{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T14:11:30Z","timestamp":1791468690070,"version":"4.3.4"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"vor","delay-in-days":20,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI20\/01368"],"award-info":[{"award-number":["PI20\/01368"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-026-36464-8","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T10:06:35Z","timestamp":1769162795000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Identification of a circulating immunological signature as a liquid biopsy approach for the diagnosis of endometriosis"],"prefix":"10.1038","volume":"16","author":[{"given":"Alicia","family":"Hern\u00e1ndez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Fern\u00e1ndez-Medina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula Almellones","family":"Araiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ver\u00f3nica","family":"Terr\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara Ruiz","family":"Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana L\u00f3pez","family":"Carrasco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Luisa Juan","family":"Rodrigo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"L\u00f3pez-Collazo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Del Fresno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Spagnolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,23]]},"reference":[{"key":"36464_CR1","doi-asserted-by":"crossref","unstructured":"Smolarz, B., Szy\u0142\u0142o, K. & Romanowicz, H. Endometriosis: Epidemiology, classification, pathogenesis, treatment and genetics (review of literature). Int. J. Mol. Sci. 22 (2021).","DOI":"10.3390\/ijms221910554"},{"key":"36464_CR2","unstructured":"World Health Organization."},{"key":"36464_CR3","doi-asserted-by":"publisher","first-page":"605","DOI":"10.5468\/ogs.2018.61.5.605","volume":"61","author":"M de Freitas-Fonseca","year":"2018","unstructured":"de Freitas-Fonseca, M., Aragao, L. C., Sessa, F. V., Dutra-de-Resende, J. A. & Crispi, C. P. Interrelationships among endometriosis-related pain symptoms and their effects on health-related quality of life: A sectional observational study. Obstet. Gynecol. Sci. 61, 605 (2018).","journal-title":"Obstet. Gynecol. Sci."},{"key":"36464_CR4","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1136\/gutjnl-2011-301095","volume":"61","author":"T Jess","year":"2012","unstructured":"Jess, T., Frisch, M., J\u00f8rgensen, K. T., Pedersen, B. V. & Nielsen, N. M. Increased risk of inflammatory bowel disease in women with endometriosis: A nationwide Danish cohort study. Gut 61, 1279\u20131283 (2012).","journal-title":"Gut"},{"key":"36464_CR5","doi-asserted-by":"publisher","first-page":"1555","DOI":"10.1093\/humrep\/der105","volume":"26","author":"NM Nielsen","year":"2011","unstructured":"Nielsen, N. M., Jorgensen, K. T., Pedersen, B. V., Rostgaard, K. & Frisch, M. The co-occurrence of endometriosis with multiple sclerosis, systemic lupus erythematosus and Sjogren syndrome. Hum. Reprod. 26, 1555\u20131559 (2011).","journal-title":"Hum. Reprod."},{"key":"36464_CR6","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1136\/annrheumdis-2015-207704","volume":"75","author":"HR Harris","year":"2016","unstructured":"Harris, H. R. et al. Endometriosis and the risks of systemic lupus erythematosus and rheumatoid arthritis in the Nurses\u2019 Health Study II. Ann. Rheum Dis. 75, 1279\u20131284 (2016).","journal-title":"Ann. Rheum Dis."},{"key":"36464_CR7","doi-asserted-by":"publisher","unstructured":"Saunders, P. T. K. & Horne, A. W. Endometriosis: Etiology, pathobiology, and therapeutic prospects. Cell 184, 2807\u20132824 Preprint at https:\/\/doi.org\/10.1016\/j.cell.2021.04.041 (2021).","DOI":"10.1016\/j.cell.2021.04.041"},{"key":"36464_CR8","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1016\/j.fertnstert.2017.01.009","volume":"107","author":"SH Ahn","year":"2017","unstructured":"Ahn, S. H., Singh, V. & Tayade, C. Biomarkers in endometriosis: Challenges and opportunities. Fertil. Steril. 