{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T17:44:06Z","timestamp":1773251046450,"version":"3.50.1"},"reference-count":69,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":26,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Hunan Normal University,China","award":["053112-3826"],"award-info":[{"award-number":["053112-3826"]}]},{"name":"National Natural Science Funding","award":["82170308"],"award-info":[{"award-number":["82170308"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-026-39063-9","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T11:24:58Z","timestamp":1770895498000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Zebrafish casr modulates cardiac structure and function"],"prefix":"10.1038","volume":"16","author":[{"given":"Ling","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuyao","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Binling","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guifang","family":"Tao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingying","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinrui","family":"Lv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huaping","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,2,12]]},"reference":[{"key":"39063_CR1","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/35036035","volume":"1","author":"MJ Berridge","year":"2000","unstructured":"Berridge, M. J., Lipp, P. & Bootman, M. D. The versatility and universality of calcium signalling. Nat. Rev. Mol. Cell. Biol. 1, 11\u201321. https:\/\/doi.org\/10.1038\/35036035 (2000).","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"39063_CR2","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1146\/annurev.ph.56.030194.001501","volume":"56","author":"OH Petersen","year":"1994","unstructured":"Petersen, O. H., Petersen, C. C. & Kasai, H. Calcium and hormone action. Annu. Rev. Physiol. 56, 297\u2013319. https:\/\/doi.org\/10.1146\/annurev.ph.56.030194.001501 (1994).","journal-title":"Annu. Rev. Physiol."},{"key":"39063_CR3","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1006\/scdb.2000.0211","volume":"12","author":"MD Bootman","year":"2001","unstructured":"Bootman, M. D. et al. Calcium signalling\u2013an overview. Semin Cell. Dev. Biol. 12, 3\u201310. https:\/\/doi.org\/10.1006\/scdb.2000.0211 (2001).","journal-title":"Semin Cell. Dev. Biol."},{"key":"39063_CR4","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1007\/s11427-016-5071-0","volume":"59","author":"AM Evans","year":"2016","unstructured":"Evans, A. M., Fameli, N., Ogunbayo, O. A., Duan, J. & Navarro-Dorado, J. From contraction to gene expression: nanojunctions of the sarco\/endoplasmic reticulum deliver site- and function-specific calcium signals. Sci. China Life Sci. 59, 749\u2013763. https:\/\/doi.org\/10.1007\/s11427-016-5071-0 (2016).","journal-title":"Sci. China Life Sci."},{"key":"39063_CR5","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1038\/27094","volume":"395","author":"MJ Berridge","year":"1998","unstructured":"Berridge, M. J., Bootman, M. D. & Lipp, P. Calcium\u2013a life and death signal. Nature 395, 645\u2013648. https:\/\/doi.org\/10.1038\/27094 (1998).","journal-title":"Nature"},{"key":"39063_CR6","doi-asserted-by":"publisher","first-page":"C221","DOI":"10.1152\/ajpcell.00139.2014","volume":"307","author":"TI Alfadda","year":"2014","unstructured":"Alfadda, T. I., Saleh, A. M., Houillier, P. & Geibel, J. P. Calcium-sensing receptor 20 years later. Am. J. Physiol. Cell. Physiol. 307, C221\u2013231. https:\/\/doi.org\/10.1152\/ajpcell.00139.2014 (2014).","journal-title":"Am. J. Physiol. Cell. Physiol."