{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T01:56:45Z","timestamp":1774403805494,"version":"3.50.1"},"reference-count":69,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T00:00:00Z","timestamp":1768608000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:00:00Z","timestamp":1770681600000},"content-version":"vor","delay-in-days":24,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2022R1A2C1004297"],"award-info":[{"award-number":["NRF-2022R1A2C1004297"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-026-36430-4","type":"journal-article","created":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T08:22:19Z","timestamp":1768638139000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["QAL333\u2019s antitumor activity and predictive modeling: integrated transcriptomic-bioinformatic analysis reveals selective cytotoxicity and sensitivity determinants"],"prefix":"10.1038","volume":"16","author":[{"given":"Hyon Hee","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suji","family":"Im","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yebin","family":"Jo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eunbi","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soon Young","family":"Jang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiha","family":"Sung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuela","family":"Jacchetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuela Teresa","family":"Raimondi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun-Ju","family":"Ryu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeong-Jun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaehyun","family":"Sim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyeon","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,1,17]]},"reference":[{"key":"36430_CR1","first-page":"025026","volume":"4","author":"J Kim","year":"2023","unstructured":"Kim, J., Lee, M. & Seok, J. Deep learning model with L1 penalty for predicting breast cancer metastasis using gene expression data. Mach. Learn. : Sci. Technol. 4, 025026 (2023).","journal-title":"Mach. Learn. : Sci. Technol."},{"key":"36430_CR2","doi-asserted-by":"publisher","first-page":"3355","DOI":"10.1038\/s41598-018-21622-4","volume":"8","author":"F Zhang","year":"2018","unstructured":"Zhang, F., Wang, M., Xi, J., Yang, J. & Li, A. A novel heterogeneous network-based method for drug response prediction in cancer cell lines. Sci. Rep. 8, 3355 (2018).","journal-title":"Sci. Rep."},{"key":"36430_CR3","doi-asserted-by":"publisher","first-page":"108449","DOI":"10.1016\/j.compbiomed.2024.108449","volume":"174","author":"C Chen","year":"2024","unstructured":"Chen, C., Zhang, Z., Tang, P., Liu, X. & Huang, B. Edge-relational window-attentional graph neural network for gene expression prediction in Spatial transcriptomics analysis. Comput. Biol. Med. 174, 108449 (2024).","journal-title":"Comput. Biol. Med."},{"key":"36430_CR4","first-page":"e2009","volume":"7","author":"M Shornale Akter","year":"2024","unstructured":"Shornale Akter, M. et al. Transcriptomic analysis revealed potential regulatory biomarkers and repurposable drugs for breast cancer treatment. Cancer Rep. (Hoboken). 7, e2009 (2024).","journal-title":"Cancer Rep. (Hoboken)"},{"key":"36430_CR5","doi-asserted-by":"publisher","first-page":"1775","DOI":"10.2174\/1386207325666221003093623","volume":"26","author":"S Mehta","year":"2023","unstructured":"Mehta, S., Mangyan, M. & Brahmchari, D. Design, synthesis, and anti-cancer activity evaluation of a 3-methyleneisoindolin- 1-one library. Comb. Chem. High. Throughput Screen. 26, 1775\u20131792 (2023).","journal-title":"Comb. Chem. High. Throughput Screen."},{"key":"36430_CR6","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.stem.2007.11.002","volume":"2","author":"RM White","year":"2008","unstructured":"White, R. M. et al. Transparent adult zebrafish as a tool for in vivo transplantation analysis. Cell. Stem Cell. 2, 183\u2013189 (2008).","journal-title":"Cell. Stem Cell."