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Individuals who have experienced trauma are more susceptible to developing accidental hypothermia. This condition has been demonstrated to be associated with poor clinical outcomes. The primary objective of this study was to identify the association between body temperature (BT) and mortality in patients with multiple trauma. A secondary objective was to ascertain whether this association remained significant in patients with body temperature\u2009&lt;\u200936\u00a0\u00b0C. A prospective cohort study was conducted in a level-3-trauma centre in Barcelona, Spain, between August 2022 and February 2024. Data pertaining to demographics, out-of-hospital and in-hospital clinical variables were collected. BT was categorised as follows: &lt;35\u00a0\u00b0C, 35\u201335.9\u00a0\u00b0C, 36\u201337\u00a0\u00b0C, and &gt;\u200937\u00a0\u00b0C. Univariable and multivariable logistic regression were conducted to assess the association between BT and mortality. A sensitivity analysis was also performed using a dichotomous BT threshold of &lt;\u200936\u00a0\u00b0C. The study comprised 334 patients, with an overall mortality rate of 10.4%. Secondary mortality endpoints were: 24-hour mortality in 6 patients (1.8%), 30-day mortality in 23 patients (6.9%), and in-hospital mortality in 25 patients (7.5%). Hypothermia (BT\u2009&lt;\u200935\u00a0\u00b0C) was observed in 11.7% of patients, resulting in a mortality rate of 23%. Patients with BT\u2009&lt;\u200936\u00a0\u00b0C constituted 43.4% of the cohort. Univariable logistic regression revealed a significant inverse relationship between BT and mortality (OR 0.51, 95%\u00a0CI 0.3\u20130.7;\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.001). Following multivariable adjustment, the association remained robust (OR 0.58, 95%\u00a0CI 0.37\u20130.91;\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.02). A subsequent sensitivity analysis demonstrated that a BT\u2009&lt;\u200936\u00a0\u00b0C was an independent predictor of mortality (OR 3.29; 95%\u00a0CI: 1.23\u20138.77;\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.017). BT was identified as an independent and significant predictor of mortality in patients with multiple trauma. For every 1\u00a0\u00b0C decrease in BT, the odds of mortality increased by 72%. Patients with a BT\u2009&lt;\u200936\u00a0\u00b0C exhibited a threefold elevated probability of mortality.\n                  <\/jats:p>","DOI":"10.1038\/s41598-026-35372-1","type":"journal-article","created":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T02:53:55Z","timestamp":1769223235000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Body temperature as a predictor of mortality in multiple trauma patients: a prospective single-centre cohort study"],"prefix":"10.1038","volume":"16","author":[{"given":"Robert","family":"Blasco Mari\u00f1o","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel \u00c1ngel","family":"Gonz\u00e1lez Posada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I\u00f1igo","family":"Soteras Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Mar\u00eda","family":"V\u00e1zquez Rever\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayana","family":"Joshi Jubert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Paal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Biarn\u00e9s-Su\u00f1\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,24]]},"reference":[{"key":"35372_CR1","unstructured":"Injuries and violence [Internet]. 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The authors declare that they have the ClinicalResearch Ethics Committee authorization for this study and the entiresturdy conducted in accordance with the principles of the Declarationof Helsinki.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Enrolment and data use followed a full waiver of informed consent approved by the CEIC (Protocol PR(AT)164\/2022).","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"6123"}}