{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T23:24:23Z","timestamp":1785885863811,"version":"3.56.0"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T00:00:00Z","timestamp":1745884800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T00:00:00Z","timestamp":1745884800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"This research was supported by the improvement of medical services and guarantee capabilities-Key clinical specialties of anesthesia, Genera Programs","award":["no. 2021-LCZDZK-01"],"award-info":[{"award-number":["no. 2021-LCZDZK-01"]}]},{"name":"This research was supported by the improvement of medical services and guarantee capabilities-Key clinical specialties of anesthesia, Genera Programs","award":["no. 2021-LCZDZK-01"],"award-info":[{"award-number":["no. 2021-LCZDZK-01"]}]},{"name":"This research was supported by the improvement of medical services and guarantee capabilities-Key clinical specialties of anesthesia, Genera Programs","award":["no. 2021-LCZDZK-01"],"award-info":[{"award-number":["no. 2021-LCZDZK-01"]}]},{"name":"This research was supported by the improvement of medical services and guarantee capabilities-Key clinical specialties of anesthesia, Genera Programs","award":["no. 2021-LCZDZK-01"],"award-info":[{"award-number":["no. 2021-LCZDZK-01"]}]},{"name":"This research was supported by the improvement of medical services and guarantee capabilities-Key clinical specialties of anesthesia, Genera Programs","award":["no. 2021-LCZDZK-01"],"award-info":[{"award-number":["no. 2021-LCZDZK-01"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-99173-8","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T03:43:39Z","timestamp":1745898219000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Risk factors and prognosis of silent cerebral infarction after transcatheter aortic valve replacement"],"prefix":"10.1038","volume":"15","author":[{"given":"Shuguang","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,29]]},"reference":[{"issue":"4","key":"99173_CR1","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1016\/j.mayocp.2018.01.020","volume":"93","author":"A Kanwar","year":"2018","unstructured":"Kanwar, A., Thaden, J. J. & Nkomo, V. T. Management of Patients With Aortic Valve Stenosis[J\/OL]. Mayo Clin. Proc. 93(4), 488\u2013508. https:\/\/doi.org\/10.1016\/j.mayocp.2018.01.020 (2018).","journal-title":"Mayo Clin. Proc."},{"issue":"10025","key":"99173_CR2","doi-asserted-by":"publisher","first-page":"1312","DOI":"10.1016\/S0140-6736(16)00586-9","volume":"387","author":"RO Bonow","year":"2016","unstructured":"Bonow, R. O. et al. Management strategies and future challenges for aortic valve disease[J\/OL]. Lancet (London, England) 387(10025), 1312\u20131323. https:\/\/doi.org\/10.1016\/S0140-6736(16)00586-9 (2016).","journal-title":"Lancet (London, England)"},{"issue":"19","key":"99173_CR3","doi-asserted-by":"publisher","first-page":"1972","DOI":"10.1016\/j.jacc.2014.02.556","volume":"63","author":"JJ Popma","year":"2014","unstructured":"Popma, J. J. et al. Transcatheter aortic valve replacement using a self-expanding bioprosthesis in patients with severe aortic stenosis at extreme risk for surgery[J\/OL]. J. Am. Coll. Cardiol. 63(19), 1972\u20131981. https:\/\/doi.org\/10.1016\/j.jacc.2014.02.556 (2014).","journal-title":"J. Am. Coll. Cardiol."},{"issue":"23","key":"99173_CR4","doi-asserted-by":"publisher","first-page":"2187","DOI":"10.1056\/NEJMoa1103510","volume":"364","author":"CR Smith","year":"2011","unstructured":"Smith, C. R. et al. Transcatheter versus surgical aortic-valve replacement in high-risk patients[J\/OL]. N. Engl. J. Med. 364(23), 2187\u20132198. https:\/\/doi.org\/10.1056\/NEJMoa1103510 (2011).","journal-title":"N. Engl. J. Med."