},{"key":"36430_CR7","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1038\/sj.clpt.6100223","volume":"82","author":"G Kari","year":"2007","unstructured":"Kari, G., Rodeck, U. & Dicker, A. P. Zebrafish: an emerging model system for human disease and drug discovery. Clin. Pharmacol. Ther. 82, 70\u201380 (2007).","journal-title":"Clin. Pharmacol. Ther."},{"key":"36430_CR8","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1038\/nature12111","volume":"496","author":"K Howe","year":"2013","unstructured":"Howe, K. et al. The zebrafish reference genome sequence and its relationship to the human genome. Nature 496, 498\u2013503 (2013).","journal-title":"Nature"},{"key":"36430_CR9","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1128\/jb.176.2.269-275.1994","volume":"176","author":"WC Fuqua","year":"1994","unstructured":"Fuqua, W. C., Winans, S. C. & Greenberg, E. P. Quorum sensing in bacteria: the LuxR-LuxI family of cell density-responsive transcriptional regulators. J. Bacteriol. 176, 269\u2013275 (1994).","journal-title":"J. Bacteriol."},{"key":"36430_CR10","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/S0076-6879(99)10005-3","volume":"310","author":"MR Parsek","year":"1999","unstructured":"Parsek, M. R. & Greenberg, E. P. Quorum sensing signals in development of Pseudomonas aeruginosa biofilms. Methods Enzymol. 310, 43\u201355 (1999).","journal-title":"Methods Enzymol."},{"key":"36430_CR11","doi-asserted-by":"publisher","first-page":"3803","DOI":"10.1093\/emboj\/cdg366","volume":"22","author":"M Hentzer","year":"2003","unstructured":"Hentzer, M. et al. Attenuation of Pseudomonas aeruginosa virulence by quorum sensing inhibitors. EMBO J. 22, 3803\u20133815 (2003).","journal-title":"EMBO J."},{"key":"36430_CR12","doi-asserted-by":"publisher","first-page":"8789","DOI":"10.1073\/pnas.97.16.8789","volume":"97","author":"MR Parsek","year":"2000","unstructured":"Parsek, M. R. & Greenberg, E. P. Acyl-homoserine lactone quorum sensing in gram-negative bacteria: a signaling mechanism involved in associations with higher organisms. Proc. Natl. Acad. Sci. U S A. 97, 8789\u20138793 (2000).","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"36430_CR13","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1111\/cmi.12109","volume":"15","author":"VV Kravchenko","year":"2013","unstructured":"Kravchenko, V. V. & Kaufmann, G. F. Bacterial Inhibition of inflammatory responses via TLR-independent mechanisms. Cell. Microbiol. 15, 527\u2013536 (2013).","journal-title":"Cell. Microbiol."},{"key":"36430_CR14","doi-asserted-by":"publisher","first-page":"a012427","DOI":"10.1101\/cshperspect.a012427","volume":"2","author":"ST Rutherford","year":"2012","unstructured":"Rutherford, S. T. & Bassler, B. L. Bacterial quorum sensing: its role in virulence and possibilities for its control. Cold Spring Harb Perspect. Med. 2, a012427 (2012).","journal-title":"Cold Spring Harb Perspect. Med."},{"key":"36430_CR15","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.biotechadv.2012.10.004","volume":"31","author":"VC Kalia","year":"2013","unstructured":"Kalia, V. C. Quorum sensing inhibitors: an overview. Biotechnol. Adv. 31, 224\u2013245 (2013).","journal-title":"Biotechnol. Adv."},{"key":"36430_CR16","doi-asserted-by":"publisher","first-page":"1680","DOI":"10.1128\/AAC.50.5.1680-1688.2006","volume":"50","author":"Y Nalca","year":"2006","unstructured":"Nalca, Y. et al. Quorum-sensing antagonistic activities of Azithromycin in Pseudomonas aeruginosa PAO1: a global approach. Antimicrob. Agents Chemother. 50, 1680\u20131688 (2006).","journal-title":"Antimicrob. Agents Chemother."},{"key":"36430_CR17","doi-asserted-by":"publisher","first-page":"2595","DOI":"10.1007\/s11030-021-10347-8","volume":"26","author":"M Beus","year":"2022","unstructured":"Beus, M. et al. Anthranilamides with Quinoline and \u03b2-carboline scaffolds: design, synthesis, and biological activity. Mol. Divers. 