{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T10:34:43Z","timestamp":1785148483681,"version":"3.55.0"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T00:00:00Z","timestamp":1745884800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T00:00:00Z","timestamp":1745884800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100012543","name":"Youth Science Foundation of Guangxi Medical University","doi-asserted-by":"crossref","award":["GXMUYSF202321"],"award-info":[{"award-number":["GXMUYSF202321"]}],"id":[{"id":"10.13039\/501100012543","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Self-funded Scientific Research Project of the Health and Family Planning Commission of Guangxi Zhuang Autonomous Region","award":["Z-A20240412"],"award-info":[{"award-number":["Z-A20240412"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-99311-2","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T18:22:58Z","timestamp":1745950978000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Association of advanced lung cancer inflammation index with all-cause and cardiovascular mortality in metabolic dysfunction associated steatotic liver disease"],"prefix":"10.1038","volume":"15","author":[{"given":"Xin","family":"Qiu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nizhen","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifei","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guodong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donghong","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,29]]},"reference":[{"issue":"6","key":"99311_CR1","doi-asserted-by":"publisher","first-page":"1542","DOI":"10.1016\/j.jhep.2023.06.003","volume":"79","author":"ME Rinella","year":"2023","unstructured":"Rinella, M. E. et al. A multisociety Delphi consensus statement on new fatty liver disease nomenclature. J. Hepatol. 79(6), 1542\u20131556 (2023).","journal-title":"J. Hepatol."},{"issue":"2","key":"99311_CR2","doi-asserted-by":"publisher","first-page":"e70","DOI":"10.1016\/j.jhep.2023.08.019","volume":"80","author":"N Luo","year":"2024","unstructured":"Luo, N., Zhang, X., Huang, J., Chen, H. & Tang, H. Prevalence of steatotic liver disease and associated fibrosis in the United States: Results from NHANES 2017-March 2020. J. Hepatol. 80(2), e70\u2013e71 (2024).","journal-title":"J. Hepatol."},{"key":"99311_CR3","doi-asserted-by":"publisher","DOI":"10.1111\/liv.15931","author":"Z Pan","year":"2024","unstructured":"Pan, Z., Shiha, G., Esmat, G., M\u00e9ndez-S\u00e1nchez, N. & Eslam, M. MAFLD predicts cardiovascular disease risk better than MASLD. Liver Int. Official J. Int. Assoc. Study Liver https:\/\/doi.org\/10.1111\/liv.15931 (2024).","journal-title":"Liver Int. Official J. Int. Assoc. Study Liver"},{"issue":"23","key":"99311_CR4","doi-asserted-by":"publisher","first-page":"4931","DOI":"10.3390\/nu15234931","volume":"15","author":"Z Tan","year":"2023","unstructured":"Tan, Z. et al. Trends in oxidative balance score and prevalence of metabolic dysfunction-associated steatotic liver disease in the United States: national health and nutrition examination survey 2001 to 2018. Nutrients 15(23), 4931 (2023).","journal-title":"Nutrients"},{"issue":"2","key":"99311_CR5","doi-asserted-by":"publisher","first-page":"168","DOI":"10.3350\/cmh.2024.0140","volume":"30","author":"JH Oh","year":"2024","unstructured":"Oh, J. H. & Jun, D. W. Clinical impact of five cardiometabolic risk factors in metabolic dysfunction-associated steatotic liver disease (MASLD): Insights into regional and ethnic differences. Clin. Mol. Hepatol.. 30(2), 168\u2013170 (2024).","journal-title":"Clin. Mol. Hepatol.."