},{"issue":"17","key":"99173_CR5","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1056\/NEJMoa1008232","volume":"363","author":"MB Leon","year":"2010","unstructured":"Leon, M. B. et al. Transcatheter aortic-valve implantation for aortic stenosis in patients who cannot undergo surgery[J\/OL]. N. Engl. J. Med. 363(17), 1597\u20131607. https:\/\/doi.org\/10.1056\/NEJMoa1008232 (2010).","journal-title":"N. Engl. J. Med."},{"key":"99173_CR6","doi-asserted-by":"publisher","unstructured":"VARC-3 WRITING COMMITTEE:, G\u00c9N\u00c9REUX P, PIAZZA N, et al. Valve Academic Research Consortium 3: Updated Endpoint Definitions for Aortic Valve Clinical Research[J\/OL]. Journal of the American College of Cardiology, 2021, 77(21): 2717\u20132746. https:\/\/doi.org\/10.1016\/j.jacc.2021.02.038.[8] LANSKY AJ, MESS\u00c9 SR, BRICKMAN AM, et al. Proposed Standardized Neurological Endpoints for Cardiovascular Clinical Trials: An Academic Research Consortium Initiative[J\/OL].\u00a0Eur Heart J. 2018;39(19):1687\u20131697. https:\/\/doi.org\/10.1093\/eurheartj\/ehx037","DOI":"10.1016\/j.jacc.2021.02.038.[8 10.1093\/eurheartj\/ehx037"},{"issue":"1","key":"99173_CR7","doi-asserted-by":"publisher","first-page":"45","DOI":"10.3390\/medicina58010045","volume":"58","author":"G Ciccarelli","year":"2021","unstructured":"Ciccarelli, G. et al. Asymptomatic Stroke in the Setting of Percutaneous Non-Coronary Intervention Procedures[J\/OL]. Medicina 58(1), 45. https:\/\/doi.org\/10.3390\/medicina58010045 (2021).","journal-title":"Medicina"},{"issue":"10","key":"99173_CR8","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1093\/eurheartj\/ehab002","volume":"42","author":"K Woldendorp","year":"2021","unstructured":"Woldendorp, K. et al. Silent brain infarcts and early cognitive outcomes after transcatheter aortic valve implantation: a systematic review and meta-analysis[J\/OL]. Eur. Heart J. 42(10), 1004\u20131015. https:\/\/doi.org\/10.1093\/eurheartj\/ehab002 (2021).","journal-title":"Eur. Heart J."},{"issue":"5","key":"99173_CR9","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1016\/j.jcin.2015.01.020","volume":"8","author":"NM Van Mieghem","year":"2015","unstructured":"Van Mieghem, N. M. et al. Incidence and Predictors of Debris Embolizing to the Brain During Transcatheter Aortic Valve Implantation. JACC: Cardiovasc. Interventions. 8(5), 718\u2013724. https:\/\/doi.org\/10.1016\/j.jcin.2015.01.020 (2015).","journal-title":"JACC: Cardiovasc. Interventions."},{"issue":"9","key":"99173_CR10","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1016\/j.jacc.2018.12.039","volume":"73","author":"D Conen","year":"2019","unstructured":"Conen, D. et al. Relationships of overt and silent Brain Lesions with cognitive function in patients with atrial fibrillation. J. Am. Coll. Cardiol. 73(9), 989\u2013999. https:\/\/doi.org\/10.1016\/j.jacc.2018.12.039 (2019).","journal-title":"J. Am. Coll. Cardiol."},{"issue":"5","key":"99173_CR11","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1002\/ccd.29842","volume":"98","author":"MZ Khan","year":"2021","unstructured":"Khan, M. Z. et al. Use and outcomes of cerebral embolic protection for transcatheter aortic valve replacement: A US nationwide study. Catheter. Cardiovasc. Interv. 98(5), 959\u2013968. https:\/\/doi.org\/10.1002\/ccd.29842 (2021).","journal-title":"Catheter. Cardiovasc. Interv."