{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:26:53Z","timestamp":1792175213355,"version":"4.4.0"},"reference-count":61,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T00:00:00Z","timestamp":1771200000000},"content-version":"vor","delay-in-days":19,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-026-35623-1","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T22:33:51Z","timestamp":1769639631000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Experimental investigation and thermodynamic correlation of chlordiazepoxide solubility in supercritical CO\u2082"],"prefix":"10.1038","volume":"16","author":[{"given":"Nedasadat","family":"Saadati Ardestani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adel","family":"Noubigh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Esfandiari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Ali","family":"Sajadian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. Antonio","family":"Est\u00e9vez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,28]]},"reference":[{"key":"35623_CR1","doi-asserted-by":"publisher","first-page":"103821","DOI":"10.1016\/j.arabjc.2022.103821","volume":"15","author":"S. Ali Sajadian","year":"2022","unstructured":"Ali Sajadian, S., Amani, M., Saadati Ardestani, N. & Shirazian, S. Experimental analysis and thermodynamic modelling of Lenalidomide solubility in supercritical carbon dioxide. Arab. J. Chem. 15, 103821 (2022).","journal-title":"Arab. J. Chem."},{"key":"35623_CR2","first-page":"100468","volume":"35","author":"N Saadati Ardestani","year":"2023","unstructured":"Saadati Ardestani, N., Amani, M. & Sajadian, S. A. Phenomenological modeling of supercritical fluid extraction of oil from elaeagnus angustifolia seeds. J. Appl. Res. Med. Aromatic Plants. 35, 100468 (2023).","journal-title":"J. Appl. Res. Med. Aromatic Plants"},{"key":"35623_CR3","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.supflu.2014.12.028","volume":"100","author":"N Esfandiari","year":"2015","unstructured":"Esfandiari, N. Production of micro and nano particles of pharmaceutical by supercritical carbon dioxide. J. Supercrit. Fluids. 100, 129\u2013141 (2015).","journal-title":"J. Supercrit. Fluids"},{"key":"35623_CR4","doi-asserted-by":"publisher","first-page":"D1123","DOI":"10.1093\/nar\/gkab957","volume":"50","author":"C Cao","year":"2022","unstructured":"Cao, C. et al. WebTWAS: a resource for disease candidate susceptibility genes identified by transcriptome-wide association study. Nucleic Acids Res. 50, D1123\u2013d1130 (2022).","journal-title":"Nucleic Acids Res."},{"key":"35623_CR5","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1016\/j.msec.2017.03.059","volume":"78","author":"G Cui","year":"2017","unstructured":"Cui, G. et al. Synthesis and characterization of Eu(III) complexes of modified d-glucosamine and poly(N-isopropylacrylamide). Mater. Sci. Engineering: C. 78, 603\u2013608 (2017).","journal-title":"Mater. Sci. Engineering: C"},{"key":"35623_CR6","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1002\/cben.202300027","volume":"10","author":"M Askarizadeh","year":"2023","unstructured":"Askarizadeh, M., Esfandiari, N., Honarvar, B., Sajadian, S. A. & Azdarpour, A. Kinetic modeling to explain the release of medicine from drug delivery systems. ChemBioEng Reviews. 10, 1006\u20131049 (2023).","journal-title":"ChemBioEng Reviews"},{"key":"35623_CR7","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1007\/s11696-020-01283-2","volume":"75","author":"H Rostamian","year":"2021","unstructured":"Rostamian, H., Lotfollahi, M. N. & Mohammadi, A. Micronization and characterization of ultrafine pure and composite aspirin by CO2-expanded solution. Chem. Pap. 75, 99\u2013113 (2021).","journal-title":"Chem. Pap."