26, 2595\u20132612 (2022).","journal-title":"Mol. Divers."},{"key":"36430_CR18","doi-asserted-by":"publisher","first-page":"127139","DOI":"10.1016\/j.jtemb.2023.127139","volume":"77","author":"H Temel","year":"2023","unstructured":"Temel, H. et al. In Silico and biological activity evaluation of quercetin-boron hybrid compounds, anti-quorum sensing effect as alternative potential against microbial resistance. J. Trace Elem. Med. Biol. 77, 127139 (2023).","journal-title":"J. Trace Elem. Med. Biol."},{"key":"36430_CR19","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.2147\/JHC.S465592","volume":"11","author":"H Ma","year":"2024","unstructured":"Ma, H. et al. An oxidative stress-related prognostic signature predicts treatment response and outcomes for hepatocellular carcinoma after transarterial chemoembolization. J. Hepatocell Carcinoma. 11, 1569\u20131580 (2024).","journal-title":"J. Hepatocell Carcinoma"},{"key":"36430_CR20","doi-asserted-by":"publisher","first-page":"1344","DOI":"10.1016\/j.apsb.2025.02.009","volume":"15","author":"Y Wu","year":"2025","unstructured":"Wu, Y. et al. Establishment of interpretable cytotoxicity prediction models using machine learning analysis of transcriptome features. Acta Pharm. Sin B. 15, 1344\u20131358 (2025).","journal-title":"Acta Pharm. Sin B"},{"key":"36430_CR21","doi-asserted-by":"publisher","first-page":"11911","DOI":"10.1038\/s41598-023-39179-2","volume":"13","author":"A Park","year":"2023","unstructured":"Park, A., Lee, Y. & Nam, S. A performance evaluation of drug response prediction models for individual drugs. Sci. Rep. 13, 11911 (2023).","journal-title":"Sci. Rep."},{"key":"36430_CR22","doi-asserted-by":"publisher","first-page":"30885","DOI":"10.1038\/s41598-024-81866-1","volume":"14","author":"F Firoozbakht","year":"2024","unstructured":"Firoozbakht, F., Yousefi, B., Tsoy, O., Baumbach, J. & Schwikowski, B. Comparative evaluation of feature reduction methods for drug response prediction. Sci. Rep. 14, 30885 (2024).","journal-title":"Sci. Rep."},{"key":"36430_CR23","doi-asserted-by":"publisher","first-page":"100949","DOI":"10.1016\/j.patter.2024.100949","volume":"5","author":"YC Hsu","year":"2024","unstructured":"Hsu, Y. C., Chiu, Y. C., Lu, T. P., Hsiao, T. H. & Chen, Y. Predicting drug response through tumor Deconvolution by cancer cell lines. Patterns (N Y). 5, 100949 (2024).","journal-title":"Patterns (N Y)"},{"key":"36430_CR24","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.aej.2024.06.052","volume":"105","author":"M Shahzad","year":"2024","unstructured":"Shahzad, M. et al. DRPO: a deep learning technique for drug response prediction in oncology cell lines. Alex Eng. J. 105, 88\u201397 (2024).","journal-title":"Alex Eng. J."},{"key":"36430_CR25","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1038\/s41598-024-84711-7","volume":"15","author":"M Xiao","year":"2025","unstructured":"Xiao, M. et al. Drug molecular representations for drug response predictions: a comprehensive investigation via machine learning methods. Sci. Rep. 15, 20 (2025).","journal-title":"Sci. Rep."},{"key":"36430_CR26","doi-asserted-by":"publisher","first-page":"1394","DOI":"10.1038\/s41401-019-0286-9","volume":"40","author":"X Shen","year":"2019","unstructured":"Shen, X. et al. Cathepsin L induced PC-12 cell apoptosis via activation of B-Myb and regulation of cell cycle proteins. Acta Pharmacol. Sin. 40, 1394\u20131403 (2019).","journal-title":"Acta Pharmacol. Sin"},{"key":"36430_CR27","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1186\/s10020-024-00832-9","volume":"30","author":"J He","year":"2024","unstructured":"He, J. et al. ECHDC2 inhibits the proliferation of gastric cancer cells by binding with NEDD4 to degrade MCCC2 and reduce aerobic Glycolysis. Mol. Med. 30, 69 (2024).","journal-title":"Mol. Med."