{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T05:01:38Z","timestamp":1788238898152,"version":"build-2803163510"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"vor","delay-in-days":21,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-026-37154-1","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T21:15:14Z","timestamp":1769116514000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A prospective study of intravenous iron effectiveness on quality of life and functional outcomes in patients with cancer"],"prefix":"10.1038","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3947-0355","authenticated-orcid":false,"given":"Fato\u015f Dilan","family":"K\u00f6seo\u011flu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8017-2384","authenticated-orcid":false,"given":"Alper","family":"Tu\u011fral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0886-3559","authenticated-orcid":false,"given":"Murat","family":"Akyol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,22]]},"reference":[{"issue":"2","key":"37154_CR1","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.mcna.2016.09.003","volume":"101","author":"MJ Cascio","year":"2017","unstructured":"Cascio, M. J. & DeLoughery, T. G. Anemia: evaluation and diagnostic tests. Med. Clin. North. Am. 101 (2), 263\u2013284 (2017).","journal-title":"Med. Clin. North. Am."},{"issue":"15","key":"37154_CR2","doi-asserted-by":"publisher","first-page":"2293","DOI":"10.1016\/j.ejca.2004.06.019","volume":"40","author":"H Ludwig","year":"2004","unstructured":"Ludwig, H. et al. The European cancer anaemia survey (ECAS): a large, multinational, prospective survey defining the prevalence, incidence, and treatment of anaemia in cancer patients. Eur. J. Cancer. 40 (15), 2293\u20132306 (2004).","journal-title":"Eur. J. Cancer"},{"issue":"9 Suppl 10","key":"37154_CR3","first-page":"17","volume":"16","author":"NS Tchekmedyian","year":"2002","unstructured":"Tchekmedyian, N. S. Anemia in cancer patients: significance, epidemiology, and current therapy. Oncol. (Williston Park). 16 (9 Suppl 10), 17\u201324 (2002).","journal-title":"Oncol. (Williston Park)"},{"issue":"10","key":"37154_CR4","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1056\/NEJMra041809","volume":"352","author":"G Weiss","year":"2005","unstructured":"Weiss, G. & Goodnough, L. T. Anemia of chronic disease. N Engl. J. Med. 352 (10), 1011\u20131023 (2005).","journal-title":"N Engl. J. Med."},{"issue":"19","key":"37154_CR5","doi-asserted-by":"publisher","first-page":"1832","DOI":"10.1056\/NEJMra1401038","volume":"372","author":"C Camaschella","year":"2015","unstructured":"Camaschella, C. Iron-deficiency anemia. N Engl. J. Med. 372 (19), 1832\u20131843 (2015).","journal-title":"N Engl. J. Med."},{"issue":"1","key":"37154_CR6","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1007\/s12032-007-9000-8","volume":"25","author":"HZ Grotto","year":"2008","unstructured":"Grotto, H. Z. Anaemia of cancer: An overview of mechanisms involved in its pathogenesis. Med. Oncol. 25 (1), 12\u201321 (2008).","journal-title":"Med. Oncol."},{"issue":"7","key":"37154_CR7","doi-asserted-by":"publisher","first-page":"1886","DOI":"10.1093\/annonc\/mdt118","volume":"24","author":"H Ludwig","year":"2013","unstructured":"Ludwig, H., Muldur, E., Endler, G. & Hubl, W. Prevalence of iron deficiency across different tumors and its association with poor performance status, disease status and anemia. Ann. Oncol. 24 (7), 1886\u20131892 (2013).","journal-title":"Ann. Oncol."},{"issue":"10","key":"37154_CR8","doi-asserted-by":"publisher","first-page":"3412","DOI":"10.1200\/JCO.1998.16.10.3412","volume":"16","author":"GD Demetri","year":"1998","unstructured":"Demetri, G. D., Kris, M., Wade, J., Degos, L. & Cella, D. Quality-of-life benefit in chemotherapy patients treated with Epoetin Alfa is independent of disease response or tumor type: Results from a prospective community oncology study. Procrit study group. J. Clin. Oncol. 16 (10), 3412\u20133425 (1998).","journal-title":"J. Clin. Oncol."},{"issue":"3 Suppl 2","key":"37154_CR9","first-page":"20","volume":"34","author":"J Glaspy","year":"1997","unstructured":"Glaspy, J. The impact of Epoetin Alfa on quality of life during cancer chemotherapy: A fresh look at an old problem. Semin Hematol. 34 (3 Suppl 2), 20\u201326 (1997).","journal-title":"Semin Hematol."