},{"key":"99311_CR6","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000786","author":"X Wang","year":"2024","unstructured":"Wang, X., Zhang, L. & Dong, B. Molecular mechanisms in MASLD\/MASH-related HCC. Hepatology https:\/\/doi.org\/10.1097\/HEP.0000000000000786 (2024).","journal-title":"Hepatology"},{"issue":"1","key":"99311_CR7","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1186\/s12933-024-02287-y","volume":"23","author":"Y Min","year":"2024","unstructured":"Min, Y. et al. Prognostic effect of triglyceride glucose-related parameters on all-cause and cardiovascular mortality in the United States adults with metabolic dysfunction-associated steatotic liver disease. Cardiovasc. Diabetol. 23(1), 188 (2024).","journal-title":"Cardiovasc. Diabetol."},{"key":"99311_CR8","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.bioactmat.2022.10.026","volume":"23","author":"W Song","year":"2023","unstructured":"Song, W. et al. Engineering white blood cell membrane-camouflaged nanocarriers for inflammation-related therapeutics. Bioact. Materials. 23, 80\u2013100 (2023).","journal-title":"Bioact. Materials."},{"key":"99311_CR9","doi-asserted-by":"publisher","first-page":"958428","DOI":"10.3389\/fphar.2022.958428","volume":"13","author":"M Wang","year":"2022","unstructured":"Wang, M., Li, L., Xu, Y., Du, J. & Ling, C. Roles of hepatic stellate cells in NAFLD: From the perspective of inflammation and fibrosis. Front. Pharmacol. 13, 958428 (2022).","journal-title":"Front. Pharmacol."},{"issue":"1","key":"99311_CR10","doi-asserted-by":"publisher","first-page":"2197652","DOI":"10.1080\/07853890.2023.2197652","volume":"55","author":"E Zhao","year":"2023","unstructured":"Zhao, E., Cheng, Y., Yu, C., Li, H. & Fan, X. The systemic immune-inflammation index was non-linear associated with all-cause mortality in individuals with nonalcoholic fatty liver disease. Ann. Med. 55(1), 2197652 (2023).","journal-title":"Ann. Med."},{"key":"99311_CR11","doi-asserted-by":"publisher","DOI":"10.3390\/nu16223901","author":"Y Berg","year":"2024","unstructured":"Berg, Y. et al. The impact of nutritional components on periodontal health: a literature review. Nutrients https:\/\/doi.org\/10.3390\/nu16223901 (2024).","journal-title":"Nutrients"},{"issue":"16","key":"99311_CR12","doi-asserted-by":"publisher","first-page":"4713","DOI":"10.3390\/jcm13164713","volume":"13","author":"E Vassilopoulou","year":"2024","unstructured":"Vassilopoulou, E., Venter, C. & Roth-Walter, F. Malnutrition and Allergies: Tipping the Immune Balance towards Health. J. Clin. Med.. 13(16), 4713 (2024).","journal-title":"J. Clin. Med.."},{"issue":"1","key":"99311_CR13","doi-asserted-by":"publisher","first-page":"5832","DOI":"10.1038\/srep05832","volume":"4","author":"J Zhang","year":"2014","unstructured":"Zhang, J. et al. Association between serum free fatty acid levels and nonalcoholic fatty liver disease: a cross-sectional study. Sci. Rep. 4(1), 5832 (2014).","journal-title":"Sci. Rep."},{"issue":"5","key":"99311_CR14","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1530\/EJE-14-0112","volume":"171","author":"DJ Cuthbertson","year":"2014","unstructured":"Cuthbertson, D. J. et al. External validation of the fatty liver index and lipid accumulation product indices, using 1H-magnetic resonance spectroscopy, to identify hepatic steatosis in healthy controls and obese, insulin-resistant individuals. Eur. J. Endocrinol. 171(5), 561\u2013569 (2014).","journal-title":"Eur. J. Endocrinol."},{"key":"99311_CR15","doi-asserted-by":"publisher","first-page":"111749","DOI":"10.1016\/j.diabres.2024.111749","volume":"213","author":"Y Feng","year":"2024","unstructured":"Feng, Y. et al. Inflammation, nutrition, and biological aging: The prognostic role of Naples prognostic score in nonalcoholic fatty liver disease outcomes. Diabetes Res. Clin. Pract. 