{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T10:36:06Z","timestamp":1772102166857,"version":"3.50.1"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T00:00:00Z","timestamp":1770422400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"vor","delay-in-days":19,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100003030","name":"Ag\u00e8ncia de Gesti\u00f3 d'Ajuts Universitaris i de Recerca","doi-asserted-by":"publisher","award":["AGAUR 2018 FIB00696, Generalitat de Catalunya and FSE (European Union)"],"award-info":[{"award-number":["AGAUR 2018 FIB00696, Generalitat de Catalunya and FSE (European Union)"]}],"id":[{"id":"10.13039\/501100003030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003030","name":"Ag\u00e8ncia de Gesti\u00f3 d'Ajuts Universitaris i de Recerca","doi-asserted-by":"publisher","award":["Suport Grups de Recerca AGAUR ( 2021-SGR-01343)"],"award-info":[{"award-number":["Suport Grups de Recerca AGAUR ( 2021-SGR-01343)"]}],"id":[{"id":"10.13039\/501100003030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003030","name":"Ag\u00e8ncia de Gesti\u00f3 d'Ajuts Universitaris i de Recerca","doi-asserted-by":"publisher","award":["Suport Grups de Recerca AGAUR  (2021-SGR-01294)"],"award-info":[{"award-number":["Suport Grups de Recerca AGAUR  (2021-SGR-01294)"]}],"id":[{"id":"10.13039\/501100003030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003030","name":"Ag\u00e8ncia de Gesti\u00f3 d'Ajuts Universitaris i de Recerca","doi-asserted-by":"publisher","award":["Suport Grups de Recerca AGAUR (2021-SGR-01172)"],"award-info":[{"award-number":["Suport Grups de Recerca AGAUR (2021-SGR-01172)"]}],"id":[{"id":"10.13039\/501100003030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003741","name":"Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats","doi-asserted-by":"publisher","award":["Academia Researcher of the \"Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats\" (ICREA) of the Generalitat de Catalunya"],"award-info":[{"award-number":["Academia Researcher of the \"Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats\" (ICREA) of the Generalitat de Catalunya"]}],"id":[{"id":"10.13039\/501100003741","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["Spanish Ministry of Science, Innovation and Universities (MCIN) & European Regional Development Fund (ERDF, \u201cA way of making Europe\u201d) PID2021-124894OB-I00"],"award-info":[{"award-number":["Spanish Ministry of Science, Innovation and Universities (MCIN) & European Regional Development Fund (ERDF, \u201cA way of making Europe\u201d) PID2021-124894OB-I00"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["Spanish Ministry of Science, Innovation and Universities (MCIN) & European Regional Development Fund (ERDF, \u201cA way of making Europe\u201d) PID2021-123054OB-I00"],"award-info":[{"award-number":["Spanish Ministry of Science, Innovation and Universities (MCIN) & European Regional Development Fund (ERDF, \u201cA way of making Europe\u201d) PID2021-123054OB-I00"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008666","name":"Fundaci\u00f3 la Marat\u00f3 de TV3","doi-asserted-by":"publisher","award":["(\u201cprojecte finan\u00e7at per Fundaci\u00f3 La Marat\u00f3 de TV3\u201d) TAIFOL project, 201933-30"],"award-info":[{"award-number":["(\u201cprojecte finan\u00e7at per Fundaci\u00f3 La Marat\u00f3 de TV3\u201d) TAIFOL project, 201933-30"]}],"id":[{"id":"10.13039\/100008666","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008666","name":"Fundaci\u00f3 la Marat\u00f3 de TV3","doi-asserted-by":"publisher","award":["(\u201cprojecte finan\u00e7at per Fundaci\u00f3 La Marat\u00f3 de TV3\u201d) 201920-30"],"award-info":[{"award-number":["(\u201cprojecte