{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T05:06:15Z","timestamp":1782277575434,"version":"3.54.5"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T00:00:00Z","timestamp":1770508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:00:00Z","timestamp":1772582400000},"content-version":"vor","delay-in-days":24,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Colegio Profesional de Fisioterapeutas de Castilla y Le\u00f3n, Spain (CPFCYL),","award":["S\/2024\/01503 CO"],"award-info":[{"award-number":["S\/2024\/01503 CO"]}]},{"name":"Colegio Profesional de Fisioterapeutas de Castilla y Le\u00f3n, Spain (CPFCYL),","award":["S\/2024\/01503 CO"],"award-info":[{"award-number":["S\/2024\/01503 CO"]}]},{"name":"Colegio Profesional de Fisioterapeutas de Castilla y Le\u00f3n, Spain (CPFCYL),","award":["S\/2024\/01503 CO"],"award-info":[{"award-number":["S\/2024\/01503 CO"]}]},{"name":"Colegio Profesional de Fisioterapeutas de Castilla y Le\u00f3n, Spain (CPFCYL),","award":["S\/2024\/01503 CO"],"award-info":[{"award-number":["S\/2024\/01503 CO"]}]},{"name":"Colegio Profesional de Fisioterapeutas de Castilla y Le\u00f3n, Spain (CPFCYL),","award":["S\/2024\/01503 CO"],"award-info":[{"award-number":["S\/2024\/01503 CO"]}]},{"name":"Colegio Profesional de Fisioterapeutas de Castilla y Le\u00f3n, Spain (CPFCYL),","award":["S\/2024\/01503 CO"],"award-info":[{"award-number":["S\/2024\/01503 CO"]}]},{"name":"Colegio Profesional de Fisioterapeutas de Castilla y Le\u00f3n, Spain (CPFCYL),","award":["S\/2024\/01503 CO"],"award-info":[{"award-number":["S\/2024\/01503 CO"]}]},{"name":"Colegio Profesional de Fisioterapeutas de Castilla y Le\u00f3n, Spain (CPFCYL),","award":["S\/2024\/01503 CO"],"award-info":[{"award-number":["S\/2024\/01503 CO"]}]},{"name":"Colegio Profesional de Fisioterapeutas de Castilla y Le\u00f3n, Spain (CPFCYL),","award":["S\/2024\/01503 CO"],"award-info":[{"award-number":["S\/2024\/01503 CO"]}]},{"name":"Colegio Profesional de Fisioterapeutas de Castilla y Le\u00f3n, Spain (CPFCYL),","award":["S\/2024\/01503 CO"],"award-info":[{"award-number":["S\/2024\/01503 CO"]}]},{"name":"Colegio Profesional de Fisioterapeutas de Castilla y Le\u00f3n, Spain (CPFCYL),","award":["S\/2024\/01503 CO"],"award-info":[{"award-number":["S\/2024\/01503 CO"]}]},{"name":"Colegio Profesional de Fisioterapeutas de Castilla y Le\u00f3n, Spain (CPFCYL),","award":["S\/2024\/01503 CO"],"award-info":[{"award-number":["S\/2024\/01503 CO"]}]},{"name":"Colegio Profesional de Fisioterapeutas de Castilla y Le\u00f3n, Spain (CPFCYL),","award":["S\/2024\/01503 CO"],"award-info":[{"award-number":["S\/2024\/01503 CO"]}]},{"name":"Colegio Profesional de Fisioterapeutas de Castilla y Le\u00f3n, Spain (CPFCYL),","award":["S\/2024\/01503 CO"],"award-info":[{"award-number":["S\/2024\/01503 CO"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-026-38721-2","type":"journal-article","created":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T12:34:56Z","timestamp":1770554096000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A pilot randomized trial of supervised resistance training plus home-based activity in chronic lymphocytic leukaemia patients"],"prefix":"10.1038","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4791-6513","authenticated-orcid":false,"given":"Juan Luis","family":"S\u00e1nchez-Gonz\u00e1lez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2175-8545","authenticated-orcid":false,"given":"Eduardo