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The anti-inflammatory activity was evaluated using lipopolysaccharides-induced nitric oxide (NO) inhibition on murine macrophage cells (RAW264.7) and cancer chemo-preventive influence was assessed in vitro utilizing Hepa1c1c7 murine carcinoma cells. The EO of\n                    <jats:italic>A. abrotanum<\/jats:italic>\n                    has the most potential activity toward inhibition of NO release, recording 96.6\u2009\u00b1\u20090.1%, as estimated by Greiss assay. Followed by EOs of\n                    <jats:italic>L. dentata<\/jats:italic>\n                    and\n                    <jats:italic>L. nobilis<\/jats:italic>\n                    with 63.6\u2009\u00b1\u20090.11 and 37.0\u2009\u00b1\u20090.23%, respectively. At the protein expression level, western blotting technique was used to evaluate the expression of iNOS. The EO of\n                    <jats:italic>A. abrotanum<\/jats:italic>\n                    at 100\u00a0\u00b5g\/ml exhibited a very high impact on inhibiting iNOS expression, followed by EOs of\n                    <jats:italic>L. dentata<\/jats:italic>\n                    and\n                    <jats:italic>L. nobilis<\/jats:italic>\n                    . On the other hand, pre-screening concentration (100\u00a0\u00b5g\/ml) revealed that the EOs of\n                    <jats:italic>L. dentata<\/jats:italic>\n                    and\n                    <jats:italic>A. abrotanum<\/jats:italic>\n                    have moderate potency to induce expression of chemo-preventive marker NQO1. The results revealed that the EO of\n                    <jats:italic>A. abrotanum<\/jats:italic>\n                    had strong anti-inflammatory activity. While the EOs of\n                    <jats:italic>L. dentata<\/jats:italic>\n                    and\n                    <jats:italic>A. abrotanum<\/jats:italic>\n                    have moderate potency to induce cancer chemoprevention.\n                  <\/jats:p>","DOI":"10.1038\/s41598-026-35195-0","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T13:28:43Z","timestamp":1769693323000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Anti-inflammatory and cancer chemopreventive potential of essential oils from some cultivated plants in Egypt"],"prefix":"10.1038","volume":"16","author":[{"given":"Mohammed I.","family":"Ali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed R.","family":"Hamed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emad M.","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faten M.","family":"Abou elella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayed A.","family":"El-Toumy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed M.","family":"Aboul-Enein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,29]]},"reference":[{"key":"35195_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-981-97-0157-5_1","volume-title":"Inflammation Resolution and Chronic Diseases","author":"D Chopra","year":"2024","unstructured":"Chopra, D. et al. 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