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Using\n                    <jats:italic>Ifnar1<\/jats:italic>\n                    <jats:sup>\u2212<\/jats:sup>\n                    \/\n                    <jats:sup>\u2212<\/jats:sup>\n                    mice, which lack type I interferon signaling, we demonstrate that ZIKV infection triggers significant infiltration of CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells into the brain, accompanied by neurological defects. ZIKV-experienced CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells exhibit enhanced cytotoxic potential, and adoptive transfer of these cells improves survival. In contrast, blocking their infiltration exacerbates brain inflammatory and injury-associated signatures, highlighting their protective contribution. Furthermore, PD-1 blockade worsens ZIKV pathology, suggesting that PD-1 expression reflects an activated rather than exhausted state. These findings underscore an important role of infiltrating CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells in reducing ZIKV-induced CNS inflammation and suggest that modulating their response could serve as a potential therapeutic strategy for ZIKV-associated neurological disease.\n                  <\/jats:p>","DOI":"10.1038\/s41598-026-35079-3","type":"journal-article","created":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T22:50:39Z","timestamp":1767653439000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Brain-infiltrating CD8 T cells retain functional activity to protect against acute Zika virus infection"],"prefix":"10.1038","volume":"16","author":[{"given":"Jaehui","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wooseong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Do Yeon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keun Bon","family":"Ku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Chan","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyun-Do","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chonsaeng","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae-Gyun","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong-Jun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sungjun","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,5]]},"reference":[{"issue":"24","key":"35079_CR1","doi-asserted-by":"publisher","first-page":"2321","DOI":"10.1056\/NEJMoa1602412","volume":"375","author":"P Brasil","year":"2016","unstructured":"Brasil, P. et al. 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