213, 111749 (2024).","journal-title":"Diabetes Res. Clin. Pract."},{"issue":"9","key":"99311_CR16","first-page":"1080","volume":"14","author":"LA M\u00e9ndez-Garc\u00eda","year":"2024","unstructured":"M\u00e9ndez-Garc\u00eda, L. A. et al. Exploring the Th2 response in obesity and metabolic dysfunction-associated steatotic liver disease (MASLD): A potential modulator of the renin-angiotensin system (RAS) pathway in hypertension development. Life (Basel, Switzerland). 14(9), 1080 (2024).","journal-title":"Life (Basel, Switzerland)."},{"key":"99311_CR17","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1186\/1471-2407-13-158","volume":"13","author":"SH Jafri","year":"2013","unstructured":"Jafri, S. H., Shi, R. & Mills, G. Advance lung cancer inflammation index (ALI) at diagnosis is a prognostic marker in patients with metastatic non-small cell lung cancer (NSCLC): a retrospective review. BMC Cancer 13, 158 (2013).","journal-title":"BMC Cancer"},{"issue":"13","key":"99311_CR18","doi-asserted-by":"publisher","first-page":"e33673","DOI":"10.1016\/j.heliyon.2024.e33673","volume":"10","author":"X Tian","year":"2024","unstructured":"Tian, X., Qu, Z., Sun, Y. & Zhang, B. Association between the advanced lung cancer inflammation index and all-cause and cardiovascular mortality in patients with RA: Insights from NHANES data analysis. Heliyon. 10(13), e33673 (2024).","journal-title":"Heliyon."},{"issue":"3","key":"99311_CR19","first-page":"35","volume":"7","author":"F Yang","year":"2024","unstructured":"Yang, F., Gao, L., Xu, C., Wang, Q. & Gao, W. Association between advanced lung cancer inflammation index in and hospital mortality in ICU patients with community-acquired pneumonia: A retrospective analysis of the MIMIC-IV database. Aging Med. (Milton (NSW)). 7(3), 35\u2013359 (2024).","journal-title":"Aging Med. (Milton (NSW))."},{"issue":"1","key":"99311_CR20","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1186\/s12933-022-01483-y","volume":"21","author":"J Park","year":"2022","unstructured":"Park, J. et al. The associations of hepatic steatosis and fibrosis using fatty liver index and BARD score with cardiovascular outcomes and mortality in patients with new-onset type 2 diabetes: a nationwide cohort study. Cardiovasc. Diabetol. 21(1), 53 (2022).","journal-title":"Cardiovasc. Diabetol."},{"key":"99311_CR21","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/1471-230X-6-33","volume":"6","author":"G Bedogni","year":"2006","unstructured":"Bedogni, G. et al. The Fatty Liver Index: a simple and accurate predictor of hepatic steatosis in the general population. BMC Gastroenterol. 6, 33 (2006).","journal-title":"BMC Gastroenterol."},{"issue":"9","key":"99311_CR22","first-page":"1201","volume":"11","author":"EM Koehler","year":"2013","unstructured":"Koehler, E. M. et al. External validation of the fatty liver index for identifying nonalcoholic fatty liver disease in a population-based study. Clin. Gastroenterol. Hepatol. Official Clin. Practice J. Am. Gastroenterol. Assoc. 11(9), 1201\u20131204 (2013).","journal-title":"Clin. Gastroenterol. Hepatol. Official Clin. Practice J. Am. Gastroenterol. Assoc."},{"issue":"2","key":"99311_CR23","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1093\/ajcn\/88.2.324","volume":"88","author":"AJ Moshfegh","year":"2008","unstructured":"Moshfegh, A. J. et al. The US Department of Agriculture Automated Multiple-Pass Method reduces bias in the collection of energy intakes. Am. J. Clin. Nutr. 88(2), 324\u2013332 (2008).","journal-title":"Am. J. Clin. Nutr."