{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:14:32Z","timestamp":1792084472854,"version":"4.4.0"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T00:00:00Z","timestamp":1771113600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"vor","delay-in-days":30,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-026-35171-8","type":"journal-article","created":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T12:15:11Z","timestamp":1771157711000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Tailored minimum examined lymph node threshold for colon cancer from large multi database analysis"],"prefix":"10.1038","volume":"16","author":[{"given":"Baohong","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingxia","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boxin","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongbo","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiyuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jungang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfeng","family":"Xi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xishan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,15]]},"reference":[{"key":"35171_CR1","doi-asserted-by":"crossref","unstructured":"Bray, F. et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 74 (3), 229\u2013263 (2024).","DOI":"10.3322\/caac.21834"},{"issue":"6","key":"35171_CR2","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.1245\/s10434-010-0985-4","volume":"17","author":"SB Edge","year":"2010","unstructured":"Edge, S. B. & Compton, C. C. The American joint committee on cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Ann. Surg. Oncol. 17 (6), 1471\u20131474 (2010).","journal-title":"Ann. Surg. Oncol."},{"key":"35171_CR3","doi-asserted-by":"publisher","first-page":"1731","DOI":"10.1002\/bjs.10218","volume":"103","author":"M Raoof","year":"2016","unstructured":"Raoof, M. et al. Prognostic significance of lymph node yield in ypN0 rectal cancer. Br. J. Surg. 103, 1731\u20131737 (2016).","journal-title":"Br. J. Surg."},{"key":"35171_CR4","first-page":"295","volume":"54","author":"CC Compton","year":"2004","unstructured":"Compton, C. C. & Greene, F. L. The staging of colorectal cancer: 2004 and beyond. CA Cancer J. Clin. 54, 295\u2013308 (2004).","journal-title":"CA Cancer J. Clin."},{"key":"35171_CR5","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1097\/PAS.0b013e3181b2e01f","volume":"33","author":"LJ Mekenkamp","year":"2009","unstructured":"Mekenkamp, L. J. et al. Lymph node retrieval in rectal cancer is dependent on many factors \u2013 the role of the tumor, the patient, the surgeon, the radiotherapist, and the pathologist. Am. J. Surg. Pathol. 33, 1547\u20131553 (2009).","journal-title":"Am. J. Surg. Pathol."},{"key":"35171_CR6","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1007\/s00384-017-2778-8","volume":"32","author":"J Betge","year":"2017","unstructured":"Betge, J. et al. Lymph node retrieval in colorectal cancer: determining factors and prognostic significance. Int. J. Colorectal Dis. 32, 991\u2013998 (2017).","journal-title":"Int. J. Colorectal Dis."},{"key":"35171_CR7","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1097\/00000478-200202000-00004","volume":"26","author":"NS Goldstein","year":"2002","unstructured":"Goldstein, N. S. Lymph node recoveries from 2427 pT3 colorectal resection specimens spanning 45 years: recommendations for a minimum number of recovered lymph nodes based on predictive probabilities. Am. J. Surg. Pathol. 26, 179\u2013189 (2002).","journal-title":"Am. J. Surg. Pathol."},{"key":"35171_CR8","doi-asserted-by":"publisher","first-page":"42","DOI":"10.21037\/jgo.2018.10.02","volume":"10","author":"DKH Chan","year":"2019","unstructured":"Chan, D. K. H. & Tan, K. K. Lower lymph node yield following neoadjuvant therapy for rectal cancer has no clinical significance. J. Gastrointest. Oncol. 10, 42\u201347 (2019).","journal-title":"J. Gastrointest. Oncol."},{"issue":"8","key":"35171_CR9","doi-asserted-by":"publisher","first-page":"2241","DOI":"10.1097\/JS9.0000000000000320","volume":"109","author":"X Guan","year":"2023","unstructured":"Guan, X. et al. Optimal examined lymph node number for accurate staging and long-term survival in rectal cancer: a population-based study. Int. J. Surg. 109 (8), 2241\u20132248 (2023).","journal-title":"Int. J. Surg."},{"issue":"7","key":"35171_CR10","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1007\/s00384-017-2778-8","volume":"32","author":"J Betge","year":"2017","unstructured":"Betge, J. et al. Lymph node retrieval in colorectal cancer: determining factors and prognostic significance. Int. J. Colorectal Dis. 32 (7), 991\u2013998 (2017).","journal-title":"Int. J. Colorectal Dis."