},{"key":"39063_CR7","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1152\/physrev.00042.2012","volume":"95","author":"M Carlstrom","year":"2015","unstructured":"Carlstrom, M., Wilcox, C. S. & Arendshorst, W. J. Renal autoregulation in health and disease. Physiol. Rev. 95, 405\u2013511. https:\/\/doi.org\/10.1152\/physrev.00042.2012 (2015).","journal-title":"Physiol. Rev."},{"key":"39063_CR8","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/s41574-018-0115-0","volume":"15","author":"FM Hannan","year":"2018","unstructured":"Hannan, F. M., Kallay, E., Chang, W., Brandi, M. L. & Thakker, R. V. The calcium-sensing receptor in physiology and in calcitropic and noncalcitropic diseases. Nat. Rev. Endocrinol. 15, 33\u201351. https:\/\/doi.org\/10.1038\/s41574-018-0115-0 (2018).","journal-title":"Nat. Rev. Endocrinol."},{"key":"39063_CR9","doi-asserted-by":"publisher","unstructured":"Brown, E. M. et al. Cloning and functional characterization of extracellular Ca(2+)-sensing receptors from parathyroid and kidney. Bone 17 https:\/\/doi.org\/10.1016\/8756-3282(95)00199-n (1995).","DOI":"10.1016\/8756-3282(95)00199-n"},{"key":"39063_CR10","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.semcdb.2015.11.006","volume":"49","author":"GN Hendy","year":"2016","unstructured":"Hendy, G. N. & Canaff, L. Calcium-sensing receptor, Proinflammatory cytokines and calcium homeostasis. Semin Cell. Dev. Biol. 49, 37\u201343. https:\/\/doi.org\/10.1016\/j.semcdb.2015.11.006 (2016).","journal-title":"Semin Cell. Dev. Biol."},{"key":"39063_CR11","doi-asserted-by":"publisher","first-page":"5202","DOI":"10.1210\/endo.136.11.7588259","volume":"136","author":"JE Garrett","year":"1995","unstructured":"Garrett, J. E. et al. Calcitonin-secreting cells of the thyroid express an extracellular calcium receptor gene. Endocrinology 136, 5202\u20135211. https:\/\/doi.org\/10.1210\/endo.136.11.7588259 (1995).","journal-title":"Endocrinology"},{"key":"39063_CR12","doi-asserted-by":"publisher","first-page":"5883","DOI":"10.1210\/endo.140.12.7190","volume":"140","author":"W Chang","year":"1999","unstructured":"Chang, W. et al. Expression and signal transduction of calcium-sensing receptors in cartilage and bone. Endocrinology 140, 5883\u20135893. https:\/\/doi.org\/10.1210\/endo.140.12.7190 (1999).","journal-title":"Endocrinology"},{"key":"39063_CR13","doi-asserted-by":"publisher","unstructured":"Chattopadhyay, N., G122-G130. & et al Identification and localization of extracellular Ca(2+)-sensing receptor in rat intestine. Am. J. Physiol. 274 https:\/\/doi.org\/10.1152\/ajpgi.1998.274.1.G122 (1998).","DOI":"10.1152\/ajpgi.1998.274.1.G122"},{"key":"39063_CR14","doi-asserted-by":"publisher","first-page":"69","DOI":"10.3389\/fonc.2020.00069","volume":"10","author":"S Das","year":"2020","unstructured":"Das, S., Clezardin, P., Kamel, S., Brazier, M. & Mentaverri, R. The CaSR in pathogenesis of breast cancer: A new target for early stage bone metastases. Front. Oncol. 10, 69. https:\/\/doi.org\/10.3389\/fonc.2020.00069 (2020).","journal-title":"Front. Oncol."},{"key":"39063_CR15","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1038\/nrm1154","volume":"4","author":"AM Hofer","year":"2003","unstructured":"Hofer, A. M. & Brown, E. M. Extracellular calcium sensing and signalling. Nat. Rev. Mol. Cell. Biol. 4, 530\u2013538. https:\/\/doi.org\/10.1038\/nrm1154 (2003).","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"39063_CR16","doi-asserted-by":"publisher","first-page":"1732","DOI":"10.1016\/j.bbamcr.2012.12.011","volume":"1833","author":"SC Brennan","year":"2013","unstructured":"Brennan, S. C. et