{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T23:12:52Z","timestamp":1770333172933,"version":"3.49.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"vor","delay-in-days":24,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82301618"],"award-info":[{"award-number":["82301618"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-026-35930-7","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T19:14:35Z","timestamp":1768245275000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Urine bis(Monoacylglycerol)Phosphate and risk of freezing of gait in parkinson\u2019s disease"],"prefix":"10.1038","volume":"16","author":[{"given":"Shushan","family":"Sang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nannan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,1,12]]},"reference":[{"key":"35930_CR1","doi-asserted-by":"publisher","unstructured":"Zhang, X., Chen, C. & Liu, Y. Navigating the metabolic maze: anomalies in fatty acid and cholesterol processes in alzheimer\u2019s astrocytes. Alzheimers Res. Ther. 16 https:\/\/doi.org\/10.1186\/s13195-024-01430-x (2024).","DOI":"10.1186\/s13195-024-01430-x"},{"key":"35930_CR2","doi-asserted-by":"publisher","unstructured":"Showalter, M. R. et al. The emerging and diverse roles of Bis(monoacylglycero) phosphate lipids in cellular physiology and disease. Int. J. Mol. Sci. 21 https:\/\/doi.org\/10.3390\/ijms21218067 (2020).","DOI":"10.3390\/ijms21218067"},{"key":"35930_CR3","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1194\/jlr.R046896","volume":"55","author":"MA Samie","year":"2014","unstructured":"Samie, M. A. & Xu, H. Lysosomal exocytosis and lipid storage disorders. J. Lipid Res. 55, 995\u20131009. https:\/\/doi.org\/10.1194\/jlr.R046896 (2014).","journal-title":"J. Lipid Res."},{"key":"35930_CR4","doi-asserted-by":"publisher","first-page":"3997","DOI":"10.1038\/s41467-023-39716-7","volume":"14","author":"D Zhong","year":"2023","unstructured":"Zhong, D. et al. Induction of lysosomal exocytosis and biogenesis via TRPML1 activation for the treatment of uranium-induced nephrotoxicity. Nat. Commun. 14, 3997. https:\/\/doi.org\/10.1038\/s41467-023-39716-7 (2023).","journal-title":"Nat. Commun."},{"key":"35930_CR5","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1146\/annurev-neuro-100720-034518","volume":"44","author":"G V\u00e1zquez-V\u00e9lez","year":"2021","unstructured":"V\u00e1zquez-V\u00e9lez, G. & Zoghbi, H. Parkinson\u2019s disease genetics and pathophysiology. Annu. Rev. Neurosci. 44, 87\u2013108. https:\/\/doi.org\/10.1146\/annurev-neuro-100720-034518 (2021).","journal-title":"Annu. Rev. Neurosci."},{"key":"35930_CR6","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1038\/s41531-022-00397-6","volume":"8","author":"A Navarro-Romero","year":"2022","unstructured":"Navarro-Romero, A. et al. Lysosomal lipid alterations caused by glucocerebrosidase deficiency promote lysosomal dysfunction, chaperone-mediated-autophagy deficiency, and alpha-synuclein pathology. NPJ Parkinsons Dis. 8, 126. https:\/\/doi.org\/10.1038\/s41531-022-00397-6 (2022).","journal-title":"NPJ Parkinsons Dis."},{"key":"35930_CR7","doi-asserted-by":"publisher","first-page":"2057","DOI":"10.1038\/s41467-023-37632-4","volume":"14","author":"A Gehrlein","year":"2023","unstructured":"Gehrlein, A. et al. Targeting neuronal lysosomal dysfunction caused by \u03b2-glucocerebrosidase deficiency with an enzyme-based brain shuttle construct. Nat. Commun. 14, 2057. https:\/\/doi.org\/10.1038\/s41467-023-37632-4 (2023).","journal-title":"Nat. Commun."},{"key":"35930_CR8","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1038\/s41531-023-00571-4","volume":"9","author":"Y Zhou","year":"2023","unstructured":"Zhou, Y. et al. Mutational spectrum and clinical features of GBA1 variants in a Chinese cohort with Parkinson\u2019s disease. NPJ Parkinsons Dis. 9, 129. https:\/\/doi.org\/10.1038\/s41531-023-00571-4 (2023).","journal-title":"NPJ Parkinsons Dis."},{"key":"35930_CR9","doi-asserted-by":"publisher","first-page":"1651","DOI":"10.1056\/NEJMoa0901281","volume":"361","author":"E Sidransky","year":"2009","unstructured":"Sidransky, E. et al. Multicenter analysis of glucocerebrosidase mutations in Parkinson\u2019s disease. N. Engl. J. Med. 361, 1651\u20131661. https:\/\/doi.org\/10.1056\/NEJMoa0901281 (2009).","journal-title":"N. Engl. J. Med."