},{"key":"35623_CR8","doi-asserted-by":"publisher","first-page":"106483","DOI":"10.1016\/j.jtice.2025.106483","volume":"180","author":"L Mei","year":"2026","unstructured":"Mei, L., Wang, T., Kanda, H., Zhu, L. & Yamamoto, T. Engineering nanoarchitectonics of \u03b2-carotene particles via coaxial nozzle-assisted supercritical CO\u2082 anti-solvent process using liquefied dimethyl ether as a green solvent. J. Taiwan Inst. Chem. Eng. 180, 106483 (2026).","journal-title":"J. Taiwan Inst. Chem. Eng."},{"key":"35623_CR9","unstructured":"Markeev, V. et al. Creation of solid dispersions by rapid expansion of supercritical fluids to improve the solubility of active pharmaceutical ingredients. Pharm. Chem. J. 10, 1\u201311 (2025)."},{"key":"35623_CR10","doi-asserted-by":"publisher","first-page":"123253","DOI":"10.1016\/j.physa.2019.123253","volume":"540","author":"H Rostamian","year":"2020","unstructured":"Rostamian, H. & Lotfollahi, M. N. Statistical modeling of aspirin solubility in organic solvents by response surface methodology and artificial neural networks. Phys. A: Stat. Mech. Its Appl. 540, 123253 (2020).","journal-title":"Phys. A: Stat. Mech. Its Appl."},{"key":"35623_CR11","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1111\/cote.12682","volume":"139","author":"M Amani","year":"2023","unstructured":"Amani, M., Saadati Ardestani, N. & Sajadian, S. A. Production of dye nanoparticles via a supercritical gas anti-solvent process and optimisation of the process conditions. Color. Technol. 139, 703\u2013718 (2023).","journal-title":"Color. Technol."},{"key":"35623_CR12","doi-asserted-by":"publisher","first-page":"109471","DOI":"10.1016\/j.dyepig.2021.109471","volume":"193","author":"NS Ardestani","year":"2021","unstructured":"Ardestani, N. S. & Amani, M. Production of anthraquinone Violet 3RN nanoparticles via the GAS process: optimization of the process parameters using Box-Behnken design. Dyes Pigm. 193, 109471 (2021).","journal-title":"Dyes Pigm."},{"key":"35623_CR13","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.addr.2018.07.010","volume":"131","author":"L Padrela","year":"2018","unstructured":"Padrela, L. et al. Supercritical carbon dioxide-based technologies for the production of drug nanoparticles\/nanocrystals\u2013a comprehensive review. Adv. Drug Deliv. Rev. 131, 22\u201378 (2018).","journal-title":"Adv. Drug Deliv. Rev."},{"key":"35623_CR14","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.supflu.2017.04.007","volume":"127","author":"G Sodeifian","year":"2017","unstructured":"Sodeifian, G., Sajadian, S. A., Saadati, N. & Ardestani Experimental optimization and mathematical modeling of the supercritical fluid extraction of essential oil from eryngium billardieri: application of simulated annealing (SA) algorithm. J. Supercrit. Fluids. 127, 146\u2013157 (2017).","journal-title":"J. Supercrit. Fluids"},{"key":"35623_CR15","doi-asserted-by":"publisher","first-page":"101465","DOI":"10.1016\/j.jcou.2021.101465","volume":"46","author":"M Amani","year":"2021","unstructured":"Amani, M., Ardestani, N. S. & Majd, N. Y. Utilization of supercritical CO\u2082 gas antisolvent (GAS) for production of capecitabine nanoparticles as anti-cancer drug: analysis and optimization of the process conditions. J. CO\u2082 Utilization. 46, 101465 (2021).","journal-title":"J. CO\u2082 Utilization"},{"key":"35623_CR16","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.supflu.2016.08.019","volume":"119","author":"G Sodeifian","year":"2017","unstructured":"Sodeifian, G., Sajadian, S. A., Saadati, N. & Ardestani Supercritical fluid extraction of omega-3 from dracocephalum kotschyi seed oil: process optimization and oil properties. J. Supercrit. Fluids. 