{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T05:08:46Z","timestamp":1770700126556,"version":"3.49.0"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:00:00Z","timestamp":1770595200000},"content-version":"vor","delay-in-days":24,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-026-35086-4","type":"journal-article","created":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T08:16:48Z","timestamp":1768551408000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Left atrial strain response to acute preload reduction in healthy dogs using a translational blood donation model"],"prefix":"10.1038","volume":"16","author":[{"given":"Renata Benedetti","family":"Cepinho","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana Aparecida Lopes","family":"de Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos Javier La\u00ednez","family":"Reyes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo","family":"Francisco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam Harumi","family":"Tsunemi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayra de Castro Ferreira","family":"Lima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz Henrique","family":"de Ara\u00fajo Machado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria L\u00facia Gomes","family":"Louren\u00e7o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,1,16]]},"reference":[{"key":"35086_CR1","first-page":"87","volume":"27","author":"AY Matsumoto","year":"2014","unstructured":"Matsumoto, A. Y. et al. Echocardiographic evaluation of left atrial function: physiological and clinical aspects. Arq. Bras. Cardiol. - Imagem Cardiovasc. 27, 87\u201396 (2014).","journal-title":"Arq. Bras. Cardiol. - Imagem Cardiovasc."},{"key":"35086_CR2","doi-asserted-by":"publisher","first-page":"e001042","DOI":"10.1136\/openhrt-2019-001042","volume":"6","author":"PN Marino","year":"2019","unstructured":"Marino, P. N., Degiovanni, A. & Zanaboni, J. Complex interaction between the atrium and the ventricular filling process: the role of conduit. Open. Heart. 6, e001042 (2019).","journal-title":"Open. Heart"},{"key":"35086_CR3","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1093\/ejechocard\/jeq175","volume":"12","author":"GG Blume","year":"2011","unstructured":"Blume, G. G. et al. Left atrial function: physiology, assessment, and clinical implications. Eur. J. Echocardiogr. 12, 421\u2013430 (2011).","journal-title":"Eur. J. Echocardiogr"},{"key":"35086_CR4","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1016\/j.echo.2018.07.016","volume":"31","author":"D Genovese","year":"2018","unstructured":"Genovese, D. et al. Load dependency of left atrial strain in normal subjects. J. Am. Soc. Echocardiogr. 31, 1221\u20131228 (2018).","journal-title":"J. Am. Soc. Echocardiogr"},{"key":"35086_CR5","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12947-022-00274-5","volume":"20","author":"P Gottfridsson","year":"2022","unstructured":"Gottfridsson, P. et al. Left atrial contraction strain and controlled preload alterations, a study in healthy individuals. Cardiovasc. Ultrasound. 20, 4\u20139 (2022).","journal-title":"Cardiovasc. Ultrasound"},{"key":"35086_CR6","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1590\/1678-5150-pvb-6441","volume":"40","author":"MR Coelho","year":"2020","unstructured":"Coelho, M. R. et al. Evaluation of left atrial function in asymptomatic dogs with chronic myxomatous mitral valve disease: two-dimensional feature-tracking echocardiography and simpson\u2019s monoplanar methods. Pesq Vet. Bras. 40, 188\u2013196 (2020).","journal-title":"Pesq Vet. Bras."},{"key":"35086_CR7","doi-asserted-by":"publisher","first-page":"105428","DOI":"10.1016\/j.rvsc.2024.105428","volume":"180","author":"P Savarino","year":"2024","unstructured":"Savarino, P. et al. Left atrial volume and function in Cavalier King Charles spaniels at different ACVIM stages. Res. Vet. Sci. 180, 105428 (2024).","journal-title":"Res. Vet. Sci."},{"key":"35086_CR8","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.vaa.2023.02.009","volume":"50","author":"VV Paranjape","year":"2023","unstructured":"Paranjape, V. V., Henao-Guerrero, N., Menciotti, G. & Saksena, S. Volumetric evaluation of fluid responsiveness using a modified passive leg Raise maneuver during experimental induction and correction of hypovolemia in anesthetized dogs. Vet. Anaesth. Analg. 