},{"key":"36430_CR28","doi-asserted-by":"publisher","first-page":"40365","DOI":"10.1074\/jbc.M007908200","volume":"275","author":"KJ Chave","year":"2000","unstructured":"Chave, K. J., Auger, I. E., Galivan, J. & Ryan, T. J. Molecular modeling and site-directed mutagenesis define the catalytic motif in human gamma -glutamyl hydrolase. J. Biol. Chem. 275, 40365\u201340370 (2000).","journal-title":"J. Biol. Chem."},{"key":"36430_CR29","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1038\/s41418-019-0363-0","volume":"27","author":"Q Zhang","year":"2020","unstructured":"Zhang, Q. et al. The MAP3K13-TRIM25-FBXW7\u03b1 axis affects c-Myc protein stability and tumor development. Cell. Death Differ. 27, 420\u2013433 (2020).","journal-title":"Cell. Death Differ."},{"key":"36430_CR30","first-page":"6819","volume":"13","author":"Z Liu","year":"2022","unstructured":"Liu, Z. et al. Clinical significance of mitogen-activated protein kinase kinase kinases in hepatitis B virus -related hepatocellular carcinoma and underlying mechanism exploration. Bioengineered 13, 6819\u20136838 (2022).","journal-title":"Bioengineered"},{"key":"36430_CR31","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.cell.2012.01.055","volume":"149","author":"R Palty","year":"2012","unstructured":"Palty, R., Raveh, A., Kaminsky, I., Meller, R. & Reuveny, E. SARAF inactivates the store operated calcium entry machinery to prevent excess calcium refilling. Cell 149, 425\u2013438 (2012).","journal-title":"Cell"},{"key":"36430_CR32","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1091\/mbc.e06-12-1066","volume":"18","author":"SRG Setty","year":"2007","unstructured":"Setty, S. R. G. et al. BLOC-1 is required for cargo-specific sorting from vacuolar early endosomes toward lysosome-related organelles. Mol. Biol. Cell. 18, 768\u2013780 (2007).","journal-title":"Mol. Biol. Cell."},{"key":"36430_CR33","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1016\/j.ajhg.2018.03.013","volume":"102","author":"CL Gall","year":"2018","unstructured":"Gall, C. L. Monoallelic mutations to DNAJB11 cause atypical autosomal-dominant polycystic kidney disease. Am. J. Hum. Genet. 102, 832\u2013844 (2018).","journal-title":"Am. J. Hum. Genet."},{"key":"36430_CR34","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.cell.2005.07.027","volume":"123","author":"A Gromley","year":"2005","unstructured":"Gromley, A. et al. Centriolin anchoring of exocyst and SNARE complexes at the midbody is required for secretory-vesicle-mediated abscission. Cell 123, 75\u201387 (2005).","journal-title":"Cell"},{"key":"36430_CR35","doi-asserted-by":"publisher","first-page":"33401","DOI":"10.1074\/jbc.M111.252262","volume":"286","author":"X Shi","year":"2011","unstructured":"Shi, X. et al. CEP70 protein interacts with \u03b3-tubulin to localize at the centrosome and is critical for mitotic spindle assembly. J. Biol. Chem. 286, 33401\u201333408 (2011).","journal-title":"J. Biol. Chem."},{"key":"36430_CR36","doi-asserted-by":"publisher","first-page":"2124","DOI":"10.1016\/j.bbrc.2018.07.169","volume":"503","author":"Z Yang","year":"2018","unstructured":"Yang, Z. et al. Bufalin inhibits cell proliferation and migration of hepatocellular carcinoma cells via APOBEC3F induced intestinal immune network for IgA production signaling pathway. Biochem. Biophys. Res. Commun. 503, 2124\u20132131 (2018).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"36430_CR37","first-page":"744","volume":"12","author":"R Wu","year":"2022","unstructured":"Wu, R. et al. APOBEC3F expression in triple-negative breast cancer is associated with tumor microenvironment infiltration and activation of cancer immunity and improved survival. Am. J. Cancer Res. 12, 744\u2013762 (2022).","journal-title":"Am. J. Cancer Res."},{"key":"36430_CR38","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1002\/cpbi.5","volume":"54","author":"G Stelzer","year":"2016","unstructured":"Stelzer, G. et al. The genecards suite: from gene data mining to disease genome sequence analyses. Curr. Protoc. Bioinf. 54, 1301\u201313033 (2016).","journal-title":"Curr. Protoc. Bioinf."