119, 139\u2013149 (2017).","journal-title":"J. Supercrit. Fluids"},{"key":"35623_CR17","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.supflu.2017.12.026","volume":"135","author":"G Sodeifian","year":"2018","unstructured":"Sodeifian, G., Ardestani, N. S., Sajadian, S. A. & Moghadamian, K. Properties of portulaca Oleracea seed oil via supercritical fluid extraction: experimental and optimization. J. Supercrit. Fluids. 135, 34\u201344 (2018).","journal-title":"J. Supercrit. Fluids"},{"key":"35623_CR18","doi-asserted-by":"publisher","first-page":"11","DOI":"10.3390\/pr11010011","volume":"11","author":"N Esfandiari","year":"2022","unstructured":"Esfandiari, N. et al. Effect of the processing conditions on the supercritical extraction and impregnation of Rosemary essential oil in linear Low-Density polyethylene films. Processes 11, 11 (2022).","journal-title":"Processes"},{"key":"35623_CR19","doi-asserted-by":"publisher","first-page":"e04947","DOI":"10.1016\/j.heliyon.2020.e04947","volume":"6","author":"N Saadati Ardestani","year":"2020","unstructured":"Saadati Ardestani, N., Sodeifian, G. & Sajadian, S. A. Preparation of phthalocyanine green nano pigment using supercritical CO\u2082 gas antisolvent (GAS): experimental and modeling. Heliyon 6, e04947 (2020).","journal-title":"Heliyon"},{"key":"35623_CR20","doi-asserted-by":"crossref","unstructured":"Amani, M., Saadati, N. & Ardestani Investigation the phase equilibrium behavior in ternary system (CO 2, DMSO, capecitabine as anticancer drug) for precipitation of CPT nanoparticle via the gas antisolvent supercritical process (GAS). Braz. J. Chem. Eng. 39, 857\u2013868 (2022).","DOI":"10.1007\/s43153-021-00185-4"},{"key":"35623_CR21","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/S0896-8446(01)00125-5","volume":"22","author":"M Cocero","year":"2002","unstructured":"Cocero, M. & Ferrero, S. Crystallization of \u03b2-carotene by a GAS process in batch effect of operating conditions. J. Supercrit Fluids. 22, 237\u2013245 (2002).","journal-title":"J. Supercrit Fluids"},{"key":"35623_CR22","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1016\/j.supflu.2008.08.015","volume":"47","author":"MJ Cocero","year":"2009","unstructured":"Cocero, M. J., Mart\u00edn, \u00c1., Mattea, F. & Varona, S. Encapsulation and co-precipitation processes with supercritical fluids: fundamentals and applications. J. Supercrit Fluids. 47, 546\u2013555 (2009).","journal-title":"J. Supercrit Fluids"},{"key":"35623_CR23","doi-asserted-by":"crossref","unstructured":"Saadati Ardestani, N. et al. Supercritical fluid extraction from Zataria multiflora Boiss and impregnation of bioactive compounds in PLA for the development of materials with antibacterial properties. in: Processes. 10, 1787 (2022).","DOI":"10.3390\/pr10091787"},{"key":"35623_CR24","doi-asserted-by":"crossref","unstructured":"Esfandiari, N. et al. Effect of the processing conditions on the supercritical extraction and impregnation of Rosemary essential oil in linear Low-Density polyethylene films. in: Processes. 11, 11 (2022).","DOI":"10.3390\/pr11010011"},{"key":"35623_CR25","doi-asserted-by":"publisher","first-page":"105989","DOI":"10.1016\/j.jddst.2024.105989","volume":"99","author":"F Rezaee","year":"2024","unstructured":"Rezaee, F., Ghoreishi, S. M. & Ardestani, N. S. Precipitation of advanced nanomedicines (curcumin) using supercritical processing; experimental study, design and optimizing operating conditions. J. Drug Deliv. Sci. Technol. 