al. Calcium sensing receptor signalling in physiology and cancer. Biochim. Biophys. Acta. 1833, 1732\u20131744. https:\/\/doi.org\/10.1016\/j.bbamcr.2012.12.011 (2013).","journal-title":"Biochim. Biophys. Acta"},{"key":"39063_CR17","doi-asserted-by":"publisher","first-page":"1980","DOI":"10.1002\/jbmr.2551","volume":"30","author":"B Dong","year":"2015","unstructured":"Dong, B. et al. Calcilytic ameliorates abnormalities of mutant Calcium-Sensing receptor (CaSR) Knock-In mice mimicking autosomal dominant hypocalcemia (ADH). J. Bone Min. Res. 30, 1980\u20131993. https:\/\/doi.org\/10.1002\/jbmr.2551 (2015).","journal-title":"J. Bone Min. Res."},{"key":"39063_CR18","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.beem.2013.04.007","volume":"27","author":"FM Hannan","year":"2013","unstructured":"Hannan, F. M. & Thakker, R. V. Calcium-sensing receptor (CaSR) mutations and disorders of calcium, electrolyte and water metabolism. Best Pract. Res. Clin. Endocrinol. Metab. 27, 359\u2013371. https:\/\/doi.org\/10.1016\/j.beem.2013.04.007 (2013).","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"39063_CR19","doi-asserted-by":"publisher","first-page":"1732","DOI":"10.1016\/j.bbamcr.2012.12.011","volume":"1833","author":"SC Brennan","year":"2012","unstructured":"Brennan, S. C. et al. Calcium sensing receptor signalling in physiology and cancer. Biochim. Biophys. Acta. 1833, 1732\u20131744. https:\/\/doi.org\/10.1016\/j.bbamcr.2012.12.011 (2012).","journal-title":"Biochim. Biophys. Acta"},{"key":"39063_CR20","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1146\/annurev-physiol-020911-153318","volume":"74","author":"D Riccardi","year":"2011","unstructured":"Riccardi, D. & Kemp, P. J. The calcium-sensing receptor beyond extracellular calcium homeostasis: conception, development, adult physiology, and disease. Annu. Rev. Physiol. 74, 271\u2013297. https:\/\/doi.org\/10.1146\/annurev-physiol-020911-153318 (2011).","journal-title":"Annu. Rev. Physiol."},{"key":"39063_CR21","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s13023-017-0570-z","volume":"12","author":"C Vahe","year":"2017","unstructured":"Vahe, C. et al. Diseases associated with calcium-sensing receptor. Orphanet J. Rare Dis. 12, 19. https:\/\/doi.org\/10.1186\/s13023-017-0570-z (2017).","journal-title":"Orphanet J. Rare Dis."},{"key":"39063_CR22","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1159\/000350091","volume":"31","author":"FH Lu","year":"2013","unstructured":"Lu, F. H. et al. Role of the calcium-sensing receptor in cardiomyocyte apoptosis via the sarcoplasmic reticulum and mitochondrial death pathway in cardiac hypertrophy and heart failure. Cell. Physiol. Biochem. 31, 728\u2013743. https:\/\/doi.org\/10.1159\/000350091 (2013).","journal-title":"Cell. Physiol. Biochem."},{"key":"39063_CR23","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1359\/jbmr.091005","volume":"25","author":"MJ Bolland","year":"2010","unstructured":"Bolland, M. J. et al. Abdominal aortic calcification on vertebral morphometry images predicts incident myocardial infarction. J. Bone Min. Res. 25, 505\u2013512. https:\/\/doi.org\/10.1359\/jbmr.091005 (2010).","journal-title":"J. Bone Min. Res."},{"key":"39063_CR24","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1001\/jama.2017.8981","volume":"318","author":"SC Larsson","year":"2017","unstructured":"Larsson, S. C., Burgess, S. & Michaelsson, K. Association of genetic variants related to serum calcium levels with coronary artery disease and myocardial infarction. JAMA 318, 371\u2013380. https:\/\/doi.org\/10.1001\/jama.2017.8981 (2017).","journal-title":"JAMA"},{"key":"39063_CR25","doi-asserted-by":"publisher","first-page":"106276","DOI":"10.1016\/j.aquatox.2022.106276","volume":"251","author":"YF Yang","year":"2022","unstructured":"Yang, Y. F. et al. Exposure to Sri lanka\u2019s local groundwater in a CKDu prevalent area causes kidney damage in zebrafish. Aquat. Toxicol. 