{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T16:40:07Z","timestamp":1747759207628,"version":"3.41.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T00:00:00Z","timestamp":1747699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T00:00:00Z","timestamp":1747699200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100024109","name":"Uniwersytet Gda\u0144ski","doi-asserted-by":"publisher","award":["BMN\/539-T080-B985-23"],"award-info":[{"award-number":["BMN\/539-T080-B985-23"]}],"id":[{"id":"10.13039\/501100024109","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Polish National Science Center","award":["Ceus-Unisono, Grant No. UMO-2020\/02\/Y\/ST4\/0011"],"award-info":[{"award-number":["Ceus-Unisono, Grant No. UMO-2020\/02\/Y\/ST4\/0011"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-99262-8","type":"journal-article","created":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T16:01:23Z","timestamp":1747756883000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Substituted benzylamino-2\u2032-deoxyadenosine a modified nucleoside with radiosensitizing properties"],"prefix":"10.1038","volume":"15","author":[{"given":"Magdalena","family":"Datta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Szczyrba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Czaja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Zdrowowicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Demkowicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janusz","family":"Rak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,5,20]]},"reference":[{"issue":"26","key":"99262_CR1","doi-asserted-by":"publisher","first-page":"8227","DOI":"10.1021\/acs.jpcb.5b03948","volume":"119","author":"J Rak","year":"2015","unstructured":"Rak, J. et al. Mechanisms of damage to DNA labeled with electrophilic nucleobases induced by ionizing or UV radiation. J. Phys. Chem. B. 119(26), 8227\u20138238. https:\/\/doi.org\/10.1021\/acs.jpcb.5b03948 (2015).","journal-title":"J. Phys. Chem. B"},{"issue":"14","key":"99262_CR2","doi-asserted-by":"publisher","first-page":"3230","DOI":"10.1021\/acs.jpclett.2c00512","volume":"13","author":"S Makurat","year":"2022","unstructured":"Makurat, S. et al. Guanosine dianions hydrated by one to four water molecules. J. Phys. Chem. Lett. 13(14), 3230\u20133236. https:\/\/doi.org\/10.1021\/acs.jpclett.2c00512 (2022).","journal-title":"J. Phys. Chem. Lett."},{"key":"99262_CR3","doi-asserted-by":"publisher","unstructured":"Lehnert, S. Biomolecular action of ionizing radiation.   https:\/\/doi.org\/10.1667\/rrxx07.1 (2007).","DOI":"10.1667\/rrxx07.1"},{"key":"99262_CR4","doi-asserted-by":"publisher","unstructured":"von Sonntag, C. Free-Radical-Induced DNA damage and its repair. https:\/\/doi.org\/10.1007\/3-540-30592-0 (2006).","DOI":"10.1007\/3-540-30592-0"},{"issue":"3","key":"99262_CR5","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/s0167-8140(97)00185-0","volume":"46","author":"A Da\u015fu","year":"1998","unstructured":"Da\u015fu, A. & Denekamp, J. New insights into factors influencing the clinically relevant oxygen enhancement ratio. Radiother Oncol. 46(3), 269\u2013277. https:\/\/doi.org\/10.1016\/s0167-8140(97)00185-0 (1998).","journal-title":"Radiother Oncol."},{"issue":"4","key":"99262_CR6","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1593\/tlo.11166","volume":"4","author":"BT Oronsky","year":"2011","unstructured":"Oronsky, B. T., Knox, S. J. & Scicinski, J. Six degrees of separation: The oxygen effect in the development of radiosensitizers. Transl Oncol. 4(4), 189\u2013198. https:\/\/doi.org\/10.1593\/tlo.11166 (2011).","journal-title":"Transl Oncol."