},{"key":"35930_CR10","doi-asserted-by":"publisher","unstructured":"Merchant, K. M. et al. LRRK2 and GBA1 variant carriers have higher urinary bis(monacylglycerol) phosphate concentrations in PPMI cohorts. NPJ Parkinsons Dis. 9 https:\/\/doi.org\/10.1038\/s41531-023-00468-2 (2023).","DOI":"10.1038\/s41531-023-00468-2"},{"key":"35930_CR11","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1093\/brain\/awz314","volume":"143","author":"D Weiss","year":"2020","unstructured":"Weiss, D. et al. Freezing of gait: Understanding the complexity of an enigmatic phenomenon. Brain J. Neurol. 143, 14\u201330. https:\/\/doi.org\/10.1093\/brain\/awz314 (2020).","journal-title":"Brain: J. Neurol."},{"key":"35930_CR12","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/s40035-020-00191-5","volume":"9","author":"C Gao","year":"2020","unstructured":"Gao, C., Liu, J., Tan, Y. & Chen, S. Freezing of gait in parkinson\u2019s disease: Pathophysiology, risk factors and treatments. Transl Neurodegener. 9, 12. https:\/\/doi.org\/10.1186\/s40035-020-00191-5 (2020).","journal-title":"Transl Neurodegener"},{"key":"35930_CR13","doi-asserted-by":"publisher","first-page":"2756","DOI":"10.1007\/s00415-023-11612-6","volume":"270","author":"N Yang","year":"2023","unstructured":"Yang, N. et al. Impact of GBA variants on longitudinal freezing of gait progression in early Parkinson\u2019s disease. J. Neurol. 270, 2756\u20132764. https:\/\/doi.org\/10.1007\/s00415-023-11612-6 (2023).","journal-title":"J. Neurol."},{"key":"35930_CR14","doi-asserted-by":"publisher","first-page":"1460","DOI":"10.1002\/acn3.644","volume":"5","author":"K Marek","year":"2018","unstructured":"Marek, K. et al. The parkinson\u2019s progression markers initiative (PPMI) - Establishing a PD biomarker cohort. Ann. Clin. Transl Neurol. 5, 1460\u20131477. https:\/\/doi.org\/10.1002\/acn3.644 (2018).","journal-title":"Ann. Clin. Transl Neurol."},{"key":"35930_CR15","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/j.taap.2014.06.014","volume":"279","author":"N Liu","year":"2014","unstructured":"Liu, N., Tengstrand, E. A., Chourb, L. & Hsieh, F. Y. Di-22:6-bis(monoacylglycerol)phosphate: A clinical biomarker of drug-induced phospholipidosis for drug development and safety assessment. Toxicol. Appl. Pharmcol. 279, 467\u2013476. https:\/\/doi.org\/10.1016\/j.taap.2014.06.014 (2014).","journal-title":"Toxicol. Appl. Pharmcol."},{"key":"35930_CR16","doi-asserted-by":"publisher","first-page":"5554","DOI":"10.1021\/bi00016a029","volume":"34","author":"B Amidon","year":"1995","unstructured":"Amidon, B., Schmitt, J. D., Thuren, T., King, L. & Waite, M. Biosynthetic conversion of phosphatidylglycerol to sn-1:sn-1\u2019 bis(monoacylglycerol) phosphate in a macrophage-like cell line. Biochemistry 34, 5554\u20135560. https:\/\/doi.org\/10.1021\/bi00016a029 (1995).","journal-title":"Biochemistry"},{"key":"35930_CR17","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1002\/mds.27818","volume":"35","author":"RN Alcalay","year":"2020","unstructured":"Alcalay, R. N. et al. Higher urine bis(Monoacylglycerol)Phosphate levels in LRRK2 G2019S mutation carriers: implications for therapeutic development. Mov. Disord. 35, 134\u2013141. https:\/\/doi.org\/10.1002\/mds.27818 (2020).","journal-title":"Mov. Disord"},{"key":"35930_CR18","doi-asserted-by":"publisher","unstructured":"Gomes, S. et al. Elevated urine BMP phospholipids in LRRK2 and VPS35 mutation carriers with and without Parkinson\u2019s disease. NPJ Parkinsons Dis. 9 https:\/\/doi.org\/10.1038\/s41531-023-00482-4 (2023).","DOI":"10.1038\/s41531-023-00482-4"},{"key":"35930_CR19","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1002\/mds.21198","volume":"22","author":"CG Goetz","year":"2007","unstructured":"Goetz, C. G. et al. Movement disorder Society-sponsored revision of the unified parkinson\u2019s disease rating scale (MDS-UPDRS): Process, format, and clinimetric testing plan. Mov. Disord. 22, 41\u201347. https:\/\/doi.org\/10.1002\/mds.21198 (2007).","journal-title":"Mov. Disord"},{"key":"35930_CR20","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1194\/jlr.M057851","volume":"56","author":"Z Akgoc","year":"2015","unstructured":"Akgoc, Z. et al. Bis(monoacylglycero)phosphate: a secondary storage lipid in the gangliosidoses. J. Lipid Res. 56, 1006\u20131013. https:\/\/doi.org\/10.1194\/jlr.M057851 (2015).","journal-title":"J. Lipid Res."