},{"issue":"4","key":"37154_CR10","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1093\/oncolo\/oyac005","volume":"27","author":"C Gluszak","year":"2022","unstructured":"Gluszak, C. et al. Impact of Iron-Deficiency management on quality of life in patients with cancer: A prospective cohort study (CAMARA study). Oncologist 27 (4), 328\u2013333 (2022).","journal-title":"Oncologist"},{"issue":"9","key":"37154_CR11","doi-asserted-by":"publisher","first-page":"e0163817","DOI":"10.1371\/journal.pone.0163817","volume":"11","author":"G Kanuri","year":"2016","unstructured":"Kanuri, G., Sawhney, R., Varghese, J., Britto, M. & Shet, A. Iron deficiency anemia coexists with cancer related anemia and adversely impacts quality of life. PLoS One. 11 (9), e0163817 (2016).","journal-title":"PLoS One"},{"issue":"7399","key":"37154_CR12","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1136\/bmj.326.7399.1124","volume":"326","author":"F Verdon","year":"2003","unstructured":"Verdon, F. et al. Iron supplementation for unexplained fatigue in non-anaemic women: Double blind randomised placebo controlled trial. BMJ 326 (7399), 1124 (2003).","journal-title":"BMJ"},{"issue":"3","key":"37154_CR13","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1042\/CS20040278","volume":"109","author":"F Dong","year":"2005","unstructured":"Dong, F. et al. Dietary iron deficiency induces ventricular dilation, mitochondrial ultrastructural aberrations and cytochrome c release: Involvement of nitric oxide synthase and protein tyrosine nitration. Clin. Sci. (Lond). 109 (3), 277\u2013286 (2005).","journal-title":"Clin. Sci. (Lond)"},{"issue":"2","key":"37154_CR14","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.tcb.2006.12.003","volume":"17","author":"LL Dunn","year":"2007","unstructured":"Dunn, L. L., Suryo Rahmanto, Y. & Richardson, D. R. Iron uptake and metabolism in the new millennium. Trends Cell. Biol. 17 (2), 93\u2013100 (2007).","journal-title":"Trends Cell. Biol."},{"issue":"2S-2","key":"37154_CR15","doi-asserted-by":"publisher","first-page":"676S","DOI":"10.1093\/jn\/131.2.676S","volume":"131","author":"JD Haas","year":"2001","unstructured":"Haas, J. D. & Brownlie, T. Iron deficiency and reduced work capacity: A critical review of the research to determine a causal relationship. J. Nutr. 131 (2S-2), 676S (2001). 88S; discussion 88S-90S.","journal-title":"J. Nutr."},{"issue":"4","key":"37154_CR16","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1002\/ejhf.640","volume":"19","author":"V Melenovsky","year":"2017","unstructured":"Melenovsky, V. et al. Myocardial iron content and mitochondrial function in human heart failure: A direct tissue analysis. Eur. J. Heart Fail. 19 (4), 522\u2013530 (2017).","journal-title":"Eur. J. Heart Fail."},{"issue":"3","key":"37154_CR17","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/j.hfc.2010.03.003","volume":"6","author":"EA Jankowska","year":"2010","unstructured":"Jankowska, E. A. & Ponikowski, P. Molecular changes in myocardium in the course of anemia or iron deficiency. Heart Fail. Clin. 6 (3), 295\u2013304 (2010).","journal-title":"Heart Fail. Clin."},{"issue":"2","key":"37154_CR18","first-page":"119","volume":"42","author":"LH Tanriverdi","year":"2025","unstructured":"Tanriverdi, L. H., Sarici, A. & Efficacy Safety, and tolerability of ferric carboxymaltose and iron sucrose in iron-Deficiency anemia: A systematic review and Meta-Analysis of randomized controlled trials. Turk. J. Haematol. 42 (2), 119\u2013135 (2025).","journal-title":"Turk. J. Haematol."},{"issue":"8","key":"37154_CR19","doi-asserted-by":"publisher","first-page":"573","DOI":"10.7326\/0003-4819-147-8-200710160-00010","volume":"147","author":"E von Elm","year":"2007","unstructured":"von Elm, E. et al. The strengthening the reporting of observational studies in epidemiology (STROBE) statement: Guidelines for reporting observational studies. Ann. Intern. Med. 147 (8), 573\u2013577 (2007).","journal-title":"Ann. Intern. Med."