{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T04:40:07Z","timestamp":1745815207937,"version":"3.40.4"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T00:00:00Z","timestamp":1745798400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T00:00:00Z","timestamp":1745798400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-98952-7","type":"journal-article","created":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T04:16:55Z","timestamp":1745813815000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Down-regulation of YAP prevents smoking- and alcohol-induced carcinogenesis of esophageal paracancerous tissue by promoting cellular pyroptosis"],"prefix":"10.1038","volume":"15","author":[{"given":"Xinyu","family":"Ding","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuning","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhifei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongfei","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zihao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,4,28]]},"reference":[{"key":"98952_CR1","doi-asserted-by":"publisher","first-page":"106880","DOI":"10.1016\/j.envint.2021.106880","volume":"157","author":"T Lipenga","year":"2021","unstructured":"Lipenga, T. et al. A Concise review towards defining the exposome of oesophageal cancer in sub-Saharan Africa. Environ Int. 157, 106880. https:\/\/doi.org\/10.1016\/j.envint.2021.106880 (2021).","journal-title":"Environ Int."},{"key":"98952_CR2","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11091815","author":"N Shi","year":"2022","unstructured":"Shi, N. & Chen, T. Chemopreventive properties of black raspberries and strawberries in esophageal cancer review. Antioxidants https:\/\/doi.org\/10.3390\/antiox11091815 (2022).","journal-title":"Antioxidants"},{"key":"98952_CR3","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/s43018-022-00473-z","volume":"4","author":"S Piccolo","year":"2023","unstructured":"Piccolo, S., Panciera, T., Contessotto, P. & Cordenonsi, M. YAP\/TAZ as master regulators in cancer: Modulation, function and therapeutic approaches. Nat. Cancer 4, 9\u201326. https:\/\/doi.org\/10.1038\/s43018-022-00473-z (2023).","journal-title":"Nat. Cancer"},{"key":"98952_CR4","doi-asserted-by":"publisher","first-page":"2399","DOI":"10.1042\/BST20240244","volume":"52","author":"R Zhu","year":"2024","unstructured":"Zhu, R., Jiao, Z. & Yu, F. X. Advances towards potential cancer therapeutics targeting hippo signaling. Biochem. Soc. Trans. 52, 2399\u20132413. https:\/\/doi.org\/10.1042\/BST20240244 (2024).","journal-title":"Biochem. Soc. Trans."},{"key":"98952_CR5","doi-asserted-by":"publisher","first-page":"109640","DOI":"10.1016\/j.abb.2023.109640","volume":"742","author":"Q Sun","year":"2023","unstructured":"Sun, Q. et al. RNF106 aggravates esophageal squamous cell carcinoma progression through LATS2\/YAP axis. Arch. Biochem. Biophys. 742, 109640. https:\/\/doi.org\/10.1016\/j.abb.2023.109640 (2023).","journal-title":"Arch. Biochem. Biophys."},{"key":"98952_CR6","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1038\/s41392-021-00507-5","volume":"6","author":"P Yu","year":"2021","unstructured":"Yu, P. et al. Pyroptosis: Mechanisms and diseases. Signal Transduct. Target Ther. 6, 128. https:\/\/doi.org\/10.1038\/s41392-021-00507-5 (2021).","journal-title":"Signal Transduct. Target Ther."