{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:57:17Z","timestamp":1787237837053,"version":"build-2736575974"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:00:00Z","timestamp":1770768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"vor","delay-in-days":26,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100004484","name":"Tehran University of Medical Sciences and Health Services","doi-asserted-by":"publisher","award":["1402-4-449-69796"],"award-info":[{"award-number":["1402-4-449-69796"]}],"id":[{"id":"10.13039\/501100004484","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-026-36449-7","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T16:35:55Z","timestamp":1770827755000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Exploratory pilot trial of astaxanthin supplementation in PCOS patients at risk of OHSS with focus on RAGE\u2013NF\u03baB pathway"],"prefix":"10.1038","volume":"16","author":[{"given":"Arezoo","family":"Maleki-Hajiagha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashraf","family":"Aleyasin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fardin","family":"Amidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,11]]},"reference":[{"key":"36449_CR1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dew218","author":"G Bozdag","year":"2016","unstructured":"Bozdag, G., Mumusoglu, S., Zengin, D., Karabulut, E. & Yildiz, B. O. The prevalence and phenotypic features of polycystic ovary syndrome: A systematic review and meta-Analysis. Hum. Reprod. https:\/\/doi.org\/10.1093\/humrep\/dew218 (2016).","journal-title":"Hum. Reprod."},{"key":"36449_CR2","doi-asserted-by":"publisher","unstructured":"Sun, B. et al. Factors associated with ovarian hyperstimulation syndrome (OHSS) severity in women with polycystic ovary syndrome undergoing IVF\/ICSI. Front endocrinol (Lausanne). Front. Media S.A.11, 615957  https:\/\/doi.org\/10.3389\/FENDO.2020.615957\/BIBTEX (2021).","DOI":"10.3389\/FENDO.2020.615957\/BIBTEX"},{"key":"36449_CR3","doi-asserted-by":"publisher","unstructured":"Nikbakht, R., Mohammadjafari, R., Rajabalipour, M. & Moghadam, M. T. Evaluation of oocyte quality in polycystic ovary syndrome patients undergoing ART cycles. Fertil. Res. Pract. 7 https:\/\/doi.org\/10.1186\/s40738-020-00094-z (2021).","DOI":"10.1186\/s40738-020-00094-z"},{"key":"36449_CR4","doi-asserted-by":"publisher","first-page":"1424837","DOI":"10.3389\/FENDO.2024.1424837\/BIBTEX","volume":"15","author":"Z Luo","year":"2024","unstructured":"Luo, Z., Xu, S. & Hao, G. Risk factors, management, and future fertility of empty follicle syndrome: a retrospective study with real-world data. Front. Endocrinol. (Lausanne) Front. Media SA. 15, 1424837. https:\/\/doi.org\/10.3389\/FENDO.2024.1424837\/BIBTEX (2024).","journal-title":"Front. Endocrinol. (Lausanne) Front. Media SA"},{"key":"36449_CR5","doi-asserted-by":"publisher","unstructured":"Lai, Q. et al. Oxidative stress in granulosa cells contributes to poor oocyte quality and IVF-ET outcomes in women with polycystic ovary syndrome. Front. Med. 12. https:\/\/doi.org\/10.1007\/s11684-017-0575-y (2018).","DOI":"10.1007\/s11684-017-0575-y"},{"key":"36449_CR6","doi-asserted-by":"publisher","DOI":"10.1530\/REP-18-0583","author":"AP Snider","year":"2019","unstructured":"Snider, A. P. & Wood, J. R. Obesity induces ovarian inflammation and reduces oocyte quality. Reproduction https:\/\/doi.org\/10.1530\/REP-18-0583 (2019).","journal-title":"Reproduction"},{"key":"36449_CR7","doi-asserted-by":"publisher","unstructured":"Palomba, S., Costanzi, F., Nelson, S. M., Caserta, D. & Humaidan, P. Interventions to prevent or reduce the incidence and severity of ovarian hyperstimulation syndrome: a systematic umbrella review of the best clinical evidence. Reprod. Biol. Endocrinol. https:\/\/doi.org\/10.1186\/S12958-023-01113-6 (2023).","DOI":"10.1186\/S12958-023-01113-6"},{"key":"36449_CR8","doi-asserted-by":"publisher","DOI":"10.3390\/IJMS241814185","author":"S Palomba","year":"2023","unstructured":"Palomba, S. et al. Beyond the umbrella: A systematic review of the interventions for the prevention of and reduction in the incidence and severity of ovarian hyperstimulation syndrome in patients who undergo in vitro fertilization treatments. Int. J. Mol. Sci. https:\/\/doi.org\/10.3390\/IJMS241814185 (2023).","journal-title":"Int. J. Mol. Sci. [Internet] Int. J. Mol. Sci."},{"key":"36449_CR9","doi-asserted-by":"publisher","DOI":"10.3390\/NU14173578","author":"M Mouanness","year":"2022","unstructured":"Mouanness, M., Nava, H., Dagher, C. & Merhi, Z. Contribution of Advanced Glycation End Products to PCOS Key Elements: A Narrative Review. Nutrients 2022 Vol. 14, 3578 https:\/\/doi.org\/10.3390\/NU14173578 (Multidisciplinary Digital Publishing Institute, 2022)."},{"key":"36449_CR10","doi-asserted-by":"publisher","first-page":"117560","DOI":"10.1016\/J.CCA.2023.117560","volume":"549","author":"F Roushenas","year":"2023","unstructured":"Roushenas, F. et al. Follicular fluid advanced glycation end products in assisted reproduction: A systematic review. Clin. Chim. Acta 549, 117560. https:\/\/doi.org\/10.1016\/J.CCA.2023.117560 (2023).","journal-title":"Clin. Chim. Acta Elsevier"},{"key":"36449_CR11","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/J.PHARMTHERA.2017.02.030","volume":"177","author":"K Byun","year":"2017","unstructured":"Byun, K. et al. Advanced glycation end-products produced systemically and by macrophages: A common contributor to inflammation and degenerative diseases. Pharmacol. Ther. Pergamon. 177, 44\u201355. https:\/\/doi.org\/10.1016\/J.PHARMTHERA.2017.02.030 (2017).","journal-title":"Pharmacol. Ther. Pergamon"},{"key":"36449_CR12","doi-asserted-by":"publisher","unstructured":"Bahreiny, S. S., Ahangarpour, A. & Aghaei, M. Circulating Levels of Advanced Glycation End Products in Females with Polycystic Ovary Syndrome: A meta-analysis. Reproductive and Developmental Medicine [Internet] 8, 93\u2013100 https:\/\/doi.org\/10.1097\/RD9.0000000000000089 (Lippincott Williams and Wilkins, 2024).","DOI":"10.1097\/RD9.0000000000000089"},{"key":"36449_CR13","doi-asserted-by":"publisher","unstructured":"Azhary, J. M. K. et al. Androgens Increase Accumulation of Advanced Glycation End Products in Granulosa Cells by Activating ER Stress in PCOS. Endocrinology 161 https:\/\/doi.org\/10.1210\/ENDOCR\/BQAA015 (Oxford Academic, 2020).","DOI":"10.1210\/ENDOCR\/BQAA015"},{"key":"36449_CR14","doi-asserted-by":"publisher","DOI":"10.1186\/S12958-017-0227-8\/FIGURES\/4","author":"Y Liao","year":"2017","unstructured":"Liao, Y. et al. An inverse association between serum soluble receptor of advanced glycation end products and hyperandrogenism and potential implication in polycystic ovary syndrome patients. Reprod. Biol. Endocrinol. 15, 1\u20139 https:\/\/doi.org\/10.1186\/S12958-017-0227-8\/FIGURES\/4 (2017)."