},{"issue":"3","key":"99262_CR7","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1084\/jem.112.3.509","volume":"112","author":"B Djordevic","year":"1960","unstructured":"Djordevic, B. & Szybalski, W. Genetics of human cell lines. III. Incorporation of 5-bromo- and 5-iododeoxyuridine into the deoxyribonucleic acid of human cells and its effect on radiation sensitivity. J. Exp. Med. 112 (3), 509\u2013531. https:\/\/doi.org\/10.1084\/jem.112.3.509 (1960).","journal-title":"J. Exp. Med."},{"issue":"1","key":"99262_CR8","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/S0969-8051(00)00193-1","volume":"28","author":"O Gudjonssona","year":"2001","unstructured":"Gudjonssona, O. et al. Analysis of 76Br-BrdU in DNA of brain tumors after a PET study does not support its use as a proliferation marker. Nucl. Med. Biol. 28 (1), 59\u201365. https:\/\/doi.org\/10.1016\/S0969-8051(00)00193-1 (2001).","journal-title":"Nucl. Med. Biol."},{"key":"99262_CR9","first-page":"260","volume":"23","author":"JP Kriss","year":"1963","unstructured":"Kriss, J. P., Maruyama, Y., Tung, L. A., Bond, S. B. & R\u00e9v\u00e9sz, L. The fate of 5-bromodeoxyuridine, 5-bromodeoxycytidine, and 5-iododeoxvcvtidine in man. Cancer Res. 23, 260\u2013268 (1963).","journal-title":"Cancer Res."},{"key":"99262_CR10","doi-asserted-by":"publisher","unstructured":"Phillips, T. L., Scott, C. B., Leibel, S. A., Rotman, M. & Weigensberg, I. J. Results of a randomized comparison of radiotherapy and bromodeoxyuridine with radiotherapy alone for brain metastases: Report of RTOG trial 89\u2009\u2013\u200905. Int. J. Radiat. Oncol. Biol. Phys. 33(2), 339\u2013348. https:\/\/doi.org\/10.1016\/0360-3016(95)00168-X (1995).","DOI":"10.1016\/0360-3016(95)00168-X"},{"issue":"19","key":"99262_CR11","doi-asserted-by":"publisher","first-page":"5612","DOI":"10.1021\/jp3008738","volume":"116","author":"L Chomicz-Ma\u0144ka","year":"2012","unstructured":"Chomicz-Ma\u0144ka, L., Rak, J. & Storoniak, P. Electron-induced elimination of the bromide anion from brominated nucleobases. A computational study. J. Phys. Chem. B  116(19), 5612\u20135619. https:\/\/doi.org\/10.1021\/jp3008738 (2012).","journal-title":"J. Phys. Chem. B"},{"issue":"6","key":"99262_CR12","doi-asserted-by":"publisher","first-page":"1932","DOI":"10.1021\/bi048105s","volume":"44","author":"S Cecchini","year":"2005","unstructured":"Cecchini, S., Girouard, S., A Huels, M., Sanche, L. & J Hunting, D. Interstrand cross-links: A new type of \u03b3-ray damage in bromodeoxyuridine-substituted DNA. Biochemistry 44(6), 1932\u20131940. https:\/\/doi.org\/10.1021\/bi048105s (2005).","journal-title":"Biochemistry"},{"issue":"41","key":"99262_CR13","doi-asserted-by":"publisher","first-page":"10362","DOI":"10.1039\/c5ob01542a","volume":"13","author":"K Westphal","year":"2015","unstructured":"Westphal, K. et al. Irreversible electron attachment \u2013 a key to DNA damage by solvated electrons in aqueous solution. Org. Biomol. Chem. 13(41), 10362\u201310369. https:\/\/doi.org\/10.1039\/c5ob01542a (2015).","journal-title":"Org. Biomol. Chem."},{"issue":"16","key":"99262_CR14","doi-asserted-by":"publisher","first-page":"2572","DOI":"10.1002\/cphc.201600240","volume":"17","author":"S Makurat","year":"2016","unstructured":"Makurat, S., Chomicz-Ma\u0144ka, L. & Rak, J. Electrophilic 5-substituted uracils as potential radiosensitizers:   Density functional theory study. ChemPhysChem 17(16), 2572\u20132578. https:\/\/doi.org\/10.1002\/cphc.201600240 (2016).","journal-title":"ChemPhysChem"},{"issue":"17","key":"99262_CR15","doi-asserted-by":"publisher","first-page":"2853","DOI":"10.1021\/jz401358w","volume":"4","author":"L Chomicz","year":"2013","unstructured":"Chomicz, L. et al. How to find out whether a 5-substituted uracil could be a potential DNA radiosensitizer. J. Phys. Chem. Lett. 4(17), 2853\u20132857. https:\/\/doi.org\/10.1021\/jz401358w (2013).","journal-title":"J. Phys. Chem. Lett."