},{"key":"98952_CR7","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s12943-024-02217-2","volume":"24","author":"P Zhao","year":"2025","unstructured":"Zhao, P., Yin, S., Qiu, Y., Sun, C. & Yu, H. Ferroptosis and pyroptosis are connected through autophagy: A new perspective of overcoming drug resistance. Mol. Cancer 24, 23. https:\/\/doi.org\/10.1186\/s12943-024-02217-2 (2025).","journal-title":"Mol. Cancer"},{"key":"98952_CR8","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1158\/0008-5472.CAN-22-1002","volume":"83","author":"A El-Kenawi","year":"2023","unstructured":"El-Kenawi, A. et al. Elevated methionine flux drives pyroptosis evasion in persister cancer cells. Cancer Res. 83, 720\u2013734. https:\/\/doi.org\/10.1158\/0008-5472.CAN-22-1002 (2023).","journal-title":"Cancer Res."},{"key":"98952_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bbcan.2019.05.001","volume":"1872","author":"CB Zhou","year":"2019","unstructured":"Zhou, C. B. & Fang, J. Y. The role of pyroptosis in gastrointestinal cancer and immune responses to intestinal microbial infection. Biochim. Biophys. Acta Rev. Cancer 1872, 1\u201310. https:\/\/doi.org\/10.1016\/j.bbcan.2019.05.001 (2019).","journal-title":"Biochim. Biophys. Acta Rev. Cancer"},{"key":"98952_CR10","doi-asserted-by":"publisher","first-page":"2114","DOI":"10.1038\/s41423-021-00740-6","volume":"18","author":"Y Huang","year":"2021","unstructured":"Huang, Y., Xu, W. & Zhou, R. NLRP3 inflammasome activation and cell death. Cell Mol. Immunol. 18, 2114\u20132127. https:\/\/doi.org\/10.1038\/s41423-021-00740-6 (2021).","journal-title":"Cell Mol. Immunol."},{"key":"98952_CR11","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1038\/s41586-022-05023-2","volume":"608","author":"A Erickson","year":"2022","unstructured":"Erickson, A. et al. Spatially resolved clonal copy number alterations in benign and malignant tissue. Nature 608, 360\u2013367. https:\/\/doi.org\/10.1038\/s41586-022-05023-2 (2022).","journal-title":"Nature"},{"key":"98952_CR12","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1042\/CS20190331","volume":"133","author":"X Sun","year":"2019","unstructured":"Sun, X. et al. Ergosterol attenuates cigarette smoke extract-Induced COPD by modulating inflammation, oxidative stress and apoptosis in vitro and in vivo. Clin. Sci. 133, 1523\u20131536. https:\/\/doi.org\/10.1042\/CS20190331 (2019).","journal-title":"Clin. Sci."},{"key":"98952_CR13","doi-asserted-by":"publisher","first-page":"2696","DOI":"10.1210\/jc.2005-2113","volume":"91","author":"R Lambrot","year":"2006","unstructured":"Lambrot, R. et al. Use of organ culture to study the human fetal testis development: Effect of retinoic acid. J. Clin. Endocrinol. Metab. 91, 2696\u20132703. https:\/\/doi.org\/10.1210\/jc.2005-2113 (2006).","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"98952_CR14","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1186\/s12885-020-07555-0","volume":"20","author":"C Wei","year":"2020","unstructured":"Wei, C. & Li, X. Verteporfin inhibits cell proliferation and induces apoptosis in different subtypes of breast cancer cell lines without light activation. BMC Cancer 20, 1042. https:\/\/doi.org\/10.1186\/s12885-020-07555-0 (2020).","journal-title":"BMC Cancer"},{"key":"98952_CR15","doi-asserted-by":"publisher","first-page":"113068","DOI":"10.1016\/j.ecoenv.2021.113068","volume":"229","author":"R Li","year":"2022","unstructured":"Li, R. et al. Combined effect of unfolded protein response and circZc3h4, circRNA scar in mouse ovary and uterus damage induced by procymidone. Ecotoxicol. Environ. Saf. 229, 113068. https:\/\/doi.org\/10.1016\/j.ecoenv.2021.113068 (2022).","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"98952_CR16","doi-asserted-by":"publisher","first-page":"698698","DOI":"10.3389\/fmolb.2021.698698","volume":"8","author":"L Hong","year":"2021","unstructured":"Hong, L., Zha, Y., Wang, C., Qiao, S. & An, J. Folic acid alleviates high glucose and fat-induced pyroptosis via inhibition of the hippo signal pathway on H9C2 cells. Front. Mol. Biosci. 