},{"key":"36449_CR15","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1007\/S00418-006-0265-3\/METRICS","volume":"127","author":"E Diamanti-Kandarakis","year":"2007","unstructured":"Diamanti-Kandarakis, E. et al. Immunohistochemical localization of advanced glycation end-products (AGEs) and their receptor (RAGE) in polycystic and normal ovaries. Histochem. Cell. Biol.. 127, 581\u2013589. https:\/\/doi.org\/10.1007\/S00418-006-0265-3\/METRICS (2007).","journal-title":"Histochem. Cell. Biol. [Internet] Springer"},{"key":"36449_CR16","doi-asserted-by":"publisher","DOI":"10.1093\/MOLEHR\/GAZ050","author":"N Takahashi","year":"2019","unstructured":"Takahashi, N. et al. Accumulation of advanced glycation end products in follicles is associated with poor oocyte developmental competence.  Mol. Hum. Reprod. 25, 684\u2013694 https:\/\/doi.org\/10.1093\/MOLEHR\/GAZ050 (2019)"},{"key":"36449_CR17","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/S0167-4889(00)00087-2","volume":"1498","author":"AM Schmidt","year":"2000","unstructured":"Schmidt, A. M., Yan, S., Du, Yan, S. F. & Stern, D. M. The biology of the receptor for advanced glycation end products and its ligands. Biochimica et biophysica acta (BBA). Mol. Cell Res.  1498, 99\u2013111. https:\/\/doi.org\/10.1016\/S0167-4889(00)00087-2 (2000).","journal-title":"Elsevier"},{"key":"36449_CR18","doi-asserted-by":"publisher","DOI":"10.1093\/HUMREP\/DET383","author":"Z Merhi","year":"2014","unstructured":"Merhi, Z. Advanced glycation end products and their relevance in female reproduction. Hum. Reprod. 29, 135\u2013145 https:\/\/doi.org\/10.1093\/HUMREP\/DET383 (2014)"},{"key":"36449_CR19","doi-asserted-by":"publisher","DOI":"10.1186\/S12958-016-0205-6\/FIGURES\/4","author":"D Garg","year":"2016","unstructured":"Garg, D. & Merhi, Z. Relationship between advanced glycation end products and steroidogenesis in PCOS.  Reprod.  Biol. Endocrinol. 14, 1\u201313, https:\/\/doi.org\/10.1186\/S12958-016-0205-6\/FIGURES\/4 (2016)."},{"key":"36449_CR20","doi-asserted-by":"publisher","unstructured":"Soares, S. R., G\u00f3mez, R., Sim\u00f3n, C., Garc\u00eda-Velasco, J. A. & Pellicer, A. Targeting the vascular endothelial growth factor system to prevent ovarian hyperstimulation syndrome. Hum. Reprod. Update 14, 321\u201333.  https:\/\/doi.org\/10.1093\/HUMUPD\/DMN008 (2008).","DOI":"10.1093\/HUMUPD\/DMN008"},{"key":"36449_CR21","doi-asserted-by":"publisher","DOI":"10.1093\/HUMREP\/15.1.66","author":"C Chen","year":"2000","unstructured":"Chen, C., Der, Wu, M. Y., Chen, H. F., Ho, H. N. & Yang, Y. S. Relationships of serum pro-inflammatory cytokines and vascular endothelial growth factor with liver dysfunction in severe ovarian hyperstimulation syndrome. Hum. Reprod. 15, 66\u201371 https:\/\/doi.org\/10.1093\/HUMREP\/15.1.66 (2000)."},{"key":"36449_CR22","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1016\/J.FERTNSTERT.2009.03.029","volume":"94","author":"EY Fujii","year":"2010","unstructured":"Fujii, E. Y. & Nakayama, M. The measurements of RAGE, VEGF, and ages in the plasma and follicular fluid of reproductive women: the influence of aging. Fertil. Steril. 94, 694\u2013700. https:\/\/doi.org\/10.1016\/J.FERTNSTERT.2009.03.029 (2010).","journal-title":"Fertil. Steril. Elsevier"},{"key":"36449_CR23","doi-asserted-by":"publisher","unstructured":"Wang, B. et al. sRAGE downregulates the VEGF expression in OHSS ovarian granulosa cells. Gynecol.  Endocrinol.  