{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T03:59:52Z","timestamp":1788235192483,"version":"build-2803163510"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:00:00Z","timestamp":1770768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:00:00Z","timestamp":1770940800000},"content-version":"vor","delay-in-days":2,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"New Valley University"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This work focuses on the synthesis of four novel lanthanide complexes: La (III), Ce (III), Nd (III), and Dy (III) with carbamazepine (CBZ). The geometric structural and bonding mode of synthesized complexes were accomplished by various analytical and spectroscopic techniques and the data reveal that the novel complexes have a 1:2 (Ln\n                    <jats:sup>3+<\/jats:sup>\n                    :CBZ) electrolytes with general formula [Ln(CBZ)\n                    <jats:sub>2<\/jats:sub>\n                    (H\n                    <jats:sub>2<\/jats:sub>\n                    O)Cl]Cl\n                    <jats:sub>2<\/jats:sub>\n                    .H\n                    <jats:sub>2<\/jats:sub>\n                    O and molecular weight: 753.83, 791.07, 777.19 and 777.43 for Ln\n                    <jats:sup>3+<\/jats:sup>\n                    complexes respectively. The spectral studies investigated that CBZ interacts as a bidentate ligand via the amide group\u2019s nitrogen and oxygen atoms in its moiety, and the geometric octahedral structure was confirmed by density function theory. On the other hand, PXRD data provided that the ligand and its complexes have nature that is crystalline. Antimicrobial activity was tested for their effectiveness against various Gram-positive and negative bacteria and anti-fungal efficacy, in addition to the efficiency of their cytotoxicity against cancer cell lines such as (Hep-G2 and MCF-7) to assess their potential as chemotherapy agents where the IC\n                    <jats:sub>50<\/jats:sub>\n                    for Ln\n                    <jats:sup>3+<\/jats:sup>\n                    complexes in the range (0.095\u20130.242) and (0.110\u20130.298) \u00b5M against Hep-G2 and MCF-7 cancer cell lines, respectively and La(III) demonstrated a high degree of activity, similarly, in the case of antimicrobials, it showed the highest activity. The ability of these complexes to bind to the active sites of the Bacillus subtilis receptor (PDB ID: 6A4M) and methionine adenosyl-transferases in liver tumors (PDB ID: 5A19) and human breast cancer MCF-7 (PDB ID: 4zvm) was evaluated using molecular docking studies utilizing MOA2022 software. According to the following pattern, the binding strength increased as the binding energy decreased: CBZ\u02c2[Dy(CBZ\n                    <jats:bold>)<\/jats:bold>\n                    <jats:sub>2<\/jats:sub>\n                    (H\n                    <jats:sub>2<\/jats:sub>\n                    O)Cl]\n                    <jats:sup>2+<\/jats:sup>\n                    \u02c2[Ce(CBZ\n                    <jats:bold>)<\/jats:bold>\n                    <jats:sub>2<\/jats:sub>\n                    (H\n                    <jats:sub>2<\/jats:sub>\n                    O)Cl]\n                    <jats:sup>2+<\/jats:sup>\n                    \u02c2 [Nd(CBZ\n                    <jats:bold>)<\/jats:bold>\n                    <jats:sub>2<\/jats:sub>\n                    (H\n                    <jats:sub>2<\/jats:sub>\n                    O)Cl]\n                    <jats:sup>2+<\/jats:sup>\n                    \u02c2[La(CBZ\n                    <jats:bold>)<\/jats:bold>\n                    <jats:sub>2<\/jats:sub>\n                    (H\n                    <jats:sub>2<\/jats:sub>\n                    O)Cl]\n                    <jats:sup>2+<\/jats:sup>\n                    , indicating that the highest binding affinity and possible biological activity were displayed by the La(III) complex.