},{"key":"99262_CR16","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-83244-5_4","author":"M Zdrowowicz","year":"2022","unstructured":"Zdrowowicz, M. et al. DNA damage radiosensitizers geared towards hydrated electrons. Pract. Aspects Comput. Chem. V  https:\/\/doi.org\/10.1007\/978-3-030-83244-5_4 (2022).","journal-title":"Pract. Aspects Comput. Chem. V"},{"issue":"17","key":"99262_CR17","doi-asserted-by":"publisher","first-page":"4023","DOI":"10.1021\/ja003814o","volume":"123","author":"SS Wesolowski","year":"2001","unstructured":"Wesolowski, S. S., Leininger, M. L., Pentchev, P. N. & Schaefer, H. F. Electron affinities of the DNA and RNA bases. J. Am. Chem. Soc. 123(17), 4023\u20134028. https:\/\/doi.org\/10.1021\/ja003814o (2001).","journal-title":"J. Am. Chem. Soc."},{"issue":"7","key":"99262_CR18","doi-asserted-by":"publisher","first-page":"075101","DOI":"10.1063\/1.3685587","volume":"136","author":"K Polska","year":"2012","unstructured":"Polska, K., Rak, J., Bass, A. D., Cloutier, P. & Sanche, L. Electron stimulated desorption of anions from native and brominated single stranded oligonucleotide trimers. J. Chem. Phys. 136(7), 075101. https:\/\/doi.org\/10.1063\/1.3685587 (2012).","journal-title":"J. Chem. Phys."},{"issue":"32","key":"99262_CR19","doi-asserted-by":"publisher","first-page":"9676","DOI":"10.1021\/jp304964r","volume":"116","author":"Y Park","year":"2012","unstructured":"Park, Y., Polska, K., Rak, J., Wagner, J. R. & Sanche, L. Fundamental mechanisms of DNA radiosensitization: Damage induced by low-energy electrons in brominated oligonucleotide trimers. J. Phys. Chem. B 116 (32), 9676\u20139682. https:\/\/doi.org\/10.1021\/jp304964r (2012).","journal-title":"J. Phys. Chem. B"},{"issue":"7","key":"99262_CR20","doi-asserted-by":"publisher","first-page":"5648","DOI":"10.1063\/1.464913","volume":"98","author":"AD Becke","year":"1993","unstructured":"Becke, A. D. Density-functional thermochemistry. III. The role of exact exchange. J. Chem. Phys. 98(7), 5648\u20135652. https:\/\/doi.org\/10.1063\/1.464913 (1993).","journal-title":"J. Chem. Phys."},{"issue":"6","key":"99262_CR21","doi-asserted-by":"publisher","first-page":"3098","DOI":"10.1103\/PhysRevA.38.3098","volume":"38","author":"AD Becke","year":"1988","unstructured":"Becke, A. D. Density-functional exchange-energy approximation with correct asymptotic behavior. Phys. Rev. Gen. Phys. 38(6), 3098\u20133100. https:\/\/doi.org\/10.1103\/PhysRevA.38.3098 (1988).","journal-title":"Phys. Rev. Gen. Phys."},{"issue":"2","key":"99262_CR22","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1103\/PhysRevB.37.785","volume":"37","author":"C Lee","year":"1988","unstructured":"Lee, C., Yang, W. & Parr, R. G. Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density. Phys. Rev. B. 37(2), 785\u2013789. https:\/\/doi.org\/10.1103\/PhysRevB.37.785 (1988).","journal-title":"Phys. Rev. B"},{"issue":"5","key":"99262_CR23","doi-asserted-by":"publisher","first-page":"2257","DOI":"10.1063\/1.1677527","volume":"56","author":"WJ Hehre","year":"1972","unstructured":"Hehre, W. J., Ditchfield, K. & Pople, J. A. Self-consistent molecular orbital methods. XII. Further extensions of Gaussian-type basis sets for use in molecular orbital studies of organic molecules. J. Chem. Phys. 56(5), 2257\u20132261. https:\/\/doi.org\/10.1063\/1.1677527 (1972).","journal-title":"J. Chem. Phys."},{"issue":"2","key":"99262_CR24","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1063\/1.1674902","volume":"54","author":"R Ditchfield","year":"1971","unstructured":"Ditchfield, R., Hehre, W. J. & Pople, J. A. Self-consistent molecular-orbital methods. IX. An extended Gaussian-type basis for molecular-orbital studies of organic molecules. J. Chem. Phys. 54(2), 724\u2013728. https:\/\/doi.org\/10.1063\/1.1674902 (1971).","journal-title":"J. Chem. Phys."