37, 836\u2013840 https:\/\/doi.org\/10.1080\/09513590.2021.1942453 (2021).","DOI":"10.1080\/09513590.2021.1942453"},{"key":"36449_CR24","doi-asserted-by":"publisher","unstructured":"Chang, M. X. & Xiong, F. Astaxanthin and its effects in inflammatory responses and inflammation-associated diseases: Recent advances and future directions. Molecules 25, 5342   https:\/\/doi.org\/10.3390\/MOLECULES25225342 (2020).","DOI":"10.3390\/MOLECULES25225342"},{"key":"36449_CR25","doi-asserted-by":"publisher","first-page":"112179","DOI":"10.1016\/J.BIOPHA.2021.112179","volume":"145","author":"Z Kohandel","year":"2022","unstructured":"Kohandel, Z., Farkhondeh, T., Aschner, M., Pourbagher-Shahri, A. M. & Samarghandian, S. Anti-inflammatory action of Astaxanthin and its use in the treatment of various diseases. Biomed. Pharmacother. 145, 112179. https:\/\/doi.org\/10.1016\/J.BIOPHA.2021.112179 (2022).","journal-title":"Biomed. Pharmacotherapy Elsevier Masson"},{"key":"36449_CR26","doi-asserted-by":"publisher","unstructured":"Park, C. H. et al. Astaxanthin and Corni fructus protect against diabetes-induced oxidative stress, inflammation, and advanced glycation end product in livers of streptozotocin-induced diabetic rats. 8, 337\u201344 https:\/\/doi.org\/10.1089\/JMF.2014.3174 (2015).","DOI":"10.1089\/JMF.2014.3174"},{"key":"36449_CR27","doi-asserted-by":"publisher","unstructured":"Sun, Z. et al. Protective actions of microalgae against endogenous and exogenous advanced glycation endproducts (AGEs) in human retinal pigment epithelial cells. Food Funct. 2, 251\u20138.  https:\/\/doi.org\/10.1039\/C1FO10021A (2011).","DOI":"10.1039\/C1FO10021A"},{"key":"36449_CR28","doi-asserted-by":"publisher","unstructured":"Rostami, S. et al. Astaxanthin ameliorates inflammation, oxidative stress, and reproductive outcomes in endometriosis patients undergoing assisted reproduction: A randomized, triple-blind placebo-controlled clinical trial. Front. Endocrinol. (Lausanne). 14. https:\/\/doi.org\/10.3389\/fendo.2023.1144323 (2023).","DOI":"10.3389\/fendo.2023.1144323"},{"key":"36449_CR29","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1186\/S13048-024-01537-7\/TABLES\/4","volume":"17","author":"A Shafie","year":"2024","unstructured":"Shafie, A. et al. Astaxanthin improves assisted reproductive technology outcomes in poor ovarian responders through alleviating oxidative stress, inflammation, and apoptosis: a randomized clinical trial. J. Ovarian Res. BioMed. Cent. 17, 212. https:\/\/doi.org\/10.1186\/S13048-024-01537-7\/TABLES\/4 (2024).","journal-title":"J. Ovarian Res. BioMed. Cent."},{"key":"36449_CR30","doi-asserted-by":"publisher","unstructured":"Jabarpour, M., Aleyasin, A., Nashtaei, M. S., Lotfi, S. & Amidi, F. Astaxanthin treatment ameliorates ER stress in polycystic ovary syndrome patients: a randomized clinical trial. Sci. Rep. 13. https:\/\/doi.org\/10.1038\/s41598-023-28956-8 (2023).","DOI":"10.1038\/s41598-023-28956-8"},{"key":"36449_CR31","doi-asserted-by":"publisher","first-page":"2337","DOI":"10.1007\/S10787-024-01504-0\/METRICS","volume":"32","author":"F Fereidouni","year":"2024","unstructured":"Fereidouni, F. et al. Astaxanthin treatment decreases pro-inflammatory cytokines and improves reproductive outcomes in patients with polycystic ovary syndrome undergoing assisted reproductive technology: A randomized clinical trial. Inflammopharmacology Springer Sci. Bus. Media Deutschland GmbH. 32, 2337\u20132347. https:\/\/doi.org\/10.1007\/S10787-024-01504-0\/METRICS (2024).","journal-title":"Inflammopharmacology Springer Sci. Bus. Media Deutschland GmbH"},{"key":"36449_CR32","doi-asserted-by":"publisher","unstructured":"Gharaei, R. et al. Randomized controlled trial of Astaxanthin impacts on antioxidant status and assisted reproductive technology outcomes in women with polycystic ovarian syndrome. J. Assist. Reprod. Genet. 