99, 105989 (2024).","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"35623_CR26","doi-asserted-by":"publisher","first-page":"1787","DOI":"10.3390\/pr10091787","volume":"10","author":"N Saadati Ardestani","year":"2022","unstructured":"Saadati Ardestani, N. et al. Supercritical fluid extraction from Zataria multiflora Boiss and impregnation of bioactive compounds in PLA for the development of materials with antibacterial properties. Processes 10, 1787 (2022).","journal-title":"Processes"},{"key":"35623_CR27","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1016\/j.supflu.2009.07.012","volume":"51","author":"F Belhadj-Ahmed","year":"2009","unstructured":"Belhadj-Ahmed, F., Badens, E., Llewellyn, P., Denoyel, R. & Charbit, G. Impregnation of vitamin E acetate on silica mesoporous phases using supercritical carbon dioxide. J. Supercrit Fluids. 51, 278\u2013286 (2009).","journal-title":"J. Supercrit Fluids"},{"key":"35623_CR28","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.ijpharm.2016.01.016","volume":"500","author":"A. Bouledjouidja","year":"2016","unstructured":"Bouledjouidja, A., Masmoudi, Y., Sergent, M., Trivedi, V. & Meniai, A. E.J.I.j.o.p. Badens, drug loading of foldable commercial intraocular lenses using supercritical impregnation. Int. J. Pharm. 500, 85\u201399 (2016).","journal-title":"Int. J. Pharm."},{"key":"35623_CR29","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/j.cherd.2018.12.020","volume":"142","author":"G Sodeifian","year":"2019","unstructured":"Sodeifian, G. & Sajadian, S. A. Utilization of Ultrasonic-Assisted RESOLV with polymeric stabilizers for production of Amiodarone hydrochloride nanoparticles: optimization of the process parameters. Chem. Eng. Res. Des. 142, 268\u2013284 (2019).","journal-title":"Chem. Eng. Res. Des."},{"key":"35623_CR30","doi-asserted-by":"publisher","first-page":"4762","DOI":"10.1021\/acs.jced.0c00183","volume":"65","author":"NS Ardestani","year":"2020","unstructured":"Ardestani, N. S., Majd, N. Y. & Amani, M. Experimental measurement and thermodynamic modeling of capecitabine (an anticancer Drug) solubility in supercritical carbon dioxide in a ternary system: effect of different cosolvents. J. Chem. Eng. Data. 65, 4762\u20134779 (2020).","journal-title":"J. Chem. Eng. Data"},{"key":"35623_CR31","doi-asserted-by":"publisher","first-page":"103212","DOI":"10.1016\/j.csite.2023.103212","volume":"49","author":"AJ Obaidullah","year":"2023","unstructured":"Obaidullah, A. J. Thermodynamic and experimental analysis of drug nanoparticles Preparation using supercritical thermal processing: solubility of Chlorothiazide in different Co-solvents. Case Stud. Therm. Eng. 49, 103212 (2023).","journal-title":"Case Stud. Therm. Eng."},{"key":"35623_CR32","doi-asserted-by":"publisher","first-page":"105539","DOI":"10.1016\/j.supflu.2022.105539","volume":"183","author":"SA Sajadian","year":"2022","unstructured":"Sajadian, S. A., Ardestani, N. S., Esfandiari, N., Askarizadeh, M. & Jouyban, A. Solubility of favipiravir (as an anti-COVID-19) in supercritical carbon dioxide: an experimental analysis and thermodynamic modeling. J. Supercrit. Fluids. 183, 105539 (2022).","journal-title":"J. Supercrit. Fluids"},{"key":"35623_CR33","doi-asserted-by":"publisher","first-page":"118219","DOI":"10.1016\/j.molliq.2021.118219","volume":"349","author":"SA Sajadian","year":"2022","unstructured":"Sajadian, S. A., Ardestani, N. S. & Jouyban, A. Solubility of Montelukast (as a potential treatment of COVID-19) in supercritical carbon dioxide: experimental data and modelling. J. Mol. Liq. 349, 118219 (2022).","journal-title":"J. Mol. Liq."