},{"key":"35930_CR21","doi-asserted-by":"publisher","first-page":"2106","DOI":"10.1002\/mds.28195","volume":"35","author":"S Petrucci","year":"2020","unstructured":"Petrucci, S. et al. GBA-Related parkinson\u2019s disease: dissection of Genotype-Phenotype correlates in a large Italian cohort. Mov. Disord. 35, 2106\u20132111. https:\/\/doi.org\/10.1002\/mds.28195 (2020).","journal-title":"Mov. Disord"},{"key":"35930_CR22","doi-asserted-by":"publisher","first-page":"15712","DOI":"10.1021\/jp108361d","volume":"114","author":"A Goursot","year":"2010","unstructured":"Goursot, A., Mineva, T., Bissig, C., Gruenberg, J. & Salahub, D. R. Structure, dynamics, and energetics of lysobisphosphatidic acid (LBPA) isomers. J. Phys. Chem. 114, 15712\u201315720. https:\/\/doi.org\/10.1021\/jp108361d (2010).","journal-title":"J. Phys. Chem."},{"key":"35930_CR23","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1007\/s12031-015-0647-x","volume":"58","author":"M Terrelonge Jr","year":"2016","unstructured":"Terrelonge, M. Jr., Marder, K. S., Weintraub, D. & Alcalay, R. N. CSF \u03b2-Amyloid 1\u201342 predicts progression to cognitive impairment in newly diagnosed Parkinson disease. J. Mol. Neurosci. 58, 88\u201392. https:\/\/doi.org\/10.1007\/s12031-015-0647-x (2016).","journal-title":"J. Mol. Neurosci."},{"key":"35930_CR24","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1016\/s1474-4422(11)70143-0","volume":"10","author":"J Nutt","year":"2011","unstructured":"Nutt, J. et al. Freezing of gait: Moving forward on a mysterious clinical phenomenon. Lancet Neurol. 10, 734\u2013744. https:\/\/doi.org\/10.1016\/s1474-4422(11)70143-0 (2011).","journal-title":"Lancet Neurol."},{"key":"35930_CR25","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1038\/s41531-022-00344-5","volume":"8","author":"R Morris","year":"2022","unstructured":"Morris, R. et al. Cognition as a mediator for gait and balance impairments in GBA-related parkinson\u2019s disease. NPJ Parkinsons Dis. 8, 78. https:\/\/doi.org\/10.1038\/s41531-022-00344-5 (2022).","journal-title":"NPJ Parkinsons Dis."},{"key":"35930_CR26","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1016\/j.parkreldis.2015.10.008","volume":"21","author":"K Brockmann","year":"2015","unstructured":"Brockmann, K. et al. Neurodegenerative CSF markers in genetic and sporadic PD: Classification and prediction in a longitudinal study. Parkinsonism Relat. Disord. 21, 1427\u20131434. https:\/\/doi.org\/10.1016\/j.parkreldis.2015.10.008 (2015).","journal-title":"Parkinsonism Relat. Disord"},{"key":"35930_CR27","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1038\/s41531-023-00509-w","volume":"9","author":"F Paolini Paoletti","year":"2023","unstructured":"Paolini Paoletti, F. et al. CSF neurochemical profile and cognitive changes in parkinson\u2019s disease with mild cognitive impairment. NPJ Parkinsons Dis. 9, 68. https:\/\/doi.org\/10.1038\/s41531-023-00509-w (2023).","journal-title":"NPJ Parkinsons Dis."},{"key":"35930_CR28","doi-asserted-by":"publisher","first-page":"e40","DOI":"10.1212\/wnl.0000000000006692","volume":"92","author":"R Kim","year":"2019","unstructured":"Kim, R. et al. CSF \u03b2-amyloid and risk of freezing of gait in early Parkinson disease. Neurology 92, e40\u2013e47. https:\/\/doi.org\/10.1212\/wnl.0000000000006692 (2019).","journal-title":"Neurology"},{"key":"35930_CR29","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1038\/s41531-021-00247-x","volume":"7","author":"JM Hatcher-Martin","year":"2021","unstructured":"Hatcher-Martin, J. M. et al. Cerebrospinal fluid biomarkers in Parkinson\u2019s disease with freezing of gait: an exploratory analysis. NPJ Parkinsons Dis. 7, 105. https:\/\/doi.org\/10.1038\/s41531-021-00247-x (2021).","journal-title":"NPJ Parkinsons Dis."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-35930-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-35930-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-35930-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T10:39:01Z","timestamp":1770287941000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-35930-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,12]]},"references-count":29,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["35930"],"URL":"https:\/\/doi.org\/10.1038\/s41598-026-35930-7","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,12]]},"assertion":[{"value":"21 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"5049"}}