},{"key":"36430_CR39","unstructured":"GeneCards ZNF594 Gene \u2013 GeneCards | ZN594 Protein | ZN594 Antibody. GeneCards https:\/\/www.genecards.org\/cgi-bin\/carddisp.pl?gene=ZNF594 (Accessed 19 Sep 2025)."},{"key":"36430_CR40","doi-asserted-by":"publisher","first-page":"12730","DOI":"10.1074\/jbc.275.17.12730","volume":"275","author":"JJ Caffrey","year":"2000","unstructured":"Caffrey, J. J., Safrany, S. T., Yang, X. & Shears, S. B. Discovery of molecular and catalytic diversity among human diphosphoinositol-polyphosphate phosphohydrolases. An expanding nudt family. J. Biol. Chem. 275, 12730\u201312736 (2000).","journal-title":"J. Biol. Chem."},{"key":"36430_CR41","doi-asserted-by":"publisher","first-page":"1540610","DOI":"10.3389\/fimmu.2025.1540610","volume":"16","author":"X Rong","year":"2025","unstructured":"Rong, X. et al. Zebrafish xenografts in breast cancer research. Front. Immunol. 16, 1540610 (2025).","journal-title":"Front. Immunol."},{"key":"36430_CR42","doi-asserted-by":"publisher","first-page":"1901","DOI":"10.1038\/s41467-017-01469-5","volume":"8","author":"S Richter","year":"2017","unstructured":"Richter, S., Schulze, U., Toman\u00e7ak, P. & Oates, A. C. Small molecule screen in embryonic zebrafish using modular variations to target segmentation. Nat. Commun. 8, 1901 (2017).","journal-title":"Nat. Commun."},{"key":"36430_CR43","doi-asserted-by":"publisher","first-page":"1978","DOI":"10.3390\/cells9091978","volume":"9","author":"P Cabezas-S\u00e1inz","year":"2020","unstructured":"Cabezas-S\u00e1inz, P., Pensado-L\u00f3pez, A., S\u00e1inz, B. Jr. & S\u00e1nchez, L. Modeling cancer using zebrafish xenografts: drawbacks for mimicking the human microenvironment. Cells 9, 1978 (2020).","journal-title":"Cells"},{"key":"36430_CR44","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1038\/nmeth.1923","volume":"9","author":"B Langmead","year":"2012","unstructured":"Langmead, B. & Salzberg, S. L. Fast gapped-read alignment with bowtie 2. Nat. Methods. 9, 357\u2013359 (2012).","journal-title":"Nat. Methods"},{"key":"36430_CR45","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1093\/bioinformatics\/btq033","volume":"26","author":"AR Quinlan","year":"2010","unstructured":"Quinlan, A. R. & Hall, I. M. BEDTools: a flexible suite of utilities for comparing genomic features. Bioinformatics 26, 841\u2013842 (2010).","journal-title":"Bioinformatics"},{"key":"36430_CR46","unstructured":"Core Team, R. R: A language and environment for statistical computing (R Foundation for Statistical Computing, Vienna, Austria, 2016). https:\/\/www.R-project.org\/."},{"key":"36430_CR47","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/nar\/28.1.27","volume":"28","author":"M Kanehisa","year":"2000","unstructured":"Kanehisa, M. & Goto, S. KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 28, 27\u201330 (2000).","journal-title":"Nucleic Acids Res."},{"key":"36430_CR48","doi-asserted-by":"publisher","first-page":"e15263","DOI":"10.1371\/journal.pone.0015263","volume":"5","author":"FM Marim","year":"2010","unstructured":"Marim, F. M., Silveira, T. N., Lima, D. S. & Zamboni, D. S. A method for generation of bone marrow-derived macrophages from cryopreserved mouse bone marrow cells. PLoS One. 5, e15263 (2010).","journal-title":"PLoS One"},{"key":"36430_CR49","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1042\/BST20230121","volume":"51","author":"Y Wu","year":"2023","unstructured":"Wu, Y., Lim, Y. W. & Parton, R. G. Caveolae and the oxidative stress response. Biochem. Soc. Trans. 51, 1377\u20131385 (2023).","journal-title":"Biochem. Soc. Trans."},{"key":"36430_CR50","doi-asserted-by":"publisher","first-page":"C693","DOI":"10.1152\/ajpcell.00401.2009","volume":"298","author":"L Xie","year":"2010","unstructured":"Xie, L., Frank, P. G., Lisanti, M. P. & Sowa, G. Endothelial cells isolated from caveolin-2 knockout mice display higher proliferation rate and cell cycle progression relative to their wild-type counterparts. Am. J. Physiol. Cell. Physiol. 