Jos\u00e9","family":"Fern\u00e1ndez-Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4486-4076","authenticated-orcid":false,"given":"Roberto","family":"M\u00e9ndez-S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8349-0441","authenticated-orcid":false,"given":"Luis","family":"Polo-Ferrero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0230-4636","authenticated-orcid":false,"given":"Silvia","family":"Puente-Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8167-6410","authenticated-orcid":false,"given":"Cristina","family":"de Ram\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4377-2953","authenticated-orcid":false,"given":"Sara","family":"Marcos-Asensio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1359-2153","authenticated-orcid":false,"given":"Patricia","family":"Bl\u00e1zquez-Benito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8289-0884","authenticated-orcid":false,"given":"M\u00f3nica","family":"Baile-Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7972-5666","authenticated-orcid":false,"given":"Almudena","family":"Navarro-Bail\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7076-7739","authenticated-orcid":false,"given":"Fermin","family":"S\u00e1nchez-Guijo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3962-7356","authenticated-orcid":false,"given":"Javier","family":"Mart\u00edn-Vallejo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0740-190X","authenticated-orcid":false,"given":"Jesus","family":"Perez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8627-3645","authenticated-orcid":false,"given":"Carlos","family":"Mart\u00edn-S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,8]]},"reference":[{"key":"38721_CR1","unstructured":"American Cancer Society. Key Statistics for Chronic Lymphocytic Leukemia (2024). https:\/\/www.cancer.org\/cancer\/types\/chronic-lymphocytic-leukemia\/about\/key-statistics.html."},{"key":"38721_CR2","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1056\/NEJMra1908213","volume":"383","author":"JA Burger","year":"2020","unstructured":"Burger, J. A. Treatment of chronic lymphocytic leukemia. N Engl. J. Med. 383, 460\u2013473 (2020).","journal-title":"N Engl. J. Med."},{"key":"38721_CR3","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1056\/NEJMoa1817073","volume":"381","author":"TD Shanafelt","year":"2019","unstructured":"Shanafelt, T. D. et al. Ibrutinib\u2013Rituximab or chemoimmunotherapy for chronic lymphocytic leukemia. N Engl. J. Med. 381, 432\u2013443 (2019).","journal-title":"N Engl. J. Med."},{"key":"38721_CR4","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1182\/blood-2017-09-746420","volume":"131","author":"GA Abel","year":"2018","unstructured":"Abel, G. A. & Klepin, H. D. Frailty and the management of hematologic malignancies. Blood 131, 515\u2013524 (2018).","journal-title":"Blood"},{"key":"38721_CR5","doi-asserted-by":"publisher","first-page":"789","DOI":"10.3109\/10428194.2015.1091933","volume":"57","author":"V Goede","year":"2016","unstructured":"Goede, V. et al. Evaluation of geriatric assessment in patients with chronic lymphocytic leukemia: results of the CLL9 trial of the German CLL study group. Leuk. Lymphoma. 57, 789\u2013796 (2016).","journal-title":"Leuk. Lymphoma"},{"key":"38721_CR6","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1093\/abm\/kax004","volume":"52","author":"NG Goyal","year":"2018","unstructured":"Goyal, N. G. et al. Cancer-Specific stress and trajectories of psychological and physical functioning in patients with Relapsed\/Refractory chronic lymphocytic leukemia. Ann. Behav. Med. 52, 287\u2013298 (2018).","journal-title":"Ann. Behav. Med."