},{"issue":"6","key":"99262_CR25","doi-asserted-by":"publisher","first-page":"1308","DOI":"10.3390\/ijms20061308","volume":"20","author":"S Makurat","year":"2019","unstructured":"Makurat, S., Spisz, P., Kozak, W., Rak, J. & Zdrowowicz, M. 5-iodo-4-thio-2\u2032-deoxyuridine as a sensitizer of x-ray induced cancer cell killing. Int. J. Mol. Sci. 20(6), 1308. https:\/\/doi.org\/10.3390\/ijms20061308 (2019).","journal-title":"Int. J. Mol. Sci."},{"issue":"25","key":"99262_CR26","doi-asserted-by":"publisher","first-page":"6139","DOI":"10.1021\/acs.jpcb.7b03633","volume":"121","author":"M Sosnowska","year":"2017","unstructured":"Sosnowska, M., Makurat, S., Zdrowowicz, M. & Rak, J. 5-selenocyanatouracil: a potential hypoxic radiosensitizer. Electron attachment induced formation of selenium centered radical. J. Phys. Chem. B. 121(25), 6139\u20136147. https:\/\/doi.org\/10.1021\/acs.jpcb.7b03633 (2017).","journal-title":"J. Phys. Chem. B"},{"issue":"15","key":"99262_CR27","doi-asserted-by":"publisher","first-page":"2819","DOI":"10.3390\/molecules24152819","volume":"24","author":"P Spisz","year":"2019","unstructured":"Spisz, P. et al. Why does the type of halogen atom matter for the radiosensitizing properties of 5-halogen substituted 4-thio-2\u2019-deoxyuridines? Molecules 24(15), 2819. https:\/\/doi.org\/10.3390\/molecules24152819 (2019).","journal-title":"Molecules"},{"issue":"38","key":"99262_CR28","doi-asserted-by":"publisher","first-page":"21378","DOI":"10.1039\/c8ra03172j","volume":"8","author":"S Makurat","year":"2018","unstructured":"Makurat, S. et al. 5-selenocyanato and 5-trifluoromethanesulfonyl derivatives of 2\u2032-deoxyuridine: Synthesis, radiation and computational chemistry as well as cytotoxicity. RSC Adv. 8(38), 21378\u201321388. https:\/\/doi.org\/10.1039\/c8ra03172j (2018).","journal-title":"RSC Adv."},{"issue":"27","key":"99262_CR29","doi-asserted-by":"publisher","first-page":"5600","DOI":"10.1021\/acs.jpcb.0c03844","volume":"124","author":"P Spisz","year":"2020","unstructured":"Spisz, P. et al. Uracil-5-yl o-sulfamate: An illusive radiosensitizer. Pitfalls in modeling the radiosensitizing derivatives of nucleobases. J. Phys. Chem. B  124(27), 5600\u20135613. https:\/\/doi.org\/10.1021\/acs.jpcb.0c03844 (2020).","journal-title":"J. Phys. Chem. B"},{"issue":"4\u20136","key":"99262_CR30","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/0009-2614(96)00349-1","volume":"255","author":"M Cossi","year":"1996","unstructured":"Cossi, M., Barone, V., Cammi, R. & Tomasi, J. Ab initio study of solvated molecules: A new implementation of the polarizable continuum model. Chem. Phys. Lett. 255(4\u20136), 327\u2013335. https:\/\/doi.org\/10.1016\/0009-2614(96)00349-1 (1996).","journal-title":"Chem. Phys. Lett."},{"key":"99262_CR31","doi-asserted-by":"publisher","unstructured":"Vivet Boudou, V. et al. 8-modified-2\u2019-deoxyadenosine analogues induce delayed polymerization arrest during hiv-1 reverse transcription. PLoS One 6(11), e27456. https:\/\/doi.org\/10.1371\/journal.pone.0027456 (2011).","DOI":"10.1371\/journal.pone.0027456"},{"key":"99262_CR32","doi-asserted-by":"publisher","unstructured":"Stockert, J. C., Horobin, R. W., Colombo, L. L. & Bl\u00e1zquez-Castro, A. Tetrazolium salts and formazan products in cell biology: viability assessment, fluorescence imaging, and labeling perspectives. Acta Histochem. 120(3), 159\u2013167. https:\/\/doi.org\/10.1016\/j.acthis.2018.02.005 (2018).","DOI":"10.1016\/j.acthis.2018.02.005"},{"issue":"17","key":"99262_CR33","doi-asserted-by":"publisher","first-page":"4148","DOI":"10.3390\/ijms20174148","volume":"20","author":"T Matsui","year":"2019","unstructured":"Matsui, T. et al. Robustness of clonogenic assays as a biomarker for cancer cell radiosensitivity. Int. J. Mol. Sci. 20(17), 4148. https:\/\/doi.org\/10.3390\/ijms20174148 (2019).","journal-title":"Int. J. Mol. Sci."},{"key":"99262_CR34","doi-asserted-by":"publisher","unstructured":"van Leeuwen, C. M. et al. The Alfa and beta of tumours: a review of parameters of the linear-quadratic model, derived from clinical radiotherapy studies. Radiat. Oncol. 