},{"issue":"22","key":"99173_CR12","doi-asserted-by":"publisher","first-page":"2579","DOI":"10.1016\/j.jacc.2020.09.605","volume":"76","author":"J Fan","year":"2020","unstructured":"Fan, J. et al. Brain Injury After Transcatheter Replacement of Bicuspid Versus Tricuspid Aortic Valves[J\/OL]. J. Am. Coll. Cardiol. 76(22), 2579\u20132590. https:\/\/doi.org\/10.1016\/j.jacc.2020.09.605 (2020).","journal-title":"J. Am. Coll. Cardiol."},{"issue":"5","key":"99173_CR13","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1111\/j.1747-4949.2012.00851.x","volume":"8","author":"KR Kov\u00e1cs","year":"2013","unstructured":"Kov\u00e1cs, K. R. et al. Silent Brain Infarction \u2013 A Review of Recent Observations[J\/OL]. Int. J. Stroke 8(5), 334\u2013347. https:\/\/doi.org\/10.1111\/j.1747-4949.2012.00851.x (2013).","journal-title":"Int. J. Stroke"},{"issue":"4","key":"99173_CR14","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1097\/ALN.0000000000004354","volume":"137","author":"PE Vlisides","year":"2022","unstructured":"Vlisides, P. E. et al. Carbon Dioxide, Blood Pressure, and Perioperative Stroke: A Retrospective Case-Control Study[J\/OL]. Anesthesiology 137(4), 434\u2013445. https:\/\/doi.org\/10.1097\/ALN.0000000000004354 (2022).","journal-title":"Anesthesiology"},{"issue":"10203","key":"99173_CR15","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1016\/S0140-6736(19)31795-7","volume":"394","author":"M Mrkobrada","year":"2019","unstructured":"Mrkobrada, M. et al. Perioperative covert stroke in patients undergoing non-cardiac surgery (NeuroVISION): a prospective cohort study[J\/OL]. The Lancet 394(10203), 1022\u20131029. https:\/\/doi.org\/10.1016\/S0140-6736(19)31795-7 (2019).","journal-title":"The Lancet"},{"key":"99173_CR16","unstructured":"Effect of Intraoperative Arterial Hypotension on the Risk of...\u202f: Anesthesia & Analgesia[EB\/OL]. [2024\u201303\u201330]. https:\/\/journals.lww.com\/anesthesia-analgesia\/fulltext\/2021\/10000\/effect_of_intraoperative_arterial_hypotension_on.25.aspx."},{"issue":"2","key":"99173_CR17","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1093\/europace\/euw279","volume":"19","author":"AJ Camm","year":"2017","unstructured":"Camm, A. J. et al. Atrial high-rate episodes and stroke prevention[J\/OL]. EP Europace 19(2), 169\u2013179. https:\/\/doi.org\/10.1093\/europace\/euw279 (2017).","journal-title":"EP Europace"},{"issue":"6","key":"99173_CR18","doi-asserted-by":"publisher","first-page":"1654","DOI":"10.1213\/ANE.0000000000005250","volume":"132","author":"A Gregory","year":"2021","unstructured":"Gregory, A. et al. Intraoperative Hypotension Is Associated With Adverse Clinical Outcomes After Noncardiac Surgery[J\/OL]. Anesth. Analg. 132(6), 1654. https:\/\/doi.org\/10.1213\/ANE.0000000000005250 (2021).","journal-title":"Anesth. Analg."},{"key":"99173_CR19","unstructured":"BIJKER J B, MOONS K G M, VAN KLEI W A. Intraoperative Hypotension and Perioperative Ischemic Stroke after General Surgery[J]. PERIOPERATIVE MEDICINE."},{"issue":"11","key":"99173_CR20","doi-asserted-by":"publisher","first-page":"1890","DOI":"10.1016\/j.hrthm.2022.07.028","volume":"19","author":"J Nuche","year":"2022","unstructured":"Nuche, J. et al. Incidence and clinical impact of tachyarrhythmic events following transcatheter aortic valve replacement: A review[J\/OL]. Heart Rhythm 19(11), 1890\u20131898. https:\/\/doi.org\/10.1016\/j.hrthm.2022.07.028 (2022).","journal-title":"Heart Rhythm"},{"issue":"12","key":"99173_CR21","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1038\/nrcardio.2013.162","volume":"10","author":"MEC Hassell","year":"2013","unstructured":"Hassell, M. E. C. et al. Silent cerebral infarcts associated with cardiac disease and procedures. Nat. Rev. Cardiol. 