},{"key":"38721_CR7","doi-asserted-by":"crossref","unstructured":"Paolo et al. Impact of idelalisib on health-related quality of life in patients with relapsed chronic lymphocytic leukemia in a phase III randomized trial. haematol 105, e519 (2020).","DOI":"10.3324\/haematol.2019.238808"},{"key":"38721_CR8","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.1080\/03007995.2023.2262378","volume":"39","author":"CS Tam","year":"2023","unstructured":"Tam, C. S. et al. Health-related quality of life outcomes associated with zanubrutinib versus ibrutinib monotherapy in patients with relapsed\/refractory chronic lymphocytic leukemia and small lymphocytic lymphoma: results from the ALPINE trial. Curr. Med. Res. Opin. 39, 1497\u20131503 (2023).","journal-title":"Curr. Med. Res. Opin."},{"key":"38721_CR9","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1136\/bjsports-2022-105669","volume":"57","author":"L Garcia","year":"2023","unstructured":"Garcia, L. et al. Non-occupational physical activity and risk of cardiovascular disease, cancer and mortality outcomes: a dose\u2013response meta-analysis of large prospective studies. Br. J. Sports Med. 57, 979\u2013989 (2023).","journal-title":"Br. J. Sports Med."},{"key":"38721_CR10","first-page":"4651","volume":"30","author":"D Medeiros Torres","year":"2022","unstructured":"Medeiros Torres, D., Koifman, J., Da Silva Santos, S. & R. & Impact on fatigue of different types of physical exercise during adjuvant chemotherapy and radiotherapy in breast cancer: systematic review and meta-analysis. Support Care Cancer. 30, 4651\u20134662 (2022).","journal-title":"Support Care Cancer"},{"key":"38721_CR11","doi-asserted-by":"publisher","first-page":"3714","DOI":"10.1002\/cam4.4746","volume":"11","author":"S Rodr\u00edguez-Ca\u00f1amero","year":"2022","unstructured":"Rodr\u00edguez-Ca\u00f1amero, S. et al. Impact of physical exercise in advanced\u2010stage cancer patients: systematic review and meta\u2010analysis. Cancer Med. 11, 3714\u20133727 (2022).","journal-title":"Cancer Med."},{"key":"38721_CR12","doi-asserted-by":"publisher","first-page":"151504","DOI":"10.1016\/j.soncn.2023.151504","volume":"39","author":"M Moore","year":"2023","unstructured":"Moore, M., Northey, J. M., Crispin, P., Semple, S. & Toohey, K. Effects of exercise rehabilitation on physical function in adults with hematological cancer receiving active treatment: a systematic review and Meta-Analysis. Semin. Oncol. Nurs. 39, 151504 (2023).","journal-title":"Semin. Oncol. Nurs."},{"key":"38721_CR13","first-page":"7111","volume":"29","author":"MC Prins","year":"2021","unstructured":"Prins, M. C. et al. The effect of exercise and nutrition interventions on physical functioning in patients undergoing Haematopoietic stem cell transplantation: a systematic review and meta-analysis. Support Care Cancer. 29, 7111\u20137126 (2021).","journal-title":"Support Care Cancer"},{"key":"38721_CR14","doi-asserted-by":"publisher","first-page":"101373","DOI":"10.1016\/j.jgo.2022.09.002","volume":"14","author":"AL Artese","year":"2023","unstructured":"Artese, A. L. et al. Effects of high-intensity interval training on health-related quality of life in chronic lymphocytic leukemia: a pilot study. J. Geriatric Oncol. 14, 101373 (2023).","journal-title":"J. Geriatric Oncol."},{"key":"38721_CR15","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1111\/ejh.13958","volume":"110","author":"JC Crane","year":"2023","unstructured":"Crane, J. C. et al. Relationships between T-lymphocytes and physical function in adults with chronic lymphocytic leukemia: results from the HEALTH4CLL pilot study. Eur. J. Haematol. 110, 732\u2013742 (2023).","journal-title":"Eur. J. Haematol."},{"key":"38721_CR16","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1007\/s11912-024-01558-x","volume":"26","author":"AP Navarrete-Reyes","year":"2024","unstructured":"Navarrete-Reyes, A. P., Mateos-Soria, A. S., S\u00e1nchez-Hern\u00e1ndez, J. J. & Negrete-Najar, J. P. Frailty and cancer prognosis. Curr. Oncol. Rep. 26, 991\u20131020 (2024).","journal-title":"Curr. Oncol. Rep."