. & Volpon, J. B. Exposure to secondhand smoke impairs fracture healing in rats. Clin. Orthop. Relat. Res. 475, 894\u2013902. https:\/\/doi.org\/10.1007\/s11999-016-5184-6 (2017).","journal-title":"Clin. Orthop. Relat. Res."},{"key":"97601_CR30","doi-asserted-by":"publisher","first-page":"246S","DOI":"10.1016\/S0012-3692(15)51013-1","volume":"117","author":"KJ Nikula","year":"2000","unstructured":"Nikula, K. J. et al. A mouse model of cigarette smoke-induced emphysema. Chest 117, 246S\u2013247S (2000).","journal-title":"Chest"},{"key":"97601_CR31","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.joen.2006.11.011","volume":"33","author":"S Hama","year":"2007","unstructured":"Hama, S., Takeichi, O., Saito, I. & Ito, K. Involvement of inducible nitric oxide synthase and receptor for advanced glycation end products in periapical granulomas. J. Endod  33, 137\u2013141. https:\/\/doi.org\/10.1016\/j.joen.2006.11.011 (2007).","journal-title":"J. Endod"},{"key":"97601_CR32","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1111\/iej.12886","volume":"51","author":"A Jakovljevic","year":"2018","unstructured":"Jakovljevic, A. et al. Levels of oxidative stress biomarkers and bone resorption regulators in apical periodontitis lesions infected by Epstein-Barr virus. Int. Endod J. 51, 593\u2013604. https:\/\/doi.org\/10.1111\/iej.12886 (2018).","journal-title":"Int. Endod J."},{"key":"97601_CR33","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1007\/s00784-022-04754-w","volume":"27","author":"C Loureiro","year":"2023","unstructured":"Loureiro, C. et al. Teeth with acute apical abscess vs. teeth with chronic apical periodontitis: a quantitative and qualitative proteomic analysis. Clin. Oral Investig.  27, 591\u2013601. https:\/\/doi.org\/10.1007\/s00784-022-04754-w (2023).","journal-title":"Clin. Oral Investig"},{"key":"97601_CR34","doi-asserted-by":"publisher","first-page":"2031","DOI":"10.2147\/JPR.S141366","volume":"10","author":"V Vengerfeldt","year":"2017","unstructured":"Vengerfeldt, V., Mandar, R., Saag, M., Piir, A. & Kullisaar, T. Oxidative stress in patients with endodontic pathologies. J. Pain Res. 10, 2031\u20132040. https:\/\/doi.org\/10.2147\/JPR.S141366 (2017).","journal-title":"J. Pain Res."},{"key":"97601_CR35","doi-asserted-by":"publisher","unstructured":"Zhao, X. et al. Quercetin protects ethanol-induced hepatocyte pyroptosis via scavenging mitochondrial ROS and promoting PGC-1alpha-regulated mitochondrial homeostasis in L02 cells. Oxid. Med. Cell. Longev. 2022 (4591134). https:\/\/doi.org\/10.1155\/2022\/4591134 (2022).","DOI":"10.1155\/2022\/4591134"},{"key":"97601_CR36","doi-asserted-by":"publisher","first-page":"1464","DOI":"10.1007\/s10753-022-01625-0","volume":"45","author":"BM Saraiva-Romanholo","year":"2022","unstructured":"Saraiva-Romanholo, B. M. et al. Exposure to sodium hypochlorite or cigarette smoke induces lung injury and mechanical impairment in wistar rats. Inflammation 45, 1464\u20131483. https:\/\/doi.org\/10.1007\/s10753-022-01625-0 (2022).","journal-title":"Inflammation"},{"key":"97601_CR37","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1080\/00016357.2018.1521005","volume":"77","author":"PH Braz-Silva","year":"2019","unstructured":"Braz-Silva, P. H. et al. Inflammatory profile of chronic apical periodontitis: a literature review. Acta Odontol. Scand. 77, 173\u2013180. https:\/\/doi.org\/10.1080\/00016357.2018.1521005 (2019).","journal-title":"Acta Odontol. Scand."},{"key":"97601_CR38","doi-asserted-by":"publisher","first-page":"H51","DOI":"10.1152\/ajpheart.00657.2019","volume":"319","author":"MA El-Mahdy","year":"2020","unstructured":"El-Mahdy, M. A. et al. Chronic cigarette smoke exposure triggers a vicious cycle of leukocyte and endothelial-mediated oxidant stress that results in vascular dysfunction. Am. J. Physiol. Heart Circ. Physiol. 319, H51\u2013H65. https:\/\/doi.org\/10.1152\/ajpheart.00657.2019 (2020).","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"97601_CR39","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1177\/0022034520952341","volume":"100","author":"F Cavalla","year":"2021","unstructured":"Cavalla, F., Letra, A., Silva, R. M. & Garlet, G. P. Determinants of periodontal\/periapical lesion stability and progression. J. Dent. Res. 100, 29\u201336. https:\/\/doi.org\/10.1177\/0022034520952341 (2021).","journal-title":"J. Dent. Res."},{"key":"97601_CR40","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1186\/s12931-024-03042-3","volume":"25","author":"J Xiong","year":"2024","unstructured":"Xiong, J. et al. Therapeutic effects of melatonin on the lungs of rats exposed to passive smoking. Respir. Res. 25, 411. https:\/\/doi.org\/10.1186\/s12931-024-03042-3 (2024).","journal-title":"Respir Res."},{"key":"97601_CR41","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1007\/s00784-024-05540-6","volume":"28","author":"AR Vaz\u00e3o","year":"2024","unstructured":"Vaz\u00e3o, A. R. et al. Experimental apical periodontitis alters salivary biochemical composition and induces local redox state disturbances in the salivary glands of male rats. Clin. Oral Investig.  