10(12), 696\u2013706. https:\/\/doi.org\/10.1038\/nrcardio.2013.162 (2013).","journal-title":"Nat. Rev. Cardiol."},{"issue":"5","key":"99173_CR22","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1007\/s00392-014-0798-8","volume":"104","author":"M Samim","year":"2015","unstructured":"Samim, M. et al. Silent ischemic brain lesions after transcatheter aortic valve replacement: lesion distribution and predictors. Clin. Res. Cardiol. 104(5), 430\u2013438. https:\/\/doi.org\/10.1007\/s00392-014-0798-8 (2015).","journal-title":"Clin. Res. Cardiol."},{"key":"99173_CR23","doi-asserted-by":"publisher","unstructured":"Frontiers | Predictors and neurological consequences of periprocedural cerebrovascular events following transcatheter aortic valve implantation with self-expanding valves[EB\/OL]. [2023\u201311\u201301]. https:\/\/www.frontiersin.org\/articles\/https:\/\/doi.org\/10.3389\/fcvm.2022.951943\/full.","DOI":"10.3389\/fcvm.2022.951943\/full"},{"key":"99173_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcha.2021.100910","author":"N Nso","year":"2022","unstructured":"Nso, N. et al. Impact of new-onset versus pre-existing atrial fibrillation on outcomes after transcatheter aortic valve replacement\/implantation. Int. J. Cardiol. Heart Vascul. https:\/\/doi.org\/10.1016\/j.ijcha.2021.100910 (2022).","journal-title":"Int. J. Cardiol. Heart Vascul."},{"issue":"15","key":"99173_CR25","doi-asserted-by":"publisher","first-page":"1795","DOI":"10.1016\/j.jcin.2024.05.040","volume":"17","author":"M Avvedimento","year":"2024","unstructured":"Avvedimento, M. et al. Incidence, Predictors, and Prognostic Impact of Neurologic Events After TAVR According to VARC-3 Criteria. JACC Cardiovasc Interv. 17(15), 1795\u20131807. https:\/\/doi.org\/10.1016\/j.jcin.2024.05.040 (2024).","journal-title":"JACC Cardiovasc Interv."},{"issue":"2","key":"99173_CR26","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1007\/s12630-012-9857-7","volume":"60","author":"JB Bijker","year":"2013","unstructured":"Bijker, J. B. & Gelb, A. W. Review article: the role of hypotension in perioperative stroke. Can. J. Anaesth. 60(2), 159\u2013167. https:\/\/doi.org\/10.1007\/s12630-012-9857-7 (2013).","journal-title":"Can. J. Anaesth."},{"issue":"1","key":"99173_CR27","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/j.jtcvs.2013.07.069","volume":"147","author":"M Ono","year":"2014","unstructured":"Ono, M. et al. Duration and magnitude of blood pressure below cerebral autoregulation threshold during cardiopulmonary bypass is associated with major morbidity and operative mortality. J. Thorac. Cardiovasc. Surg. 147(1), 483\u2013489. https:\/\/doi.org\/10.1016\/j.jtcvs.2013.07.069 (2014).","journal-title":"J. Thorac. Cardiovasc. Surg."},{"issue":"1","key":"99173_CR28","doi-asserted-by":"publisher","first-page":"27","DOI":"10.15420\/icr.2017:25:1","volume":"13","author":"G Mohammed Imran","year":"2018","unstructured":"Mohammed Imran, G. & Alexandra, L. Understanding Neurologic Complications Following TAVR. Intl. Cardiol. Rev. 13(1), 27\u201332. https:\/\/doi.org\/10.15420\/icr.2017:25:1 (2018).","journal-title":"Intl. Cardiol. Rev."