{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T01:14:46Z","timestamp":1790126086530,"version":"4.0.1"},"reference-count":65,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"vor","delay-in-days":42,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100010425","name":"Tri-Service General Hospital","doi-asserted-by":"publisher","award":["TSGH-D-112080, TSGH-E-112213, TSGH_C04_113042, TSGH_E_113234"],"award-info":[{"award-number":["TSGH-D-112080, TSGH-E-112213, TSGH_C04_113042, TSGH_E_113234"]}],"id":[{"id":"10.13039\/501100010425","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of National Defense-Medical Affairs Bureau, Taiwan","award":["MND-MAB-D-112151, MND-MAB-D-113102, MND-MAB-D-113082"],"award-info":[{"award-number":["MND-MAB-D-112151, MND-MAB-D-113102, MND-MAB-D-113082"]}]},{"name":"National Science and Technology Council","award":["MOST 111-2314-B-016-005 -MY3"],"award-info":[{"award-number":["MOST 111-2314-B-016-005 -MY3"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-026-38164-9","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T16:34:37Z","timestamp":1773160477000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cold exposure increases aortic dissection risk through extracellular cold inducible RNA binding protein and toll like receptor 4 signaling"],"prefix":"10.1038","volume":"16","author":[{"given":"Hsiao-Ya","family":"Tsai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wu-Chien","family":"Chien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Hsiang","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Yuan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Juei","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Chien","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin-Wang","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Hung","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,10]]},"reference":[{"key":"38164_CR1","doi-asserted-by":"publisher","first-page":"7434","DOI":"10.1038\/s41598-020-64299-4","volume":"10","author":"M Wundram","year":"2020","unstructured":"Wundram, M. et al. Incidence of acute type A aortic dissection in emergency departments. Sci. Rep. 10, 7434. https:\/\/doi.org\/10.1038\/s41598-020-64299-4 (2020).","journal-title":"Sci. Rep."},{"key":"38164_CR2","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezae039","author":"K Teurneau-Hermansson","year":"2024","unstructured":"Teurneau-Hermansson, K. et al. Mortality after non-surgically treated acute type a aortic dissection higher than previously reported. Eur. J. cardio-thoracic Surgery: Official J. Eur. Association Cardio-thoracic Surg. https:\/\/doi.org\/10.1093\/ejcts\/ezae039 (2024).","journal-title":"Eur. J. cardio-thoracic Surgery: Official J. Eur. Association Cardio-thoracic Surg."},{"key":"38164_CR3","doi-asserted-by":"publisher","first-page":"3802","DOI":"10.1161\/CIRCULATIONAHA.105.534198","volume":"112","author":"TT Tsai","year":"2005","unstructured":"Tsai, T. T., Nienaber, C. A. & Eagle, K. A. Acute aortic syndromes. Circulation 112, 3802\u20133813. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.105.534198 (2005).","journal-title":"Circulation"},{"key":"38164_CR4","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1161\/atvbaha.116.307211","volume":"36","author":"B Trachet","year":"2016","unstructured":"Trachet, B. et al. Ascending aortic aneurysm in angiotensin II-Infused mice: Formation, Progression, and the role of focal dissections. Arterioscler. Thromb. Vasc. Biol. 36, 673\u2013681. https:\/\/doi.org\/10.1161\/atvbaha.116.307211 (2016).","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"38164_CR5","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1093\/aje\/155.1.80","volume":"155","author":"FC Curriero","year":"2002","unstructured":"Curriero, F. C. et al. Temperature and mortality in 11 cities of the Eastern united States. Am. J. Epidemiol. 