},{"issue":"10440","key":"37154_CR20","doi-asserted-by":"publisher","first-page":"1963","DOI":"10.1016\/S0140-6736(24)00502-6","volume":"403","author":"SR Pasricha","year":"2024","unstructured":"Pasricha, S. R., Rogers, L., Branca, F. & Garcia-Casal, M. N. Measuring haemoglobin concentration to define anaemia: WHO guidelines. Lancet 403 (10440), 1963\u20131966 (2024).","journal-title":"Lancet"},{"issue":"6","key":"37154_CR21","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1097\/00005650-199206000-00002","volume":"30","author":"JE Ware Jr","year":"1992","unstructured":"Ware, J. E. Jr. & Sherbourne, C. D. The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med. Care. 30 (6), 473\u2013483 (1992).","journal-title":"Med. Care"},{"issue":"1","key":"37154_CR22","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1007\/s11136-004-2393-3","volume":"14","author":"R Pinar","year":"2005","unstructured":"Pinar, R. Reliability and construct validity of the SF-36 in Turkish cancer patients. Qual. Life Res. 14 (1), 259\u2013264 (2005).","journal-title":"Qual. Life Res."},{"issue":"1","key":"37154_CR23","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1164\/ajrccm.166.1.at1102","volume":"166","author":"Laboratories ATSCoPSfCPF","year":"2002","unstructured":"Laboratories ATSCoPSfCPF. ATS statement: Guidelines for the six-minute walk test. Am. J. Respir Crit. Care Med. 166 (1), 111\u2013117 (2002).","journal-title":"Am. J. Respir Crit. Care Med."},{"issue":"5","key":"37154_CR24","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1249\/00005768-198205000-00012","volume":"14","author":"GA Borg","year":"1982","unstructured":"Borg, G. A. Psychophysical bases of perceived exertion. Med. Sci. Sports Exerc. 14 (5), 377\u2013381 (1982).","journal-title":"Med. Sci. Sports Exerc."},{"issue":"8","key":"37154_CR25","doi-asserted-by":"publisher","first-page":"1930","DOI":"10.3906\/sag-2001-155","volume":"50","author":"B Ozcan Kahraman","year":"2020","unstructured":"Ozcan Kahraman, B. et al. Validity and reliability of the Turkish version of the multidimensional dyspnea profile in outpatients with respiratory disease. Turk. J. Med. Sci. 50 (8), 1930\u20131940 (2020).","journal-title":"Turk. J. Med. Sci."},{"issue":"7","key":"37154_CR26","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1055\/s-0032-1323746","volume":"34","author":"K Schmidt","year":"2013","unstructured":"Schmidt, K., Vogt, L., Thiel, C., Jager, E. & Banzer, W. Validity of the six-minute walk test in cancer patients. Int. J. Sports Med. 34 (7), 631\u2013636 (2013).","journal-title":"Int. J. Sports Med."},{"issue":"9","key":"37154_CR27","first-page":"804","volume":"33","author":"M Meyers","year":"2025","unstructured":"Meyers, M., Paesmans, M., Fleur, W., Libert, I. & Klastersky, J. Iron-deficiency anemia evaluation and treatment in hospitalized cancer patients: A feasibility study. Support Care Cancer. 33 (9), 804 (2025).","journal-title":"Support Care Cancer"},{"issue":"9","key":"37154_CR28","doi-asserted-by":"publisher","first-page":"2148","DOI":"10.1097\/CORR.0000000000001341","volume":"478","author":"K Ogura","year":"2020","unstructured":"Ogura, K. et al. What are the minimum clinically important differences in SF-36 scores in patients with orthopaedic oncologic conditions? Clin. Orthop. Relat. Research\u00ae. 478 (9), 2148\u20132158 (2020).","journal-title":"Clin. Orthop. Relat. Research\u00ae"},{"issue":"9","key":"37154_CR29","doi-asserted-by":"publisher","first-page":"104559","DOI":"10.1016\/j.jpain.2024.104559","volume":"25","author":"R Gr\u00f6nkvist","year":"2024","unstructured":"Gr\u00f6nkvist, R., Vixner, L., \u00c4ng, B. & Grimby-Ekman, A. Measurement error, minimal detectable change, and minimal clinically important difference of the short form-36 health survey, hospital anxiety and depression scale, and pain numeric rating scale in patients with chronic pain. J. Pain. 25 (9), 104559 (2024).","journal-title":"J. Pain"},{"issue":"3","key":"37154_CR30","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1002\/bjs.10328","volume":"104","author":"BD Keeler","year":"2017","unstructured":"Keeler, B. D. et al. Randomized clinical trial of preoperative oral versus intravenous iron in anaemic patients with colorectal cancer. Br. J. Surg. 104 (3), 214\u2013221 (2017).","journal-title":"Br. J. Surg."},{"issue":"12","key":"37154_CR31","doi-asserted-by":"publisher","first-page":"2018","DOI":"10.1111\/codi.15342","volume":"22","author":"EA Dickson","year":"2020","unstructured":"Dickson, E. A. et al. Preoperative intravenous iron therapy and survival after colorectal cancer surgery: long-term results from the IVICA randomised controlled trial. Colorectal Dis. 22 (12), 2018\u20132027 (2020).","journal-title":"Colorectal Dis."