},{"key":"35623_CR34","doi-asserted-by":"publisher","first-page":"113880","DOI":"10.1016\/j.fluid.2023.113880","volume":"574","author":"RS Alwi","year":"2023","unstructured":"Alwi, R. S. et al. Experimental study and thermodynamic modeling of clonazepam solubility in supercritical carbon dioxide. Fluid Phase Equilib. 574, 113880 (2023).","journal-title":"Fluid Phase Equilib."},{"key":"35623_CR35","doi-asserted-by":"publisher","first-page":"17506","DOI":"10.1038\/s41598-023-44787-z","volume":"13","author":"NS Ardestani","year":"2023","unstructured":"Ardestani, N. S., Sajadian, S. A., Esfandiari, N., Rojas, A. & Garlapati, C. Experimental and modeling of solubility of sitagliptin phosphate, in supercritical carbon dioxide: proposing a new association model. Sci. Rep. 13, 17506 (2023).","journal-title":"Sci. Rep."},{"key":"35623_CR36","doi-asserted-by":"publisher","first-page":"17089","DOI":"10.1038\/s41598-023-44280-7","volume":"13","author":"N Esfandiari","year":"2023","unstructured":"Esfandiari, N. et al. Solubility measurement of verapamil for the Preparation of developed nanomedicines using supercritical fluid. Sci. Rep. 13, 17089 (2023).","journal-title":"Sci. Rep."},{"key":"35623_CR37","doi-asserted-by":"crossref","unstructured":"Sajadian, S. A., Esfandiari, N., Saadati Ardestani, N., Amani, M. & Est\u00e9vez, L. A. Measurement and Modeling of the Solubility of Mebeverine Hydrochloride in Supercritical Carbon Dioxide Vol. 47, 811\u2013821 (Chemical Engineering & Technology, 2024).","DOI":"10.1002\/ceat.202300449"},{"key":"35623_CR38","doi-asserted-by":"publisher","first-page":"119467","DOI":"10.1016\/j.molliq.2022.119467","volume":"360","author":"N Esfandiari","year":"2022","unstructured":"Esfandiari, N. & Ali Sajadian, S. Solubility of lacosamide in supercritical carbon dioxide: an experimental analysis and thermodynamic modeling. J. Mol. Liq. 360, 119467 (2022).","journal-title":"J. Mol. Liq."},{"key":"35623_CR39","doi-asserted-by":"publisher","first-page":"102649","DOI":"10.1016\/j.csite.2022.102649","volume":"41","author":"K Venkatesan","year":"2023","unstructured":"Venkatesan, K. et al. Experimental - Theoretical approach for determination of Metformin solubility in supercritical carbon dioxide: thermodynamic modeling. Case Stud. Therm. Eng. 41, 102649 (2023).","journal-title":"Case Stud. Therm. Eng."},{"key":"35623_CR40","doi-asserted-by":"crossref","unstructured":"Mirzaie, M., Amani, M., Ardestani, N. S. & Vaferi, B. Experimental Measurement and thermodynamic\/intelligent Modeling of Yellow 2 G Solubility in Supercritical Carbon Dioxide with\/without Co-solvent (Chemical Engineering Research and Design, 2024).","DOI":"10.1016\/j.cherd.2024.05.036"},{"key":"35623_CR41","doi-asserted-by":"publisher","first-page":"4767","DOI":"10.1021\/ie000339u","volume":"39","author":"J Mendez-Santiago","year":"2000","unstructured":"Mendez-Santiago, J. & Teja, A. S. Solubility of solids in supercritical fluids: consistency of data and a new model for cosolvent systems. Ind. Eng. Chem. Res. 39, 4767\u20134771 (2000).","journal-title":"Ind. Eng. Chem. Res."},{"key":"35623_CR42","doi-asserted-by":"publisher","first-page":"106165","DOI":"10.1016\/j.supflu.2023.106165","volume":"206","author":"F Arabgol","year":"2024","unstructured":"Arabgol, F., Amani, M., Ardestani, N. S. & Sajadian, S. A. Experimental and thermodynamic investigation of Gemifloxacin solubility in supercritical CO\u2082 for the production of nanoparticles. J. Supercrit Fluids. 206, 106165 (2024).","journal-title":"J. Supercrit Fluids"},{"key":"35623_CR43","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1002\/ceat.202300398","volume":"47","author":"F Arabgol","year":"2024","unstructured":"Arabgol, F., Amani, M., Ardestani, N. S. & Sajadian, S. A. Nanomedicine formulation using green supercritical processing: experimental solubility measurement and theoretical investigation. Chem. Eng. Technol. 