155, 80\u201387. https:\/\/doi.org\/10.1093\/aje\/155.1.80 (2002).","journal-title":"Am. J. Epidemiol."},{"key":"38164_CR6","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/s004840000072","volume":"45","author":"GC Donaldson","year":"2001","unstructured":"Donaldson, G. C., Rintam\u00e4ki, H. & N\u00e4yh\u00e4, S. Outdoor clothing: its relationship to geography, climate, behaviour and cold-related mortality in Europe. Int. J. Biometeorol. 45, 45\u201351. https:\/\/doi.org\/10.1007\/s004840000072 (2001).","journal-title":"Int. J. Biometeorol."},{"key":"38164_CR7","doi-asserted-by":"publisher","first-page":"1733","DOI":"10.1007\/s00484-018-1573-8","volume":"62","author":"Z Wu","year":"2018","unstructured":"Wu, Z. et al. Seasonal incidence of ruptured abdominal aortic aneurysm and the influence of atmospheric pressure: a systematic review and meta-analysis. Int. J. Biometeorol. 62, 1733\u20131743. https:\/\/doi.org\/10.1007\/s00484-018-1573-8 (2018).","journal-title":"Int. J. Biometeorol."},{"key":"38164_CR8","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1177\/1358863x20923399","volume":"25","author":"G Mestres","year":"2020","unstructured":"Mestres, G. et al. Climatic influence on the risk of abdominal aortic aneurysm rupture. Vasc Med. 25, 443\u2013449. https:\/\/doi.org\/10.1177\/1358863x20923399 (2020).","journal-title":"Vasc Med."},{"key":"38164_CR9","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.ijcard.2014.11.088","volume":"179","author":"N Kumar","year":"2015","unstructured":"Kumar, N., Pandey, A., Venkatraman, A. & Garg, N. Seasonality in acute aortic dissection related hospitalizations and mortality in the United States: A nationwide analysis from 2004\u20132011. Int. J. Cardiol. 179, 321\u2013322. https:\/\/doi.org\/10.1016\/j.ijcard.2014.11.088 (2015).","journal-title":"Int. J. Cardiol."},{"key":"38164_CR10","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.cmet.2013.06.003","volume":"18","author":"M Dong","year":"2013","unstructured":"Dong, M. et al. Cold exposure promotes atherosclerotic plaque growth and instability via UCP1-dependent lipolysis. Cell. Metab. 18, 118\u2013129. https:\/\/doi.org\/10.1016\/j.cmet.2013.06.003 (2013).","journal-title":"Cell. Metab."},{"key":"38164_CR11","doi-asserted-by":"publisher","first-page":"580811","DOI":"10.3389\/fphys.2020.580811","volume":"11","author":"X Kong","year":"2020","unstructured":"Kong, X., Liu, H., He, X., Sun, Y. & Ge, W. Unraveling the mystery of cold Stress-Induced myocardial injury. Front. Physiol. 11, 580811. https:\/\/doi.org\/10.3389\/fphys.2020.580811 (2020).","journal-title":"Front. Physiol."},{"key":"38164_CR12","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1080\/10253890.2019.1568987","volume":"22","author":"H Shi","year":"2019","unstructured":"Shi, H. et al. Regulating glycolysis, the TLR4 signal pathway and expression of RBM3 in mouse liver in response to acute cold exposure. Stress (Amsterdam Netherlands). 22, 366\u2013376. https:\/\/doi.org\/10.1080\/10253890.2019.1568987 (2019).","journal-title":"Stress (Amsterdam Netherlands)"},{"key":"38164_CR13","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.brainres.2011.12.053","volume":"1441","author":"S Li","year":"2012","unstructured":"Li, S., Zhang, Z., Xue, J., Liu, A. & Zhang, H. Cold-inducible RNA binding protein inhibits H\u2082O\u2082-induced apoptosis in rat cortical neurons. Brain Res. 1441, 47\u201352. https:\/\/doi.org\/10.1016\/j.brainres.2011.12.053 (2012).","journal-title":"Brain Res."