{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:25:25Z","timestamp":1791329125584,"version":"4.3.1"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T00:00:00Z","timestamp":1745366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T00:00:00Z","timestamp":1745366400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"European Union\u2019s Horizon Europe Research and Innovation programme","award":["Grant Agreement n\u00b0 101080117"],"award-info":[{"award-number":["Grant Agreement n\u00b0 101080117"]}]},{"name":"European Union\u2019s Horizon Europe Research and Innovation programme","award":["Grant Agreement n\u00b0 101080117"],"award-info":[{"award-number":["Grant Agreement n\u00b0 101080117"]}]},{"name":"European Union\u2019s Horizon Europe Research and Innovation programme","award":["Grant Agreement n\u00b0 101080117"],"award-info":[{"award-number":["Grant Agreement n\u00b0 101080117"]}]},{"name":"European Union\u2019s Horizon Europe Research and Innovation programme","award":["Grant Agreement n\u00b0 101080117"],"award-info":[{"award-number":["Grant Agreement n\u00b0 101080117"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-99347-4","type":"journal-article","created":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:45:05Z","timestamp":1745423105000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A randomized clinical trial of a dietary intervention and mental health associations in adults with increased genetic risk for obesity"],"prefix":"10.1038","volume":"15","author":[{"given":"Maria","family":"Kafyra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioanna Panagiota","family":"Kalafati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iraklis","family":"Varlamis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andriana. C.","family":"Kaliora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis","family":"Moulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George V.","family":"Dedoussis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,23]]},"reference":[{"issue":"1","key":"99347_CR1","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1186\/s12955-020-01581-z","volume":"18","author":"M Vajdi","year":"2020","unstructured":"Vajdi, M. & Farhangi, M. A. A systematic review of the association between dietary patterns and health-related quality of life. Health Qual. Life Outcomes. 18 (1), 337. https:\/\/doi.org\/10.1186\/s12955-020-01581-z (2020).","journal-title":"Health Qual. Life Outcomes"},{"key":"99347_CR2","doi-asserted-by":"publisher","first-page":"100629","DOI":"10.1016\/j.jadr.2023.100629","volume":"14","author":"CA Djamila Eliby","year":"2023","unstructured":"Djamila Eliby, C. A. et al. Associations between diet quality and anxiety and depressive disorders: A systematic review. J. Affect. Disorders Rep. 14, 100629. https:\/\/doi.org\/10.1016\/j.jadr.2023.100629 (2023).","journal-title":"J. Affect. Disorders Rep."},{"issue":"Suppl-1","key":"99347_CR3","doi-asserted-by":"publisher","first-page":"156","DOI":"10.2174\/1745017902016010156","volume":"16","author":"A Ventriglio","year":"2020","unstructured":"Ventriglio, A. et al. Mediterranean diet and its benefits on health and mental health: A literature review. Clin. Pract. Epidemiol. Mental Health: CP EMH. 16 (Suppl-1), 156\u2013164. https:\/\/doi.org\/10.2174\/1745017902016010156 (2020).","journal-title":"Clin. Pract. Epidemiol. Mental Health: CP EMH"},{"key":"99347_CR4","doi-asserted-by":"publisher","first-page":"111032","DOI":"10.1016\/j.jpsychores.2022.111032","volume":"162","author":"H Ding","year":"2022","unstructured":"Ding, H. et al. Shared genetics between classes of obesity and psychiatric disorders: A large-scale genome-wide cross-trait analysis. J. Psychosom. Res. 162, 111032. https:\/\/doi.org\/10.1016\/j.jpsychores.2022.111032 (2022).","journal-title":"J. Psychosom. Res."},{"issue":"3","key":"99347_CR5","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1097\/00005650-199603000-00003","volume":"34","author":"J Ware Jr","year":"1996","unstructured":"Ware, J. Jr, Kosinski, M. & Keller, S. D. A 12-Item Short-Form health survey: construction of scales and preliminary tests of reliability and validity. Med. Care. 34 (3), 220\u2013233. https:\/\/doi.org\/10.1097\/00005650-199603000-00003 (1996).","journal-title":"Med. Care"},{"issue":"10","key":"99347_CR6","doi-asserted-by":"publisher","first-page":"3495","DOI":"10.3390\/nu13103495","volume":"13","author":"M Kafyra","year":"2021","unstructured":"Kafyra, M. et al. The iMPROVE study; design, dietary patterns, and development of a lifestyle index in overweight and obese Greek adults. Nutrients 13 (10), 3495. https:\/\/doi.org\/10.3390\/nu13103495 (2021).","journal-title":"Nutrients"},{"issue":"17","key":"99347_CR7","doi-asserted-by":"publisher","first-page":"2842","DOI":"10.3390\/nu16172842","volume":"16","author":"M