251, 106276. https:\/\/doi.org\/10.1016\/j.aquatox.2022.106276 (2022).","journal-title":"Aquat. Toxicol."},{"key":"39063_CR26","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1038\/nature12111","volume":"496","author":"K Howe","year":"2013","unstructured":"Howe, K. et al. The zebrafish reference genome sequence and its relationship to the human genome. Nature 496, 498\u2013503. https:\/\/doi.org\/10.1038\/nature12111 (2013).","journal-title":"Nature"},{"key":"39063_CR27","doi-asserted-by":"publisher","first-page":"5807","DOI":"10.1021\/es8005173","volume":"42","author":"L Gunnarsson","year":"2008","unstructured":"Gunnarsson, L., Jauhiainen, A., Kristiansson, E., Nerman, O. & Larsson, D. G. J. Evolutionary conservation of human drug targets in organisms used for environmental risk assessments. Environ. Sci. Technol. 42, 5807\u20135813. https:\/\/doi.org\/10.1021\/es8005173 (2008).","journal-title":"Environ. Sci. Technol."},{"key":"39063_CR28","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1089\/zeb.2009.0616","volume":"7","author":"BW Lindsey","year":"2010","unstructured":"Lindsey, B. W., Smith, F. M. & Croll, R. P. From inflation to flotation: contribution of the swimbladder to whole-body density and swimming depth during development of the zebrafish (Danio rerio). Zebrafish 7, 85\u201396. https:\/\/doi.org\/10.1089\/zeb.2009.0616 (2010).","journal-title":"Zebrafish"},{"key":"39063_CR29","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/j.chemosphere.2019.06.199","volume":"235","author":"X Li","year":"2019","unstructured":"Li, X. et al. Exposure to water-accommodated fractions of two different crude oils alters morphology, cardiac function and swim bladder development in early-life stages of zebrafish. Chemosphere 235, 423\u2013433. https:\/\/doi.org\/10.1016\/j.chemosphere.2019.06.199 (2019).","journal-title":"Chemosphere"},{"key":"39063_CR30","doi-asserted-by":"publisher","first-page":"e109","DOI":"10.1371\/journal.pbio.0060109","volume":"6","author":"NC Chi","year":"2008","unstructured":"Chi, N. C. et al. Genetic and physiologic dissection of the vertebrate cardiac conduction system. PLoS Biol. 6, e109. https:\/\/doi.org\/10.1371\/journal.pbio.0060109 (2008).","journal-title":"PLoS Biol."},{"key":"39063_CR31","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1002\/aja.1002030302","volume":"203","author":"CB Kimmel","year":"1995","unstructured":"Kimmel, C. B., Ballard, W. W., Kimmel, S. R., Ullmann, B. & Schilling, T. F. Stages of embryonic development of the zebrafish. Dev. Dyn. 203, 253\u2013310. https:\/\/doi.org\/10.1002\/aja.1002030302 (1995).","journal-title":"Dev. Dyn."},{"key":"39063_CR32","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1038\/cr.2013.45","volume":"23","author":"N Chang","year":"2013","unstructured":"Chang, N. et al. Genome editing with RNA-guided Cas9 nuclease in zebrafish embryos. Cell. Res. 23, 465\u2013472. https:\/\/doi.org\/10.1038\/cr.2013.45 (2013).","journal-title":"Cell. Res."