},{"issue":"6","key":"99311_CR24","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1097\/HEP.0000000000000664","volume":"79","author":"CM Lee","year":"2024","unstructured":"Lee, C. M. et al. Prevalence, distribution, and hepatic fibrosis burden of the different subtypes of steatotic liver disease in primary care settings. Hepatology 79(6), 1393\u20131400 (2024).","journal-title":"Hepatology"},{"issue":"1","key":"99311_CR25","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1186\/s12933-024-02343-7","volume":"23","author":"Q Chen","year":"2024","unstructured":"Chen, Q. et al. Association between triglyceride-glucose related indices and mortality among individuals with non-alcoholic fatty liver disease or metabolic dysfunction-associated steatotic liver disease. Cardiovasc. Diabetol. 23(1), 232 (2024).","journal-title":"Cardiovasc. Diabetol."},{"issue":"1","key":"99311_CR26","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1111\/apt.18011","volume":"60","author":"D Kim","year":"2024","unstructured":"Kim, D., Wijarnpreecha, K., Cholankeril, G. & Ahmed, A. Steatotic liver disease-associated all-cause\/cause-specific mortality in the United States. Aliment. Pharmacol. Ther. 60(1), 33\u201342 (2024).","journal-title":"Aliment. Pharmacol. Ther."},{"issue":"12","key":"99311_CR27","doi-asserted-by":"publisher","first-page":"1190","DOI":"10.1001\/jama.2020.14545","volume":"324","author":"P Muntner","year":"2020","unstructured":"Muntner, P. et al. Trends in Blood Pressure Control Among US Adults With Hypertension, 1999\u20132000 to 2017\u20132018. JAMA 324(12), 1190 (2020).","journal-title":"JAMA"},{"issue":"1","key":"99311_CR28","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1186\/s12877-025-05832-w","volume":"25","author":"X Hou","year":"2025","unstructured":"Hou, X. et al. Association between physical activity, trouble sleeping, and obesity among older Americans: a cross-sectional study based on NHANES data from 2007 to 2018. BMC Geriatr. 25(1), 165 (2025).","journal-title":"BMC Geriatr."},{"issue":"1","key":"99311_CR29","doi-asserted-by":"publisher","first-page":"1432","DOI":"10.1038\/s41467-025-56741-w","volume":"16","author":"PJ Pickhardt","year":"2025","unstructured":"Pickhardt, P. J. et al. Biological age model using explainable automated CT-based cardiometabolic biomarkers for phenotypic prediction of longevity. Nat. Commun. 16(1), 1432 (2025).","journal-title":"Nat. Commun."},{"issue":"10","key":"99311_CR30","doi-asserted-by":"publisher","first-page":"5655","DOI":"10.1039\/D3FO04177H","volume":"15","author":"X Chen","year":"2024","unstructured":"Chen, X. et al. From cup to clock: exploring coffee\u2019s role in slowing down biological aging. Food Funct. 15(10), 5655\u20135663 (2024).","journal-title":"Food Funct."},{"issue":"6","key":"99311_CR31","doi-asserted-by":"publisher","first-page":"2795","DOI":"10.1007\/s11357-021-00480-5","volume":"43","author":"D Kwon","year":"2021","unstructured":"Kwon, D. & Belsky, D. W. A toolkit for quantification of biological age from blood chemistry and organ function test data: BioAge. GeroScience. 43(6), 2795\u20132808 (2021).","journal-title":"GeroScience."},{"issue":"3","key":"99311_CR32","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/j.ecl.2023.01.003","volume":"52","author":"SD Anwar","year":"2023","unstructured":"Anwar, S. D., Foster, C. & Ashraf, A. Lipid Disorders and Metabolic-Associated Fatty Liver Disease. Endocrinol. Metab. Clin. North Am. 52(3), 445\u2013457 (2023).","journal-title":"Endocrinol. Metab. Clin. North Am."},{"issue":"12","key":"99311_CR33","doi-asserted-by":"publisher","first-page":"e70107","DOI":"10.1002\/iid3.70107","volume":"12","author":"Y Nong","year":"2024","unstructured":"Nong, Y., Lu, J., Yu, D. & Wei, X. Neohesperidin dihydrochalcone alleviates lipopolysaccharide-induced vascular endothelium dysfunction by regulating antioxidant capacity. Immun. Inflamm. Dis. 12(12), e70107 (2024).","journal-title":"Immun. Inflamm. Dis."