{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T12:51:19Z","timestamp":1777294279136,"version":"3.51.4"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"vor","delay-in-days":18,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-026-37799-y","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T12:15:56Z","timestamp":1769775356000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["COL8A1 promotes prostate cancer progression via modulating tumor immune infiltration and activating the FAK\/PI3K\/AKT pathway through ADAMTS2 regulation"],"prefix":"10.1038","volume":"16","author":[{"given":"Jinrun","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinzhuo","family":"Ning","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lizhe","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,1,30]]},"reference":[{"key":"37799_CR1","doi-asserted-by":"publisher","first-page":"e1950","DOI":"10.7196\/SAMJ.2024.v114i4.1950","volume":"114","author":"B Marais","year":"2024","unstructured":"Marais, B., Klopper, G. & John, J. Prostate cancer perspective: Africa versus the world. South Afr. Med. Journal 114, e1950 (2024).","journal-title":"South Afr. Med. Journal"},{"key":"37799_CR2","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.eururo.2023.10.011","volume":"85","author":"II de Vos","year":"2024","unstructured":"de Vos, I. I., Remmers, S., Hogenhout, R. & Roobol, M. J. Prostate cancer mortality among elderly men after discontinuing organised screening: Long-term results from the European randomized study of screening for prostate cancer Rotterdam. Eur. Urol. 85, 74\u201381 (2024).","journal-title":"Eur. Urol."},{"key":"37799_CR3","doi-asserted-by":"publisher","first-page":"14257","DOI":"10.3390\/ijms232214257","volume":"23","author":"S Wasim","year":"2022","unstructured":"Wasim, S., Lee, S. Y. & Kim, J. Complexities of Prostate Cancer. Int J. Mol. Sci 23, 14257 (2022).","journal-title":"Int J. Mol. Sci"},{"key":"37799_CR4","doi-asserted-by":"crossref","unstructured":"Ayad, S., Boot-Handford, R., Humphries, M. J., Kadler, K. E. & Shuttleworth, A. Collagen type VIII. The Extracell. Matrix FactsBook 81\u201383 (1998).","DOI":"10.1016\/B978-012068911-8.50113-5"},{"key":"37799_CR5","doi-asserted-by":"crossref","unstructured":"Labissiere, X., Rojas, M. G., Martinez, L. & Vazquez-Padron, R. Abstract 2146: Vascular Loss Of Type VIII Collagen Improves Venous Remodeling After Arteriovenous Fistula Creation In Mice. Arteriosclerosis, Thrombosis, and Vascular Biology 44 (2024).","DOI":"10.1161\/atvb.44.suppl_1.2146"},{"key":"37799_CR6","doi-asserted-by":"publisher","first-page":"111712","DOI":"10.1016\/j.cellsig.2025.111712","volume":"131","author":"L Yi","year":"2025","unstructured":"Yi, L. et al. LPAR3 and COL8A1, as matrix stiffness-related biomarkers, promote nasopharyngeal carcinoma metastasis by triggering EMT and angiogenesis. Cell. Signal. 131, 111712 (2025).","journal-title":"Cell. Signal."},{"key":"37799_CR7","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1002\/iub.151","volume":"61","author":"Y Zhao","year":"2009","unstructured":"Zhao, Y. et al. siRNA-targeted COL8A1 inhibits proliferation, reduces invasion and enhances sensitivity to D-limonence treatment in hepatocarcinoma cells. IUBMB Life. 61, 74\u201379 (2009).","journal-title":"IUBMB Life"},{"key":"37799_CR8","doi-asserted-by":"publisher","first-page":"3502","DOI":"10.1245\/s10434-023-14370-x","volume":"31","author":"J Hu","year":"2024","unstructured":"Hu, J. et al. COL8A1 regulates esophageal squamous carcinoma proliferation and invasion through PI3K\/AKT pathway. Ann. Surg. Oncol. 31, 3502\u20133512 (2024).","journal-title":"Ann. Surg. Oncol."},{"key":"37799_CR9","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1016\/j.immuni.2013.10.003","volume":"39","author":"G Bindea","year":"2013","unstructured":"Bindea, G. et al. Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer. Immunity 39, 782\u2013795 (2013).","journal-title":"Immunity"},{"key":"37799_CR10","doi-asserted-by":"publisher","first-page":"D672","DOI":"10.1093\/nar\/gkae909","volume":"53","author":"M Kanehisa","year":"2025","unstructured":"Kanehisa, M., Furumichi, M., Sato, Y., Matsuura, Y. & Ishiguro-Watanabe, M. KEGG: biological systems database as a model of the real world. Nucleic Acids Res. 53, D672\u2013d677 (2025).","journal-title":"Nucleic Acids Res."