50, 211\u2013219 (2023).","journal-title":"Vet. Anaesth. Analg"},{"key":"35086_CR9","doi-asserted-by":"publisher","first-page":"1238549","DOI":"10.3389\/fvets.2023.1238549","volume":"10","author":"VV Paranjape","year":"2023","unstructured":"Paranjape, V. V., Henao-Guerrero, N., Menciotti, G. & Saksena, S. Performance of four cardiac output monitoring techniques vs. intermittent pulmonary artery thermodilution during a modified passive leg Raise maneuver in isoflurane-anesthetized dogs. Front. Vet. Sci. 10, 1238549 (2023).","journal-title":"Front. Vet. Sci."},{"key":"35086_CR10","first-page":"973","volume":"59","author":"KA Marshall","year":"2018","unstructured":"Marshall, K. A. et al. Ultrasound measurements of the caudal Vena Cava before and after blood donation in 9 Greyhound dogs. Can. Vet. J. 59, 973\u2013980 (2018).","journal-title":"Can. Vet. J."},{"key":"35086_CR11","doi-asserted-by":"publisher","first-page":"97","DOI":"10.34019\/2596-3325.2018.v19.24741","volume":"19","author":"TA Tr\u00e9z","year":"2018","unstructured":"Tr\u00e9z, T. A. Considera\u00e7\u00f5es sobre o conceito Dos 3Rs e o potencial conflito com novas compreens\u00f5es do animal experimental. Rev. Bras. Zooci\u00eancias. 19, 97\u2013113 (2018).","journal-title":"Rev. Bras. Zooci\u00eancias"},{"key":"35086_CR12","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1016\/j.cvsm.2020.07.001","volume":"50","author":"KW Kuo","year":"2020","unstructured":"Kuo, K. W. & McMichael, M. Small animal transfusion medicine. Vet. Clin. North. Am. Small Anim. Pract. 50, 1203\u20131214 (2020).","journal-title":"Vet. Clin. North. Am. Small Anim. Pract."},{"key":"35086_CR13","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1111\/j.1939-1676.2010.0663.x","volume":"25","author":"A Decloedt","year":"2011","unstructured":"Decloedt, A., Verheyen, T., Sys, S., De Clercq, D. & van Loon, G. Quantification of left ventricular longitudinal strain, strain rate, velocity, and displacement in healthy horses by 2-dimensional speckle tracking. J. Vet. Intern. Med. 25, 330\u2013338 (2011).","journal-title":"J. Vet. Intern. Med."},{"key":"35086_CR14","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1037\/1082-989X.1.1.30","volume":"1","author":"KO McGraw","year":"1996","unstructured":"McGraw, K. O. & Wong, S. P. Forming inferences about some intraclass correlation coefficients. Psychol. Methods. 1, 30\u201346 (1996).","journal-title":"Psychol. Methods"},{"key":"35086_CR15","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1111\/jvim.15488","volume":"33","author":"BW Keene","year":"2019","unstructured":"Keene, B. W. et al. ACVIM consensus guidelines for the diagnosis and treatment of myxomatous mitral valve disease in dogs. J. Vet. Intern. Med. 33, 1127\u20131140 (2019).","journal-title":"J. Vet. Intern. Med."},{"key":"35086_CR16","doi-asserted-by":"publisher","first-page":"105577","DOI":"10.1016\/j.tvjl.2020.105577","volume":"270","author":"M Baron Toaldo","year":"2021","unstructured":"Baron Toaldo, M. et al. Left atrial speckle tracking echocardiography in clinically healthy dogs: variability and prediction intervals. Vet. J. 270, 105577 (2021).","journal-title":"Vet. J."},{"key":"35086_CR17","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1111\/j.1939-1676.1993.tb01015.x","volume":"7","author":"WP Thomas","year":"1993","unstructured":"Thomas, W. P. et al. Recommendations for standards in transthoracic two-dimensional echocardiography in the dog and Cat. J. Vet. Intern. Med. 7, 247\u2013252 (1993).","journal-title":"J. Vet. Intern. Med."},{"key":"35086_CR18","unstructured":"Hall, J. E. & Hall, M. E. Guyton and Hall Textbook of Medical Physiology. 14th ed. (Elsevier, Philadelphia, 2020)."},{"key":"35086_CR19","doi-asserted-by":"crossref","unstructured":"Gan, G. C. H., Bhat, A., Chen, H. H. L., Fernandez, F., Byth, K., Eshoo, S. & Thomas, L. Determinants of left atrial reservoir strain: independent effects of left atrial volume and left ventricular global longitudinal strain. Echocardiography 37, 2018\u20132028 (2020).","DOI":"10.1111\/echo.14922"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-35086-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-35086-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-35086-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T10:51:49Z","timestamp":1770634309000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-35086-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,16]]},"references-count":19,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["35086"],"URL":"https:\/\/doi.org\/10.1038\/s41598-026-35086-4","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,16]]},"assertion":[{"value":"8 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"5479"}}