},{"issue":"2","key":"99311_CR34","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.numecd.2023.09.018","volume":"34","author":"J Huang","year":"2024","unstructured":"Huang, J. et al. Association between updated cardiovascular health construct and risks of non-alcoholic fatty liver disease. Nutr. Metab. Cardiovasc. Dis. 34(2), 317\u2013325 (2024).","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"99311_CR35","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-024-03448-1","author":"P Wang","year":"2024","unstructured":"Wang, P., Yu, J., Zhao, Y., Simayi, R. & Shi, D. The independent and joint associations of vitamin B12 and methylmalonic acid on the risk of mortality in individuals with metabolic dysfunction-associated steatotic liver disease. Eur. J. Nutr. https:\/\/doi.org\/10.1007\/s00394-024-03448-1 (2024).","journal-title":"Eur. J. Nutr."},{"issue":"8","key":"99311_CR36","doi-asserted-by":"publisher","first-page":"1922","DOI":"10.1016\/j.numecd.2024.04.018","volume":"34","author":"Y Yin","year":"2024","unstructured":"Yin, Y., Zhu, W. & Xu, Q. The systemic inflammation response index as a risk factor for hepatic fibrosis and long-term mortality among individuals with metabolic dysfunction-associated steatotic liver disease. Nutr. Metab. Cardiovasc. Dis. 34(8), 1922\u20131931 (2024).","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"issue":"1","key":"99311_CR37","doi-asserted-by":"publisher","first-page":"30403","DOI":"10.1038\/s41598-024-80801-8","volume":"14","author":"K Dong","year":"2024","unstructured":"Dong, K., Zheng, Y., Wang, Y. & Guo, Q. Predictive role of neutrophil percentage-to-albumin ratio, neutrophil-to-lymphocyte ratio, and systemic immune-inflammation index for mortality in patients with MASLD. Sci. Rep. 14(1), 30403 (2024).","journal-title":"Sci. Rep."},{"issue":"12","key":"99311_CR38","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1111\/apt.17995","volume":"59","author":"T Tsutsumi","year":"2024","unstructured":"Tsutsumi, T. et al. Hepatic inflammation and fibrosis are profiles related to mid-term mortality in biopsy-proven MASLD: A multicenter study in Japan. Aliment. Pharmacol. Ther. 59(12), 1559\u20131570 (2024).","journal-title":"Aliment. Pharmacol. Ther."},{"key":"99311_CR39","doi-asserted-by":"publisher","first-page":"1074672","DOI":"10.3389\/fphys.2023.1074672","volume":"14","author":"J Tu","year":"2023","unstructured":"Tu, J. et al. Advanced lung cancer inflammation index is associated with long-term cardiovascular death in hypertensive patients: national health and nutrition examination study, 1999\u20132018. Front. Physiol. 14, 1074672 (2023).","journal-title":"Front. Physiol."},{"key":"99311_CR40","doi-asserted-by":"publisher","first-page":"989914","DOI":"10.3389\/fnut.2022.989914","volume":"9","author":"Y Zhang","year":"2022","unstructured":"Zhang, Y. et al. The advanced lung cancer inflammation index predicts long-term outcomes in patients with hypertension: National health and nutrition examination study, 1999\u20132014. Front. Nutr. 9, 989914 (2022).","journal-title":"Front. Nutr."},{"key":"99311_CR41","doi-asserted-by":"publisher","first-page":"1298345","DOI":"10.3389\/fendo.2023.1298345","volume":"14","author":"Y Chen","year":"2023","unstructured":"Chen, Y., Guan, M., Wang, R. & Wang, X. Relationship between advanced lung cancer inflammation index and long-term all-cause, cardiovascular, and cancer mortality among type 2 diabetes mellitus patients: NHANES, 1999\u20132018. Front. Endocrinol. 14, 1298345 (2023).","journal-title":"Front. Endocrinol."},{"issue":"1","key":"99311_CR42","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1186\/s12944-023-01947-4","volume":"22","author":"Q Liu","year":"2023","unstructured":"Liu, Q. et al. Shift in prevalence and systemic inflammation levels from NAFLD to MAFLD: a population-based cross-sectional study. Lipids Health Dis. 22(1), 185 (2023).","journal-title":"Lipids Health Dis."