107, 523\u2013532 (2017).","journal-title":"Fertil. Steril."},{"key":"36464_CR9","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.ejogrb.2016.04.021","volume":"209","author":"F Parazzini","year":"2017","unstructured":"Parazzini, F., Esposito, G., Tozzi, L., Noli, S. & Bianchi, S. Epidemiology of endometriosis and its comorbidities. Eur. J. Obstet. Gynecol. Reprod. Biol. 209, 3\u20137 (2017).","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"36464_CR10","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1016\/j.fertnstert.2017.10.026","volume":"108","author":"M Bazot","year":"2017","unstructured":"Bazot, M. & Dara\u00ef, E. Diagnosis of deep endometriosis: Clinical examination, ultrasonography, magnetic resonance imaging, and other techniques. Fertil. Steril. 108, 886\u2013894 (2017).","journal-title":"Fertil. Steril."},{"issue":"354","key":"36464_CR11","first-page":"e1","volume":"220","author":"SK Agarwal","year":"2019","unstructured":"Agarwal, S. K. et al. Clinical diagnosis of endometriosis: A call to action. Am. J. Obstet. Gynecol. 220(354), e1-354.e12 (2019).","journal-title":"Am. J. Obstet. Gynecol."},{"key":"36464_CR12","first-page":"597","volume":"11","author":"B Berker","year":"2015","unstructured":"Berker, B. & Seval, M. Problems with the diagnosis of endometriosis. Women\u2019s Health 11, 597\u2013601 (2015).","journal-title":"Women\u2019s Health"},{"key":"36464_CR13","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1007\/s43032-019-00081-w","volume":"27","author":"E Waelkens","year":"2020","unstructured":"Waelkens, E., Vanhie, A., Peterse, D., Fassbender, A. & D\u2019Hooghe, T. The use of antibody arrays in the discovery of new plasma biomarkers for endometriosis. Reprod. Sci. 27, 751\u2013762 (2020).","journal-title":"Reprod. Sci."},{"key":"36464_CR14","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.ejogrb.2004.02.039","volume":"116","author":"H Kafali","year":"2004","unstructured":"Kafali, H., Artuc, H. & Demir, N. Use of CA125 fluctuation during the menstrual cycle as a tool in the clinical diagnosis of endometriosis: A preliminary report. Eur. J. Obstet. Gynecol. Reprod. Biol. 116, 85\u201388 (2004).","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"36464_CR15","doi-asserted-by":"crossref","unstructured":"Bendifallah, S. et al. Validation of a salivary miRNA signature of endometriosis\u2014interim data. NEJM Evid. 2 (2023).","DOI":"10.1056\/EVIDoa2200282"},{"key":"36464_CR16","doi-asserted-by":"crossref","unstructured":"Chico-Sordo, L. et al. Identification of miR-30c-5p microRNA in serum as a candidate biomarker to diagnose endometriosis. Int. J. Mol. Sci. 25 (2024).","DOI":"10.3390\/ijms25031853"},{"key":"36464_CR17","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s12916-019-1470-y","volume":"18","author":"M Guo","year":"2020","unstructured":"Guo, M. et al. Mass cytometry analysis reveals a distinct immune environment in peritoneal fluid in endometriosis: A characterisation study. BMC Med 18, 3 (2020).","journal-title":"BMC Med"},{"key":"36464_CR18","doi-asserted-by":"crossref","unstructured":"Wang, L. et al. A history of endometriosis is associated with decreased peripheral NK cytotoxicity and increased infiltration of uterine CD68+ macrophages. Front. Immunol. 12 (2021).","DOI":"10.3389\/fimmu.2021.711231"},{"key":"36464_CR19","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1016\/S1472-6483(10)60147-2","volume":"16","author":"R Gajbhiye","year":"2008","unstructured":"Gajbhiye, R. et al. Multiple endometrial antigens are targeted in autoimmune endometriosis. Reprod. Biomed. Online 16, 817\u2013824 (2008).","journal-title":"Reprod. Biomed. Online"},{"key":"36464_CR20","doi-asserted-by":"publisher","unstructured":"Riccio, L. da G. C. et al. Immunology of endometriosis. Best Pract. Res. Clin.Obstet. Gynaecol. 