298, C693\u2013701 (2010).","journal-title":"Am. J. Physiol. Cell. Physiol."},{"key":"36430_CR51","doi-asserted-by":"publisher","first-page":"634119","DOI":"10.3389\/fimmu.2021.634119","volume":"12","author":"AJ Sawyer","year":"2021","unstructured":"Sawyer, A. J., Garand, M., Chaussabel, D. & Feng, C. G. Transcriptomic profiling identifies Neutrophil-Specific upregulation of Cystatin F as a marker of acute inflammation in humans. Front. Immunol. 12, 634119 (2021).","journal-title":"Front. Immunol."},{"key":"36430_CR52","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/s13578-025-01399-6","volume":"15","author":"Y Bai","year":"2025","unstructured":"Bai, Y., Jiang, M., Chen, X. & Zhou, G. Disrupting lipid homeostasis with CAV2 in OSCC triggers apoptosis, lipolysis, and mitochondrial dysfunction by transcriptional repression of PPAR\u03b3. Cell. Biosci. 15, 59 (2025).","journal-title":"Cell. Biosci."},{"key":"36430_CR53","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1038\/s41419-022-04946-y","volume":"13","author":"N Gehrke","year":"2022","unstructured":"Gehrke, N. et al. Hepatocyte Bcl-3 protects from death-receptor mediated apoptosis and subsequent acute liver failure. Cell. Death Dis. 13, 510 (2022).","journal-title":"Cell. Death Dis."},{"key":"36430_CR54","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1038\/s41419-020-03220-3","volume":"11","author":"C Ploeger","year":"2020","unstructured":"Ploeger, C. et al. STAT3 and SH2D4A physically and functionally interact in tumor cell mitochondria. Cell. Death Dis. 11, 1023 (2020). Prohibitin.","journal-title":"Cell. Death Dis."},{"key":"36430_CR55","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1038\/s41416-021-01660-y","volume":"126","author":"T Matsumoto","year":"2022","unstructured":"Matsumoto, T. et al. SH2D4A downregulation due to loss of chromosome 8p is associated with poor prognosis and low T cell infiltration in colorectal cancer. Br. J. Cancer. 126, 917\u2013926 (2022).","journal-title":"Br. J. Cancer"},{"key":"36430_CR56","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1007\/s00204-024-03696-4","volume":"98","author":"K Jomova","year":"2024","unstructured":"Jomova, K. et al. Several lines of antioxidant defense against oxidative stress: antioxidant enzymes, nanomaterials with multiple enzyme-mimicking activities, and low-molecular-weight antioxidants. Arch. Toxicol. 98, 1323\u20131367 (2024).","journal-title":"Arch. Toxicol."},{"key":"36430_CR57","doi-asserted-by":"publisher","first-page":"16116","DOI":"10.1074\/jbc.M110.116210","volume":"285","author":"CM Krejsa","year":"2010","unstructured":"Krejsa, C. M. et al. Rapid activation of glutamate cysteine ligase following oxidative stress. J. Biol. Chem. 285, 16116\u201316124 (2010).","journal-title":"J. Biol. Chem."},{"key":"36430_CR58","doi-asserted-by":"publisher","first-page":"1679","DOI":"10.1038\/s41418-025-01505-8","volume":"32","author":"Z Chen","year":"2025","unstructured":"Chen, Z. et al. GCLC desuccinylation regulated by oxidative stress protects human cancer cells from ferroptosis. Cell. Death Differ. 32, 1679\u20131690 (2025).","journal-title":"Cell. Death Differ."},{"key":"36430_CR59","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1097\/WOX.0b013e3182439613","volume":"5","author":"E Birben","year":"2012","unstructured":"Birben, E., Sahiner, U. M., Sackesen, C., Erzurum, S. & Kalayci, O. Oxidative stress and antioxidant defense. World Allergy Organ. J. 5, 9\u201319 (2012).","journal-title":"World Allergy Organ. J."},{"key":"36430_CR60","doi-asserted-by":"publisher","first-page":"2599","DOI":"10.1210\/en.2010-1420","volume":"152","author":"C Khoo","year":"2011","unstructured":"Khoo, C. et al. Endoplasmic reticulum oxidoreductin-1-like \u03b2 (ERO1l\u03b2) regulates susceptibility to Endoplasmic reticulum stress and is induced by insulin flux in \u03b2-cells. Endocrinology 152, 2599\u20132608 (2011).","journal-title":"Endocrinology"},{"key":"36430_CR61","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.1128\/MCB.01647-13","volume":"34","author":"M Awazawa","year":"2014","unstructured":"Awazawa, M. et al. Deregulation of pancreas-specific oxidoreductin ERO1\u03b2 in the pathogenesis of diabetes mellitus. Mol. Cell. Biol. 34, 1290\u20131299 (2014).","journal-title":"Mol. Cell. Biol."