\n                  <\/jats:p>","DOI":"10.1038\/s41598-026-35893-9","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T13:16:51Z","timestamp":1770815811000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Lanthanide\u2013carbamazepine complexes: synthesis, spectroscopic characterization, DFT Insights, molecular docking, and biological evaluation"],"prefix":"10.1038","volume":"16","author":[{"given":"Nora S.","family":"Mohamed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud M. A.","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed R.","family":"Shehata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ehab M.","family":"Abdalla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,11]]},"reference":[{"key":"35893_CR1","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.jhazmat.2013.02.045","volume":"252","author":"SP Sun","year":"2013","unstructured":"Sun, S. P., Zeng, X. & Lemley, A. T. Kinetics and mechanism of carbamazepine degradation by a modified Fenton-like reaction with ferric-nitrilotriacetate complexes. J. Hazard. Mater. 252, 155\u2013165 (2013).","journal-title":"J. Hazard. Mater."},{"key":"35893_CR2","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1007\/s10847-009-9698-3","volume":"67","author":"JG Panchal","year":"2010","unstructured":"Panchal, J. G., Patel, R. V. & Menon, S. K. Preparation and physicochemical characterization of carbamazepine (CBMZ): para-sulfonated Calix [n] Arene inclusion complexes. J. Incl. Phenom. Macrocycl. Chem. 67, 201\u2013208 (2010).","journal-title":"J. Incl. Phenom. Macrocycl. Chem."},{"key":"35893_CR3","doi-asserted-by":"crossref","unstructured":"Prajapati, S., Gohel, M. & Patel, L. Studies to enhance dissolution properties of carbamazepine. Indian J. Pharm. Sci., 69 (3), 427-430 (2007).","DOI":"10.4103\/0250-474X.34555"},{"issue":"4","key":"35893_CR4","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1016\/j.watres.2011.11.063","volume":"46","author":"A Jelic","year":"2012","unstructured":"Jelic, A. et al. Degradation of carbamazepine by trametes versicolor in an air pulsed fluidized bed bioreactor and identification of intermediates. Water Res. 46 (4), 955\u2013964 (2012).","journal-title":"Water Res."},{"issue":"5","key":"35893_CR5","doi-asserted-by":"publisher","first-page":"e6178","DOI":"10.1002\/aoc.6178","volume":"35","author":"AA Mohamed","year":"2021","unstructured":"Mohamed, A. A. & Sadeek, S. A. Ligational and biological studies of Fe (III), Co (II), Ni (II), Cu (II), and Zr (IV) complexes with carbamazepine as antiepileptic drug. Appl. Organomet. Chem. 35 (5), e6178 (2021).","journal-title":"Appl. Organomet. Chem."},{"key":"35893_CR6","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1016\/j.fct.2018.06.038","volume":"118","author":"\u0130\u00d6 Aycan","year":"2018","unstructured":"Aycan, \u0130. \u00d6. et al. Diclofenac induced Gastrointestinal and renal toxicity is alleviated by thymoquinone treatment. Food Chem. Toxicol. 118, 795\u2013804 (2018).","journal-title":"Food Chem. Toxicol."},{"issue":"4","key":"35893_CR7","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1016\/j.watres.2003.10.058","volume":"38","author":"M Clara","year":"2004","unstructured":"Clara, M., Strenn, B. & Kreuzinger, N. Carbamazepine as a possible anthropogenic marker in the aquatic environment: investigations on the behaviour of carbamazepine in wastewater treatment and during groundwater infiltration. Water Res. 38 (4), 947\u2013954 (2004).","journal-title":"Water Res."