Kafyra","year":"2024","unstructured":"Kafyra, M. et al. A dietary intervention in adults with overweight or obesity leads to weight loss irrespective of macronutrient composition. Nutrients 16 (17), 2842. https:\/\/doi.org\/10.3390\/nu16172842 (2024).","journal-title":"Nutrients"},{"issue":"3","key":"99347_CR8","doi-asserted-by":"publisher","first-page":"238","DOI":"10.3390\/nu9030238","volume":"9","author":"AP Meegan","year":"2017","unstructured":"Meegan, A. P., Perry, I. J. & Phillips, C. M. The association between dietary quality and dietary guideline adherence with mental health outcomes in adults: A Cross-Sectional analysis. Nutrients 9 (3), 238. https:\/\/doi.org\/10.3390\/nu9030238 (2017).","journal-title":"Nutrients"},{"issue":"1","key":"99347_CR9","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/s12902-023-01284-8","volume":"23","author":"AM Ardekani","year":"2023","unstructured":"Ardekani, A. M. et al. Evaluating the association between the Mediterranean-DASH intervention for neurodegenerative delay (MIND) diet, mental health, and cardio-metabolic risk factors among individuals with obesity. BMC Endocr. Disorders. 23 (1), 29. https:\/\/doi.org\/10.1186\/s12902-023-01284-8 (2023).","journal-title":"BMC Endocr. Disorders"},{"key":"99347_CR10","doi-asserted-by":"publisher","first-page":"112121","DOI":"10.1016\/j.exger.2023.112121","volume":"174","author":"LJ Dominguez","year":"2023","unstructured":"Dominguez, L. J. et al. Mediterranean diet in the management and prevention of obesity. Exp. Gerontol. 174, 112121. https:\/\/doi.org\/10.1016\/j.exger.2023.112121 (2023).","journal-title":"Exp. Gerontol."},{"issue":"1","key":"99347_CR11","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1186\/s12966-021-01227-3","volume":"18","author":"W Yin","year":"2021","unstructured":"Yin, W. et al. Mediterranean diet and depression: a population-based cohort study. Int. J. Behav. Nutr. Phys. Act. 18 (1), 153. https:\/\/doi.org\/10.1186\/s12966-021-01227-3 (2021).","journal-title":"Int. J. Behav. Nutr. Phys. Act."},{"issue":"4","key":"99347_CR12","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1017\/S0029665117002026","volume":"76","author":"W Marx","year":"2017","unstructured":"Marx, W., Moseley, G., Berk, M. & Jacka, F. Nutritional psychiatry: the present state of the evidence. Proc. Nutr. Soc. 76 (4), 427\u2013436. https:\/\/doi.org\/10.1017\/S0029665117002026 (2017).","journal-title":"Proc. Nutr. Soc."},{"key":"99347_CR13","doi-asserted-by":"publisher","first-page":"1489489","DOI":"10.3389\/fnut.2024.1489489","volume":"11","author":"P Picone","year":"2024","unstructured":"Picone, P., Girgenti, A., Buttacavoli, M. & Nuzzo, D. Enriching the mediterranean diet could nourish the brain more effectively. Front. Nutr. 11, 1489489. https:\/\/doi.org\/10.3389\/fnut.2024.1489489 (2024).","journal-title":"Front. Nutr."},{"key":"99347_CR14","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1016\/j.jad.2024.01.252","volume":"351","author":"X Song","year":"2024","unstructured":"Song, X. et al. Association of macronutrient consumption quality, food source and timing with depression among US adults: A cross-sectional study. J. Affect. Disord. 351, 641\u2013648. https:\/\/doi.org\/10.1016\/j.jad.2024.01.252 (2024).","journal-title":"J. Affect. Disord."},{"issue":"1","key":"99347_CR15","doi-asserted-by":"publisher","first-page":"21647","DOI":"10.1038\/s41598-022-25337-5","volume":"12","author":"J Kose","year":"2022","unstructured":"Kose, J. et al. Associations of overall and specific carbohydrate intake with anxiety status evolution in the prospective NutriNet-Sant\u00e9 population-based cohort. Sci. Rep. 12 (1), 21647. https:\/\/doi.org\/10.1038\/s41598-022-25337-5 (2022).","journal-title":"Sci. Rep."},{"key":"99347_CR16","doi-asserted-by":"publisher","first-page":"207","DOI":"10.3389\/fpsyt.2020.00207","volume":"11","author":"J Oh","year":"2020","unstructured":"Oh, J., Yun, K., Chae, J. H. & Kim, T. S. Association between macronutrients intake and depression in the united States and South Korea. Front. Psychiatry. 11, 207. https:\/\/doi.org\/10.3389\/fpsyt.2020.00207 (2020).","journal-title":"Front. Psychiatry"},{"key":"99347_CR17","doi-asserted-by":"publisher","unstructured":"Hajihashemi, P. et al. Corrigendum to The association of dietary macronutrient quality indices with depression and anxiety symptoms and quality of life in Iranian adults: The LipoKAP study [J. Affect. Disord. 317 (2022) 409\u2013416]. Journal of affective disorders, 318, 465. https:\/\/doi.org\/10.1016\/j.jad.2022.09.026 (2022).","DOI":"10.1016\/j.jad.2022.09.026"},{"issue":"19","key":"99347_CR18","doi-asserted-by":"publisher","first-page":"1934","DOI":"10.3390\/healthcare12191934","volume":"12","author":"AM Dicu","year":"2024","unstructured":"Dicu, A. M. et al. Exploration of food attitudes and management of eating behavior from a Psycho-Nutritional perspective. Healthc. (Basel Switzerland). 