finan\u00e7at per Fundaci\u00f3 La Marat\u00f3 de TV3\u201d) 201920-30"]}],"id":[{"id":"10.13039\/100008666","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013276","name":"Interreg","doi-asserted-by":"publisher","award":["POCTEFA program (IMLINFO EFA281\/16 and THERAVLINFO EFA123\/1"],"award-info":[{"award-number":["POCTEFA program (IMLINFO EFA281\/16 and THERAVLINFO EFA123\/1"]}],"id":[{"id":"10.13039\/100013276","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014139","name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer","doi-asserted-by":"publisher","award":["CIBERONC (ONCG09\/2025)"],"award-info":[{"award-number":["CIBERONC (ONCG09\/2025)"]}],"id":[{"id":"10.13039\/501100014139","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-026-38971-0","type":"journal-article","created":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T09:49:01Z","timestamp":1770457741000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The expression of MALAT1 long non-coding RNA is associated with good prognosis in mantle cell lymphoma"],"prefix":"10.1038","volume":"16","author":[{"given":"Elena Mar\u00eda","family":"Fern\u00e1ndez-Garnacho","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Mart\u00ednez-Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferran","family":"Nadeu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillem","family":"Clot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Garc\u00eda","family":"Valero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferran","family":"Araujo-Ayala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ares","family":"Mart\u00ednez-Farran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"De Bol\u00f2s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dolors","family":"Colomer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"Mozas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Rivero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Gin\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armando","family":"L\u00f3pez-Guillermo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Itziar","family":"Salaverria","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00edlvia","family":"Be\u00e0","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginia","family":"Amador","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santiago","family":"Demajo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Jares","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Ignacio","family":"Mart\u00edn-Subero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"P\u00e9rez-Gal\u00e1n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"El\u00edas","family":"Campo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Llu\u00eds","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,2,7]]},"reference":[{"issue":"4","key":"38971_CR1","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1007\/s13105-012-0166-y","volume":"68","author":"Y Huang","year":"2012","unstructured":"Huang, Y. et al. Regulatory long non-coding RNA and its functions. J. Physiol. Biochem. 68 (4), 611\u2013618. https:\/\/doi.org\/10.1007\/s13105-012-0166-y (2012).","journal-title":"J. Physiol. Biochem."},{"issue":"15","key":"38971_CR2","doi-asserted-by":"publisher","first-page":"3965","DOI":"10.1158\/0008-5472.CAN-16-2634","volume":"77","author":"A Bhan","year":"2017","unstructured":"Bhan, A., Soleimani, M. & Mandal, S. S. Long noncoding RNA and cancer: A new paradigm. Cancer Res. 77 (15), 3965\u20133981. https:\/\/doi.org\/10.1158\/0008-5472.CAN-16-2634 (2017).","journal-title":"Cancer Res."