},{"key":"38164_CR14","doi-asserted-by":"publisher","first-page":"26720","DOI":"10.1074\/jbc.272.42.26720","volume":"272","author":"MS Sheikh","year":"1997","unstructured":"Sheikh, M. S. et al. Identification of several human homologs of hamster DNA damage-inducible transcripts. Cloning and characterization of a novel UV-inducible cDNA that codes for a putative RNA-binding protein. J. Biol. Chem. 272, 26720\u201326726. https:\/\/doi.org\/10.1074\/jbc.272.42.26720 (1997).","journal-title":"J. Biol. Chem."},{"key":"38164_CR15","doi-asserted-by":"publisher","first-page":"2164","DOI":"10.1002\/ijc.30833","volume":"141","author":"Y Liao","year":"2017","unstructured":"Liao, Y., Tong, L., Tang, L. & Wu, S. The role of cold-inducible RNA binding protein in cell stress response. Int. J. Cancer. 141, 2164\u20132173. https:\/\/doi.org\/10.1002\/ijc.30833 (2017).","journal-title":"Int. J. Cancer"},{"key":"38164_CR16","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1038\/s42003-025-08838-7","volume":"8","author":"P Dey","year":"2025","unstructured":"Dey, P., Lal, H., Saha, P. & Ramanathan, A. Molecular mediators of cold adaptation in mammalian cells. Commun. Biology. 8, 1441. https:\/\/doi.org\/10.1038\/s42003-025-08838-7 (2025).","journal-title":"Commun. Biology"},{"key":"38164_CR17","doi-asserted-by":"publisher","unstructured":"Su, F. et al. CIRBP ameliorates neuronal amyloid toxicity via antioxidative and antiapoptotic pathways in primary cortical neurons. Oxidative Med. Cell. Longev. 2020 (2786139). https:\/\/doi.org\/10.1155\/2020\/2786139 (2020).","DOI":"10.1155\/2020\/2786139"},{"key":"38164_CR18","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1016\/j.bbrc.2019.05.012","volume":"517","author":"M Chen","year":"2019","unstructured":"Chen, M., Fu, H., Zhang, J., Huang, H. & Zhong, P. CIRP downregulation renders cardiac cells prone to apoptosis in heart failure. Biochem. Biophys. Res. Commun. 517, 545\u2013550. https:\/\/doi.org\/10.1016\/j.bbrc.2019.05.012 (2019).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"38164_CR19","doi-asserted-by":"publisher","first-page":"41363","DOI":"10.1038\/srep41363","volume":"7","author":"MM Khan","year":"2017","unstructured":"Khan, M. M., Yang, W. L., Brenner, M., Bolognese, A. C. & Wang, P. Cold-inducible RNA-binding protein (CIRP) causes sepsis-associated acute lung injury via induction of Endoplasmic reticulum stress. Sci. Rep. 7, 41363. https:\/\/doi.org\/10.1038\/srep41363 (2017).","journal-title":"Sci. Rep."},{"key":"38164_CR20","doi-asserted-by":"publisher","first-page":"12205","DOI":"10.1007\/s12035-025-05029-7","volume":"62","author":"Y Fan","year":"2025","unstructured":"Fan, Y. et al. Cold-Induced RNA-Binding protein (CIRP) affects cerebral Ischemia-Reperfusion injury through NF-\u03baB pathway. Mol. Neurobiol. 62, 12205\u201312220. https:\/\/doi.org\/10.1007\/s12035-025-05029-7 (2025).","journal-title":"Mol. Neurobiol."},{"key":"38164_CR21","doi-asserted-by":"publisher","unstructured":"Yamaga, S., Murao, A., Aziz, M., Wang, P. & Brenner, M. High\u2013dose X\u2013ray irradiation induces NETosis via the eCIRP\/TREM\u20131 axis in mouse neutrophils. Int. J. Mol. Med. 56 https:\/\/doi.org\/10.3892\/ijmm.2025.5598 (2025).","DOI":"10.3892\/ijmm.2025.5598"},{"key":"38164_CR22","doi-asserted-by":"publisher","first-page":"e70955","DOI":"10.1096\/fj.202402540RRR","volume":"39","author":"Y Ding","year":"2025","unstructured":"Ding, Y. et al. Cold-Inducible RNA-binding protein causes prolonged immersion-induced hypothermic acute lung injury in a rat model through TREM-1 and NF-\u03baB. FASEB Journal: Official Publication Federation Am. Soc. Experimental Biology. 