},{"key":"36430_CR62","doi-asserted-by":"publisher","first-page":"14718","DOI":"10.1074\/jbc.M111.335547","volume":"287","author":"L Tian","year":"2012","unstructured":"Tian, L., McClafferty, H., Knaus, H. G., Ruth, P. & Shipston, M. J. Distinct acyl protein transferases and thioesterases control surface expression of calcium-activated potassium channels. J. Biol. Chem. 287, 14718\u201314725 (2012).","journal-title":"J. Biol. Chem."},{"key":"36430_CR63","doi-asserted-by":"publisher","first-page":"335","DOI":"10.31083\/j.fbl2909335","volume":"29","author":"H Wang","year":"2024","unstructured":"Wang, H., Wu, B., He, X., Li, W. & Guan, W. ZNF429 participates in the progression of coronary heart disease through regulating inflammatory and adhesive factors. Front. Biosci. (Landmark Ed). 29, 335 (2024).","journal-title":"Front. Biosci. (Landmark Ed)"},{"key":"36430_CR64","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1038\/ncb1864","volume":"11","author":"C Tian","year":"2009","unstructured":"Tian, C. et al. KRAB-type zinc-finger protein Apak specifically regulates p53-dependent apoptosis. Nat. Cell. Biol. 11, 580\u2013591 (2009).","journal-title":"Nat. Cell. Biol."},{"key":"36430_CR65","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1038\/s41467-018-02919-4","volume":"9","author":"P Navarro Negredo","year":"2018","unstructured":"Navarro Negredo, P., Edgar, J. R., Manna, P. T., Antrobus, R. & Robinson, M. S. The WDR11 complex facilitates the tethering of AP-1-derived vesicles. Nat. Commun. 9, 596 (2018).","journal-title":"Nat. Commun."},{"key":"36430_CR66","doi-asserted-by":"publisher","first-page":"2107","DOI":"10.1016\/j.biocel.2007.06.002","volume":"39","author":"D Li","year":"2007","unstructured":"Li, D. et al. An alternative splice form of CMTM8 induces apoptosis. Int. J. Biochem. Cell. Biol. 39, 2107\u20132119 (2007).","journal-title":"Int. J. Biochem. Cell. Biol."},{"key":"36430_CR67","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/S0378-1119(02)00467-5","volume":"288","author":"A Caricasole","year":"2002","unstructured":"Caricasole, A., Ferraro, T., Rimland, J. M. & Terstappen, G. C. Molecular cloning and initial characterization of the MG61\/PORC gene, the human homologue of the drosophila segment Polarity gene Porcupine. Gene 288, 147\u2013157 (2002).","journal-title":"Gene"},{"key":"36430_CR68","doi-asserted-by":"publisher","first-page":"4114","DOI":"10.1158\/0008-5472.CAN-20-0493","volume":"80","author":"C Yang","year":"2020","unstructured":"Yang, C. et al. Circadian rhythm is disrupted by ZNF704 in breast carcinogenesis. Cancer Res. 80, 4114\u20134128 (2020).","journal-title":"Cancer Res."},{"key":"36430_CR69","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/j.cell.2011.03.023","volume":"145","author":"P Paul","year":"2011","unstructured":"Paul, P. et al. A Genome-wide multidimensional RNAi screen reveals pathways controlling MHC class II antigen presentation. Cell 145, 268\u2013283 (2011).","journal-title":"Cell"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-36430-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-36430-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-36430-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T23:04:03Z","timestamp":1770764643000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-36430-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,17]]},"references-count":69,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["36430"],"URL":"https:\/\/doi.org\/10.1038\/s41598-026-36430-4","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,17]]},"assertion":[{"value":"3 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"5648"}}