},{"key":"37154_CR32","doi-asserted-by":"crossref","unstructured":"Yeung, I. et al. Intravenous iron as an alternative to blood transfusion in cancer patients: A single center experience. Am. J. Hosp. Palliat. Care :10499091251335266 (2025).","DOI":"10.1177\/10499091251335266"},{"issue":"5","key":"37154_CR33","doi-asserted-by":"publisher","first-page":"e0302964","DOI":"10.1371\/journal.pone.0302964","volume":"19","author":"S Nandakumar","year":"2024","unstructured":"Nandakumar, S., Singh, N., Tharani, A. R., Pankiw, M. & Brezden-Masley, C. Intravenous iron and iron deficiency anemia in patients with Gastrointestinal cancer: A systematic review. PLoS One. 19 (5), e0302964 (2024).","journal-title":"PLoS One"},{"key":"37154_CR34","doi-asserted-by":"publisher","first-page":"939","DOI":"10.2147\/DDDT.S45674","volume":"7","author":"H Abdel-Razeq","year":"2013","unstructured":"Abdel-Razeq, H., Abbasi, S., Saadi, I., Jaber, R. & Abdelelah, H. Intravenous iron monotherapy for the treatment of non-iron-deficiency anemia in cancer patients undergoing chemotherapy: a pilot study. Drug Des. Devel Ther. 7, 939\u2013944 (2013).","journal-title":"Drug Des. Devel Ther."},{"issue":"1","key":"37154_CR35","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1007\/s44313-024-00030-w","volume":"59","author":"JS Koh","year":"2024","unstructured":"Koh, J. S. & Song, I. C. Functional iron deficiency anemia in patients with cancer. Blood Res. 59 (1), 26 (2024).","journal-title":"Blood Res."},{"issue":"10","key":"37154_CR36","doi-asserted-by":"publisher","first-page":"1611","DOI":"10.1200\/JCO.2006.10.4620","volume":"26","author":"L Bastit","year":"2008","unstructured":"Bastit, L. et al. Randomized, multicenter, controlled trial comparing the efficacy and safety of Darbepoetin alpha administered every 3 weeks with or without intravenous iron in patients with chemotherapy-induced anemia. J. Clin. Oncol. 26 (10), 1611\u20131618 (2008).","journal-title":"J. Clin. Oncol."},{"issue":"10","key":"37154_CR37","doi-asserted-by":"publisher","first-page":"1619","DOI":"10.1200\/JCO.2007.12.2051","volume":"26","author":"P Pedrazzoli","year":"2008","unstructured":"Pedrazzoli, P. et al. Randomized trial of intravenous iron supplementation in patients with chemotherapy-related anemia without iron deficiency treated with Darbepoetin alpha. J. Clin. Oncol. 26 (10), 1619\u20131625 (2008).","journal-title":"J. Clin. Oncol."},{"issue":"1","key":"37154_CR38","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1200\/JCO.2010.30.3644","volume":"29","author":"DP Steensma","year":"2011","unstructured":"Steensma, D. P. et al. Phase III, randomized study of the effects of parenteral iron, oral iron, or no iron supplementation on the erythropoietic response to Darbepoetin Alfa for patients with chemotherapy-associated anemia. J. Clin. Oncol. 29 (1), 97\u2013105 (2011).","journal-title":"J. Clin. Oncol."},{"issue":"2","key":"37154_CR39","doi-asserted-by":"publisher","first-page":"e129","DOI":"10.1111\/ajco.12762","volume":"14","author":"V Noronha","year":"2018","unstructured":"Noronha, V. et al. Phase III randomized trial comparing intravenous to oral iron in patients with cancer-related iron deficiency anemia not on erythropoiesis stimulating agents. Asia Pac. J. Clin. Oncol. 14 (2), e129\u2013e37 (2018).","journal-title":"Asia Pac. J. Clin. Oncol."},{"issue":"1","key":"37154_CR40","doi-asserted-by":"publisher","first-page":"100","DOI":"10.4103\/2045-8932.109923","volume":"3","author":"LS Howard","year":"2013","unstructured":"Howard, L. S. et al. Supplementation of iron in pulmonary hypertension: Rationale and design of a phase II clinical trial in idiopathic pulmonary arterial hypertension. Pulm Circ. 3 (1), 100\u2013107 (2013).","journal-title":"Pulm Circ."