47, 318\u2013326 (2024).","journal-title":"Chem. Eng. Technol."},{"key":"35623_CR44","doi-asserted-by":"publisher","first-page":"5338","DOI":"10.1021\/acs.jced.9b00550","volume":"64","author":"G Sodeifian","year":"2019","unstructured":"Sodeifian, G., Hazaveie, S. M., Sajadian, S. A. & Saadati Ardestani, N. Determination of the solubility of the repaglinide drug in supercritical carbon dioxide: experimental data and thermodynamic modeling. J. Chem. Eng. Data. 64, 5338\u20135348 (2019).","journal-title":"J. Chem. Eng. Data"},{"key":"35623_CR45","doi-asserted-by":"publisher","first-page":"105752","DOI":"10.1016\/j.supflu.2022.105752","volume":"190","author":"M Amani","year":"2022","unstructured":"Amani, M., Ardestani, N. S., Jouyban, A. & Sajadian, S. A. Solubility measurement of the fludrocortisone acetate in supercritical carbon dioxide: experimental and modeling assessments. J. Supercrit Fluids. 190, 105752 (2022).","journal-title":"J. Supercrit Fluids"},{"key":"35623_CR46","doi-asserted-by":"publisher","first-page":"104371","DOI":"10.1016\/j.arabjc.2022.104371","volume":"15","author":"NS Ardestani","year":"2022","unstructured":"Ardestani, N. S., Amani, M., Grishina, M. & Shirazian, S. Theoretical and experimental study on chloroquine drug solubility in supercritical carbon dioxide via the thermodynamic, multi-layer perceptron neural network (MLPNN), and molecular modeling. Arab. J. Chem. 15, 104371 (2022).","journal-title":"Arab. J. Chem."},{"key":"35623_CR47","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.supflu.2017.05.019","volume":"128","author":"G Sodeifian","year":"2017","unstructured":"Sodeifian, G., Sajadian, S. A. & Ardestani, N. S. Determination of solubility of aprepitant (an antiemetic drug for chemotherapy) in supercritical carbon dioxide: empirical and thermodynamic models. J. Supercrit Fluids. 128, 102\u2013111 (2017).","journal-title":"J. Supercrit Fluids"},{"key":"35623_CR48","unstructured":"Walas, S. M. Phase Equilibria in Chemical Engineering (Elsevier Science, 2013)."},{"key":"35623_CR49","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/S0378-3812(01)00431-9","volume":"183-184","author":"J Marrero","year":"2001","unstructured":"Marrero, J. & Gani, R. Group-contribution based Estimation of pure component properties. Fluid. Phase. Equilibria. 183-184, 183\u2013208 (2001).","journal-title":"Fluid. Phase. Equilibria"},{"key":"35623_CR50","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1002\/aic.690210313","volume":"21","author":"BI Lee","year":"1975","unstructured":"Lee, B. I. & Kesler, M. G. A generalized thermodynamic correlation based on three-parameter corresponding States. AIChE J. 21, 510\u2013527 (1975).","journal-title":"AIChE J."},{"key":"35623_CR51","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1107\/S0567739477000448","volume":"33","author":"A Immirzi","year":"1977","unstructured":"Immirzi, A. & Perini, B. Prediction of density in organic crystals. Acta Crystallogr. Sect. A. 33, 216\u2013218 (1977).","journal-title":"Acta Crystallogr. Sect. A"},{"key":"35623_CR52","unstructured":"Poling, B. E., Prausnitz, J. M. & O\u2019Connell, J. P. The Properties of Gases and Liquids (McGraw-Hill New York, 2001)."},{"key":"35623_CR53","unstructured":"Prausnitz, J. M., Lichtenthaler, R. N. & De Azevedo, E. G. Molecular thermodynamics of fluid-phase equilibria. Pearson Education. (1998)."