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Despite its ubiquity, basic aspects like its composition and structure are as of yet undetermined, and its method of binding to ATTR amyloid fibrils is likewise hitherto unknown. This complicates the diagnostic process, as it introduces inexplicable losses of sensitivity in some ATTR and AL variants. In this paper we report the results of our comprehensive investigation into the physiologically active structure of Tc-PYP and its closely related, but experimentally more approachable counterpart, Re-PYP, built on a robust theoretical basis and backed up by multiple spectroscopic methods (focusing on the rhenium analogue). We conclude that the Re\/Tc-PYP tracers possess a flexible geometry, but ultimately appear as octahedral Re(IV)\/Tc(IV) diaqua dipyrophosphate complexes under physiological conditions, and predict that this structure is the reason for the high affinity of\n                    <jats:inline-formula>\n                      <jats:tex-math>$$\\phantom{0}^{99m}$$<\/jats:tex-math>\n                    <\/jats:inline-formula>\n                    Tc-PYP for certain amyloids.\n                  <\/jats:p>","DOI":"10.1038\/s41598-026-35746-5","type":"journal-article","created":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T13:15:53Z","timestamp":1769260553000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Physiologically relevant forms of Tc- and Re-pyrophosphate radioactive tracers and the basis of their transthyretin amyloid sensitivity"],"prefix":"10.1038","volume":"16","author":[{"given":"Kevin Zsolt","family":"Simon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kende Attila","family":"B\u00e9res","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Attila","family":"Farkas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00e1ndor","family":"Papp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Bodor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronika","family":"Harmat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e1vid","family":"Papp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Gracheva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1t\u00e9","family":"Sulyok-Eiler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e1s","family":"Perczel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e1szl\u00f3","family":"K\u00f3tai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00f3ra K.","family":"Menyh\u00e1rd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,24]]},"reference":[{"issue":"2","key":"35746_CR1","first-page":"195","volume":"6","author":"S Bokhari","year":"2013","unstructured":"Bokhari, S., Casta\u00f1o, A., Pozniakoff, T., Deslisle, S. & Latif, F. 99mTc-Pyrophosphate Scintigraphy for Differentiating Light-Chain Cardiac Amyloidosis From the Transthyretin-Related Familial and Senile Cardiac Amyloidoses. 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