},{"issue":"7","key":"99173_CR29","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1212\/wnl.57.7.1222","volume":"57","author":"C Bernick","year":"2001","unstructured":"Bernick, C. et al. Silent MRI infarcts and the risk of future stroke: the cardiovascular health study. Neurology 57(7), 1222\u20131229. https:\/\/doi.org\/10.1212\/wnl.57.7.1222 (2001).","journal-title":"Neurology"},{"issue":"5","key":"99173_CR30","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.1161\/STROKEAHA.119.028389","volume":"51","author":"C Andreasen","year":"2020","unstructured":"Andreasen, C. et al. Incidence of Ischemic Stroke in individuals with and without aortic valve stenosis: A danish retrospective cohort study. Stroke 51(5), 1364\u20131371. https:\/\/doi.org\/10.1161\/STROKEAHA.119.028389 (2020).","journal-title":"Stroke"},{"issue":"2","key":"99173_CR31","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1007\/s11065-022-09548-1","volume":"33","author":"A Gerstenecker","year":"2023","unstructured":"Gerstenecker, A. et al. Silent Brain Infarction, Delirium, and Cognition in Three Invasive Cardiovascular Procedures: A Systematic Review. Neuropsychol. Rev. 33(2), 474\u2013491. https:\/\/doi.org\/10.1007\/s11065-022-09548-1 (2023).","journal-title":"Neuropsychol. Rev."},{"issue":"3","key":"99173_CR32","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/j.jacc.2015.05.018","volume":"66","author":"BS Larsen","year":"2015","unstructured":"Larsen, B. S. et al. Excessive atrial ectopy and short atrial runs increase the risk of stroke beyond incident atrial fibrillation. J. Am. Coll. Cardiol. 66(3), 232\u2013241. https:\/\/doi.org\/10.1016\/j.jacc.2015.05.018 (2015).","journal-title":"J. Am. Coll. Cardiol."},{"issue":"3","key":"99173_CR33","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1007\/s12630-023-02653-6","volume":"71","author":"T Nakanishi","year":"2024","unstructured":"Nakanishi, T. et al. Association between postinduction hypotension and postoperative mortality: a single-centre retrospective cohort study Association entre hypotension post-induction et mortalit\u00e9 postop\u00e9ratoire une \u00e9tude de cohorte r\u00e9trospective monocentrique. Canadian J. Anaesthesia J. Canadien d\u2019Anesthesie. 71(3), 343\u2013352 (2024).","journal-title":"Canadian J. Anaesthesia J. Canadien d\u2019Anesthesie."},{"issue":"19","key":"99173_CR34","doi-asserted-by":"publisher","first-page":"2302","DOI":"10.1161\/CIRCULATIONAHA.112.112300","volume":"126","author":"D Conen","year":"2012","unstructured":"Conen, D. et al. Premature atrial contractions in the general population: frequency and risk factors. Circulation 126(19), 2302\u20132308. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.112.112300 (2012).","journal-title":"Circulation"},{"issue":"5","key":"99173_CR35","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1016\/j.bja.2021.07.021","volume":"127","author":"LA Evered","year":"2021","unstructured":"Evered, L. A. et al. Anaesthetic depth and delirium after major surgery: a randomised clinical trial. Br. J. Anaesth. 127(5), 704\u2013712. https:\/\/doi.org\/10.1016\/j.bja.2021.07.021 (2021).","journal-title":"Br. J. Anaesth."},{"issue":"20","key":"99173_CR36","doi-asserted-by":"publisher","first-page":"2129","DOI":"10.1016\/j.jacc.2016.08.046","volume":"68","author":"V Auffret","year":"2016","unstructured":"Auffret, V. et al. Serial Changes in Cognitive Function Following Transcatheter Aortic Valve Replacement. J. Am. Coll. Cardiol. 68(20), 2129\u20132141. https:\/\/doi.org\/10.1016\/j.jacc.2016.08.046 (2016).","journal-title":"J. Am. Coll. Cardiol."