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This study employed a case-control design, involving 60 participants diagnosed with bronchiectasis (cases) and a control group of healthy individuals matched by age and gender. HRV data was collected over a five-minute interval, focusing on frequency domain parameters including total power, very low frequency (VLF), low frequency (LF), high frequency (HF), and the LF\/HF ratio. The bronchiectasis group exhibited a significantly elevated LF\/HF ratio, indicating a shift in cardiac sympathovagal balance, relative to the control group (2.25\u2009\u00b1\u20090.39 vs. 2.05\u2009\u00b1\u20090.38;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.006). Additionally, marked differences were found in specific frequency domain parameters: LF (2.33\u2009\u00b1\u20090.55 vs. 2.55\u2009\u00b1\u20090.46;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.021) and HF (2.06\u2009\u00b1\u20090.75 vs. 2.5\u2009\u00b1\u20090.56;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001). The results suggest a notable disturbance in cardiac autonomic regulation among individuals with bronchiectasis, compared to healthy individuals.\n                  <\/jats:p>","DOI":"10.1038\/s41598-026-36722-9","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T05:16:43Z","timestamp":1770095803000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cardiac autonomic function in bronchiectasis and age and gender-matched healthy participants: case\u2013control study"],"prefix":"10.1038","volume":"16","author":[{"given":"Dhiya","family":"Dinesh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Vaishali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anup","family":"Bhat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mukesh Kumar","family":"Sinha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amithash M.","family":"Prabhudev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,2,3]]},"reference":[{"key":"36722_CR1","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1056\/NEJMra012519","volume":"346","author":"A Barker","year":"2002","unstructured":"Barker, A. 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