},{"key":"99311_CR43","doi-asserted-by":"publisher","first-page":"5197","DOI":"10.2147\/JIR.S468215","volume":"17","author":"X Qiu","year":"2024","unstructured":"Qiu, X. et al. Predictive efficacy of the advanced lung cancer inflammation index in hepatocellular carcinoma after hepatectomy. J. Inflamm. Res. 17, 5197\u20135210 (2024).","journal-title":"J. Inflamm. Res."},{"key":"99311_CR44","doi-asserted-by":"publisher","first-page":"3631","DOI":"10.2147\/JIR.S421021","volume":"16","author":"X Wang","year":"2023","unstructured":"Wang, X. et al. Advanced lung cancer inflammation index for predicting prognostic risk for patients with acute coronary syndrome undergoing percutaneous coronary intervention. J. Inflamm. Res. 16, 3631\u20133641 (2023).","journal-title":"J. Inflamm. Res."},{"key":"99311_CR45","doi-asserted-by":"publisher","first-page":"4570219","DOI":"10.1155\/2020\/4570219","volume":"2020","author":"L Antonucci","year":"2020","unstructured":"Antonucci, L. et al. Circulating neutrophils of nonalcoholic steatohepatitis patients show an activated phenotype and suppress T Lymphocytes activity. J. Immunol. Res. 2020, 4570219 (2020).","journal-title":"J. Immunol. Res."},{"key":"99311_CR46","doi-asserted-by":"publisher","first-page":"1445634","DOI":"10.3389\/fimmu.2024.1445634","volume":"15","author":"M Cebi","year":"2024","unstructured":"Cebi, M. & Yilmaz, Y. Immune system dysregulation in the pathogenesis of non-alcoholic steatohepatitis: unveiling the critical role of T and B lymphocytes. Front. Immunol. 15, 1445634 (2024).","journal-title":"Front. Immunol."},{"key":"99311_CR47","doi-asserted-by":"publisher","first-page":"1720827","DOI":"10.1155\/2016\/1720827","volume":"2016","author":"A Arce-Sillas","year":"2016","unstructured":"Arce-Sillas, A. et al. Regulatory T cells: molecular actions on effector cells in immune regulation. J. Immunol. Res. 2016, 1720827 (2016).","journal-title":"J. Immunol. Res."},{"issue":"9","key":"99311_CR48","doi-asserted-by":"publisher","first-page":"2014","DOI":"10.3390\/nu15092014","volume":"15","author":"H Takahashi","year":"2023","unstructured":"Takahashi, H. et al. Association of serum albumin levels and long-term prognosis in patients with biopsy-confirmed nonalcoholic fatty liver disease. Nutrients 15(9), 2014 (2023).","journal-title":"Nutrients"},{"key":"99311_CR49","doi-asserted-by":"publisher","first-page":"1251601","DOI":"10.3389\/fnut.2023.1251601","volume":"10","author":"HTT Nguyen","year":"2023","unstructured":"Nguyen, H. T. T. et al. Relationship between BMI and prognosis of chronic heart failure outpatients in Vietnam: a single-center study. Front. Nutr. 10, 1251601 (2023).","journal-title":"Front. Nutr."},{"issue":"7","key":"99311_CR50","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1080\/01635581.2024.2347396","volume":"76","author":"T Mistry","year":"2024","unstructured":"Mistry, T. et al. Impact of low BMI and nutritional status on quality of life and disease outcome in breast cancer patients: insights from a tertiary cancer center in India. Nutr. Cancer 76(7), 596\u2013607 (2024).","journal-title":"Nutr. Cancer"},{"issue":"12","key":"99311_CR51","doi-asserted-by":"publisher","first-page":"2853","DOI":"10.1111\/jgh.16760","volume":"39","author":"L Pan","year":"2024","unstructured":"Pan, L., Wang, L., Ma, H. & Ding, F. Relevance of combined influence of nutritional and inflammatory status on non-alcoholic fatty liver disease and advanced fibrosis: A mediation analysis of lipid biomarkers. J. Gastroenterol. Hepatol. 39(12), 2853\u20132862 (2024).","journal-title":"J. Gastroenterol. Hepatol."