},{"key":"39063_CR33","doi-asserted-by":"publisher","unstructured":"Chitramuthu, B. P. & Bennett, H. P. High resolution whole mount in situ hybridization within zebrafish embryos to study gene expression and function. J Vis Exp, e50644 (2013). https:\/\/doi.org\/10.3791\/50644","DOI":"10.3791\/50644"},{"key":"39063_CR34","doi-asserted-by":"publisher","first-page":"979","DOI":"10.2174\/1566524011313060010","volume":"13","author":"H Xie","year":"2013","unstructured":"Xie, H. et al. The LIM protein FhlA is essential for heart chamber development in zebrafish embryos. Curr. Mol. Med. 13, 979\u2013992. https:\/\/doi.org\/10.2174\/1566524011313060010 (2013).","journal-title":"Curr. Mol. Med."},{"key":"39063_CR35","doi-asserted-by":"publisher","DOI":"10.3791\/1435","author":"K Ocorr","year":"2009","unstructured":"Ocorr, K., Fink, M., Cammarato, A., Bernstein, S. & Bodmer, R. Semi-automated optical heartbeat analysis of small hearts. J. Visualized Experiments: JoVE. https:\/\/doi.org\/10.3791\/1435 (2009).","journal-title":"J. Visualized Experiments: JoVE"},{"key":"39063_CR36","doi-asserted-by":"publisher","first-page":"15545","DOI":"10.1073\/pnas.0506580102","volume":"102","author":"A Subramanian","year":"2005","unstructured":"Subramanian, A. et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc. Natl. Acad. Sci. U S A. 102, 15545\u201315550. https:\/\/doi.org\/10.1073\/pnas.0506580102 (2005).","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"39063_CR37","doi-asserted-by":"publisher","first-page":"6775","DOI":"10.18632\/oncotarget.14286","volume":"8","author":"WX Li","year":"2017","unstructured":"Li, W. X. et al. Comprehensive tissue-specific gene set enrichment analysis and transcription factor analysis of breast cancer by integrating 14 gene expression datasets. Oncotarget 8, 6775\u20136786. https:\/\/doi.org\/10.18632\/oncotarget.14286 (2017).","journal-title":"Oncotarget"},{"key":"39063_CR38","doi-asserted-by":"publisher","unstructured":"Shen, W. et al. Sangerbox: A comprehensive, interaction-friendly clinical bioinformatics analysis platform. iMeta 1, e36 (2022). https:\/\/doi.org\/10.1002\/imt2.36","DOI":"10.1002\/imt2.36"},{"key":"39063_CR39","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1038\/12692","volume":"23","author":"R Geisler","year":"1999","unstructured":"Geisler, R. et al. A radiation hybrid map of the zebrafish genome. Nat. Genet. 23, 86\u201389. https:\/\/doi.org\/10.1038\/12692 (1999).","journal-title":"Nat. Genet."},{"key":"39063_CR40","doi-asserted-by":"publisher","unstructured":"Iovine, M. K. & Johnson, S. L. A genetic, deletion, physical, and human homology map of the long fin region on zebrafish linkage group 2. Genomics 79, 756\u2013759 (2002). https:\/\/doi.org\/10.1006\/geno.2002.6769","DOI":"10.1006\/geno.2002.6769"},{"key":"39063_CR41","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1016\/j.tplants.2019.09.006","volume":"24","author":"H Manghwar","year":"2019","unstructured":"Manghwar, H., Lindsey, K., Zhang, X., Jin, S. C. R. I. S. P. R. C. & System Recent advances and future prospects for genome editing. Trends Plant. Sci. 24, 1102\u20131125. https:\/\/doi.org\/10.1016\/j.tplants.2019.09.006 (2019).","journal-title":"Trends Plant. Sci."},{"key":"39063_CR42","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1002\/jez.1401750404","volume":"175","author":"BS Spooner","year":"1970","unstructured":"Spooner, B. S. & Wessells, N. K. Mammalian lung development: interactions in primordium formation and bronchial morphogenesis. J. Exp. Zool. 175, 445\u2013454. https:\/\/doi.org\/10.1002\/jez.1401750404 (1970).","journal-title":"J. Exp. Zool."},{"key":"39063_CR43","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/s0012-1606(03)00308-7","volume":"261","author":"HA Field","year":"2003","unstructured":"Field, H. A., Dong, P. D. S., Beis, D. & Stainier, D. Y. R. Formation of the digestive system in zebrafish. II. Pancreas morphogenesis. Dev. Biol. 261, 197\u2013208. https:\/\/doi.org\/10.1016\/s0012-1606(03)00308-7 (2003).","journal-title":"Dev. Biol."