50, 39\u201349. Preprint at https:\/\/doi.org\/10.1016\/j.bpobgyn.2018.01.010 (2018).","DOI":"10.1016\/j.bpobgyn.2018.01.010"},{"key":"36464_CR21","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.ejogrb.2014.04.037","volume":"178","author":"E Ozhan","year":"2014","unstructured":"Ozhan, E., Kokcu, A., Yanik, K. & Gunaydin, M. Investigation of diagnostic potentials of nine different biomarkers in endometriosis. Eur. J. Obstet. Gynecol. Reprod. Biol. 178, 128\u2013133 (2014).","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"36464_CR22","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1093\/humrep\/12.Suppl_2.112-a","volume":"12","author":"T Gurgan","year":"1997","unstructured":"Gurgan, T. et al. O-228. Serum and peritoneal fluid concentrations of IGF-I, IGF-II and IGFBP-3 in endometriosis. Hum. Reprod. 12, 112\u2013113 (1997).","journal-title":"Hum. Reprod."},{"key":"36464_CR23","first-page":"582","volume":"18","author":"N Nasiri","year":"2017","unstructured":"Nasiri, N. et al. Oxidative stress statues in serum and follicular fluid of women with endometriosis citation. Cell J. (Yakhteh) 18, 582\u2013587 (2017).","journal-title":"Cell J. (Yakhteh)"},{"key":"36464_CR24","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.imlet.2018.10.011","volume":"201","author":"J Sikora","year":"2018","unstructured":"Sikora, J., Smycz-Kuba\u0144ska, M., Mielczarek-Palacz, A., Bednarek, I. & Kondera-Anasz, Z. The involvement of multifunctional TGF-\u03b2 and related cytokines in pathogenesis of endometriosis. Immunol. Lett. 201, 31\u201337 (2018).","journal-title":"Immunol. Lett."},{"key":"36464_CR25","doi-asserted-by":"crossref","unstructured":"Santoso, B. et al. Soluble immune checkpoints CTLA-4, HLA-G, PD-1, and PD-L1 are associated with endometriosis-related infertility. Am. J. Reprod. Immunol. 84 (2020).","DOI":"10.1111\/aji.13296"},{"key":"36464_CR26","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1111\/aogs.14556","volume":"102","author":"A Kristjansdottir","year":"2023","unstructured":"Kristjansdottir, A., Rafnsson, V. & Geirsson, R. T. Comprehensive evaluation of the incidence and prevalence of surgically diagnosed pelvic endometriosis in a complete population. Acta Obstet Gynecol Scand 102, 1329\u20131337 (2023).","journal-title":"Acta Obstet Gynecol Scand"},{"key":"36464_CR27","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1186\/s12905-020-00974-y","volume":"20","author":"H Kwok","year":"2020","unstructured":"Kwok, H. et al. Lesion distribution characteristics of deep infiltrating endometriosis with ovarian endometrioma: An observational clinical study. BMC Womens Health 20, 111 (2020).","journal-title":"BMC Womens Health"},{"key":"36464_CR28","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.ejogrb.2015.09.046","volume":"195","author":"P Giampaolino","year":"2015","unstructured":"Giampaolino, P. et al. Endometrioma size is a relevant factor in selection of the most appropriate surgical technique: A prospective randomized preliminary study. Eur. J. Obst. Gynecol. Reprod. Biol. 195, 88\u201393 (2015).","journal-title":"Eur. J. Obst. Gynecol. Reprod. Biol."},{"key":"36464_CR29","doi-asserted-by":"publisher","unstructured":"Dai, Y., Ye, Z., Lin, X. & Zhang, S. Immunopathological insights into endometriosis: From research advances to future treatments. Semin. Immunopathol. 47 Preprint at https:\/\/doi.org\/10.1007\/s00281-025-01058-5 (2025).","DOI":"10.1007\/s00281-025-01058-5"},{"key":"36464_CR30","doi-asserted-by":"crossref","unstructured":"Bindra, V. et al. Mapping deep endometriosis in patients with ovarian endometriomas according to the #Enzian classification: A single-center retrospective analysis. Front. Med. (Lausanne) 12 (2025).","DOI":"10.3389\/fmed.2025.1626445"},{"key":"36464_CR31","unstructured":"Hughes, S. M. et al. Changes in concentrations of cervicovaginal immune mediators across the menstrual cycle: A systematic review and meta-analysis of individual patient data. BMC Med. 20 (2022)."