39, e70955. https:\/\/doi.org\/10.1096\/fj.202402540RRR (2025).","journal-title":"FASEB Journal: Official Publication Federation Am. Soc. Experimental Biology"},{"key":"38164_CR23","doi-asserted-by":"publisher","DOI":"10.1111\/all.14287","author":"LL Shi","year":"2020","unstructured":"Shi, L. L. et al. Cold-inducible RNA-binding protein contributes to tissue remodeling in chronic rhinosinusitis with nasal polyps. Allergy https:\/\/doi.org\/10.1111\/all.14287 (2020).","journal-title":"Allergy"},{"key":"38164_CR24","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1002\/jlb.3a0817-327rr","volume":"103","author":"Y Ode","year":"2018","unstructured":"Ode, Y., Aziz, M. & Wang, P. CIRP increases ICAM-1(+) phenotype of neutrophils exhibiting elevated iNOS and NETs in sepsis. J. Leukoc. Biol. 103, 693\u2013707. https:\/\/doi.org\/10.1002\/jlb.3a0817-327rr (2018).","journal-title":"J. Leukoc. Biol."},{"key":"38164_CR25","doi-asserted-by":"publisher","first-page":"111525","DOI":"10.1016\/j.intimp.2024.111525","volume":"128","author":"F Yao","year":"2024","unstructured":"Yao, F. et al. Extracellular CIRP induces abnormal activation of fibroblast-like synoviocytes from patients with RA via the TLR4-mediated HDAC3 pathways. Int. Immunopharmacol. 128, 111525. https:\/\/doi.org\/10.1016\/j.intimp.2024.111525 (2024).","journal-title":"Int. Immunopharmacol."},{"key":"38164_CR26","doi-asserted-by":"publisher","first-page":"2053","DOI":"10.1016\/j.jpedsurg.2018.12.020","volume":"54","author":"NL Denning","year":"2019","unstructured":"Denning, N. L., Yang, W. L., Hansen, L., Prince, J. & Wang, P. C23, an oligopeptide derived from cold-inducible RNA-binding protein, suppresses inflammation and reduces lung injury in neonatal sepsis. J. Pediatr. Surg. 54, 2053\u20132060. https:\/\/doi.org\/10.1016\/j.jpedsurg.2018.12.020 (2019).","journal-title":"J. Pediatr. Surg."},{"key":"38164_CR27","doi-asserted-by":"publisher","first-page":"3628","DOI":"10.1007\/s12035-021-02368-z","volume":"58","author":"A Sharma","year":"2021","unstructured":"Sharma, A., Brenner, M., Jacob, A., Marambaud, P. & Wang, P. Extracellular CIRP activates the IL-6R\u03b1\/STAT3\/Cdk5 pathway in neurons. Mol. Neurobiol. 58, 3628\u20133640. https:\/\/doi.org\/10.1007\/s12035-021-02368-z (2021).","journal-title":"Mol. Neurobiol."},{"key":"38164_CR28","doi-asserted-by":"publisher","first-page":"2661","DOI":"10.1161\/CIRCULATIONAHA.113.005062","volume":"129","author":"LM Fan","year":"2014","unstructured":"Fan, L. M. et al. Endothelial cell-specific reactive oxygen species production increases susceptibility to aortic dissection. Circulation 129, 2661\u20132672. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.113.005062 (2014).","journal-title":"Circulation"},{"key":"38164_CR29","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1161\/circresaha.125.326230","volume":"137","author":"K Kimura","year":"2025","unstructured":"Kimura, K. et al. Novel aortic dissection model links endothelial dysfunction and immune infiltration. Circ. Res. 137, 26\u201342. https:\/\/doi.org\/10.1161\/circresaha.125.326230 (2025).","journal-title":"Circ. Res."},{"key":"38164_CR30","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/s0895-7061(01)02268-3","volume":"15","author":"Z Zhu","year":"2002","unstructured":"Zhu, Z., Zhu, S., Zhu, J., van der Giet, M. & Tepel, M. Endothelial dysfunction in cold-induced hypertensive rats. Am. J. Hypertens. 15, 176\u2013180. https:\/\/doi.org\/10.1016\/s0895-7061(01)02268-3 (2002).","journal-title":"Am. J. Hypertens."},{"key":"38164_CR31","doi-asserted-by":"publisher","first-page":"26571","DOI":"10.1038\/srep26571","volume":"6","author":"WL Yang","year":"2016","unstructured":"Yang, W. L. et al. Cold-inducible RNA-binding protein causes endothelial dysfunction via activation of Nlrp3 inflammasome. Sci. Rep. 6, 26571. https:\/\/doi.org\/10.1038\/srep26571 (2016).","journal-title":"Sci. Rep."