},{"key":"39063_CR44","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1186\/1471-213X-8-84","volume":"8","author":"S Korzh","year":"2008","unstructured":"Korzh, S. et al. Requirement of vasculogenesis and blood circulation in late stages of liver growth in zebrafish. BMC Dev. Biol. 8, 84. https:\/\/doi.org\/10.1186\/1471-213X-8-84 (2008).","journal-title":"BMC Dev. Biol."},{"key":"39063_CR45","doi-asserted-by":"publisher","first-page":"1358","DOI":"10.1016\/s0960-9822(01)00402-x","volume":"11","author":"S Roy","year":"2001","unstructured":"Roy, S., Qiao, T., Wolff, C. & Ingham, P. W. Hedgehog signaling pathway is essential for pancreas specification in the zebrafish embryo. Curr. Biol. 11, 1358\u20131363. https:\/\/doi.org\/10.1016\/s0960-9822(01)00402-x (2001).","journal-title":"Curr. Biol."},{"key":"39063_CR46","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/s0012-1606(02)00034-9","volume":"255","author":"KN Wallace","year":"2003","unstructured":"Wallace, K. N. & Pack, M. Unique and conserved aspects of gut development in zebrafish. Dev. Biol. 255, 12\u201329. https:\/\/doi.org\/10.1016\/s0012-1606(02)00034-9 (2003).","journal-title":"Dev. Biol."},{"key":"39063_CR47","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/1471-213X-10-3","volume":"10","author":"CL Winata","year":"2010","unstructured":"Winata, C. L., Korzh, S., Kondrychyn, I., Korzh, V. & Gong, Z. The role of vasculature and blood circulation in zebrafish swimbladder development. BMC Dev. Biol. 10, 3. https:\/\/doi.org\/10.1186\/1471-213X-10-3 (2010).","journal-title":"BMC Dev. Biol."},{"key":"39063_CR48","doi-asserted-by":"publisher","first-page":"1079529","DOI":"10.3389\/fnmol.2023.1079529","volume":"16","author":"S Yang","year":"2023","unstructured":"Yang, S. et al. cdh23 affects congenital hearing loss through regulating purine metabolism. Front. Mol. Neurosci. 16, 1079529. https:\/\/doi.org\/10.3389\/fnmol.2023.1079529 (2023).","journal-title":"Front. Mol. Neurosci."},{"key":"39063_CR49","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/nar\/28.1.27","volume":"28","author":"M Kanehisa","year":"2000","unstructured":"Kanehisa, M. & Goto, S. KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 28, 27\u201330 (2000).","journal-title":"Nucleic Acids Res."},{"key":"39063_CR50","doi-asserted-by":"publisher","first-page":"1947","DOI":"10.1002\/pro.3715","volume":"28","author":"M Kanehisa","year":"2019","unstructured":"Kanehisa, M. Toward Understanding the origin and evolution of cellular organisms. Protein Sci. 28, 1947\u20131951. https:\/\/doi.org\/10.1002\/pro.3715 (2019).","journal-title":"Protein Sci."},{"key":"39063_CR51","doi-asserted-by":"publisher","first-page":"D587","DOI":"10.1093\/nar\/gkac963","volume":"51","author":"M Kanehisa","year":"2023","unstructured":"Kanehisa, M., Furumichi, M., Sato, Y., Kawashima, M. & Ishiguro-Watanabe, M. KEGG for taxonomy-based analysis of pathways and genomes. Nucleic Acids Res. 51, D587\u2013D592. https:\/\/doi.org\/10.1093\/nar\/gkac963 (2023).","journal-title":"Nucleic Acids Res."},{"key":"39063_CR52","doi-asserted-by":"publisher","first-page":"ra1","DOI":"10.1126\/scisignal.1159945","volume":"1","author":"W Chang","year":"2008","unstructured":"Chang, W., Tu, C., Chen, T. H., Bikle, D. & Shoback, D. The extracellular calcium-sensing receptor (CaSR) is a critical modulator of skeletal development. Sci. Signal. 1, ra1. https:\/\/doi.org\/10.1126\/scisignal.1159945 (2008).","journal-title":"Sci. Signal."