},{"key":"36464_CR32","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1186\/s13046-025-03337-3","volume":"44","author":"P Mata-Mart\u00ednez","year":"2025","unstructured":"Mata-Mart\u00ednez, P. et al. A blood-based liquid biopsy analyzing soluble immune checkpoints and cytokines identifies distinct neuroendocrine tumors. J. Exp. Clin. Cancer Res. 44, 82 (2025).","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"36464_CR33","doi-asserted-by":"publisher","first-page":"3287","DOI":"10.3390\/jcm11123287","volume":"11","author":"R Lozano-Rodr\u00edguez","year":"2022","unstructured":"Lozano-Rodr\u00edguez, R. et al. Differential immune checkpoint and Ig-like V-type receptor profiles in COVID-19: Associations with severity and treatment. J. Clin. Med. 11, 3287 (2022).","journal-title":"J. Clin. Med."},{"key":"36464_CR34","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1080\/03610910701723625","volume":"37","author":"Q Wang","year":"2007","unstructured":"Wang, Q., Koval, J. J., Mills, C. A. & Lee, K.-I.D. Determination of the Selection statistics and best significance level in backward stepwise logistic regression. Commun. Stat. Simul. Comput. 37, 62\u201372 (2007).","journal-title":"Commun. Stat. Simul. Comput."},{"key":"36464_CR35","doi-asserted-by":"publisher","first-page":"e573","DOI":"10.1002\/ctm2.573","volume":"11","author":"J Avenda\u00f1o-Ortiz","year":"2021","unstructured":"Avenda\u00f1o-Ortiz, J. et al. The immune checkpoints storm in COVID-19: Role as severity markers at emergency department admission. Clin. Transl. Med. 11, e573 (2021).","journal-title":"Clin. Transl. Med."},{"key":"36464_CR36","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.3390\/biomedicines10051047","volume":"10","author":"K Montalb\u00e1n-Hern\u00e1ndez","year":"2022","unstructured":"Montalb\u00e1n-Hern\u00e1ndez, K. et al. Identification of sSIGLEC5 and sLAG3 as new relapse predictors in lung cancer. Biomedicines 10, 1047 (2022).","journal-title":"Biomedicines"},{"key":"36464_CR37","doi-asserted-by":"publisher","first-page":"96","DOI":"10.5114\/ceji.2015.50840","volume":"1","author":"AM Malutan","year":"2015","unstructured":"Malutan, A. M. et al. Clinical immunology pro-inflammatory cytokines for evaluation of inflammatory status in endometriosis. Central Eur. J Immunol. 1, 96\u2013102 (2015).","journal-title":"Central Eur. J Immunol."},{"key":"36464_CR38","doi-asserted-by":"crossref","unstructured":"Sommar, A. et al. Chemokines and their association with symptom severity in women with endometriosis. Am. J. Reprod. Immunol. 94 (2025).","DOI":"10.1111\/aji.70156"},{"key":"36464_CR39","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1586\/14737159.2014.899905","volume":"14","author":"T Lani\u0161nik Ri\u017ener","year":"2014","unstructured":"Lani\u0161nik Ri\u017ener, T. Noninvasive biomarkers of endometriosis: Myth or reality?. Expert Rev. Mol. Diagn. 14, 365\u2013385 (2014).","journal-title":"Expert Rev. Mol. Diagn."},{"key":"36464_CR40","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1093\/humrep\/det401","volume":"29","author":"GM Borrelli","year":"2014","unstructured":"Borrelli, G. M., Abrao, M. S. & Mechsner, S. Can chemokines be used as biomarkers for endometriosis? A systematic review. Hum. Reprod. 29, 253\u2013266 (2014).","journal-title":"Hum. Reprod."},{"key":"36464_CR41","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1093\/humupd\/dmr013","volume":"17","author":"KE May","year":"2011","unstructured":"May, K. E., Villar, J., Kirtley, S., Kennedy, S. H. & Becker, C. M. Endometrial alterations in endometriosis: A systematic review of putative biomarkers. Hum Reprod Update 17, 637\u2013653 (2011).","journal-title":"Hum Reprod Update"},{"key":"36464_CR42","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1093\/humrep\/del516","volume":"22","author":"S Podgaec","year":"2007","unstructured":"Podgaec, S. et al. Endometriosis: An inflammatory disease with a Th2 immune response component. Hum. Reprod. 