},{"key":"35893_CR8","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/j.chemosphere.2015.12.035","volume":"146","author":"A Pires","year":"2016","unstructured":"Pires, A. et al. Long-term exposure to caffeine and carbamazepine: impacts on the regenerative capacity of the polychaete diopatra Neapolitana. Chemosphere 146, 565\u2013573 (2016).","journal-title":"Chemosphere"},{"issue":"1","key":"35893_CR9","doi-asserted-by":"publisher","first-page":"37728","DOI":"10.1038\/s41598-025-22252-3","volume":"15","author":"EM Abdalla","year":"2025","unstructured":"Abdalla, E. M. et al. Effect of gamma irradiation on the Cu (II), Ru (III) and Pd (II) complexes of Azo antipyrine moiety and their biological applications. Sci. Rep. 15 (1), 37728 (2025).","journal-title":"Sci. Rep."},{"issue":"1","key":"35893_CR10","doi-asserted-by":"publisher","first-page":"3199","DOI":"10.1038\/s41598-023-29386-2","volume":"13","author":"LH Abdel-Rahman","year":"2023","unstructured":"Abdel-Rahman, L. H. et al. Novel bromo and methoxy substituted schiff base complexes of Mn (II), Fe (III), and cr (III) for anticancer, antimicrobial, docking, and ADMET studies. Sci. Rep. 13 (1), 3199 (2023).","journal-title":"Sci. Rep."},{"issue":"15","key":"35893_CR11","doi-asserted-by":"publisher","first-page":"5443","DOI":"10.3390\/ijms21155443","volume":"21","author":"J Malinowski","year":"2020","unstructured":"Malinowski, J., Zych, D., Jacewicz, D., Gawdzik, B. & Drze\u017cd\u017con, J. Application of coordination compounds with transition metal ions in the chemical industry\u2014A review. Int. J. Mol. Sci. 21 (15), 5443 (2020).","journal-title":"Int. J. Mol. Sci."},{"issue":"9","key":"35893_CR12","doi-asserted-by":"publisher","first-page":"e7622","DOI":"10.1002\/aoc.7622","volume":"38","author":"RS Abo-Rehab","year":"2024","unstructured":"Abo-Rehab, R. S. et al. Synthesis, characterization, anticancer, antibacterial, antioxidant, DFT, and molecular Docking of novel La (III), Ce (III), Nd (III), and dy (III) lanthanide complexes with schiff base derived from 2\u2010aminobenzothiazole and coumarin. Appl. Organomet. Chem. 38 (9), e7622 (2024).","journal-title":"Appl. Organomet. Chem."},{"issue":"14","key":"35893_CR13","doi-asserted-by":"publisher","first-page":"4611","DOI":"10.1039\/C9DT00640K","volume":"48","author":"MPC Campello","year":"2019","unstructured":"Campello, M. P. C. et al. Lanthanide complexes with phenanthroline-based ligands: insights into cell death mechanisms obtained by microscopy techniques. Dalton Trans. 48 (14), 4611\u20134624 (2019).","journal-title":"Dalton Trans."},{"key":"35893_CR14","doi-asserted-by":"publisher","first-page":"115387","DOI":"10.1016\/j.poly.2021.115387","volume":"207","author":"NS Chundawat","year":"2021","unstructured":"Chundawat, N. S., Jadoun, S., Zarrintaj, P. & Chauhan, N. P. S. Lanthanide complexes as anticancer agents: A review. Polyhedron 207, 115387 (2021).","journal-title":"Polyhedron"},{"key":"35893_CR15","doi-asserted-by":"publisher","first-page":"726813","DOI":"10.3389\/fchem.2021.726813","volume":"9","author":"JY Zhao","year":"2021","unstructured":"Zhao, J. Y., Ren, N., Zhang, Y. Y., Tang, K. & Zhang, J. J. Five dinuclear lanthanide complexes based on 2, 4-dimethylbenzoic acid and 5, 5\u2032-dimethy-2, 2\u2032-bipyridine: crystal Structures, thermal behaviour and luminescent property. Front. Chem. 9, 726813 (2021).","journal-title":"Front. Chem."},{"issue":"7","key":"35893_CR16","doi-asserted-by":"publisher","first-page":"e7129","DOI":"10.1002\/aoc.7129","volume":"37","author":"SM Abd El-Hamid","year":"2023","unstructured":"Abd El-Hamid, S. M., Sadeek, S. A., Mohammed, S. F., Ahmed, F. M. & El\u2010Gedamy, M. S. Newly synthesised schiff base metal complexes, characterisation, and contribution as enhancers of colon cancer cell apoptosis by overexpression of P53 protein. Appl. Organomet. Chem. 37 (7), e7129 (2023).","journal-title":"Appl. Organomet. Chem."