39. https:\/\/doi.org\/10.1007\/s10815-022-02432-0 (2022).","DOI":"10.1007\/s10815-022-02432-0"},{"key":"36449_CR33","doi-asserted-by":"publisher","unstructured":"Jabarpour, M., Amidi, F., Aleyasin, A., Nashtaei, M. S. & Marghmaleki, M. S. Randomized clinical trial of astaxanthin supplement on serum inflammatory markers and ER stress-apoptosis gene expression in PBMCs of women with PCOS. J. Cell Mol. Med. 28, e18464.  https:\/\/doi.org\/10.1111\/JCMM.18464 (2024).","DOI":"10.1111\/JCMM.18464"},{"key":"36449_CR34","doi-asserted-by":"publisher","unstructured":"Darabi, Z., Basir, Z., Tabandeh, M. R. & Ghotbeddin, Z. Coenzyme Q10 improves ovarian histology and attenuates the expression of angiogenesis-associated proteins in the ovary of rats with experimental hyperstimulation syndrome. Iran J. Basic Med. Sci. 25, 989  https:\/\/doi.org\/10.22038\/IJBMS.2022.64010.14096 (2022).","DOI":"10.22038\/IJBMS.2022.64010.14096"},{"key":"36449_CR35","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/J.TJOG.2018.04.010","volume":"57","author":"S Ozgur","year":"2018","unstructured":"Ozgur, S. et al. The effects of Resveratrol on ovarian hyperstimulation syndrome in a rat model. Taiwan. J. Obstet. Gynecol. 57, 383\u2013388. https:\/\/doi.org\/10.1016\/J.TJOG.2018.04.010 (2018).","journal-title":"Taiwan. J. Obstet. Gynecol. [Internet] Taiwan. J. Obstet. Gynecol."},{"key":"36449_CR36","doi-asserted-by":"publisher","unstructured":"Schulz, K. F., Altman, D. G. & Moher, D. CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials. BMC Med.  8, 1\u20139. https:\/\/doi.org\/10.1186\/1741-7015-8-18\/FIGURES\/1 (2010).","DOI":"10.1186\/1741-7015-8-18\/FIGURES\/1"},{"key":"36449_CR37","doi-asserted-by":"publisher","DOI":"10.22092\/ARI.2022.358889.2329","author":"MJ Alhilali","year":"2022","unstructured":"Alhilali, M. J., Parham, A., Attaranzadeh, A., Amirian, M. & Azizzadeh, M. Polycystic ovary syndrome develops the complications of assisted reproductive technologies. Arch. Razi Inst. 77, 1459\u20131464 https:\/\/doi.org\/10.22092\/ARI.2022.358889.2329 (2022)."},{"key":"36449_CR38","doi-asserted-by":"publisher","first-page":"e227","DOI":"10.1016\/j.fertnstert.2017.07.686","volume":"108","author":"M Peigne","year":"2017","unstructured":"Peigne, M. et al. Prevalence of ovarian hyperstimulation syndrome (OHSS) and hypercoagulability in patients triggered by GnRH agonist for excessive follicular response: a systematic follow-up. Fertil. Steril.. 108, e227. https:\/\/doi.org\/10.1016\/j.fertnstert.2017.07.686 (2017).","journal-title":"Fertil. Steril. [Internet] Elsevier BV"},{"key":"36449_CR39","doi-asserted-by":"publisher","DOI":"10.34133\/HDS.0009","author":"D Zheng","year":"2023","unstructured":"Zheng, D. et al. The incidence of moderate and severe ovarian hyperstimulation syndrome in hospitalized patients in China. Health data science. Am. Assoc. Adv. Sci. 3, 0009 https:\/\/doi.org\/10.34133\/HDS.0009 (2023)."},{"key":"36449_CR40","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/J.FERTNSTERT.2023.11.013","volume":"121","author":"Practice Committee of the American Society for Reproductive Medicine","year":"2024","unstructured":"Practice Committee of the American Society for Reproductive Medicine. Prevention of moderate and severe ovarian hyperstimulation syndrome: a guideline. Fertil. Steril.. 