},{"key":"38164_CR32","doi-asserted-by":"publisher","first-page":"349","DOI":"10.2147\/CLEP.S196293","volume":"11","author":"CY Hsieh","year":"2019","unstructured":"Hsieh, C. Y. et al. Taiwan\u2019s National health insurance research database: past and future. Clin. Epidemiol. 11, 349\u2013358. https:\/\/doi.org\/10.2147\/CLEP.S196293 (2019).","journal-title":"Clin. Epidemiol."},{"key":"38164_CR33","doi-asserted-by":"publisher","first-page":"e89406","DOI":"10.1371\/journal.pone.0089406","volume":"9","author":"S Pan","year":"2014","unstructured":"Pan, S. et al. JAK2-centered interactome hotspot identified by an integrative network algorithm in acute Stanford type A aortic dissection. PloS One. 9, e89406. https:\/\/doi.org\/10.1371\/journal.pone.0089406 (2014).","journal-title":"PloS One"},{"key":"38164_CR34","doi-asserted-by":"publisher","first-page":"3143","DOI":"10.3892\/mmr.2017.6404","volume":"15","author":"K Lee","year":"2017","unstructured":"Lee, K. et al. Inhibitory effect of Angelica gigas on cold\u2013induced RhoA activation in vascular cells. Mol. Med. Rep. 15, 3143\u20133146. https:\/\/doi.org\/10.3892\/mmr.2017.6404 (2017).","journal-title":"Mol. Med. Rep."},{"key":"38164_CR35","doi-asserted-by":"publisher","unstructured":"Liu, P. et al. Effects of cold-inducible RNA-binding protein (CIRP) on liver Glycolysis during acute cold exposure in C57BL\/6 mice. Int. J. Mol. Sci. 20 https:\/\/doi.org\/10.3390\/ijms20061470 (2019).","DOI":"10.3390\/ijms20061470"},{"key":"38164_CR36","doi-asserted-by":"publisher","first-page":"1799","DOI":"10.1007\/s00018-010-0276-z","volume":"67","author":"C Grond-Ginsbach","year":"2010","unstructured":"Grond-Ginsbach, C. et al. Spontaneous arterial dissection: phenotype and molecular pathogenesis. Cell. Mol. Life Sci. 67, 1799\u20131815. https:\/\/doi.org\/10.1007\/s00018-010-0276-z (2010).","journal-title":"Cell. Mol. Life Sci."},{"key":"38164_CR37","doi-asserted-by":"publisher","first-page":"101353","DOI":"10.1016\/j.jacbts.2025.101353","volume":"10","author":"Z Zhou","year":"2025","unstructured":"Zhou, Z. et al. Focal adhesion kinase drives Rho\/ROCK and mTOR signaling to protect and augment aortic dissections. JACC Basic. Translational Sci. 10, 101353. https:\/\/doi.org\/10.1016\/j.jacbts.2025.101353 (2025).","journal-title":"JACC Basic. Translational Sci."},{"key":"38164_CR38","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1067\/mva.1991.26737","volume":"13","author":"KW Johnston","year":"1991","unstructured":"Johnston, K. W. et al. Suggested standards for reporting on arterial aneurysms: Subcommittee on reporting standards for arterial Aneurysms, ad hoc committee on reporting standards, society for vascular surgery and North American Chapter, international society for cardiovascular surgery. J. Vasc Surg. 13, 452\u2013458. https:\/\/doi.org\/10.1067\/mva.1991.26737 (1991).","journal-title":"J. Vasc Surg."},{"key":"38164_CR39","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1161\/atvbaha.116.307648","volume":"37","author":"D Wu","year":"2017","unstructured":"Wu, D. et al. NLRP3 (Nucleotide oligomerization domain-Like receptor Family, Pyrin domain containing 3)-Caspase-1 inflammasome degrades contractile proteins: implications for aortic Biomechanical dysfunction and aneurysm and dissection formation. Arterioscler. Thromb. Vasc. Biol. 37, 694\u2013706. https:\/\/doi.org\/10.1161\/atvbaha.116.307648 (2017).","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"38164_CR40","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1038\/nm.1958","volume":"15","author":"K Satoh","year":"2009","unstructured":"Satoh, K. et al. Cyclophilin A enhances vascular oxidative stress and the development of angiotensin II-induced aortic aneurysms. Nat. Med. 15, 649\u2013656. https:\/\/doi.org\/10.1038\/nm.1958 (2009).","journal-title":"Nat. Med."