12 (19), 1934. https:\/\/doi.org\/10.3390\/healthcare12191934 (2024).","journal-title":"Healthc. (Basel Switzerland)"},{"issue":"9","key":"99347_CR19","doi-asserted-by":"publisher","first-page":"1889","DOI":"10.1080\/1028415X.2021.1913316","volume":"25","author":"M Mehrdad","year":"2022","unstructured":"Mehrdad, M., Eftekhari, M. H., Jafari, F., Nikbakht, H. A. & Gholamalizadeh, M. Associations between FTO rs9939609 polymorphism, serum vitamin D, mental health, and eating behaviors in overweight adults. Nutr. Neurosci. 25 (9), 1889\u20131897. https:\/\/doi.org\/10.1080\/1028415X.2021.1913316 (2022).","journal-title":"Nutr. Neurosci."},{"issue":"8","key":"99347_CR20","doi-asserted-by":"publisher","first-page":"3130","DOI":"10.3390\/nu6083130","volume":"6","author":"J Harbron","year":"2014","unstructured":"Harbron, J., van der Merwe, L., Zaahl, M. G., Kotze, M. J. & Senekal, M. Fat mass and obesity-associated (FTO) gene polymorphisms are associated with physical activity, food intake, eating behaviors, psychological health, and modeled change in body mass index in overweight\/obese Caucasian adults. Nutrients 6 (8), 3130\u20133152. https:\/\/doi.org\/10.3390\/nu6083130 (2014).","journal-title":"Nutrients"},{"key":"99347_CR21","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1016\/j.neubiorev.2021.05.013","volume":"127","author":"JA Zarza-Rebollo","year":"2021","unstructured":"Zarza-Rebollo, J. A., Molina, E. & Rivera, M. The role of the FTO gene in the relationship between depression and obesity. A systematic review. Neurosci. Biobehav. Rev. 127, 630\u2013637. https:\/\/doi.org\/10.1016\/j.neubiorev.2021.05.013 (2021).","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"1","key":"99347_CR22","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1038\/s41398-022-01783-7","volume":"12","author":"A Anguita-Ruiz","year":"2022","unstructured":"Anguita-Ruiz, A. et al. Body mass index interacts with a genetic-risk score for depression increasing the risk of the disease in high-susceptibility individuals. Translational Psychiatry. 12 (1), 30. https:\/\/doi.org\/10.1038\/s41398-022-01783-7 (2022).","journal-title":"Translational Psychiatry"},{"issue":"4","key":"99347_CR23","doi-asserted-by":"publisher","first-page":"905S","DOI":"10.3945\/jn.115.218354","volume":"146","author":"L Goni","year":"2015","unstructured":"Goni, L., Cuervo, M., Milagro, F. I. & Mart\u00ednez, J. A. Future perspectives of personalized weight loss interventions based on nutrigenetic, epigenetic, and metagenomic data. J. Nutr. 146 (4), 905S\u2013912S. https:\/\/doi.org\/10.3945\/jn.115.218354 (2015).","journal-title":"J. Nutr."},{"key":"99347_CR24","doi-asserted-by":"publisher","first-page":"c332","DOI":"10.1136\/bmj.c332","volume":"340","author":"KF Schulz","year":"2010","unstructured":"Schulz, K. F., Altman, D. G., Moher, D. & CONSORT Group. CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials. BMJ (Clinical Res. ed.). 340, c332. https:\/\/doi.org\/10.1136\/bmj.c332 (2010).","journal-title":"BMJ (Clinical Res. ed.)"},{"key":"99347_CR25","unstructured":"Ware, J., Kosinski, M. & Keller, S. How to score the SF-12 physical and mental health summary scales. Boston, MA. The Health Institute, New England Medical Center, Second Edition. Available at: Wareetal_HowtoScoreSF-12PhysicalMentalHealthSummaryScales_1996.pdf (1995)"},{"key":"99347_CR26","unstructured":"IMPUTE2. https:\/\/mathgen.stats.ox.ac.uk\/impute\/impute_v2.html."},{"issue":"3","key":"99347_CR27","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1086\/519795","volume":"81","author":"S Purcell","year":"2007","unstructured":"Purcell, S. et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am. J. Hum. Genet. 81 (3), 559\u2013575. https:\/\/doi.org\/10.1086\/519795 (2007).","journal-title":"Am. J. Hum. Genet."},{"key":"99347_CR28","unstructured":"The R Project for Statistical Computing. Last Modified in 2020. https:\/\/www.rproject.org\/."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-99347-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-99347-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-99347-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:45:15Z","timestamp":1745423115000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-99347-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,23]]},"references-count":28,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["99347"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-99347-4","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,23]]},"assertion":[{"value":"12 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"14188"}}