},{"issue":"19","key":"37154_CR41","doi-asserted-by":"publisher","first-page":"1958","DOI":"10.1001\/jama.2017.5427","volume":"317","author":"GD Lewis","year":"2017","unstructured":"Lewis, G. D. et al. Effect of oral iron repletion on exercise capacity in patients with heart failure with reduced ejection fraction and iron deficiency: the IRONOUT HF randomized clinical trial. JAMA 317 (19), 1958\u20131966 (2017).","journal-title":"JAMA"},{"key":"37154_CR42","doi-asserted-by":"crossref","unstructured":"Perez-Peiro, M. et al. Iron replacement and redox balance in Non-Anemic and mildly anemic iron deficiency COPD patients: insights from a clinical trial. Biomedicines ;9(9). (2021).","DOI":"10.3390\/biomedicines9091191"},{"issue":"8","key":"37154_CR43","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1016\/j.amjmed.2019.02.018","volume":"132","author":"X Zhou","year":"2019","unstructured":"Zhou, X., Xu, W., Xu, Y. & Qian, Z. Iron supplementation improves cardiovascular outcomes in patients with heart failure. Am. J. Med. 132 (8), 955\u2013963 (2019).","journal-title":"Am. J. Med."},{"key":"37154_CR44","doi-asserted-by":"publisher","first-page":"103361","DOI":"10.1016\/j.eclinm.2025.103361","volume":"86","author":"C Liu","year":"2025","unstructured":"Liu, C. et al. Timing of intravenous iron for treatment of anaemia in surgical patients: A systematic review and network meta-analysis. EClinicalMedicine 86, 103361 (2025).","journal-title":"EClinicalMedicine"},{"issue":"5","key":"37154_CR45","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1080\/09638288.2022.2043461","volume":"45","author":"I Cantarero-Villanueva","year":"2023","unstructured":"Cantarero-Villanueva, I. et al. The minimal clinically important difference in the treadmill six-minute walk test in active women with breast cancer during and after oncological treatments. Disabil. Rehabil. 45 (5), 871\u2013878 (2023).","journal-title":"Disabil. Rehabil."},{"issue":"2","key":"37154_CR46","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1177\/1479972315575715","volume":"12","author":"CL Granger","year":"2015","unstructured":"Granger, C. L., Holland, A. E., Gordon, I. R. & Denehy, L. Minimal important difference of the 6-minute walk distance in lung cancer. Chronic Resp. Dis. 12 (2), 146\u2013154 (2015).","journal-title":"Chronic Resp. Dis."},{"issue":"9","key":"37154_CR47","doi-asserted-by":"publisher","first-page":"2187","DOI":"10.1007\/s00432-022-04088-w","volume":"148","author":"R Falz","year":"2022","unstructured":"Falz, R. et al. Effects and duration of exercise-based prehabilitation in surgical therapy of colon and rectal cancer: A systematic review and meta-analysis. J. Cancer Res. Clin. Oncol. 148 (9), 2187\u20132213 (2022).","journal-title":"J. Cancer Res. Clin. Oncol."},{"issue":"2","key":"37154_CR48","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1111\/jep.12629","volume":"23","author":"RW Bohannon","year":"2017","unstructured":"Bohannon, R. W. & Crouch, R. Minimal clinically important difference for change in 6-minute walk test distance of adults with pathology: A systematic review. J. Eval. Clin. Pract. 23 (2), 377\u2013381 (2017).","journal-title":"J. Eval. Clin. Pract."},{"issue":"9","key":"37154_CR49","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1002\/ajh.21779","volume":"85","author":"M Auerbach","year":"2010","unstructured":"Auerbach, M. et al. Darbepoetin Alfa 300 or 500 mug once every 3 weeks with or without intravenous iron in patients with chemotherapy-induced anemia. Am. J. Hematol. 85 (9), 655\u2013663 (2010).","journal-title":"Am. J. Hematol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-37154-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-37154-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-37154-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T11:04:44Z","timestamp":1770894284000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-37154-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,22]]},"references-count":49,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["37154"],"URL":"https:\/\/doi.org\/10.1038\/s41598-026-37154-1","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,22]]},"assertion":[{"value":"3 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no financial, employment, or other significant\/relevant relationships to disclose that could appear to have influenced the submitted work.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Ethical approval was granted by Izmir Bakircay University Ethical Board of Clinical Studies with the following protocol number before the enrollment of patients: 2023\/939.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"N\/A.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}}],"article-number":"6030"}}