},{"issue":"11","key":"35893_CR17","doi-asserted-by":"publisher","first-page":"e7650","DOI":"10.1002\/aoc.7650","volume":"38","author":"SM Abd El-Hamid","year":"2024","unstructured":"Abd El-Hamid, S. M., Aziz, S. W., Sadeek, S. A., Sabry, M. A. & El\u2010Gedamy, M. S. Synthesis, spectral analysis, XRD, molecular Docking simulation of dithranol and Glycine mixed ligand complexes and their potential role in suppressing breast cancer cells via down\u2010regulating the expression of protein metalloproteinase\u20109. Appl. Organomet. Chem. 38 (11), e7650 (2024).","journal-title":"Appl. Organomet. Chem."},{"issue":"2","key":"35893_CR18","first-page":"69","volume":"19","author":"A C\u00e2r\u00e2c","year":"2017","unstructured":"C\u00e2r\u00e2c, A. Biological and biomedical applications of the lanthanides compounds: a mini review. Proc. Rom Acad. Ser. B. 19 (2), 69\u201374 (2017).","journal-title":"Proc. Rom Acad. Ser. B"},{"key":"35893_CR19","doi-asserted-by":"publisher","first-page":"113645","DOI":"10.1016\/j.ab.2020.113645","volume":"598","author":"AAA Aziz","year":"2020","unstructured":"Aziz, A. A. A. & Sayed, M. A. Some novel rare Earth metal ions complexes: synthesis, characterization, luminescence and biocidal efficiency. Anal. Biochem. 598, 113645 (2020).","journal-title":"Anal. Biochem."},{"issue":"2","key":"35893_CR20","doi-asserted-by":"publisher","first-page":"e6958","DOI":"10.1002\/aoc.6958","volume":"37","author":"SM Abd El-Hamid","year":"2023","unstructured":"Abd El-Hamid, S. M., Sadeek, S. A., Mohammed, S. F., Ahmed, F. M. & El\u2010Gedamy, M. S. N2O2\u2010chelate metal complexes with schiff base ligand: synthesis, characterisation and contribution as a promising antiviral agent against human cytomegalovirus. Appl. Organomet. Chem. 37 (2), e6958 (2023).","journal-title":"Appl. Organomet. Chem."},{"key":"35893_CR21","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.ccr.2018.05.012","volume":"370","author":"MT Kaczmarek","year":"2018","unstructured":"Kaczmarek, M. T., Zabiszak, M., Nowak, M. & Jastrzab, R. Lanthanides: schiff base complexes, applications in cancer diagnosis, therapy, and antibacterial activity. Coord. Chem. Rev. 370, 42\u201354 (2018).","journal-title":"Coord. Chem. Rev."},{"issue":"1","key":"35893_CR22","doi-asserted-by":"publisher","first-page":"e6484","DOI":"10.1002\/aoc.6484","volume":"36","author":"LH Abdel-Rahman","year":"2022","unstructured":"Abdel-Rahman, L. H., Basha, M. T., Al\u2010Farhan, B. S., Shehata, M. R. & Abdalla, E. M. Synthesis, characterization, potential antimicrobial, antioxidant, anticancer, DNA binding, and molecular Docking activities and DFT on novel Co (II), Ni (II), VO (II), cr (III), and La (III) schiff base complexes. Appl. Organomet. Chem. 36 (1), e6484 (2022).","journal-title":"Appl. Organomet. Chem."},{"issue":"6","key":"35893_CR23","doi-asserted-by":"publisher","first-page":"e70192","DOI":"10.1002\/aoc.70192","volume":"39","author":"SM Abdel-Fatah","year":"2025","unstructured":"Abdel-Fatah, S. M., Basha, M. T., Al-Sulami, A. I., Shehata, M. R. & Abdel-Rahman, L. H. Synthesis, spectroscopic Characterization, DFT studies of novel Praseodymium (III), neodymium (III), and samarium (III) complexes of a tridentate schiff base: aspects of their Antimicrobial, Antitumor, and biological profiles. Appl. Organomet. Chem. 39 (6), e70192 (2025).","journal-title":"Appl. Organomet. Chem."},{"key":"35893_CR24","unstructured":"Frisch et al. M. J., Gaussian 09, Revision D. 01; Gaussian, Gaussian 09, Revision D Vol. 01 (Gaussian; Inc., 2013)."},{"issue":"3\u20134","key":"35893_CR25","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1515\/znc-2022-0043","volume":"78","author":"AJ Rasras","year":"2023","unstructured":"Rasras, A. J. et al. Design, synthesis and antimicrobial assessments of aminoacetylenic-piperazine nitroimidazole hybrid compounds. Z. Naturforsch C. 78 (3\u20134), 113\u2013121 (2023).","journal-title":"Z. Naturforsch C"},{"key":"35893_CR26","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.ejmech.2018.10.008","volume":"160","author":"MF Abo-Ashour","year":"2018","unstructured":"Abo-Ashour, M. F. et al. Novel indole-thiazolidinone conjugates: Design, synthesis and whole-cell phenotypic evaluation as a novel class of antimicrobial agents. Eur. J. Med. Chem. 160, 49\u201360 (2018).","journal-title":"Eur. J. Med. Chem."