},{"key":"38164_CR41","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1016\/j.omtn.2021.12.028","volume":"27","author":"HY Tsai","year":"2022","unstructured":"Tsai, H. Y. et al. miR-424\/322 protects against abdominal aortic aneurysm formation by modulating the Smad2\/3\/runt-related transcription factor 2 axis. Mol. Therapy Nucleic Acids. 27, 656\u2013669. https:\/\/doi.org\/10.1016\/j.omtn.2021.12.028 (2022).","journal-title":"Mol. Therapy Nucleic Acids"},{"key":"38164_CR42","doi-asserted-by":"publisher","first-page":"101815","DOI":"10.1016\/j.ijcha.2025.101815","volume":"61","author":"HY Tsai","year":"2025","unstructured":"Tsai, H. Y. et al. Cardamonin attenuates angiotensin II-induced abdominal aortic aneurysms through activation of the Nrf2\/HO-1 pathway. Int. J. Cardiol. Heart Vasculature. 61, 101815. https:\/\/doi.org\/10.1016\/j.ijcha.2025.101815 (2025).","journal-title":"Int. J. Cardiol. Heart Vasculature"},{"key":"38164_CR43","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.jjcc.2024.02.009","volume":"84","author":"CW Hong","year":"2024","unstructured":"Hong, C. W. et al. The associations among peptic ulcer disease, Helicobacter pylori infection, and abdominal aortic aneurysms: A nationwide population-based cohort study. J. Cardiol. 84, 180\u2013188. https:\/\/doi.org\/10.1016\/j.jjcc.2024.02.009 (2024).","journal-title":"J. Cardiol."},{"key":"38164_CR44","doi-asserted-by":"publisher","first-page":"100562","DOI":"10.1016\/j.lanwpc.2022.100562","volume":"28","author":"Q Zhang","year":"2022","unstructured":"Zhang, Q. et al. Low temperature and temperature decline increase acute aortic dissection risk and burden: A nationwide case crossover analysis at hourly level among 40,270 patients. Lancet Reg. Health Western Pac. 28, 100562. https:\/\/doi.org\/10.1016\/j.lanwpc.2022.100562 (2022).","journal-title":"Lancet Reg. Health Western Pac."},{"key":"38164_CR45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/bs.pmbts.2017.02.005","volume":"147","author":"N Cui","year":"2017","unstructured":"Cui, N., Hu, M. & Khalil, R. A. Biochemical and biological attributes of matrix metalloproteinases. Prog. Mol. Biol. Transl. Sci. 147, 1\u201373. https:\/\/doi.org\/10.1016\/bs.pmbts.2017.02.005 (2017).","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"38164_CR46","doi-asserted-by":"publisher","first-page":"1829","DOI":"10.4049\/jimmunol.1601386","volume":"200","author":"W Ren","year":"2018","unstructured":"Ren, W. et al. The complement C3a-C3aR axis promotes development of thoracic aortic dissection via regulation of MMP2 expression. J. Immunol. 200, 1829\u20131838. https:\/\/doi.org\/10.4049\/jimmunol.1601386 (2018).","journal-title":"J. Immunol."},{"key":"38164_CR47","doi-asserted-by":"publisher","first-page":"1679","DOI":"10.3892\/mmr.2014.2464","volume":"10","author":"X Zheng","year":"2014","unstructured":"Zheng, X. et al. Intermittent cold stress enhances features of atherosclerotic plaque instability in Apolipoprotein E\u2013deficient mice. Mol. Med. Rep. 10, 1679\u20131684. https:\/\/doi.org\/10.3892\/mmr.2014.2464 (2014).","journal-title":"Mol. Med. Rep."},{"key":"38164_CR48","doi-asserted-by":"publisher","unstructured":"Liu, X., Zhang, A., Dong, N. & Wang, Z. Expression of TLR4 is upregulated in patients with sporadic acute Stanford type A aortic dissection. Cardiol. Res. Pract. 2022 (3806462). https:\/\/doi.org\/10.1155\/2022\/3806462 (2022).","DOI":"10.1155\/2022\/3806462"},{"key":"38164_CR49","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1186\/s12872-018-0958-2","volume":"18","author":"T Li","year":"2018","unstructured":"Li, T. et al. Serum levels of matrix metalloproteinase 9 and toll-like receptor 4 in acute aortic dissection: A case-control study. BMC Cardiovasc. Disord. 