},{"key":"38971_CR3","doi-asserted-by":"publisher","first-page":"6757","DOI":"10.2147\/CMAR.S169406","volume":"10","author":"Z-X Li","year":"2018","unstructured":"Li, Z-X. et al. MALAT1: a potential biomarker in cancer. Cancer Manag Res. 10, 6757\u20136768. https:\/\/doi.org\/10.2147\/CMAR.S169406 (2018).","journal-title":"Cancer Manag Res."},{"issue":"12","key":"38971_CR4","doi-asserted-by":"publisher","first-page":"1705","DOI":"10.1080\/15476286.2017.1358347","volume":"14","author":"X Zhang","year":"2017","unstructured":"Zhang, X., Hamblin, M. H. & Yin, K-J. The long noncoding RNA Malat1: its physiological and pathophysiological functions. RNA Biol. 14 (12), 1705\u20131714. https:\/\/doi.org\/10.1080\/15476286.2017.1358347 (2017).","journal-title":"RNA Biol."},{"issue":"6","key":"38971_CR5","doi-asserted-by":"publisher","first-page":"2898","DOI":"10.1093\/nar\/gkw047","volume":"44","author":"X Zong","year":"2016","unstructured":"Zong, X. et al. Natural antisense RNA promotes 3\u2019 end processing and maturation of MALAT1 LncRNA. Nucleic Acids Res. 44 (6), 2898\u20132908. https:\/\/doi.org\/10.1093\/nar\/gkw047 (2016).","journal-title":"Nucleic Acids Res."},{"issue":"29","key":"38971_CR6","doi-asserted-by":"publisher","first-page":"11213","DOI":"10.1074\/jbc.RA118.006889","volume":"294","author":"JK Stone","year":"2019","unstructured":"Stone, J. K. et al. Hypoxia induces cancer cell-specific chromatin interactions and increases MALAT1 expression in breast cancer cells. J. Biol. Chem. 294 (29), 11213\u201311224. https:\/\/doi.org\/10.1074\/jbc.RA118.006889 (2019).","journal-title":"J. Biol. Chem."},{"issue":"1","key":"38971_CR7","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1186\/s12885-019-5962-0","volume":"19","author":"CP Gomes","year":"2019","unstructured":"Gomes, C. P. et al. An antisense transcript mediates MALAT1 response in human breast cancer. BMC Cancer. 19 (1), 771. https:\/\/doi.org\/10.1186\/s12885-019-5962-0 (2019).","journal-title":"BMC Cancer"},{"issue":"1","key":"38971_CR8","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1186\/s12967-016-1100-9","volume":"14","author":"X Wang","year":"2016","unstructured":"Wang, X. et al. LncRNA MALAT1 promotes development of mantle cell lymphoma by associating with EZH2. J. Transl Med. 14 (1), 346. https:\/\/doi.org\/10.1186\/s12967-016-1100-9 (2016).","journal-title":"J. Transl Med."},{"issue":"8","key":"38971_CR9","doi-asserted-by":"publisher","first-page":"991","DOI":"10.7150\/jca.14663","volume":"7","author":"Y Wang","year":"2016","unstructured":"Wang, Y. et al. The long noncoding RNA MALAT-1 is A novel biomarker in various cancers: A Meta-analysis based on the GEO database and literature. J. Cancer. 7 (8), 991\u20131001. https:\/\/doi.org\/10.7150\/jca.14663 (2016).","journal-title":"J. Cancer"},{"issue":"22","key":"38971_CR10","doi-asserted-by":"publisher","first-page":"2313","DOI":"10.1056\/NEJMoa0802885","volume":"359","author":"G Lenz","year":"2008","unstructured":"Lenz, G. et al. Stromal gene signatures in large-B-cell lymphomas. N Engl. J. Med. 359 (22), 2313\u20132323. https:\/\/doi.org\/10.1056\/NEJMoa0802885 (2008).","journal-title":"N Engl. J. Med."},{"issue":"3","key":"38971_CR11","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1002\/ijc.31386","volume":"143","author":"ZH Kwok","year":"2018","unstructured":"Kwok, Z. H., Roche, V., Chew, X. H., Fadieieva, A. & Tay, Y. A non-canonical tumor suppressive role for the long non-coding RNA MALAT1 in colon and breast cancers. Int. J. Cancer. 143 (3), 668\u2013678. https:\/\/doi.org\/10.1002\/ijc.31386 (2018).","journal-title":"Int. J. Cancer"},{"issue":"12","key":"38971_CR12","doi-asserted-by":"publisher","first-page":"1705","DOI":"10.1038\/s41588-018-0252-3","volume":"50","author":"J Kim","year":"2018","unstructured":"Kim, J. et al. Long noncoding RNA MALAT1 suppresses breast cancer metastasis. Nat. Genet. 