},{"key":"35893_CR27","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1016\/j.ejmech.2014.08.016","volume":"85","author":"HS Ibrahim","year":"2014","unstructured":"Ibrahim, H. S., Eldehna, W. M., Abdel-Aziz, H. A., Elaasser, M. M. & Abdel-Aziz, M. M. Improvement of antibacterial activity of some Sulfa drugs through linkage to certain phthalazin-1 (2H)-one scaffolds. Eur. J. Med. Chem. 85, 480\u2013486 (2014).","journal-title":"Eur. J. Med. Chem."},{"key":"35893_CR28","doi-asserted-by":"publisher","first-page":"111768","DOI":"10.1016\/j.ejmech.2019.111768","volume":"184","author":"MF Abo-Ashour","year":"2019","unstructured":"Abo-Ashour, M. F. et al. 3-Hydrazinoisatin-based benzenesulfonamides as novel carbonic anhydrase inhibitors endowed with anticancer activity: Synthesis, in vitro biological evaluation and in Silico insights. Eur. J. Med. Chem. 184, 111768 (2019).","journal-title":"Eur. J. Med. Chem."},{"issue":"6","key":"35893_CR29","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.3987\/COM-15-13210","volume":"91","author":"SM Gomha","year":"2015","unstructured":"Gomha, S. M., Riyadh, S. M., Mahmmoud, E. A. & Elaasser, M. M. Synthesis and anticancer activities of thiazoles, 1, 3-thiazines, and Thiazolidine using chitosan-grafted-poly (vinylpyridine) as basic catalyst. Heterocycles 91 (6), 1227\u20131243 (2015).","journal-title":"Heterocycles"},{"key":"35893_CR30","unstructured":"Inc, C. C. G. & Canada Molecular Operating Environment (MOE), 2022.02, Chemical Computing Group ULC, 1010 Sherbrooke St. West, Suite #910, Montreal, QC, H3A 2R7, (2022)."},{"issue":"3","key":"35893_CR31","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/j.jsb.2015.12.011","volume":"193","author":"DC Gay","year":"2016","unstructured":"Gay, D. C. et al. The LINKS motif zippers trans-acyltransferase polyketide synthase assembly lines into a biosynthetic megacomplex. J. Struct. Biol. 193 (3), 196\u2013205 (2016).","journal-title":"J. Struct. Biol."},{"issue":"31","key":"35893_CR32","doi-asserted-by":"publisher","first-page":"4300","DOI":"10.3748\/wjg.v25.i31.4300","volume":"25","author":"B Murray","year":"2019","unstructured":"Murray, B., Barbier-Torres, L., Fan, W., Mato, J. M. & Lu, S. C. Methionine adenosyltransferases in liver cancer. World J. Gastroenterol. 25 (31), 4300 (2019).","journal-title":"World J. Gastroenterol."},{"key":"35893_CR33","doi-asserted-by":"publisher","first-page":"131612","DOI":"10.1016\/j.molstruc.2021.131612","volume":"1249","author":"EA Khalil","year":"2022","unstructured":"Khalil, E. A. & Mohamed, G. G. Preparation, spectroscopic characterization and antitumor-antimicrobial studies of some schiff base transition and inner transition mixed ligand complexes. J. Mol. Struct. 1249, 131612 (2022).","journal-title":"J. Mol. Struct."},{"issue":"1","key":"35893_CR34","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/S0731-7085(00)00262-4","volume":"23","author":"C Rustichelli","year":"2000","unstructured":"Rustichelli, C. et al. Solid-state study of polymorphic drugs: carbamazepine. J. Pharm. Biomed. Anal. 23 (1), 41\u201354 (2000).","journal-title":"J. Pharm. Biomed. Anal."},{"key":"35893_CR35","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1134\/S1070363220030238","volume":"90","author":"W El-Shwiniy","year":"2020","unstructured":"El-Shwiniy, W., Abbass, L., Sadeek, S. & Zordok, W. Synthesis, structure, and biological activity of some transition metal complexes with the mixed ligand of Metformin and 1, 4-diacetylbenzene. Russ J. Gen. Chem. 90, 483\u2013488 (2020).","journal-title":"Russ J. Gen. Chem."