},{"key":"38721_CR17","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.mcna.2022.04.006","volume":"107","author":"CI Cohen","year":"2023","unstructured":"Cohen, C. I. et al. Med. Clin. North Am. 107, 183\u2013197 (2023).","journal-title":"Med. Clin. North Am."},{"key":"38721_CR18","doi-asserted-by":"crossref","unstructured":"Miles, E. E. et al. Physical activity, symptoms, quality of life and exercise program preferences in people eith chronic lymphocytic leukaemia. eJHaem 6, e70100 (2025).","DOI":"10.1002\/jha2.70100"},{"key":"38721_CR19","doi-asserted-by":"publisher","first-page":"e198398","DOI":"10.1001\/jamanetworkopen.2019.8398","volume":"2","author":"R Ofori-Asenso","year":"2019","unstructured":"Ofori-Asenso, R. et al. Global incidence of frailty and prefrailty among Community-Dwelling older adults: a systematic review and Meta-analysis. JAMA Netw. Open. 2, e198398 (2019).","journal-title":"JAMA Netw. Open."},{"key":"38721_CR20","doi-asserted-by":"publisher","first-page":"1534861","DOI":"10.3389\/fspor.2025.1534861","volume":"7","author":"JL S\u00e1nchez-Gonz\u00e1lez","year":"2025","unstructured":"S\u00e1nchez-Gonz\u00e1lez, J. L. et al. Effects of a strength physical exercise program in chronic lymphocytic leukemia patients on quality of life, mental health, and frailty: a randomized controlled trial study protocol. Front. Sports Act. Living. 7, 1534861 (2025).","journal-title":"Front. Sports Act. Living"},{"key":"38721_CR21","doi-asserted-by":"publisher","first-page":"M85","DOI":"10.1093\/geronj\/49.2.M85","volume":"49","author":"JM Guralnik","year":"1994","unstructured":"Guralnik, J. M. et al. A short physical performance battery assessing lower extremity function: association with Self-Reported disability and prediction of mortality and nursing home admission. J. Gerontol. 49, M85\u2013M94 (1994).","journal-title":"J. Gerontol."},{"key":"38721_CR22","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1093\/ageing\/afy169","volume":"48","author":"AJ Cruz-Jentoft","year":"2019","unstructured":"Cruz-Jentoft, A. J. et al. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing. 48, 16\u201331 (2019).","journal-title":"Age Ageing"},{"key":"38721_CR23","doi-asserted-by":"publisher","first-page":"1430","DOI":"10.1016\/j.clnu.2004.09.012","volume":"23","author":"UG Kyle","year":"2004","unstructured":"Kyle, U. G. et al. Bioelectrical impedance analysis\u2014part II: utilization in clinical practice. Clin. Nutr. 23, 1430\u20131453 (2004).","journal-title":"Clin. Nutr."},{"key":"38721_CR24","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1093\/ageing\/afv192","volume":"45","author":"RM Dodds","year":"2016","unstructured":"Dodds, R. M. et al. Global variation in grip strength: a systematic review and meta-analysis of normative data. Age Ageing. 45, 209\u2013216 (2016).","journal-title":"Age Ageing"},{"key":"38721_CR25","doi-asserted-by":"crossref","unstructured":"Weis, J. et al. International psychometric validation of an EORTC quality of life module measuring cancer related fatigue (EORTC QLQ-FA12). JNCI: J. Natl. Cancer Inst. 109, 1452 (2017).","DOI":"10.1093\/jnci\/djw273"},{"key":"38721_CR26","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1093\/jnci\/85.5.365","volume":"85","author":"NK Aaronson","year":"1993","unstructured":"Aaronson, N. K. et al. The European organization for research and treatment of cancer QLQ-C30: a Quality-of-Life instrument for use in international clinical trials in oncology. JNCI J. Natl. Cancer Inst. 85, 365\u2013376 (1993).","journal-title":"JNCI J. Natl. Cancer Inst."