},{"issue":"13","key":"99173_CR37","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1056\/NEJMoa022066","volume":"348","author":"SE Vermeer","year":"2003","unstructured":"Vermeer, S. E. et al. Silent Brain infarcts and the risk of dementia and cognitive decline. N. Engl. J. Med. 348(13), 1215\u20131222. https:\/\/doi.org\/10.1056\/NEJMoa022066 (2003).","journal-title":"N. Engl. J. Med."},{"issue":"4","key":"99173_CR38","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/j.jacc.2016.10.023","volume":"69","author":"SR Kapadia","year":"2017","unstructured":"Kapadia, S. R. et al. Protection against cerebral embolism during transcatheter aortic valve replacement. J. Am. Coll. Cardiol. 69(4), 367\u2013377. https:\/\/doi.org\/10.1016\/j.jacc.2016.10.023 (2017).","journal-title":"J. Am. Coll. Cardiol."},{"issue":"11","key":"99173_CR39","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1016\/j.jcin.2020.03.004","volume":"13","author":"M De Carlo","year":"2020","unstructured":"De Carlo, M. et al. Evolution, predictors, and neurocognitive effects of silent cerebral embolism during transcatheter aortic valve replacement. JACC: Cardiova. Interventions. 13(11), 1291\u20131300. https:\/\/doi.org\/10.1016\/j.jcin.2020.03.004 (2020).","journal-title":"JACC: Cardiova. Interventions."},{"issue":"2","key":"99173_CR40","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.jcin.2015.09.037","volume":"9","author":"M Abawi","year":"2016","unstructured":"Abawi, M. et al. Incidence predictive factors and effect of delirium after transcatheter aortic valve replacement. JACC Cardiovasc. Interv. 9(2), 160\u2013168. https:\/\/doi.org\/10.1016\/j.jcin.2015.09.037 (2016).","journal-title":"JACC Cardiovasc. Interv."},{"issue":"6","key":"99173_CR41","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1097\/ALN.0000000000004754","volume":"139","author":"S Dragovic","year":"2023","unstructured":"Dragovic, S. et al. Predictors of Low Risk for Delirium during Anesthesia Emergence. Anesthesiology 139(6), 757\u2013768. https:\/\/doi.org\/10.1097\/ALN.0000000000004754 (2023).","journal-title":"Anesthesiology"},{"issue":"8\u20139","key":"99173_CR42","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/j.acvd.2016.01.016","volume":"109","author":"G Avin\u00e9e","year":"2016","unstructured":"Avin\u00e9e, G. et al. Trends over the past 4 years in population characteristics, 30-day outcomes and 1-year survival in patients treated with transcatheter aortic valve implantation. Arch. Cardiovasc. Dis. 109(8\u20139), 457\u2013464. https:\/\/doi.org\/10.1016\/j.acvd.2016.01.016 (2016).","journal-title":"Arch. Cardiovasc. Dis."},{"key":"99173_CR43","unstructured":"SERGI D, ACCONCIA M C, MUSCOLI S, et al. Meta-analysis of the impact on early and late mortality of TAVI compared to surgical aortic valve replacement in high and low-intermediate surgical risk patients[J]."},{"issue":"2","key":"99173_CR44","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.jstrokecerebrovasdis.2005.11.001","volume":"15","author":"H Bokura","year":"2006","unstructured":"Bokura, H. et al. Silent Brain infarction and subcortical white matter lesions increase the risk of stroke and mortality: A prospective cohort study. J. Stroke Cerebrovasc. Dis. 15(2), 57\u201363. https:\/\/doi.org\/10.1016\/j.jstrokecerebrovasdis.2005.11.001 (2006).","journal-title":"J. Stroke Cerebrovasc. Dis."