},{"key":"35893_CR36","doi-asserted-by":"crossref","unstructured":"Nakamoto, K. Infrared and Raman spectra of inorganic and coordination compounds, part B: applications in coordination, organometallic, and bioinorganic chemistry, John Wiley & Sons, Edition 6, 424 page (2009).","DOI":"10.1002\/9780470405888"},{"issue":"2","key":"35893_CR37","doi-asserted-by":"publisher","first-page":"e5334","DOI":"10.1002\/aoc.5334","volume":"34","author":"S Sadeek","year":"2020","unstructured":"Sadeek, S., Mohamed, A., El-Sayed, H. & El\u2010Attar, M. Spectroscopic characterization, thermogravimetric and antimicrobial studies of some new metal complexes derived from4\u2010(4\u2010Isopropyl phenyl)\u20102\u2010oxo\u20106\u2010phenyl 1, 2\u2010dihyropyridine\u20103\u2010carbonitrile (L). Appl. Organomet. Chem. 34 (2), e5334 (2020).","journal-title":"Appl. Organomet. Chem."},{"key":"35893_CR38","first-page":"28","volume":"15","author":"M Alias","year":"2014","unstructured":"Alias, M., Kassum, H. & Shakir, C. Synthesis, physical characterization and biological evaluation of schiff base M (II) complexes. J. Association Arab. Universities Basic. Appl. Sci. 15, 28\u201334 (2014).","journal-title":"J. Association Arab. Universities Basic. Appl. Sci."},{"key":"35893_CR39","doi-asserted-by":"publisher","first-page":"111903","DOI":"10.1016\/j.inoche.2023.111903","volume":"160","author":"D Dinku","year":"2024","unstructured":"Dinku, D. et al. Antimicrobial activities and Docking studies of new schiff base ligand and its Cu (II), Zn (II) and Ni (II) complexes: synthesis and characterization. Inorg. Chem. Commun. 160, 111903 (2024).","journal-title":"Inorg. Chem. Commun."},{"issue":"6","key":"35893_CR40","doi-asserted-by":"publisher","first-page":"101770","DOI":"10.1016\/j.jscs.2023.101770","volume":"27","author":"EM Abdalla","year":"2023","unstructured":"Abdalla, E. M. et al. Synthesis, characterization, DNA binding, DFT, anticancer, antibacterial, and the effect of gamma irradiation of novel Co (II), ag (I), and cd (II) complexes with hydrazone derivatives. J. Saudi Chem. Soc. 27 (6), 101770 (2023).","journal-title":"J. Saudi Chem. Soc."},{"issue":"3","key":"35893_CR41","doi-asserted-by":"publisher","first-page":"220333","DOI":"10.20964\/2022.03.45","volume":"17","author":"HM Al-Saidi","year":"2022","unstructured":"Al-Saidi, H. M. et al. Synthesis and characterization of Ni (II), Cu (II), Zn (II) and Azo dye based on 1, 10-o-phenanthroline binary complexes: corrosion Inhibition properties and computational studies. Int. J. Electrochem. Sci. 17 (3), 220333 (2022).","journal-title":"Int. J. Electrochem. Sci."},{"key":"35893_CR42","doi-asserted-by":"publisher","first-page":"123274","DOI":"10.1016\/j.molliq.2023.123274","volume":"391","author":"SM Abd El-Hamid","year":"2023","unstructured":"Abd El-Hamid, S. M., Sadeek, S. A., Sadek, N. B., Sabry, M. A. & El-Gedamy, M. S. Novel nano-sized metal complexes based on aceclofenac and Glycine ligands: synthesis, characterization, molecular Docking studies and their enhanced efficacy in ameliorating testicular and spermatological oxidative damages in male rats. J. Mol. Liq. 391, 123274 (2023).","journal-title":"J. Mol. Liq"},{"issue":"2","key":"35893_CR43","doi-asserted-by":"publisher","first-page":"221","DOI":"10.4314\/bcse.v30i2.6","volume":"30","author":"B Moksharagni","year":"2016","unstructured":"Moksharagni, B. & Reddy, K. H. Spectral characterization and DNA binding properties of lanthanide (III) complexes with 2-acetylpyridine isonicotinoylhydrazone (APINH). Bull. Chem. Soc. Ethiop. 30 (2), 221\u2013230 (2016).","journal-title":"Bull. Chem. Soc. Ethiop."