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We included 60 eyes of 49 participants being treated for cataract, of which 30 eyes underwent additional ab-interno trabeculectomy via KDB (Kahook group) and 30 eyes received additional Trabectome surgery (Trabectome group). For this comparative analysis, the Kahook group and Trabectome group were matched at a 1:1-ratio, based on the following criteria: preoperative IOP, maximum known preoperative IOP, preoperative medication score, cup\/disc-ratio, follow-up time, best-corrected visual acuity and age. Successful surgery was defined by three scores: IOP at longest follow-up &lt;\u200921 mmHg (Score A) or &lt;\u200918 mmHg (Score B) without re-surgery and an IOP reduction\u2009&gt;\u200920% or IOP\u2009\u2264\u200915 mmHg without re-surgery and an IOP reduction\u2009\u2265\u200940% (Score C). Furthermore, we compared postoperative IOP, as well as medication score, and side effects between both groups. Both surgical techniques led to a relative IOP reduction of 29% within their respective groups. Specifically, preoperative IOP decreased from 19.5\u2009\u00b1\u20095.0 mmHg to 13.8\u2009\u00b1\u20093.9 mmHg in the Kahook group, and from 19.8\u2009\u00b1\u20094.5 mmHg to 14.0\u2009\u00b1\u20093.9 mmHg in the Trabectome group during an average follow-up period of 23\u201324 months. There was no statistical significant difference noted. Both the KDB and Trabectome yielded similar success rates, according to Score A (67% vs. 70%), Score B (63% vs. 67%) and Score C (33% vs. 23%). There were no severe side effects notes in either group. In conclusion, the KDB and Trabectome showed similar IOP-lowering properties and safety profiles within our two matched groups of Caucasian patients.<\/jats:p>","DOI":"10.1038\/s41598-026-39331-8","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T06:03:20Z","timestamp":1773381800000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Case-matched comparison of combined phacoemulsification with ab-interno trabeculectomy via Kahook dual blade and trabectome in a Caucasian population"],"prefix":"10.1038","volume":"16","author":[{"given":"David","family":"Kiessling","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Bleiel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gernot F.","family":"Roessler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas S.","family":"Dietlein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randolf A.","family":"Widder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Lappas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,13]]},"reference":[{"issue":"6","key":"39331_CR1","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1016\/j.ophtha.2004.12.043","volume":"112","author":"DS Minckler","year":"2005","unstructured":"Minckler, D. 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All tenets of the Declaration of Helsinki have been regarded.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"For this type of study (anonymized data, retrospective analysis), formal consent is not required. Informed consent was obtained from all subjects.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}}],"article-number":"8944"}}