28, 154. https:\/\/doi.org\/10.1007\/s00784-024-05540-6 (2024).","journal-title":"Clin. Oral Investig"},{"key":"97601_CR42","doi-asserted-by":"publisher","first-page":"1581","DOI":"10.1111\/iej.13562","volume":"54","author":"AM Samanovic","year":"2021","unstructured":"Samanovic, A. M. et al. Cardiac, biochemical and histopathological analysis reveals impaired heart function in hypertensive rats with apical periodontitis. Int. Endod J. 54, 1581\u20131596. https:\/\/doi.org\/10.1111\/iej.13562 (2021).","journal-title":"Int. Endod J."},{"key":"97601_CR43","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1016\/j.joen.2016.07.007","volume":"42","author":"N Khalighinejad","year":"2016","unstructured":"Khalighinejad, N. et al. Association between systemic diseases and apical periodontitis. J. Endod  42, 1427\u20131434. https:\/\/doi.org\/10.1016\/j.joen.2016.07.007 (2016).","journal-title":"J. Endod"},{"key":"97601_CR44","doi-asserted-by":"publisher","first-page":"e0239562","DOI":"10.1371\/journal.pone.0239562","volume":"15","author":"T Salaets","year":"2020","unstructured":"Salaets, T. et al. A semi-automated method for unbiased alveolar morphometry: validation in a bronchopulmonary dysplasia model. PLoS One  15, e0239562. https:\/\/doi.org\/10.1371\/journal.pone.0239562 (2020).","journal-title":"PLoS One"},{"key":"97601_CR45","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1164\/rccm.200809-1522ST","volume":"181","author":"CC Hsia","year":"2010","unstructured":"Hsia, C. C.,\u00a0Hyde, D. M., Ochs, M., Weibel, E.R., ATS\/ERS Joint Task Force on Quantitative Assessment of Lung Structure. An official research policy statement of the American Thoracic Society\/European Respiratory Society: standards for quantitative assessment of lung structure. Am. J. Respir. Crit. Care Med. 181, 394\u2013418. https:\/\/doi.org\/10.1164\/rccm.200809-1522ST (2010).","journal-title":"Am. J. Respir Crit. Care Med."},{"key":"97601_CR46","doi-asserted-by":"publisher","first-page":"717","DOI":"10.2147\/COPD.S110520","volume":"12","author":"J Sun","year":"2017","unstructured":"Sun, J. et al. Effect of Simvastatin on MMPs and timps in cigarette smoke-induced rat COPD model. Int. J. Chron. Obstruct Pulmon. Dis. 12, 717\u2013724. https:\/\/doi.org\/10.2147\/COPD.S110520 (2017).","journal-title":"Int. J. Chron. Obstruct Pulmon Dis."},{"key":"97601_CR47","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.toxlet.2009.06.850","volume":"189","author":"H Zheng","year":"2009","unstructured":"Zheng, H. et al. Development and characterization of a rat model of chronic obstructive pulmonary disease (COPD) induced by sidestream cigarette smoke. Toxicol. Lett. 189, 225\u2013234. https:\/\/doi.org\/10.1016\/j.toxlet.2009.06.850 (2009).","journal-title":"Toxicol. Lett."},{"key":"97601_CR48","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1111\/iej.13096","volume":"52","author":"TVS Tsosura","year":"2019","unstructured":"Tsosura, T. V. S. et al. Maternal apical periodontitis is associated with insulin resistance in adult offspring. Int. Endod J. 52, 1040\u20131050. https:\/\/doi.org\/10.1111\/iej.13096 (2019).","journal-title":"Int. Endod J."},{"key":"97601_CR49","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1111\/iej.13477","volume":"54","author":"V Nagendrababu","year":"2021","unstructured":"Nagendrababu, V. et al. PRIASE 2021 guidelines for reporting animal studies in endodontology: a consensus-based development. Int. Endod J. 54, 848\u2013857. https:\/\/doi.org\/10.1111\/iej.13477 (2021).","journal-title":"Int. Endod J."},{"key":"97601_CR50","doi-asserted-by":"publisher","first-page":"e1000412","DOI":"10.1371\/journal.pbio.1000412","volume":"8","author":"C Kilkenny","year":"2010","unstructured":"Kilkenny, C., Browne, W. J., Cuthill, I. C., Emerson, M. & Altman, D. G. Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research. PLoS Biol. 8, e1000412. https:\/\/doi.org\/10.1371\/journal.pbio.1000412 (2010).","journal-title":"PLoS Biol."},{"key":"97601_CR51","doi-asserted-by":"publisher","first-page":"1595","DOI":"10.1007\/s00784-012-0853-7","volume":"17","author":"LT Cintra","year":"2013","unstructured":"Cintra, L. T. et al. Pulpal and periodontal diseases increase triglyceride levels in diabetic rats. Clin. Oral Investig.  17, 1595\u20131599. https:\/\/doi.org\/10.1007\/s00784-012-0853-7 (2013).","journal-title":"Clin. Oral Investig"},{"key":"97601_CR52","doi-asserted-by":"publisher","first-page":"319","DOI":"10.2223\/JPED.1645","volume":"83","author":"A Aycicek","year":"2007","unstructured":"Aycicek, A. & Erel, O. Total oxidant\/antioxidant status in jaundiced newborns before and after phototherapy. J. Pediatr. (Rio J)  83, 319\u2013322. https:\/\/doi.org\/10.2223\/JPED.1645 (2007).","journal-title":"J. Pediatr. (Rio J)"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-97601-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-97601-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-97601-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T08:43:25Z","timestamp":1744793005000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-97601-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,16]]},"references-count":52,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["97601"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-97601-3","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,16]]},"assertion":[{"value":"23 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"13088"}}