},{"key":"37799_CR11","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.1038\/s41556-022-01002-x","volume":"24","author":"KC Kao","year":"2022","unstructured":"Kao, K. C., Vilbois, S., Tsai, C. H. & Ho, P. C. Metabolic communication in the tumour-immune microenvironment. Nat. Cell. Biol. 24, 1574\u20131583 (2022).","journal-title":"Nat. Cell. Biol."},{"key":"37799_CR12","doi-asserted-by":"publisher","first-page":"1001297","DOI":"10.3389\/fimmu.2022.1001297","volume":"13","author":"W Wu","year":"2022","unstructured":"Wu, W. et al. Immune microenvironment infiltration landscape and immune-related subtypes in prostate cancer. Front. Immunol. 13, 1001297 (2022).","journal-title":"Front. Immunol."},{"key":"37799_CR13","doi-asserted-by":"publisher","first-page":"5358","DOI":"10.1002\/cam4.4063","volume":"10","author":"Z Ma","year":"2021","unstructured":"Ma, Z. et al. Immune infiltration phenotypes of prostate adenocarcinoma and their clinical implications. Cancer Med. 10, 5358\u20135374 (2021).","journal-title":"Cancer Med."},{"key":"37799_CR14","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1002\/path.5817","volume":"256","author":"KS Sfanos","year":"2022","unstructured":"Sfanos, K. S. Immune cell infiltrates and prognosis in localized prostate cancer(\u2020). J. Pathol. 256, 135\u2013138 (2022).","journal-title":"J. Pathol."},{"key":"37799_CR15","doi-asserted-by":"publisher","first-page":"527","DOI":"10.4111\/icu.20240229","volume":"65","author":"S Kumar Am","year":"2024","unstructured":"Kumar Am, S., Rajan, P., Alkhamees, M., Holley, M. & Lakshmanan V. K. Prostate cancer theragnostics biomarkers: an update. Investig Clin. Urol. 65, 527\u2013539 (2024).","journal-title":"Investig Clin. Urol."},{"key":"37799_CR16","doi-asserted-by":"crossref","unstructured":"Fontana, F. & Limonta, P. Dissecting the hormonal signaling landscape in Castration-Resistant prostate cancer. Cells 10 (2021).","DOI":"10.3390\/cells10051133"},{"key":"37799_CR17","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1016\/j.acuro.2022.04.007","volume":"47","author":"J G\u00f3mez Rivas","year":"2023","unstructured":"G\u00f3mez Rivas, J., Fernandez, L., Abad-Lopez, P. & Moreno-Sierra, J. Androgen deprivation therapy in localized prostate cancer. Current status and future trends. Actas Urol. Esp. (Engl Ed). 47, 398\u2013407 (2023).","journal-title":"Actas Urol. Esp. (Engl Ed)"},{"key":"37799_CR18","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/j.eururo.2021.12.039","volume":"81","author":"Q Cheng","year":"2022","unstructured":"Cheng, Q. et al. Pre-existing Castration-resistant prostate cancer-like cells in primary prostate cancer promote resistance to hormonal therapy. Eur. Urol. 81, 446\u2013455 (2022).","journal-title":"Eur. Urol."},{"key":"37799_CR19","doi-asserted-by":"publisher","first-page":"a004978","DOI":"10.1101\/cshperspect.a004978","volume":"3","author":"S Ricard-Blum","year":"2011","unstructured":"Ricard-Blum, S. The collagen family. Cold Spring Harb Perspect. Biol. 3, a004978 (2011).","journal-title":"Cold Spring Harb Perspect. Biol."},{"key":"37799_CR20","doi-asserted-by":"crossref","unstructured":"Sun, W., Shahrajabian, M. H., Ma, K. & Wang, S. Advances in molecular function and Recombinant expression of human collagen. Pharmaceuticals (Basel) 18 (2025).","DOI":"10.3390\/ph18030430"},{"key":"37799_CR21","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1186\/s12943-024-02180-y","volume":"23","author":"X Zhou","year":"2024","unstructured":"Zhou, X. et al. THBS2\u2009+\u2009cancer-associated fibroblasts promote EMT leading to oxaliplatin resistance via COL8A1-mediated PI3K\/AKT activation in colorectal cancer. Mol. Cancer. 23, 282 (2024).","journal-title":"Mol. Cancer"},{"key":"37799_CR22","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1007\/s10549-022-06635-y","volume":"194","author":"F Sato","year":"2022","unstructured":"Sato, F. et al. COL8A1 facilitates the growth of triple-negative breast cancer via FAK\/Src activation. Breast Cancer Res. Treat. 194, 243\u2013256 (2022).","journal-title":"Breast Cancer Res. Treat."