},{"issue":"2","key":"99173_CR45","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1161\/01.str.0000052631.98405.15","volume":"34","author":"SE Vermeer","year":"2003","unstructured":"Vermeer, S. E. et al. Incidence and risk factors of silent brain infarcts in the population-based Rotterdam Scan Study. Stroke 34(2), 392\u2013396. https:\/\/doi.org\/10.1161\/01.str.0000052631.98405.15 (2003).","journal-title":"Stroke"},{"issue":"10","key":"99173_CR46","doi-asserted-by":"publisher","first-page":"2376","DOI":"10.1161\/01.str.0000032241.58727.49","volume":"33","author":"WT Longstreth","year":"2002","unstructured":"Longstreth, W. T. et al. Incidence, manifestations, and predictors of brain infarcts defined by serial cranial magnetic resonance imaging in the elderly: the Cardiovascular Health Study. Stroke 33(10), 2376\u20132382. https:\/\/doi.org\/10.1161\/01.str.0000032241.58727.49 (2002).","journal-title":"Stroke"},{"issue":"4","key":"99173_CR47","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.jacc.2016.04.057","volume":"68","author":"JB Hermiller","year":"2016","unstructured":"Hermiller, J. B. et al. Predicting Early and Late Mortality After Transcatheter Aortic Valve Replacement. J. Am. Coll. Cardiol. 68(4), 343\u2013352. https:\/\/doi.org\/10.1016\/j.jacc.2016.04.057 (2016).","journal-title":"J. Am. Coll. Cardiol."},{"issue":"12","key":"99173_CR48","doi-asserted-by":"publisher","first-page":"1584","DOI":"10.1093\/ehjci\/jeac191","volume":"23","author":"A Apor","year":"2022","unstructured":"Apor, A. et al. Subclinical leaflet thrombosis after transcatheter aortic valve implantation is associated with silent brain injury on brain magnetic resonance imaging. Eur. Heart J. Cardiovasc. Imaging 23(12), 1584\u20131595. https:\/\/doi.org\/10.1093\/ehjci\/jeac191 (2022).","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"issue":"9","key":"99173_CR49","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1016\/j.jacc.2020.07.005","volume":"76","author":"SH Yoon","year":"2020","unstructured":"Yoon, S. H. et al. Bicuspid aortic valve morphology and outcomes after transcatheter aortic valve replacement. J. Am. Coll. Cardiol. 76(9), 1018\u20131030. https:\/\/doi.org\/10.1016\/j.jacc.2020.07.005 (2020).","journal-title":"J. Am. Coll. Cardiol."},{"issue":"10","key":"99173_CR50","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1001\/jama.2015.1474","volume":"313","author":"DR Holmes","year":"2015","unstructured":"Holmes, D. R. et al. Clinical outcomes at 1 year following transcatheter aortic valve replacement. JAMA 313(10), 1019\u20131028. https:\/\/doi.org\/10.1001\/jama.2015.1474 (2015).","journal-title":"JAMA"},{"issue":"9","key":"99173_CR51","doi-asserted-by":"publisher","first-page":"e010920","DOI":"10.1161\/JAHA.118.010920","volume":"8","author":"B Indja","year":"2019","unstructured":"Indja, B. et al. Silent Brain Infarcts Following Cardiac Procedures: A systematic review and meta-analysis. J. Am. Heart Assoc. 8(9), e010920. https:\/\/doi.org\/10.1161\/JAHA.118.010920 (2019).","journal-title":"J. Am. Heart Assoc."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-99173-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-99173-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-99173-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T03:43:41Z","timestamp":1745898221000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-99173-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,29]]},"references-count":51,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["99173"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-99173-8","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-5948260\/v1","asserted-by":"object"}]},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,29]]},"assertion":[{"value":"3 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"15006"}}