},{"issue":"1","key":"99311_CR52","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1186\/s12876-025-03762-w","volume":"25","author":"C Yu","year":"2025","unstructured":"Yu, C. et al. The role of the advanced lung cancer inflammation index (ALI) in the risk of liver fibrosis and mortality among US adult MAFLD patients: a cross-sectional study of NHANES 1999\u20132018. BMC Gastroenterol. 25(1), 190 (2025).","journal-title":"BMC Gastroenterol."},{"key":"99311_CR53","doi-asserted-by":"publisher","first-page":"105477","DOI":"10.1016\/j.archger.2024.105477","volume":"124","author":"H Wang","year":"2024","unstructured":"Wang, H. et al. Association between biological aging and the risk of mortality in individuals with non-alcoholic fatty liver disease: A prospective cohort study. Arch. Gerontol. Geriatr. 124, 105477 (2024).","journal-title":"Arch. Gerontol. Geriatr."},{"issue":"1","key":"99311_CR54","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1038\/s41591-019-0719-5","volume":"26","author":"S Ahadi","year":"2020","unstructured":"Ahadi, S. et al. Personal aging markers and ageotypes revealed by deep longitudinal profiling. Nat. Med. 26(1), 83\u201390 (2020).","journal-title":"Nat. Med."},{"issue":"30","key":"99311_CR55","doi-asserted-by":"publisher","first-page":"E4104","DOI":"10.1073\/pnas.1506264112","volume":"112","author":"DW Belsky","year":"2015","unstructured":"Belsky, D. W. et al. Quantification of biological aging in young adults. Proc. Natl. Acad. Sci. U.S.A. 112(30), E4104-4110 (2015).","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"3","key":"99311_CR56","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1007\/s10147-023-02293-2","volume":"28","author":"T Horino","year":"2023","unstructured":"Horino, T. et al. The impact of the advanced lung cancer inflammation index on the outcomes of patients with metastatic colorectal cancer who receive chemotherapy. Int. J. Clin. Oncol. 28(3), 400\u2013408 (2023).","journal-title":"Int. J. Clin. Oncol."},{"issue":"1","key":"99311_CR57","doi-asserted-by":"publisher","first-page":"17401","DOI":"10.1038\/s41598-020-74596-7","volume":"10","author":"R Xu","year":"2020","unstructured":"Xu, R. et al. Gender- and age-related differences in homocysteine concentration: a cross-sectional study of the general population of China. Sci. Rep. 10(1), 17401 (2020).","journal-title":"Sci. Rep."},{"issue":"1","key":"99311_CR58","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1186\/s12979-024-00462-z","volume":"21","author":"S Talley","year":"2024","unstructured":"Talley, S. et al. Characterization of age-associated inflammasome activation reveals tissue specific differences in transcriptional and post-translational inflammatory responses. Immun. Ageing I A. 21(1), 60 (2024).","journal-title":"Immun. Ageing I A."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-99311-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-99311-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-99311-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T06:02:10Z","timestamp":1746338530000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-99311-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,29]]},"references-count":58,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["99311"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-99311-2","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,29]]},"assertion":[{"value":"21 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The study\u2019s ethical framework received approval from the Ethics Review Board at the National Center for Health Statistics (NCHS). All participants have been provided informed consent.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}}],"article-number":"15121"}}