121, 230\u2013245. https:\/\/doi.org\/10.1016\/J.FERTNSTERT.2023.11.013 (2024).","journal-title":"Fertil. Steril. Elsevier"},{"key":"36449_CR41","doi-asserted-by":"publisher","unstructured":"Cao, M. et al. Optimized personalized management approach for moderate\/severe OHSS: development and prospective validation of an OHSS risk assessment index. Human Reprod. 39, 2320\u201330.  https:\/\/doi.org\/10.1093\/HUMREP\/DEAE197 (2024).","DOI":"10.1093\/HUMREP\/DEAE197"},{"key":"36449_CR42","unstructured":"Mathur, R., Drakeley, A., Raine-Fenning, M. N., Evbuomwan, I. & Hamoda, H. Green-top guideline No. 5: the management of ovarian hyperstimulation syndrome. Royal College Obstetr. Gynaecol. ( 2016)."},{"key":"36449_CR43","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/3.3.255","author":"B Rizk","year":"1997","unstructured":"Rizk, B., Aboulghar, M., Smitz, J. & Ron-El, R. The role of vascular endothelial growth factor and interleukins in the pathogenesis of severe ovarian hyperstimulation syndrome. Hum. Reprod. Update. https:\/\/doi.org\/10.1093\/humupd\/3.3.255 (1997).","journal-title":"Hum. Reprod. Update"},{"key":"36449_CR44","doi-asserted-by":"publisher","unstructured":"Aboulghar, M. A., Mansour, R. T., Serour, G. I., El Helw, B. A. & Shaarawy, M. Elevated levels of interleukin-2, soluble interleukin-2 receptor alpha, interleukin-6, soluble interleukin-6 receptor and vascular endothelial growth factor in serum and ascitic fluid of patients with severe ovarian hyperstimulation syndrome. Eur. J. Obstet. Gynecol. Reprod. Biol.. 87. https:\/\/doi.org\/10.1016\/S0301-2115(99)00082-2 (1999).","DOI":"10.1016\/S0301-2115(99)00082-2"},{"key":"36449_CR45","doi-asserted-by":"publisher","unstructured":"Artini, P. G. et al. Vascular endothelial growth factor, interleukin-6 and interleukin-2 in serum and follicular fluid of patients with ovarian hyperstimulation syndrome. Eur. J. Obstet. Gynecol. Reprod. Biol.. 101. https:\/\/doi.org\/10.1016\/S0301-2115(01)00568-1 (2002).","DOI":"10.1016\/S0301-2115(01)00568-1"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-36449-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-36449-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-36449-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T09:49:18Z","timestamp":1773049758000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-36449-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,11]]},"references-count":45,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["36449"],"URL":"https:\/\/doi.org\/10.1038\/s41598-026-36449-7","relation":{"references":[{"id-type":"doi","id":"10.3390\/NU14173578","asserted-by":"subject"},{"id-type":"doi","id":"10.1186\/S12958-017-0227-8\/FIGURES\/4","asserted-by":"subject"},{"id-type":"doi","id":"10.1093\/MOLEHR\/GAZ050","asserted-by":"subject"},{"id-type":"doi","id":"10.1093\/HUMREP\/DET383","asserted-by":"subject"},{"id-type":"doi","id":"10.1186\/S12958-016-0205-6\/FIGURES\/4","asserted-by":"subject"},{"id-type":"doi","id":"10.1093\/HUMREP\/15.1.66","asserted-by":"subject"},{"id-type":"doi","id":"10.22092\/ARI.2022.358889.2329","asserted-by":"subject"},{"id-type":"doi","id":"10.34133\/HDS.0009","asserted-by":"subject"}]},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,11]]},"assertion":[{"value":"10 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"8416"}}