},{"issue":"72","key":"35893_CR44","doi-asserted-by":"publisher","first-page":"42010","DOI":"10.1039\/C9RA08080E","volume":"9","author":"S Abou El-Enein","year":"2019","unstructured":"Abou El-Enein, S., Ali, A., Abdel-Monem, Y., Senna, M. & Madkour, M. Novel lanthanide (III) 4-methylbenzoylhydrazide complexes as precursors for lanthanide oxide nanophotocatalysts. RSC adv. 9 (72), 42010\u201342019 (2019).","journal-title":"RSC adv."},{"issue":"5","key":"35893_CR45","doi-asserted-by":"publisher","first-page":"775","DOI":"10.3906\/kim-1303-28","volume":"37","author":"MR Karekal","year":"2013","unstructured":"Karekal, M. R. & MATHADA, M. B. H. Synthesis, spectroscopic characterization, and biological screening of binuclear transition metal complexes of bicompartmental schiff bases containing Indole and resorcinol moieties. Turk. J. Chem. 37 (5), 775\u2013795 (2013).","journal-title":"Turk. J. Chem."},{"key":"35893_CR46","doi-asserted-by":"crossref","unstructured":"Farhan, N. et al. Engineered for impact: multifunctional Co (II), Ni (II), Cu (II), and cd (II) complexes of 2-Aminobenzothiazole with potent Antitumor, Antibacterial, and antioxidant actions supported by theoretical approaches. J. Mol. Struct. 1351 (1), 144295 (2026).","DOI":"10.1016\/j.molstruc.2025.144295"},{"key":"35893_CR47","doi-asserted-by":"crossref","unstructured":"Alamri, H. M. et al. Liver, breast and colon Anticancer, DNA binding and antimigration investigation of Mono-and binuclear metal complexes with theoretical studies.Sci. Afr. 30, e02991 (2025).","DOI":"10.1016\/j.sciaf.2025.e02991"},{"key":"35893_CR48","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1016\/j.molstruc.2018.06.055","volume":"1171","author":"T Manjuraj","year":"2018","unstructured":"Manjuraj, T., Krishnamurthy, G., Bodke, Y. D., Naik, H. B. & Kumar, H. A. Synthesis, XRD, thermal, spectroscopic studies and biological evaluation of Co (II), Ni (II) Cu (II) metal complexes derived from 2-benzimidazole. J. Mol. Struct. 1171, 481\u2013487 (2018).","journal-title":"J. Mol. Struct."},{"issue":"2","key":"35893_CR49","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1016\/j.saa.2009.02.043","volume":"73","author":"M Omar","year":"2009","unstructured":"Omar, M., Mohamed, G. G. & Ibrahim, A. A. Spectroscopic characterization of metal complexes of novel schiff base. Synthesis, thermal and biological activity studies. Spectrochim. Acta Part A Mol. Biomol. Spectrosc. 73 (2), 358\u2013369 (2009).","journal-title":"Spectrochim. Acta Part A Mol. Biomol. Spectrosc."},{"key":"35893_CR50","doi-asserted-by":"publisher","first-page":"113279","DOI":"10.1016\/j.inoche.2024.113279","volume":"170","author":"SS Hassan","year":"2024","unstructured":"Hassan, S. S. et al. Synthesis, characterization, antimicrobial, anticancer and the theoretical calculation of a novel N, O-multidentate chelating ligand and its Cu (II) and Fe (III) complexes. Inorg. Chem. Commun. 170, 113279 (2024).","journal-title":"Inorg. Chem. Commun."},{"key":"35893_CR51","doi-asserted-by":"crossref","unstructured":"Azam, M. et al. Chiral anionic binuclear zinc complexes based on diaminocyclohexane ligand and their in vitro antiproliferative studies, Inorg. Chem. Commun.\u00a046, 73\u201380 73\u201380 (2014).","DOI":"10.1016\/j.inoche.2014.05.029"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-35893-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-35893-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-35893-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T12:04:54Z","timestamp":1770984294000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-35893-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,11]]},"references-count":51,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["35893"],"URL":"https:\/\/doi.org\/10.1038\/s41598-026-35893-9","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,11]]},"assertion":[{"value":"20 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"6340"}}