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Amino acids have been suggested to support hepatic metabolism and recovery following alcohol consumption. This study investigated the effects of Amino Liver (AL), an amino acid mixture, on alcohol metabolism and alcohol-related symptoms in healthy adults. In a randomized, double-blind, placebo-controlled, crossover clinical trial, healthy adults consumed AL or placebo prior to alcohol consumption. Blood alcohol and acetaldehyde concentrations were measured at predefined time points up to 13\u00a0h after alcohol consumption. Alcohol-related symptoms were assessed using the Alcohol Hangover Severity Scale (AHSS). Safety parameters were also evaluated. AL intake was associated with a more rapid reduction in blood alcohol and acetaldehyde concentrations compared with placebo. Participants who received AL reported lower severity of alcohol-related symptoms, particularly fatigue and cognitive difficulty, at 13\u00a0h after alcohol consumption. No clinically significant adverse effects were observed. The findings suggest that AL supplementation is associated with favorable modulation of alcohol metabolism and reduced severity of alcohol-related symptoms. Although further studies are required to confirm these findings and clarify underlying mechanisms, AL may represent a potential nutritional approach for supporting alcohol metabolism following alcohol consumption. Trial registration: Clinical Research Information Service (CRIS), Republic of Korea (KCT0010612). Registered 10 June 2025. Retrospectively registered.<\/jats:p>","DOI":"10.1038\/s41598-026-35178-1","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T10:47:37Z","timestamp":1767869257000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of an amino acid mixture on alcohol metabolism and alcohol-related symptoms in healthy adults"],"prefix":"10.1038","volume":"16","author":[{"given":"Hyeongyeong","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyung Joo","family":"Suh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kisoo","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nari","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Young","family":"Jung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joon Young","family":"Shim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,1,8]]},"reference":[{"key":"35178_CR1","doi-asserted-by":"publisher","first-page":"89","DOI":"10.15740\/HAS\/AJBS\/10.1\/89-100","volume":"10","author":"DK Dey","year":"2015","unstructured":"Dey, D. 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All other authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The study was conducted in accordance with the Declaration of Helsinki, approved by the Institutional Review Board of Jeonju University (approval number: jjIRB-240730-HR-2024-0609), and registered with the Clinical Research Information Service (CRIS), Republic of Korea (registration number: KCT0010612). Written informed consent was obtained from all participants prior to study enrollment.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable. This manuscript does not contain any individual person\u2019s data in any form (including individual details, images, or videos).","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"4845"}}