18, 219. https:\/\/doi.org\/10.1186\/s12872-018-0958-2 (2018).","journal-title":"BMC Cardiovasc. Disord."},{"key":"38164_CR50","doi-asserted-by":"publisher","first-page":"2813","DOI":"10.1161\/atvbaha.111.238642","volume":"31","author":"AP Owens 3rd","year":"2011","unstructured":"Owens, A. P. 3rd et al. MyD88 deficiency attenuates angiotensin II-induced abdominal aortic aneurysm formation independent of signaling through Toll-like receptors 2 and 4. Arterioscler. Thromb. Vasc. Biol. 31, 2813\u20132819. https:\/\/doi.org\/10.1161\/atvbaha.111.238642 (2011).","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"38164_CR51","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/s10020-024-00790-2","volume":"30","author":"Y Akama","year":"2024","unstructured":"Akama, Y., Murao, A., Aziz, M. & Wang, P. Extracellular: CIRP induces CD4CD8\u03b1\u03b1 intraepithelial lymphocyte cytotoxicity in sepsis. Mol. Med. (Cambridge Mass). 30, 17. https:\/\/doi.org\/10.1186\/s10020-024-00790-2 (2024).","journal-title":"Mol. Med. (Cambridge Mass)"},{"key":"38164_CR52","doi-asserted-by":"publisher","unstructured":"Liu, W. et al. Blocking CIRP protects against acute pancreatitis by improving mitochondrial function and suppressing pyroptosis in acinar cells. Cell. Death Discovery. 10 https:\/\/doi.org\/10.1038\/s41420-024-01923-6 (2024).","DOI":"10.1038\/s41420-024-01923-6"},{"key":"38164_CR53","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1093\/jleuko\/qiae066","volume":"116","author":"K Murata","year":"2024","unstructured":"Murata, K., Murao, A., Tan, C., Wang, P. & Aziz, M. B-1a cells scavenge NETs to attenuate sepsis. J. Leukoc. Biol. 116, 632\u2013643. https:\/\/doi.org\/10.1093\/jleuko\/qiae066 (2024).","journal-title":"J. Leukoc. Biol."},{"key":"38164_CR54","doi-asserted-by":"publisher","unstructured":"Wortmann, M. et al. Inflammasomes in the pathophysiology of aortic disease. Cells 10 https:\/\/doi.org\/10.3390\/cells10092433 (2021).","DOI":"10.3390\/cells10092433"},{"key":"38164_CR55","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.avsg.2017.10.001","volume":"46","author":"AW Akerman","year":"2018","unstructured":"Akerman, A. W. et al. Elevated wall tension initiates Interleukin-6 expression and abdominal aortic dilation. Ann. Vasc. Surg. 46, 193\u2013204. https:\/\/doi.org\/10.1016\/j.avsg.2017.10.001 (2018).","journal-title":"Ann. Vasc. Surg."},{"key":"38164_CR56","doi-asserted-by":"publisher","first-page":"8","DOI":"10.3400\/avd.ra.23-00003","volume":"16","author":"M Sano","year":"2023","unstructured":"Sano, M. Complexity of inflammation in the trajectory of vascular disease: Interleukin 6 and beyond. Annals Vascular Dis. 16, 8\u201316. https:\/\/doi.org\/10.3400\/avd.ra.23-00003 (2023).","journal-title":"Annals Vascular Dis."},{"key":"38164_CR57","doi-asserted-by":"publisher","first-page":"14893","DOI":"10.1038\/s41598-024-65931-3","volume":"14","author":"T Inoue","year":"2024","unstructured":"Inoue, T. et al. Intense impact of IL-1\u03b2 expressing inflammatory macrophages in acute aortic dissection. Sci. Rep. 14, 14893. https:\/\/doi.org\/10.1038\/s41598-024-65931-3 (2024).","journal-title":"Sci. Rep."},{"key":"38164_CR58","doi-asserted-by":"publisher","first-page":"9498","DOI":"10.1096\/fj.201902550RRR","volume":"34","author":"SH Tsai","year":"2020","unstructured":"Tsai, S. H. et al. Aldehyde dehydrogenase 2 protects against abdominal aortic aneurysm formation by reducing reactive oxygen species, vascular inflammation, and apoptosis of vascular smooth muscle cells. FASEB J. Off. Publ. Fed. Am. Soc. Exper. Biol.. 34, 9498\u20139511. https:\/\/doi.org\/10.1096\/fj.201902550RRR (2020).","journal-title":"FASEB J. Off. Publ. Fed. Am. Soc. Exper. Biol."