8, 698698. https:\/\/doi.org\/10.3389\/fmolb.2021.698698 (2021).","journal-title":"Front. Mol. Biosci."},{"key":"98952_CR17","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1093\/stmcls\/sxac063","volume":"40","author":"T Zhang","year":"2022","unstructured":"Zhang, T. et al. Exosome from BMMSC attenuates cardiopulmonary bypass-induced acute lung injury via YAP\/beta-catenin oathway: Downregulation of pyroptosis. Stem Cells. 40, 1122\u20131133. https:\/\/doi.org\/10.1093\/stmcls\/sxac063 (2022).","journal-title":"Stem Cells."},{"key":"98952_CR18","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1053\/j.gastro.2017.08.023","volume":"154","author":"CC Abnet","year":"2018","unstructured":"Abnet, C. C., Arnold, M. & Wei, W. Q. Epidemiology of esophageal squamous cell carcinoma. Gastroenterology 154, 360\u2013373. https:\/\/doi.org\/10.1053\/j.gastro.2017.08.023 (2018).","journal-title":"Gastroenterology"},{"key":"98952_CR19","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/j.bpg.2017.09.002","volume":"31","author":"J Dong","year":"2017","unstructured":"Dong, J. & Thrift, A. P. Alcohol, smoking and risk of oesophago-gastric cancer. Best Pract. Res. Clin. Gastroenterol. 31, 509\u2013517. https:\/\/doi.org\/10.1016\/j.bpg.2017.09.002 (2017).","journal-title":"Best Pract. Res. Clin. Gastroenterol."},{"key":"98952_CR20","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1007\/s10552-019-01226-7","volume":"30","author":"B Viner","year":"2019","unstructured":"Viner, B., Barberio, A. M., Haig, T. R., Friedenreich, C. M. & Brenner, D. R. The individual and combined effects of alcohol consumption and cigarette smoking on site-specific cancer risk in a prospective cohort of 26,607 adults: Results from Alberta\u2019s tomorrow project. Cancer Causes Control. 30, 1313\u20131326. https:\/\/doi.org\/10.1007\/s10552-019-01226-7 (2019).","journal-title":"Cancer Causes Control."},{"key":"98952_CR21","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1016\/j.jhep.2021.05.041","volume":"75","author":"SM Bou","year":"2021","unstructured":"Bou, S. M. et al. Loss of hepatocyte identity following aberrant YAP activation: A key mechanism in alcoholic hepatitis. J. Hepatol. 75, 912\u2013923. https:\/\/doi.org\/10.1016\/j.jhep.2021.05.041 (2021).","journal-title":"J. Hepatol."},{"key":"98952_CR22","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1002\/hep.31800","volume":"74","author":"P Kusumanchi","year":"2021","unstructured":"Kusumanchi, P. et al. Stress-responsive gene FK506-binding protein 51 mediates alcohol-induced liver injury through the hippo pathway and chemokine (C-X-C Motif) ligand 1 signaling. Hepatology 74, 1234\u20131250. https:\/\/doi.org\/10.1002\/hep.31800 (2021).","journal-title":"Hepatology"},{"key":"98952_CR23","doi-asserted-by":"publisher","first-page":"4591134","DOI":"10.1155\/2022\/4591134","volume":"2022","author":"X Zhao","year":"2022","unstructured":"Zhao, X. et al. Quercetin protects ethanol-induced hepatocyte pyroptosis via scavenging mitochondrial ROS and promoting PGC-1alpha-regulated mitochondrial homeostasis in L02 cells. Oxid. Med. Cell. Longev. 2022, 4591134. https:\/\/doi.org\/10.1155\/2022\/4591134 (2022).","journal-title":"Oxid. Med. Cell. Longev."},{"key":"98952_CR24","doi-asserted-by":"publisher","first-page":"668708","DOI":"10.3389\/fphar.2021.668708","volume":"12","author":"J Chu","year":"2021","unstructured":"Chu, J. et al. Sinapic acid reduces oxidative stress and pyroptosis via inhibition of BRD4 in alcoholic liver disease. Front. Pharmacol. 12, 668708. https:\/\/doi.org\/10.3389\/fphar.2021.668708 (2021).","journal-title":"Front. Pharmacol."