},{"key":"35171_CR11","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1186\/1471-2407-10-267","volume":"10","author":"HK Choi","year":"2010","unstructured":"Choi, H. K., Law, W. L. & Poon, J. T. The optimal number of lymph nodes examined in stage II colorectal cancer and its impact on outcomes. BMC Cancer. 10, 267 (2010).","journal-title":"BMC Cancer"},{"key":"35171_CR12","unstructured":"Katsoulis, I. E., Tzelves, L., Lysikatou, J. & Karaitianos, I. G. Factors associated with lymph node retrieval in surgery for colorectal cancer. J. BUON. 25 (4), 1854\u20131859 (2020)."},{"issue":"1","key":"35171_CR13","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1186\/s12885-018-4431-5","volume":"18","author":"L Yang","year":"2018","unstructured":"Yang, L. et al. Prognostic value of total number of lymph nodes retrieved differs between left-sided colon cancer and right-sided colon cancer in stage III patients with colon cancer. BMC Cancer. 18 (1), 558 (2018).","journal-title":"BMC Cancer"},{"issue":"11\u201312","key":"35171_CR14","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1101\/gad.348226.120","volume":"35","author":"J Li","year":"2021","unstructured":"Li, J., Ma, X., Chakravarti, D., Shalapour, S. & DePinho, R. A. Genetic and biological hallmarks of colorectal cancer. Genes Dev. 35 (11\u201312), 787\u2013820 (2021).","journal-title":"Genes Dev."},{"key":"35171_CR15","doi-asserted-by":"publisher","first-page":"1499","DOI":"10.2147\/RMHP.S262171","volume":"13","author":"F Khalili","year":"2020","unstructured":"Khalili, F. et al. Cost-effectiveness analysis of colorectal cancer screening: A systematic review. Risk Manag. Healthc. Policy. 13, 1499\u20131512 (2020).","journal-title":"Risk Manag. Healthc. Policy"},{"issue":"5","key":"35171_CR16","doi-asserted-by":"publisher","first-page":"466","DOI":"10.4251\/wjgo.v8.i5.466","volume":"8","author":"P Wood","year":"2016","unstructured":"Wood, P., Peirce, C. & Mulsow, J. Non-surgical factors influencing lymph node yield in colon cancer. World J. Gastrointest. Oncol. 8 (5), 466\u2013473 (2016).","journal-title":"World J. Gastrointest. Oncol."},{"issue":"7","key":"35171_CR17","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1002\/jso.26152","volume":"122","author":"JC Sebasti\u00e1n-Tom\u00e1s","year":"2020","unstructured":"Sebasti\u00e1n-Tom\u00e1s, J. C. et al. Laparoscopic staged colon-first resection for metastatic colorectal cancer: perioperative and midterm outcomes from a single-center experience. J. Surg. Oncol. 122 (7), 1453\u20131461 (2020).","journal-title":"J. Surg. Oncol."},{"issue":"10","key":"35171_CR18","doi-asserted-by":"publisher","first-page":"1348","DOI":"10.1016\/S1470-2045(17)30456-4","volume":"18","author":"H Sekhar","year":"2017","unstructured":"Sekhar, H. et al. Nodal stage migration and prognosis in anal cancer: a systematic review, meta-regression, and simulation study. Lancet Oncol. 18 (10), 1348\u20131359 (2017).","journal-title":"Lancet Oncol."},{"issue":"3","key":"35171_CR19","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1007\/s12029-020-00525-6","volume":"52","author":"M Shetiwy","year":"2021","unstructured":"Shetiwy, M., Elalfy, A. F., Eldamshety, O., Abbas, R. & Abdelkhalek, M. The prognostic significance of lymph node status and lymph node ratio (LNR) on survival of right colon cancer patients: a tertiary center experience. J. Gastrointest. Cancer. 52 (3), 1010\u20131015 (2021).","journal-title":"J. Gastrointest. Cancer"},{"issue":"1","key":"35171_CR20","doi-asserted-by":"publisher","first-page":"9","DOI":"10.4240\/wjgs.v4.i1.9","volume":"4","author":"JR McDonald","year":"2012","unstructured":"McDonald, J. R., Renehan, A. G., O\u2019Dwyer, S. T. & Haboubi, N. Y. Lymph node harvest in colon and rectal cancer: current considerations. World J. Gastrointest. Surg. 4 (1), 9\u201319 (2012).","journal-title":"World J. Gastrointest. Surg."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-35171-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-35171-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-35171-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T23:02:06Z","timestamp":1773788526000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-35171-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,15]]},"references-count":20,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["35171"],"URL":"https:\/\/doi.org\/10.1038\/s41598-026-35171-8","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,15]]},"assertion":[{"value":"12 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Ethical approval for this study was granted by the Ethics Committee of Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences (Approval number: KY-2024063).Written informed consent was obtained from all patients or their guardians.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"9182"}}