},{"key":"35623_CR54","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/j.cherd.2020.04.026","volume":"159","author":"N Saadati Ardestani","year":"2020","unstructured":"Saadati Ardestani, N., Amani, M. & Moharrery, L. Determination of anthraquinone Violet 3RN solubility in supercritical carbon dioxide with\/without co-solvent: experimental data and modeling (empirical and thermodynamic models). Chem. Eng. Res. Des. 159, 529\u2013542 (2020).","journal-title":"Chem. Eng. Res. Des."},{"key":"35623_CR55","doi-asserted-by":"publisher","first-page":"116268","DOI":"10.1016\/j.ces.2020.116268","volume":"232","author":"L Antonio Est\u00e9vez","year":"2021","unstructured":"Antonio Est\u00e9vez, L., Colpas, F. J. & M\u00fcller, E. A. A simple thermodynamic model for the solubility of thermolabile solids in supercritical fluids. Chem. Eng. Sci. 232, 116268 (2021).","journal-title":"Chem. Eng. Sci."},{"key":"35623_CR56","doi-asserted-by":"publisher","first-page":"1747","DOI":"10.1021\/acs.jced.9b01069","volume":"65","author":"G Sodeifian","year":"2020","unstructured":"Sodeifian, G., Saadati Ardestani, N., Sajadian, S. A., Golmohammadi, M. R. & Fazlali, A. Prediction of solubility of sodium valproate in supercritical carbon dioxide: experimental study and thermodynamic modeling. J. Chem. Eng. Data. 65, 1747\u20131760 (2020).","journal-title":"J. Chem. Eng. Data"},{"key":"35623_CR57","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/j.crci.2016.09.009","volume":"20","author":"C Si-Moussa","year":"2017","unstructured":"Si-Moussa, C., Belghait, A., Khaouane, L., Hanini, S. & Halilali, A. Novel density-based model for the correlation of solid drugs solubility in supercritical carbon dioxide. CR CHIM. 20, 559\u2013572 (2017).","journal-title":"CR CHIM."},{"key":"35623_CR58","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.jct.2016.09.032","volume":"104","author":"K Tamura","year":"2017","unstructured":"Tamura, K., Alwi, R. S., Tanaka, T. & Shimizu, K. Solubility of 1-aminoanthraquinone and 1-nitroanthraquinone in supercritical carbon dioxide. J. Chem. Thermodyn. 104, 162\u2013168 (2017).","journal-title":"J. Chem. Thermodyn."},{"key":"35623_CR59","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/0896-8446(88)90005-8","volume":"1","author":"SK Kumar","year":"1988","unstructured":"Kumar, S. K. & Johnston, K. P. Modelling the solubility of solids in supercritical fluids with density as the independent variable. J. Supercrit Fluids. 1, 15\u201322 (1988).","journal-title":"J. Supercrit Fluids"},{"key":"35623_CR60","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1063\/1.555893","volume":"20","author":"K Bartle","year":"1991","unstructured":"Bartle, K., Clifford, A., Jafar, S. & Shilstone, G. Solubilities of solids and liquids of low volatility in supercritical carbon dioxide. J. Phys. Chem. Ref. Data. 20, 713\u2013756 (1991).","journal-title":"J. Phys. Chem. Ref. Data"},{"key":"35623_CR61","doi-asserted-by":"publisher","first-page":"3016","DOI":"10.1021\/j100212a041","volume":"86","author":"J Chrastil","year":"1982","unstructured":"Chrastil, J. Solubility of solids and liquids in supercritical gases. J. Phys. Chem. 86, 3016\u20133021 (1982).","journal-title":"J. Phys. Chem."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-35623-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-35623-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-35623-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T17:08:39Z","timestamp":1771434519000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-35623-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,28]]},"references-count":61,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["35623"],"URL":"https:\/\/doi.org\/10.1038\/s41598-026-35623-1","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,28]]},"assertion":[{"value":"5 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"6552"}}