},{"key":"39063_CR53","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cellsig.2018.07.004","volume":"51","author":"AV Maltsev","year":"2018","unstructured":"Maltsev, A. V. Agmatine modulates calcium handling in cardiomyocytes of hibernating ground squirrels through calcium-sensing receptor signaling. Cell. Signal. 51, 1\u201312. https:\/\/doi.org\/10.1016\/j.cellsig.2018.07.004 (2018).","journal-title":"Cell. Signal."},{"key":"39063_CR54","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.3389\/fphar.2018.01163","volume":"9","author":"M Lu","year":"2018","unstructured":"Lu, M. et al. Calcium sensing Receptor-Related pathway contributes to cardiac injury and the mechanism of Astragaloside IV on cardioprotection. Front. Pharmacol. 9, 1163. https:\/\/doi.org\/10.3389\/fphar.2018.01163 (2018).","journal-title":"Front. Pharmacol."},{"issue":"Suppl 4","key":"39063_CR55","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1111\/sms.12619","volume":"25","author":"C Siebenmann","year":"2015","unstructured":"Siebenmann, C. & Lundby, C. Regulation of cardiac output in hypoxia. Scand. J. Med. Sci. Sports. 25 (Suppl 4), 53\u201359. https:\/\/doi.org\/10.1111\/sms.12619 (2015).","journal-title":"Scand. J. Med. Sci. Sports"},{"key":"39063_CR56","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1002\/cphy.c140055","volume":"6","author":"E Tanai","year":"2015","unstructured":"Tanai, E. & Frantz, S. Pathophysiology of heart failure. Compr. Physiol. 6, 187\u2013214. https:\/\/doi.org\/10.1002\/cphy.c140055 (2015).","journal-title":"Compr. Physiol."},{"key":"39063_CR57","doi-asserted-by":"publisher","first-page":"e18431","DOI":"10.1371\/journal.pone.0018431","volume":"6","author":"A Yin","year":"2011","unstructured":"Yin, A., Korzh, S., Winata, C. L., Korzh, V. & Gong, Z. Wnt signaling is required for early development of zebrafish swimbladder. PloS One. 6, e18431. https:\/\/doi.org\/10.1371\/journal.pone.0018431 (2011).","journal-title":"PloS One"},{"key":"39063_CR58","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1242\/dev.124.1.53","volume":"124","author":"S Bellusci","year":"1997","unstructured":"Bellusci, S. et al. Involvement of Sonic Hedgehog (Shh) in mouse embryonic lung growth and morphogenesis. Development 124, 53\u201363. https:\/\/doi.org\/10.1242\/dev.124.1.53 (1997).","journal-title":"Development"},{"key":"39063_CR59","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.resp.2004.07.020","volume":"144","author":"HR Duncker","year":"2004","unstructured":"Duncker, H. R. Vertebrate lungs: structure, topography and mechanics. A comparative perspective of the progressive integration of respiratory system, locomotor apparatus and ontogenetic development. Respir Physiol. Neurobiol. 144, 111\u2013124. https:\/\/doi.org\/10.1016\/j.resp.2004.07.020 (2004).","journal-title":"Respir Physiol. Neurobiol."},{"key":"39063_CR60","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1161\/01.RES.0000074908.17214.FD","volume":"92","author":"F Brette","year":"2003","unstructured":"Brette, F. & Orchard, C. T-tubule function in mammalian cardiac myocytes. Circ. Res. 92, 1182\u20131192 (2003).","journal-title":"Circ. Res."},{"key":"39063_CR61","doi-asserted-by":"publisher","first-page":"16307","DOI":"10.1038\/s41598-019-52592-w","volume":"9","author":"Y Wakamatsu","year":"2019","unstructured":"Wakamatsu, Y., Ogino, K. & Hirata, H. Swimming capability of zebrafish is governed by water temperature, caudal fin length and genetic background. Sci. Rep. 9, 16307. https:\/\/doi.org\/10.1038\/s41598-019-52592-w (2019).","journal-title":"Sci. Rep."