22, 1373\u20131379 (2007).","journal-title":"Hum. Reprod."},{"key":"36464_CR43","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.jri.2015.01.003","volume":"109","author":"GM Borrelli","year":"2015","unstructured":"Borrelli, G. M., Kaufmann, A. M., Abr\u00e3o, M. S. & Mechsner, S. Addition of MCP-1 and MIP-3\u03b2 to the IL-8 appraisal in peritoneal fluid enhances the probability of identifying women with endometriosis. J. Reprod. Immunol. 109, 66\u201373 (2015).","journal-title":"J. Reprod. Immunol."},{"key":"36464_CR44","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1080\/09513590.2017.1409717","volume":"34","author":"YY Fan","year":"2018","unstructured":"Fan, Y. Y. et al. Expression of inflammatory cytokines in serum and peritoneal fluid from patients with different stages of endometriosis. Gynecol. Endocrinol. 34, 507\u2013512 (2018).","journal-title":"Gynecol. Endocrinol."},{"key":"36464_CR45","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1586\/14737159.2015.1015994","volume":"15","author":"TL Ri\u017ener","year":"2015","unstructured":"Ri\u017ener, T. L. Diagnostic potential of peritoneal fluid biomarkers of endometriosis. Expert Rev. Mol. Diagn. 15, 557\u2013580 (2015).","journal-title":"Expert Rev. Mol. Diagn."},{"key":"36464_CR46","doi-asserted-by":"crossref","unstructured":"Suszczyk, D. et al. Clinical value of the PD-1\/PD-L1\/PD-L2 pathway in patients suffering from endometriosis. Int. J. Mol. Sci. 23 (2022).","DOI":"10.3390\/ijms231911607"},{"key":"36464_CR47","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1016\/j.cyto.2012.05.019","volume":"60","author":"A Biancotto","year":"2012","unstructured":"Biancotto, A., Feng, X., Langweiler, M., Young, N. S. & Philip McCoy, J. Effect of anticoagulants on multiplexed measurement of cytokine\/chemokines in healthy subjects. Cytokine 60, 438\u2013446 (2012).","journal-title":"Cytokine"},{"key":"36464_CR48","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.jim.2015.01.006","volume":"418","author":"THA Tvedt","year":"2015","unstructured":"Tvedt, T. H. A., Rye, K. P., Reikvam, H., Brenner, A. K. & Bruserud, \u00d8. The importance of sample collection when using single cytokine levels and systemic cytokine profiles as biomarkers\u2014a comparative study of serum versus plasma samples. J. Immunol. Methods 418, 19\u201328 (2015).","journal-title":"J. Immunol. Methods"},{"key":"36464_CR49","doi-asserted-by":"crossref","unstructured":"Goh, K. Y. et al. Cell migration in endometriosis responds to omentum-derived molecular cues similar to ovarian cancer. Int. J. Mol. Sci. 26 (2025).","DOI":"10.3390\/ijms26051822"},{"key":"36464_CR50","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1016\/j.atherosclerosis.2012.01.009","volume":"221","author":"P Ramos-Mozo","year":"2012","unstructured":"Ramos-Mozo, P. et al. Plasma profiling by a protein array approach identifies IGFBP-1 as a novel biomarker of abdominal aortic aneurysm. Atherosclerosis 221, 544\u2013550 (2012).","journal-title":"Atherosclerosis"},{"key":"36464_CR51","doi-asserted-by":"publisher","first-page":"R5","DOI":"10.1186\/ar4431","volume":"16","author":"J Ram\u00edrez","year":"2014","unstructured":"Ram\u00edrez, J. et al. Patients with rheumatoid arthritis in clinical remission and ultrasound-defined active synovitis exhibit higher disease activity and increased serum levels of angiogenic biomarkers. Arthritis Res. Ther. 16, R5 (2014).","journal-title":"Arthritis Res. Ther."