},{"key":"98952_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.neo.2023.100888","volume":"38","author":"Y Bai","year":"2023","unstructured":"Bai, Y. et al. Comprehensive profiling of EGFR mutation subtypes reveals genomic-clinical associations in non-small-cell lung cancer patients on first-generation EGFR inhibitors. Neoplasia 38, 100888. https:\/\/doi.org\/10.1016\/j.neo.2023.100888 (2023).","journal-title":"Neoplasia"},{"key":"98952_CR26","doi-asserted-by":"publisher","first-page":"e90836","DOI":"10.1371\/journal.pone.0090836","volume":"9","author":"Y Zhao","year":"2014","unstructured":"Zhao, Y., Zhou, W., Xue, L., Zhang, W. & Zhan, Q. Nicotine activates YAP1 through nAChRs mediated signaling in esophageal squamous cell cancer (ESCC). PLoS ONE 9, e90836. https:\/\/doi.org\/10.1371\/journal.pone.0090836 (2014).","journal-title":"PLoS ONE"},{"key":"98952_CR27","doi-asserted-by":"publisher","first-page":"902","DOI":"10.1093\/toxres\/tfad085","volume":"12","author":"H Wang","year":"2023","unstructured":"Wang, H. et al. Testicular tissue response following a 90-day subchronic exposure to HTP aerosols and cigarette smoke in rats. Toxicol. Res. 12, 902\u2013912. https:\/\/doi.org\/10.1093\/toxres\/tfad085 (2023).","journal-title":"Toxicol. Res."},{"key":"98952_CR28","doi-asserted-by":"publisher","first-page":"2743","DOI":"10.1007\/s10565-023-09799-5","volume":"39","author":"X Liu","year":"2023","unstructured":"Liu, X. et al. Role of GSDM family members in airway epithelial cells of lung diseases: A systematic and comprehensive transcriptomic analysis. Cell. Biol. Toxicol. 39, 2743\u20132760. https:\/\/doi.org\/10.1007\/s10565-023-09799-5 (2023).","journal-title":"Cell. Biol. Toxicol."},{"key":"98952_CR29","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1093\/stmcls\/sxac063","volume":"40","author":"T Zhang","year":"2022","unstructured":"Zhang, T. et al. Exosome from BMMSC attenuates cardiopulmonary bypass-induced acute lung injury via YAP\/beta-catenin pathway: Downregulation of pyroptosis. Stem Cells 40, 1122\u20131133. https:\/\/doi.org\/10.1093\/stmcls\/sxac063 (2022).","journal-title":"Stem Cells"},{"key":"98952_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bcp.2017.06.113","volume":"144","author":"Y Abreu-Villaca","year":"2017","unstructured":"Abreu-Villaca, Y., Manhaes, A. C., Krahe, T. E., Filgueiras, C. C. & Ribeiro-Carvalho, A. Tobacco and alcohol use during adolescence: Interactive mechanisms in animal models. Biochem. Pharmacol. 144, 1\u201317. https:\/\/doi.org\/10.1016\/j.bcp.2017.06.113 (2017).","journal-title":"Biochem. Pharmacol."},{"key":"98952_CR31","doi-asserted-by":"publisher","DOI":"10.1007\/s12033-023-00891-z","author":"XW Wang","year":"2023","unstructured":"Wang, X. W. et al. Verteporfin exerts anticancer effects and reverses resistance to paclitaxel via inducing ferroptosis in esophageal squamous cell cancer cells. Mol. Biotechnol. https:\/\/doi.org\/10.1007\/s12033-023-00891-z (2023).","journal-title":"Mol. Biotechnol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-98952-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-98952-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-98952-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T04:16:55Z","timestamp":1745813815000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-98952-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,28]]},"references-count":31,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["98952"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-98952-7","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,28]]},"assertion":[{"value":"8 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"14766"}}