50 (12), 1705\u20131715. https:\/\/doi.org\/10.1038\/s41588-018-0252-3 (2018).","journal-title":"Nat. Genet."},{"issue":"12","key":"38971_CR13","doi-asserted-by":"publisher","first-page":"3121","DOI":"10.1158\/1078-0432.CCR-12-3077","volume":"19","author":"A Navarro","year":"2013","unstructured":"Navarro, A. et al. MicroRNA expression profiles identify subtypes of mantle cell lymphoma with different clinicobiological characteristics. Clin. Cancer Res. 19 (12), 3121\u20133129. https:\/\/doi.org\/10.1158\/1078-0432.CCR-12-3077 (2013).","journal-title":"Clin. Cancer Res."},{"issue":"9","key":"38971_CR14","doi-asserted-by":"publisher","first-page":"1867","DOI":"10.3109\/10428194.2013.766731","volume":"54","author":"S Husby","year":"2013","unstructured":"Husby, S., Geisler, C. & Gr\u00f8nb\u00e6k, K. MicroRNAs in mantle cell lymphoma. Leuk. Lymphoma. 54 (9), 1867\u20131875. https:\/\/doi.org\/10.3109\/10428194.2013.766731 (2013).","journal-title":"Leuk. Lymphoma"},{"key":"38971_CR15","doi-asserted-by":"publisher","unstructured":"Kersy, O., Salmon-Divon, M., Shpilberg, O. & Hershkovitz-Rokah, O. Non-Coding RNAs in normal B-cell development and in mantle cell lymphoma: from molecular mechanism to biomarker and therapeutic agent potential. Int. J. Mol. Sci. 22 (17). https:\/\/doi.org\/10.3390\/ijms22179490 (2021).","DOI":"10.3390\/ijms22179490"},{"issue":"1","key":"38971_CR16","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1158\/1078-0432.CCR-20-2868","volume":"27","author":"S Demajo","year":"2021","unstructured":"Demajo, S. et al. A Cyclin D1-Dependent transcriptional program predicts clinical outcome in mantle cell lymphoma. Clin. Cancer Res. 27 (1), 213\u2013225. https:\/\/doi.org\/10.1158\/1078-0432.CCR-20-2868 (2021).","journal-title":"Clin. Cancer Res."},{"issue":"15","key":"38971_CR17","doi-asserted-by":"publisher","first-page":"1668","DOI":"10.1200\/JCO.2016.70.7901","volume":"35","author":"DW Scott","year":"2017","unstructured":"Scott, D. W. et al. New molecular assay for the proliferation signature in mantle cell lymphoma applicable to Formalin-Fixed Paraffin-Embedded biopsies. J. Clin. Oncol. 35 (15), 1668\u20131677. https:\/\/doi.org\/10.1200\/JCO.2016.70.7901 (2017).","journal-title":"J. Clin. Oncol."},{"issue":"1","key":"38971_CR18","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1182\/blood-2015-11-681460","volume":"128","author":"NS Saba","year":"2016","unstructured":"Saba, N. S. et al. Pathogenic role of B-cell receptor signaling and canonical NF-\u03baB activation in mantle cell lymphoma. Blood 128 (1), 82\u201392. https:\/\/doi.org\/10.1182\/blood-2015-11-681460 (2016).","journal-title":"Blood"},{"issue":"8","key":"38971_CR19","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.3324\/haematol.2011.040659","volume":"97","author":"DJ Medina","year":"2012","unstructured":"Medina, D. J. et al. Mesenchymal stromal cells protect mantle cell lymphoma cells from spontaneous and drug-induced apoptosis through secretion of B-cell activating factor and activation of the canonical and non-canonical nuclear factor \u03baB pathways. Haematologica 97 (8), 1255\u20131263. https:\/\/doi.org\/10.3324\/haematol.2011.040659 (2012).","journal-title":"Haematologica"},{"issue":"9","key":"38971_CR20","doi-asserted-by":"publisher","first-page":"e75280","DOI":"10.1371\/journal.pone.0075280","volume":"8","author":"S Manni","year":"2013","unstructured":"Manni, S. et al. Protein kinase CK2 Inhibition down modulates the NF-\u03baB and STAT3 survival pathways, enhances the cellular proteotoxic stress and synergistically boosts the cytotoxic effect of bortezomib on multiple myeloma and mantle cell lymphoma cells. PLoS One. 8 (9), e75280. https:\/\/doi.org\/10.1371\/journal.pone.0075280 (2013).","journal-title":"PLoS One"},{"key":"38971_CR21","doi-asserted-by":"publisher","first-page":"959138","DOI":"10.3389\/fimmu.2022.959138","volume":"13","author":"L Quotti Tubi","year":"2022","unstructured":"Quotti Tubi, L. et al. CK2\u03b2-regulated signaling controls B cell differentiation and function. Front. Immunol. 