},{"key":"37799_CR23","doi-asserted-by":"crossref","unstructured":"Liang, W. et al. High expression of COL8A1 predicts poor prognosis and promotes EMT in papillary thyroid cancer. Endocr Connect 13 (2024).","DOI":"10.1530\/EC-24-0279"},{"key":"37799_CR24","doi-asserted-by":"publisher","first-page":"1390","DOI":"10.3892\/ol.2015.3400","volume":"10","author":"W Hu","year":"2015","unstructured":"Hu, W. et al. Alternatively activated macrophages are associated with metastasis and poor prognosis in prostate adenocarcinoma. Oncol. Lett. 10, 1390\u20131396 (2015).","journal-title":"Oncol. Lett."},{"key":"37799_CR25","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1038\/s41423-018-0004-4","volume":"15","author":"HM Knochelmann","year":"2018","unstructured":"Knochelmann, H. M. et al. When worlds collide: Th17 and Treg cells in cancer and autoimmunity. Cell. Mol. Immunol. 15, 458\u2013469 (2018).","journal-title":"Cell. Mol. Immunol."},{"key":"37799_CR26","doi-asserted-by":"publisher","first-page":"101686","DOI":"10.1016\/j.gendis.2025.101686","volume":"12","author":"R Vanlerberghe","year":"2025","unstructured":"Vanlerberghe, R., Colige, A., Malfait, A. M., Syx, D. & Malfait, F. ADAMTS2: more than a Procollagen N-proteinase. Genes Dis. 12, 101686 (2025).","journal-title":"Genes Dis."},{"key":"37799_CR27","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.matbio.2018.06.002","volume":"71\u201372","author":"TJ Mead","year":"2018","unstructured":"Mead, T. J. & Apte, S. S. ADAMTS proteins in human disorders. Matrix Biol 71\u201372, 225\u2013239 (2018).","journal-title":"Matrix Biol"},{"key":"37799_CR28","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/S1357-2725(00)00061-3","volume":"33","author":"BL Tang","year":"2001","unstructured":"Tang, B. L. ADAMTS: a novel family of extracellular matrix proteases. Int. J. Biochem. Cell. Biol. 33, 33\u201344 (2001).","journal-title":"Int. J. Biochem. Cell. Biol."},{"key":"37799_CR29","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.matbio.2015.01.013","volume":"44\u201346","author":"S Cal","year":"2015","unstructured":"Cal, S. & L\u00f3pez-Ot\u00edn, C. ADAMTS proteases and cancer. Matrix Biol 44\u201346, 77\u201346 (2015).","journal-title":"Matrix Biol"},{"key":"37799_CR30","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1038\/s41568-020-00329-7","volume":"21","author":"TR Cox","year":"2021","unstructured":"Cox, T. R. The matrix in cancer. Nat. Rev. Cancer. 21, 217\u2013238 (2021).","journal-title":"Nat. Rev. Cancer"},{"key":"37799_CR31","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.ctrv.2003.07.007","volume":"30","author":"JA Fresno Vara","year":"2004","unstructured":"Fresno Vara, J. A. et al. PI3K\/Akt signalling pathway and cancer. Cancer Treat. Rev. 30, 193\u2013204 (2004).","journal-title":"Cancer Treat. Rev."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-37799-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-37799-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-37799-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T09:29:47Z","timestamp":1771320587000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-37799-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,30]]},"references-count":31,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["37799"],"URL":"https:\/\/doi.org\/10.1038\/s41598-026-37799-y","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,30]]},"assertion":[{"value":"23 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The experimental protocols adhered to the protocols set by the National Institutes of Health for the use and care of laboratory animals. Furthermore, they received approval from the Wuhan University Animal Care and Use Committee (Approval No. 20250101D).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Each participant gave informed consent prior to their participation. The study was conducted in accordance with the Declaration of Helsinki. The consent process and documentation received approval from the Medical Ethics Committee of Renmin Hospital of Wuhan University (Reference No.: WDRY2021-KS010).","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}}],"article-number":"6744"}}