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Therefore, it is crucial to maximize the acquisition of cardiovascular information (CVI) through non-invasive methods to enhance early screening, diagnosis, and evaluation of CVDs. Numerous studies have demonstrated that obtaining more CVI by simultaneously acquiring multi-site signals and applying pressure stimulation at specific sites, such as blood pressure measurement, is an effective approach. Based on this evidence, we proposed a novel signal acquisition-and-analysis system to gather comprehensive CVI through a combination of a non-pressure and six pressure-stimulation sub-processes. This system involves the novelty of applying slowly gradual decrease, personalized maximum-pulse amplitude, and blocking blood-flow pressure to six cuffs placed on both arms, wrists, and ankles in a predetermined time sequence. During each sub-process, the system has newly integrated the multi-site simultaneous collection of 27-channel non-invasive signals, including electrocardiogram, heart sound, lung sound, photoplethysmographic-and-pressure pulse. To ensure measurement accuracy, three types of verification-and-calibration instruments were employed. Our results demonstrate that the system can achieve simultaneous acquisition of 27-channel signals during each sub-process, yielding both novel and traditional cardiovascular parameters with high accuracy and good stability. Furthermore, the results suggest that the system can facilitate in-depth research into the relationships between collected signals and CVDs, provide rich raw data for cardiovascular health assessment and disease prediction models based on machine learning algorithms, and offer a new non-invasive method for early diagnosis, evaluation, and prediction of CVDs.<\/jats:p>","DOI":"10.1038\/s41598-025-97812-8","type":"journal-article","created":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T05:28:52Z","timestamp":1744954132000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Design and validation of a novel multiple sites signal acquisition and analysis system based on pressure stimulation for human cardiovascular information"],"prefix":"10.1038","volume":"15","author":[{"given":"Gaiqin","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longcong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panpan","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,18]]},"reference":[{"key":"97812_CR1","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1007\/978-3-031-33851-9_24","volume-title":"Global Health Essentials","author":"A Berner-Rodoreda","year":"2023","unstructured":"Berner-Rodoreda, A., Kanyama, C., Supady, A. & B\u00e4rnighausen, T. 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