{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T10:58:17Z","timestamp":1771844297278,"version":"3.50.1"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T00:00:00Z","timestamp":1771804800000},"content-version":"vor","delay-in-days":18,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This study aimed to investigate the relationship between myopia and retinal vascular oxygen saturation, after accounting for optical factors and individual variations. This was a prospective, observational, single-center study. Adults with anisometropia were included. All the participants underwent femtosecond-assisted laser in situ keratomileusis (FS-LASIK), and before and after the surgery, all the patients underwent the examination of visual acuity, intraocular pressure (IOP), spherical equivalent (SE), average keratometry (K), central corneal thickness, and retinal oximeter. A total of 196 adult patients with myopic anisometropia were enrolled. The SE of the less myopic eyes before surgery was \u2212\u20093.89\u2009\u00b1\u20093.24 D, which was significantly higher than that of the more myopic eyes\u2009\u2212\u20096.75\u2009\u00b1\u20093.10 D (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). The retinal arterial oxygen saturation (SaO\n                    <jats:sub>2<\/jats:sub>\n                    ) of the less myopic eyes was 94.08\u2009\u00b1\u20091.61%, which was significantly higher than that of the more myopic eyes 93.36\u2009\u00b1\u20091.74% (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.003). After FS-LASIK, the SaO\n                    <jats:sub>2<\/jats:sub>\n                    of the less myopic eyes (93.29\u2009\u00b1\u20091.72%) remained significantly higher than that of the more myopic eyes (92.76\u2009\u00b1\u20091.83%) (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.038). In the multivariate regression analysis, the postoperative SaO\n                    <jats:sub>2<\/jats:sub>\n                    was still significantly negatively correlated with axial length (AL) (\n                    <jats:italic>B<\/jats:italic>\n                    = -0.252,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.009). After excluding optical factors and individual variations, SaO\n                    <jats:sub>2<\/jats:sub>\n                    remains negatively correlated with AL. Myopia exerts an optical magnification effect on SaO\n                    <jats:sub>2<\/jats:sub>\n                    .\n                  <\/jats:p>","DOI":"10.1038\/s41598-026-37955-4","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T20:06:20Z","timestamp":1770321980000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Changes in retinal oxygen saturation before and after femtosecond LASIK in adult myopic individuals with anisometropia"],"prefix":"10.1038","volume":"16","author":[{"given":"Shanshan","family":"Ge","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqi","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuli","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuehua","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,2,5]]},"reference":[{"issue":"3","key":"37955_CR1","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1111\/aos.14043","volume":"97","author":"X Liu","year":"2019","unstructured":"Liu, X. et al. Retinal oxygen saturation in 1461 healthy children aged 7\u201319 and its associated factors. Acta Ophthalmol. 97(3), 287\u2013295 (2019).","journal-title":"Acta Ophthalmol."},{"issue":"4","key":"37955_CR2","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1167\/tvst.8.4.22","volume":"8","author":"LS Lim","year":"2019","unstructured":"Lim, L. S., Lim, X. H. & Tan, L. Retinal vascular oxygen saturation and its variation with refractive error and axial length. Transl Vis. Sci. Technol. 8(4), 22 (2019).","journal-title":"Transl Vis. Sci. Technol."},{"issue":"1","key":"37955_CR3","doi-asserted-by":"publisher","first-page":"e54","DOI":"10.1111\/aos.13167","volume":"95","author":"X Liu","year":"2017","unstructured":"Liu, X. et al. Retinal oxygen saturation in Chinese adolescents. Acta Ophthalmol. 95(1), e54\u2013e61 (2017).","journal-title":"Acta Ophthalmol."},{"issue":"4","key":"37955_CR4","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1167\/tvst.12.4.14","volume":"12","author":"S Ge","year":"2023","unstructured":"Ge, S., Yang, L., Zhou, Y., Li, C. & Zhang, J. Retinal vascular oxygen saturation in adults with anisometropia. Transl Vis. Sci. Technol. 12(4), 14 (2023).","journal-title":"Transl Vis. Sci. Technol."},{"issue":"14","key":"37955_CR5","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1167\/iovs.64.14.13","volume":"64","author":"S Ge","year":"2023","unstructured":"Ge, S., Zhou, Y., Li, C. & Zhang, M. Retinal vascular oxygen saturation in a sample of Chinese myopic adults. Invest. Ophthalmol. Vis. Sci. 64(14), 13 (2023).","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"37955_CR6","doi-asserted-by":"crossref","unstructured":"Ma, X., Ge, S., Yang, X. & Zhou, Y. 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The study was in accordance with the Helsinki Declaration of 1964.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"7426"}}