13, 959138. https:\/\/doi.org\/10.3389\/fimmu.2022.959138 (2022).","journal-title":"Front. Immunol."},{"issue":"6","key":"38971_CR22","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1038\/s41375-023-01885-1","volume":"37","author":"F Araujo-Ayala","year":"2023","unstructured":"Araujo-Ayala, F. et al. A novel patient-derived 3D model recapitulates mantle cell lymphoma lymph node signaling, immune profile and in vivo ibrutinib responses. Leukemia 37 (6), 1311\u20131323. https:\/\/doi.org\/10.1038\/s41375-023-01885-1 (2023).","journal-title":"Leukemia"},{"issue":"5","key":"38971_CR23","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1016\/j.hoc.2020.05.002","volume":"34","author":"A Navarro","year":"2020","unstructured":"Navarro, A., Be\u00e0, S., Jares, P. & Campo, E. Molecular pathogenesis of mantle cell lymphoma. Hematol. Oncol. Clin. North. Am. 34 (5), 795\u2013807. https:\/\/doi.org\/10.1016\/j.hoc.2020.05.002 (2020).","journal-title":"Hematol. Oncol. Clin. North. Am."},{"issue":"12","key":"38971_CR24","doi-asserted-by":"publisher","first-page":"1891","DOI":"10.1182\/bloodadvances.2018030262","volume":"3","author":"E Chartomatsidou","year":"2019","unstructured":"Chartomatsidou, E. et al. Inhibition of EZH2 and immune signaling exerts synergistic antitumor effects in chronic lymphocytic leukemia. Blood Adv. 3 (12), 1891\u20131896. https:\/\/doi.org\/10.1182\/bloodadvances.2018030262 (2019).","journal-title":"Blood Adv."},{"issue":"12","key":"38971_CR25","doi-asserted-by":"publisher","first-page":"2183","DOI":"10.1038\/s41379-021-00885-9","volume":"34","author":"D Martinez-Baquero","year":"2021","unstructured":"Martinez-Baquero, D. et al. EZH2 expression is associated with inferior overall survival in mantle cell lymphoma. Mod. Pathol. 34 (12), 2183\u20132191. https:\/\/doi.org\/10.1038\/s41379-021-00885-9 (2021).","journal-title":"Mod. Pathol."},{"issue":"1","key":"38971_CR26","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1093\/biostatistics\/kxj037","volume":"8","author":"WE Johnson","year":"2007","unstructured":"Johnson, W. E., Li, C. & Rabinovic, A. Adjusting batch effects in microarray expression data using empirical Bayes methods. Biostatistics 8 (1), 118\u2013127. https:\/\/doi.org\/10.1093\/biostatistics\/kxj037 (2007).","journal-title":"Biostatistics"},{"key":"38971_CR27","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1186\/1471-2164-8-200","volume":"8","author":"S Oeder","year":"2007","unstructured":"Oeder, S., Mages, J., Flicek, P. & Lang, R. Uncovering information on expression of natural antisense transcripts in affymetrix MOE430 datasets. BMC Genom. 8, 200. https:\/\/doi.org\/10.1186\/1471-2164-8-200 (2007).","journal-title":"BMC Genom."