},{"key":"39063_CR62","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1101\/gr.4791006","volume":"16","author":"V Guryev","year":"2006","unstructured":"Guryev, V. et al. Genetic variation in the zebrafish. Genome Res. 16, 491\u2013497. https:\/\/doi.org\/10.1101\/gr.4791006 (2006).","journal-title":"Genome Res."},{"key":"39063_CR63","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.ntt.2012.03.002","volume":"34","author":"C de Esch","year":"2012","unstructured":"de Esch, C. et al. Locomotor activity assay in zebrafish larvae: influence of age, strain and ethanol. Neurotoxicol Teratol. 34, 425\u2013433. https:\/\/doi.org\/10.1016\/j.ntt.2012.03.002 (2012).","journal-title":"Neurotoxicol Teratol"},{"key":"39063_CR64","doi-asserted-by":"publisher","first-page":"3362","DOI":"10.1111\/febs.14080","volume":"284","author":"JE Kammenga","year":"2017","unstructured":"Kammenga, J. E. The background puzzle: how identical mutations in the same gene lead to different disease symptoms. FEBS J. 284, 3362\u20133373. https:\/\/doi.org\/10.1111\/febs.14080 (2017).","journal-title":"FEBS J."},{"key":"39063_CR65","doi-asserted-by":"publisher","first-page":"327","DOI":"10.2217\/pme-2021-0175","volume":"19","author":"KY Alrajeh","year":"2022","unstructured":"Alrajeh, K. Y. & Roman, Y. M. The frequency of major CYP2C19 genetic polymorphisms in women of Asian, native Hawaiian and Pacific Islander subgroups. Per Med. 19, 327\u2013339. https:\/\/doi.org\/10.2217\/pme-2021-0175 (2022).","journal-title":"Per Med."},{"key":"39063_CR66","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1038\/s41398-024-02981-1","volume":"14","author":"D Li","year":"2024","unstructured":"Li, D. et al. Metabolic activity of CYP2C19 and CYP2D6 on antidepressant response from 13 clinical studies using genotype imputation: a meta-analysis. Transl Psychiatry. 14, 296. https:\/\/doi.org\/10.1038\/s41398-024-02981-1 (2024).","journal-title":"Transl Psychiatry"},{"key":"39063_CR67","doi-asserted-by":"publisher","unstructured":"Neeve, V. C. M. et al. What is influencing the phenotype of the common homozygous polymerase-\u03b3 mutation p.Ala467Thr? Brain 135, 3614\u20133626 (2012). https:\/\/doi.org\/10.1093\/brain\/aws298","DOI":"10.1093\/brain\/aws298"},{"key":"39063_CR68","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/j.cell.2015.06.037","volume":"162","author":"V Vu","year":"2015","unstructured":"Vu, V. et al. Natural variation in gene expression modulates the severity of mutant phenotypes. Cell 162, 391\u2013402. https:\/\/doi.org\/10.1016\/j.cell.2015.06.037 (2015).","journal-title":"Cell"},{"key":"39063_CR69","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1093\/cvr\/cvn073","volume":"79","author":"Z Chen","year":"2008","unstructured":"Chen, Z. et al. Depletion of zebrafish essential and regulatory myosin light chains reduces cardiac function through distinct mechanisms. Cardiovasc. Res. 79, 97\u2013108. https:\/\/doi.org\/10.1093\/cvr\/cvn073 (2008).","journal-title":"Cardiovasc. Res."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-39063-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-39063-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-39063-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T22:02:25Z","timestamp":1773180145000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-39063-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,12]]},"references-count":69,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["39063"],"URL":"https:\/\/doi.org\/10.1038\/s41598-026-39063-9","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,12]]},"assertion":[{"value":"3 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"8543"}}