},{"key":"38164_CR59","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.1038\/nm.3368","volume":"19","author":"X Qiang","year":"2013","unstructured":"Qiang, X. et al. Cold-inducible RNA-binding protein (CIRP) triggers inflammatory responses in hemorrhagic shock and sepsis. Nat. Med. 19, 1489\u20131495. https:\/\/doi.org\/10.1038\/nm.3368 (2013).","journal-title":"Nat. Med."},{"key":"38164_CR60","doi-asserted-by":"publisher","first-page":"72S","DOI":"10.1016\/j.jvs.2017.09.042","volume":"68","author":"SH Tsai","year":"2018","unstructured":"Tsai, S. H. et al. Fucoidan attenuates angiotensin II-induced abdominal aortic aneurysms through the inhibition of c-Jun N-terminal kinase and nuclear factor kappab activation. J. Vasc Surg. 68, 72S\u201381. S.e71 (2018).","journal-title":"J. Vasc Surg."},{"key":"38164_CR61","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.intimp.2016.07.007","volume":"39","author":"L Chen","year":"2016","unstructured":"Chen, L., Ran, D., Xie, W., Xu, Q. & Zhou, X. Cold-inducible RNA-binding protein mediates cold air inducible airway mucin production through TLR4\/NF-\u03baB signaling pathway. Int. Immunopharmacol. 39, 48\u201356. https:\/\/doi.org\/10.1016\/j.intimp.2016.07.007 (2016).","journal-title":"Int. Immunopharmacol."},{"key":"38164_CR62","doi-asserted-by":"publisher","unstructured":"Han, J. et al. Exosome-derived CIRP: an amplifier of inflammatory diseases. Front. Immunol. 14 https:\/\/doi.org\/10.3389\/fimmu.2023.1066721 (2023).","DOI":"10.3389\/fimmu.2023.1066721"},{"key":"38164_CR63","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1186\/s40779-024-00574-z","volume":"11","author":"T Gong","year":"2024","unstructured":"Gong, T. et al. Mechanism of lactic acidemia-promoted pulmonary endothelial cells death in sepsis: Role for CIRP-ZBP1-PANoptosis pathway. Mil Med. Res. 11, 71. https:\/\/doi.org\/10.1186\/s40779-024-00574-z (2024).","journal-title":"Mil Med. Res."},{"key":"38164_CR64","doi-asserted-by":"publisher","DOI":"10.1172\/jci82337","author":"C Zhang","year":"2016","unstructured":"Zhang, C. et al. Matricellular protein CCN3 mitigates abdominal aortic aneurysm. J. Clin. Invest. https:\/\/doi.org\/10.1172\/jci82337 (2016).","journal-title":"J. Clin. Invest."},{"key":"38164_CR65","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/j.omtn.2020.06.005","volume":"21","author":"L Zhong","year":"2020","unstructured":"Zhong, L. et al. METTL3 induces AAA development and progression by modulating N6-Methyladenosine-dependent primary miR34a processing. Mol. Therapy Nucleic Acids. 21, 394\u2013411. https:\/\/doi.org\/10.1016\/j.omtn.2020.06.005 (2020).","journal-title":"Mol. Therapy Nucleic Acids"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-38164-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-38164-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-38164-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T23:27:38Z","timestamp":1776727658000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-38164-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,10]]},"references-count":65,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["38164"],"URL":"https:\/\/doi.org\/10.1038\/s41598-026-38164-9","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,10]]},"assertion":[{"value":"14 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"All experimental protocols and procedures (IACUC-21-275) were approved by the institutional animal care committee of the National Defense Medical Center (Taipei, Taiwan) and complied with the Guide for the Care and Use of Laboratory Animals published by the US National Institutes of Health (8th edition, 2011).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"12964"}}