},{"key":"38721_CR27","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1007\/s11136-017-1718-y","volume":"27","author":"L Van De Poll-Franse","year":"2018","unstructured":"Van De Poll-Franse, L. et al. International development of four EORTC disease-specific quality of life questionnaires for patients with hodgkin lymphoma, high- and low-grade non-Hodgkin lymphoma and chronic lymphocytic leukaemia. Qual. Life Res. 27, 333\u2013345 (2018).","journal-title":"Qual. Life Res."},{"key":"38721_CR28","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1111\/j.1600-0447.1983.tb09716.x","volume":"67","author":"AS Zigmond","year":"1983","unstructured":"Zigmond, A. S. & Snaith, R. P. The hospital anxiety and depression scale. Acta Psychiatr Scand. 67, 361\u2013370 (1983).","journal-title":"Acta Psychiatr Scand."},{"key":"38721_CR29","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1016\/S0022-3999(00)00095-7","volume":"48","author":"CR Soldatos","year":"2000","unstructured":"Soldatos, C. R., Dikeos, D. G. & Paparrigopoulos, T. J. Athens insomnia scale: validation of an instrument based on ICD-10 criteria. J. Psychosom. Res. 48, 555\u2013560 (2000).","journal-title":"J. Psychosom. Res."},{"key":"38721_CR30","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/S0022-3999(02)00604-9","volume":"55","author":"CR Soldatos","year":"2003","unstructured":"Soldatos, C. R., Dikeos, D. G. & Paparrigopoulos, T. J. The diagnostic validity of the Athens insomnia scale. J. Psychosom. Res. 55, 263\u2013267 (2003).","journal-title":"J. Psychosom. Res."},{"key":"38721_CR31","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1007\/BF03324831","volume":"18","author":"S Bandinelli","year":"2006","unstructured":"Bandinelli, S. et al. A randomized, controlled trial of disability prevention in frail older patients screened in primary care: the FRASI Study. Design and baseline evaluation. Aging Clin. Exp. Res. 18, 359\u2013366 (2006).","journal-title":"Aging Clin. Exp. Res."},{"key":"38721_CR32","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1111\/j.1532-5415.2006.00701.x","volume":"54","author":"S Perera","year":"2006","unstructured":"Perera, S., Mody, S. H., Woodman, R. C. & Studenski, S. A. Meaningful change and responsiveness in common physical performance measures in older adults. J. Am. Geriatr. Soc. 54, 743\u2013749 (2006).","journal-title":"J. Am. Geriatr. Soc."},{"key":"38721_CR33","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1037\/1082-989X.7.3.370","volume":"7","author":"DG Bonett","year":"2002","unstructured":"Bonett, D. G. & Price, R. M. Statistical inference for a linear function of medians: confidence intervals, hypothesis testing, and sample size requirements. Psychol. Methods 7, 370\u2013383 (2002).","journal-title":"Psychol. Methods"},{"key":"38721_CR34","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1002\/ejsp.2420020412","volume":"2","author":"HW Wendt","year":"1972","unstructured":"Wendt, H. W. Dealing with a common problem in social science: a simplified rank-biserial coefficient of correlation based on the U statistic. Euro. J. Soc. Psych. 2, 463\u2013465 (1972).","journal-title":"Euro. J. Soc. Psych."},{"key":"38721_CR35","doi-asserted-by":"publisher","unstructured":"Cohen, J. Statistical Power Analysis for the Behavioral Sciences (Routledge, 2013). https:\/\/doi.org\/10.4324\/9780203771587.","DOI":"10.4324\/9780203771587"},{"key":"38721_CR36","unstructured":"The jamovi project (2025)."},{"key":"38721_CR37","doi-asserted-by":"publisher","first-page":"1472551","DOI":"10.3389\/fonc.2024.1472551","volume":"14","author":"FF Brown","year":"2024","unstructured":"Brown, F. F. et al. A 16-week progressive exercise training intervention in treatment-na\u00efve chronic lymphocytic leukaemia: a randomised-controlled pilot study. Front. Oncol. 14, 1472551 (2024).","journal-title":"Front. Oncol."