13(96). https:\/\/doi.org\/10.1186\/s13014-018-1040-z (2018).","DOI":"10.1186\/s13014-018-1040-z"},{"key":"99262_CR35","doi-asserted-by":"publisher","unstructured":"Franken, N. A. P.et al cell survival and radiosensitisation: modulation of the linear and quadratic parameters of the LQ model (review). Int. J. Oncol. 42(15), 1501\u20131515. https:\/\/doi.org\/10.3892\/ijo.2013.1857 (2013).","DOI":"10.3892\/ijo.2013.1857"},{"issue":"6","key":"99262_CR36","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1016\/S0959-8049","volume":"39","author":"B Pauwels","year":"2003","unstructured":"Pauwels, B. et al. The radiosensitising effect of gemcitabine and the influence of the rescue agent amifostine in vitro. Eur. J. Cancer  39(6), 838\u2013846. https:\/\/doi.org\/10.1016\/S0959-8049 (2003).","journal-title":"Eur. J. Cancer"},{"issue":"3","key":"99262_CR37","doi-asserted-by":"publisher","first-page":"2273","DOI":"10.1074\/jbc.M310030200","volume":"279","author":"N Taneja","year":"2004","unstructured":"Taneja, N. et al. Histone H2AX phosphorylation as a predictor of radiosensitivity and target for radiotherapy. J. Biol. Chem. 279(3), 2273\u20132280. https:\/\/doi.org\/10.1074\/jbc.M310030200 (2004).","journal-title":"J. Biol. Chem."},{"issue":"2","key":"99262_CR38","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1007\/BF01275210","volume":"34","author":"EJ Bernhard","year":"1995","unstructured":"Bernhard, E. J., Maity, A., Muschel, R. J. & McKenna, W. G. Effects of ionizing radiation on cell cycle progression\u2014a review. Radiat. Environ. Biophys. 34(2), 79\u201383. https:\/\/doi.org\/10.1007\/BF01275210 (1995).","journal-title":"Radiat. Environ. Biophys."},{"issue":"4","key":"99262_CR39","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1016\/j.ijrobp.2004.03.005","volume":"59","author":"TM Pawlik","year":"2004","unstructured":"Pawlik, T. M. & Keyomarsi, K. Role of cell cycle in mediating sensitivity to radiotherapy. Int. J. Radiat. Oncol. Biol. Phys. 59(4), 928\u2013942. https:\/\/doi.org\/10.1016\/j.ijrobp.2004.03.005 (2004).","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"issue":"12","key":"99262_CR40","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1021\/ar00072a001","volume":"14","author":"K Fukui","year":"1981","unstructured":"Fukui, K. The path of chemical reactions - the IRC approach. Acc. Chem. Res. 14(12), 363\u2013368. https:\/\/doi.org\/10.1021\/ar00072a001 (1981).","journal-title":"Acc. Chem. Res."},{"issue":"12","key":"99262_CR41","doi-asserted-by":"publisher","first-page":"8991","DOI":"10.1063\/1.461230","volume":"95","author":"MW Wong","year":"1991","unstructured":"Wong, M. W., Wiberg, K. B. & Frisch, M. Hartree-Fock second derivatives and electric field properties in a solvent reaction field: Theory and application. J. Chem. Phys. 95(12), 8991\u20138998. https:\/\/doi.org\/10.1063\/1.461230 (1991).","journal-title":"J. Chem. Phys."},{"key":"99262_CR42","unstructured":"Frisch, M. J. et al. Gaussian 09, Rev. D.01. (Gaussian Inc., Wallingford, CT, 2016)."},{"key":"99262_CR43","unstructured":"Dennington, R., Keith, T. A. & Millam, J. M. GaussView 6. (Gaussian, 2016)."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-99262-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-99262-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-99262-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T16:01:24Z","timestamp":1747756884000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-99262-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,20]]},"references-count":43,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["99262"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-99262-8","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,20]]},"assertion":[{"value":"4 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"17535"}}