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This study investigated the co-existence of multi-drug resistant <jats:italic>Salmonella typhimurium<\/jats:italic> (<jats:italic>S. typhimurium<\/jats:italic>) and residual traces of antibiotics in chilled chicken meat collected from Fayoum province in Egypt. Our data reported that 22.2% of chicken meat and liver were contaminated with <jats:italic>S. typhimurium<\/jats:italic> with 100% being drug resistant to a wide range of antimicrobials including tylosin, chloramphenicol, and oxytetracycline (OTC). The residual analysis of chicken meat samples revealed that they contained residues of 3antibacterial drugs including tylosin, chloramphenicol, OTC and its metabolite (4-epi-OTC). The statistical analysis of obtained data also revealed a relationship between <jats:italic>S. typhimurium<\/jats:italic> resistance and the presence of antibiotic residues in chicken samples, as isolates derived from samples with residual drug content higher than maximum residue levels (MRL) were found to be resistant to the same antibiotic. This confirms the importance of integrating sustainable practices in the veterinary field with a strict commitment to monitoring the bacterial content and residual antibiotics in foods of animal origin before marketing them, to protect the effectiveness of antibiotics for future generations.<\/jats:p>","DOI":"10.1038\/s41598-025-98189-4","type":"journal-article","created":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T05:46:01Z","timestamp":1745991961000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Antibiotic residues correlate with antibiotic resistance of Salmonella typhimurium isolated from edible chicken meat"],"prefix":"10.1038","volume":"15","author":[{"given":"Hala R.","family":"Ali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esraa G.","family":"Hefny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naglaa F.","family":"Koraney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samah F.","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed I.","family":"AbdAllah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai A.","family":"Fadel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara M.","family":"Elnomrosy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Momataz A.","family":"Shahein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,30]]},"reference":[{"issue":"7","key":"98189_CR1","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1086\/433191","volume":"41","author":"P Collignon","year":"2005","unstructured":"Collignon, P., Wegener, H. 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