},{"issue":"4","key":"38971_CR28","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1111\/j.1541-0420.2008.00995.x","volume":"64","author":"T Hothorn","year":"2008","unstructured":"Hothorn, T. & Zeileis, A. Generalized maximally selected statistics. Biometrics 64 (4), 1263\u20131269. https:\/\/doi.org\/10.1111\/j.1541-0420.2008.00995.x (2008).","journal-title":"Biometrics"},{"issue":"4","key":"38971_CR29","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1182\/blood-2018-03-838136","volume":"132","author":"G Clot","year":"2018","unstructured":"Clot, G. et al. A gene signature that distinguishes conventional and leukemic nonnodal mantle cell lymphoma helps predict outcome. Blood 132 (4), 413\u2013422. https:\/\/doi.org\/10.1182\/blood-2018-03-838136 (2018).","journal-title":"Blood"},{"issue":"1","key":"38971_CR30","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1038\/s41467-019-09234-6","volume":"10","author":"Y Zhou","year":"2019","unstructured":"Zhou, Y. et al. Metascape provides a biologist-oriented resource for the analysis of systems-level datasets. Nat. Commun. 10 (1), 1523. https:\/\/doi.org\/10.1038\/s41467-019-09234-6 (2019).","journal-title":"Nat. Commun."},{"key":"38971_CR31","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1007\/978-1-61779-424-7_25","volume":"815","author":"HS Soifer","year":"2012","unstructured":"Soifer, H. S. et al. Silencing of gene expression by gymnotic delivery of antisense oligonucleotides. Methods Mol. Biol. 815, 333\u2013346. https:\/\/doi.org\/10.1007\/978-1-61779-424-7_25 (2012).","journal-title":"Methods Mol. Biol."},{"issue":"1","key":"38971_CR32","doi-asserted-by":"publisher","first-page":"16839","DOI":"10.1038\/s41598-023-44174-8","volume":"13","author":"EM Fern\u00e1ndez-Garnacho","year":"2023","unstructured":"Fern\u00e1ndez-Garnacho, E. M. et al. MALAT1 expression is associated with aggressive behavior in indolent B-cell neoplasms. Sci. Rep. 13 (1), 16839. https:\/\/doi.org\/10.1038\/s41598-023-44174-8 (2023).","journal-title":"Sci. Rep."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-38971-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-38971-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-38971-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T09:46:30Z","timestamp":1772099190000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-38971-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,7]]},"references-count":32,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["38971"],"URL":"https:\/\/doi.org\/10.1038\/s41598-026-38971-0","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,7]]},"assertion":[{"value":"12 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"E.C. has been a consultant for Takeda, NanoString, AbbVie and Illumina; has received honoraria from Janssen, EUSPharma and Roche for speaking at educational activities and research funding from AstraZeneca and is an inventor on 2 patents filed by the National Institutes of Health, National Cancer Institute: \u201cMethods for selecting and treating lymphoma types,\u201d licensed to NanoString Technologies, and \u201cEvaluation of mantle cell lymphoma and methods related thereof\u201d, not related to this project. F.N. has received honoraria from AbbVie, AstraZeneca, Janssen, and Sophia Genetics for speaking at educational activities. F.N. and E.C. have licensed to Diagnostica Longwood and Sophia Genetics the IgCaller algorithm. D.C. has received honoraria from AbbVie, Sophia Genetics, Thermofisher and AstraZeneca for speaking at educational activities. The remaining authors declare no competing financial interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The cryopreserved samples used for the functional studies were obtained from MCL patients were obtained from the Hematopathology collection of the Biobank of the Hospital Cl\u00ednic de Barcelona-IDIBAPS (Spain), in accordance with Declaration of Helsinki and national regulations, including the approval of the Institutional Review Board of Hospital Cl\u00ednic de Barcelona. All patients provided written informed consent.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}}],"article-number":"7655"}}