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However, the release of iron ions leads to the formation of reactive oxygen species (ROS), resulting in cell damage. In this study, we developed MRI contrast agents containing amine-functionalized MnFe\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    nanoparticles with a Prussian blue (PB) surface coating to enhance their biocompatibility. The prepared MNPs were embedded in polyvinylpyrrolidone and dried. The resulting crystals can be redispersed in water immediately before use, forming a stable colloid. The particle size of nanoparticles (43\u2009\u00b1\u200913\u00a0nm) is suitable for the intended application. The values of Hc (52 Oe) and Mr (3.7 emu\/g) for the particles indicate a soft ferromagnetic nature. The coating of the particles with PB results in a significant reduction of their toxicity, as evidenced by a toxicological test on HEK293 cells. This colloid was tested in vitro as an MRI contrast agent as well as in healthy animal. The longitudinal relaxivity (r\n                    <jats:sub>1<\/jats:sub>\n                    ) of the PB-MnFe\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    -NH\n                    <jats:sub>2<\/jats:sub>\n                    sample was determined to be 0.01 (mg\/mL)\n                    <jats:sup>\u22121<\/jats:sup>\n                    ms\n                    <jats:sup>\u2212\u20091<\/jats:sup>\n                    . The transversal relaxivity was measured as well (r\n                    <jats:sub>2<\/jats:sub>\n                    : 0.77 (mg\/mL)\n                    <jats:sup>\u22121<\/jats:sup>\n                    ms\n                    <jats:sup>\u2212\u20091<\/jats:sup>\n                    and r\n                    <jats:sub>2<\/jats:sub>\n                    *: 1.48 (mg\/mL)\n                    <jats:sup>\u22121<\/jats:sup>\n                    ms\n                    <jats:sup>\u2212\u20091<\/jats:sup>\n                    , which were in the same range as Feraheme and Endorem. Prussian blue-coated MnFe\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    emerges as a promising T2-weighted contrast material, representing a novel combination of two well-known contrast-capable materials.\n                  <\/jats:p>","DOI":"10.1038\/s41598-025-98348-7","type":"journal-article","created":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T08:53:52Z","timestamp":1745398432000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Development of manganese ferrite coated with Prussian blue as an efficient contrast agent for applications in magnetic resonance imaging"],"prefix":"10.1038","volume":"15","author":[{"given":"\u00c1gnes Maria","family":"Ilosvai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Heydari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e1szl\u00f3","family":"Forg\u00e1ch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"No\u00e9mi","family":"Kov\u00e1cs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kriszti\u00e1n","family":"Szigeti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domokos","family":"M\u00e1th\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferenc","family":"Krist\u00e1ly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lajos","family":"Dar\u00f3czi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9la","family":"Viskolcz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikl\u00f3s","family":"Nagy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikl\u00f3s","family":"N\u00e9meth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tam\u00e1s","family":"Oll\u00e1r","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e1szl\u00f3","family":"Vanyorek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,23]]},"reference":[{"key":"98348_CR1","doi-asserted-by":"publisher","first-page":"126117","DOI":"10.1016\/j.matchemphys.2022.126117","volume":"286","author":"A Manohar","year":"2022","unstructured":"Manohar, A., Vijayakanth, V., Vattikuti, S. 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