},{"key":"38721_CR38","first-page":"94","volume":"33","author":"J Huesmann","year":"2025","unstructured":"Huesmann, J. et al. H\u00e4matrain-Hybrid movement therapy during inpatient and outpatient hematological treatment: correlations with physical and psychological parameters. Support Care Cancer. 33, 94 (2025).","journal-title":"Support Care Cancer"},{"key":"38721_CR39","first-page":"685","volume":"33","author":"Y Luo","year":"2025","unstructured":"Luo, Y. et al. Safety, feasibility, and effectiveness of exercise interventions in patients with hematologic malignancy during chemotherapy: a systematic review and meta-analysis. Support Care Cancer. 33, 685 (2025).","journal-title":"Support Care Cancer"},{"key":"38721_CR40","first-page":"1697","volume":"24","author":"BJ Furzer","year":"2016","unstructured":"Furzer, B. J. et al. A randomised controlled trial comparing the effects of a 12-week supervised exercise versus usual care on outcomes in haematological cancer patients. Support Care Cancer. 24, 1697\u20131707 (2016).","journal-title":"Support Care Cancer"},{"key":"38721_CR41","first-page":"CD009075","volume":"1","author":"L Knips","year":"2019","unstructured":"Knips, L. et al. Aerobic physical exercise for adult patients with haematological malignancies. Cochrane Database Syst. Rev. 1, CD009075 (2019).","journal-title":"Cochrane Database Syst. Rev."},{"key":"38721_CR42","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1007\/s11764-024-01555-w","volume":"19","author":"CY Lee","year":"2025","unstructured":"Lee, C. Y. et al. Optimization of mHealth behavioral interventions for patients with chronic lymphocytic leukemia: the HEALTH4CLL study. J. Cancer Surviv. 19, 1325\u20131334 (2025).","journal-title":"J. Cancer Surviv"},{"key":"38721_CR43","first-page":"61","volume":"31","author":"MA Accogli","year":"2023","unstructured":"Accogli, M. A., Denti, M., Costi, S. & Fugazzaro, S. Therapeutic education and physical activity are feasible and safe in hematologic cancer patients referred to chemotherapy: results of a randomized controlled trial. Support Care Cancer. 31, 61 (2023).","journal-title":"Support Care Cancer"},{"key":"38721_CR44","doi-asserted-by":"publisher","first-page":"467","DOI":"10.3390\/healthcare13050467","volume":"13","author":"A Borsati","year":"2025","unstructured":"Borsati, A. et al. The effect of exercise-based interventions on health-related quality of life of patients with hematological malignancies: a systematic review and meta-analysis. Healthcare 13, 467 (2025).","journal-title":"Healthcare"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-38721-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-38721-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-38721-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T09:37:09Z","timestamp":1772617029000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-38721-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,8]]},"references-count":44,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["38721"],"URL":"https:\/\/doi.org\/10.1038\/s41598-026-38721-2","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,8]]},"assertion":[{"value":"29 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The studies involving humans were approved by this study involving human participants has been reviewed and approved by the Research Ethics Committee for Medicinal Products of the University Hospital of Salamanca (record number2024\/11). The studies were conducted in accordance with the local legislation and institutional requirements. The participants provided their written informed consent to participate in this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}],"article-number":"8053"}}