},{"key":"36464_CR52","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046851","volume":"7","author":"Q Zhou","year":"2012","unstructured":"Zhou, Q. et al. Development of IGF signaling antibody arrays for the identification of hepatocellular carcinoma biomarkers. PLoS ONE 7, e46851 (2012).","journal-title":"PLoS ONE"},{"key":"36464_CR53","doi-asserted-by":"publisher","first-page":"3955","DOI":"10.1158\/1078-0432.CCR-14-0434","volume":"20","author":"CG Patel","year":"2014","unstructured":"Patel, C. G. et al. Biomarkers of bone remodeling in multiple myeloma patients to tailor bisphosphonate therapy. Clin. Cancer Res. 20, 3955\u20133961 (2014).","journal-title":"Clin. Cancer Res."},{"key":"36464_CR54","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1161\/CIRCRESAHA.116.305834","volume":"116","author":"T-M Ko","year":"2015","unstructured":"Ko, T.-M. et al. CXCL10\/IP-10 is a biomarker and mediator for Kawasaki disease. Circ. Res. 116, 876\u2013883 (2015).","journal-title":"Circ. Res."},{"key":"36464_CR55","doi-asserted-by":"publisher","DOI":"10.1002\/0471249688","volume-title":"Categorical Data Analysis","author":"A Agresti","year":"2002","unstructured":"Agresti, A. Categorical Data Analysis (Wiley, New York, 2002)."},{"key":"36464_CR56","doi-asserted-by":"publisher","first-page":"16738","DOI":"10.1038\/s41598-019-52899-8","volume":"9","author":"T Knific","year":"2019","unstructured":"Knific, T. et al. Multiplex analysis of 40 cytokines do not allow separation between endometriosis patients and controls. Sci. Rep. 9, 16738 (2019).","journal-title":"Sci. Rep."},{"key":"36464_CR57","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1016\/j.fertnstert.2017.03.013","volume":"107","author":"H J\u00f8rgensen","year":"2017","unstructured":"J\u00f8rgensen, H. et al. Peritoneal fluid cytokines related to endometriosis in patients evaluated for infertility. Fertil. Steril. 107, 1191-1199.e2 (2017).","journal-title":"Fertil. Steril."},{"key":"36464_CR58","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.jmoldx.2015.01.006","volume":"17","author":"V Kocbek","year":"2015","unstructured":"Kocbek, V., Vouk, K., Bersinger, N. A., Mueller, M. D. & Ri\u017ener, T. L. Panels of cytokines and other secretory proteins as potential biomarkers of ovarian endometriosis. J. Mol. Diagn. 17, 325\u2013334 (2015).","journal-title":"J. Mol. Diagn."},{"key":"36464_CR59","doi-asserted-by":"publisher","first-page":"1580","DOI":"10.1016\/j.fertnstert.2021.07.1205","volume":"116","author":"A Fauconnier","year":"2021","unstructured":"Fauconnier, A. et al. Early identification of women with endometriosis by means of a simple patient-completed questionnaire screening tool: A diagnostic study. Fertil. Steril. 116, 1580\u20131589 (2021).","journal-title":"Fertil. Steril."},{"key":"36464_CR60","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.fertnstert.2007.11.038","volume":"91","author":"BJ Stegmann","year":"2009","unstructured":"Stegmann, B. J. et al. A logistic model for the prediction of endometriosis. Fertil. Steril. 91, 51\u201355 (2009).","journal-title":"Fertil. Steril."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-36464-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-36464-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-36464-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T11:02:30Z","timestamp":1770894150000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-36464-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,23]]},"references-count":60,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["36464"],"URL":"https:\/\/doi.org\/10.1038\/s41598-026-36464-8","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,23]]},"assertion":[{"value":"2 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study involving human participants was reviewed and approved by local ethics committee of \u201cLa Paz University Hospital\u201d with the reference number PI-4623.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"6052"}}