{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T21:41:40Z","timestamp":1773351700441,"version":"3.50.1"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:00:00Z","timestamp":1770940800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"vor","delay-in-days":27,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Takeda Science Foundation Medical Research Grants"},{"name":"JSPS KAKENHI","award":["JP 19H03108"],"award-info":[{"award-number":["JP 19H03108"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-026-39396-5","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T04:15:09Z","timestamp":1770956109000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Changes in ovarian hardness and elasticity affect the development and function of secondary follicles"],"prefix":"10.1038","volume":"16","author":[{"given":"Tomoko","family":"Kawai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Shimada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,2,13]]},"reference":[{"key":"39396_CR1","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1038\/nrm3904","volume":"15","author":"C Bonnans","year":"2014","unstructured":"Bonnans, C., Chou, J. & Werb, Z. Remodelling the extracellular matrix in development and disease. Nat. Rev. Mol. Cell Biol. 15, 786\u2013801 (2014).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"39396_CR2","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1038\/s41576-020-00292-x","volume":"22","author":"E Armingol","year":"2021","unstructured":"Armingol, E., Officer, A., Harismendy, O. & Lewis, N. E. Deciphering cell-cell interactions and communication from gene expression. Nat. Rev. Genet. 22, 71\u201388 (2021).","journal-title":"Nat. Rev. Genet."},{"key":"39396_CR3","doi-asserted-by":"publisher","first-page":"4045","DOI":"10.1042\/BCJ20210043","volume":"478","author":"KF Sonnen","year":"2021","unstructured":"Sonnen, K. F. & Janda, C. Y. Signalling dynamics in embryonic development. Biochem J. 478, 4045\u20134070 (2021).","journal-title":"Biochem J."},{"key":"39396_CR4","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1016\/j.tcb.2020.05.003","volume":"30","author":"JA Fafian-Labora","year":"2020","unstructured":"Fafian-Labora, J. A. & O\u2019Loghlen, A. Classical and nonclassical intercellular communication in senescence and ageing. Trends Cell Biol. 30, 628\u2013639 (2020).","journal-title":"Trends Cell Biol."},{"key":"39396_CR5","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.visres.2017.04.014","volume":"139","author":"S Roy","year":"2017","unstructured":"Roy, S., Kim, D. & Lim, R. Cell-cell communication in diabetic retinopathy. Vision Res. 139, 115\u2013122 (2017).","journal-title":"Vision Res."},{"key":"39396_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1126\/sciadv.1600584","volume":"2","author":"S Pal","year":"2016","unstructured":"Pal, S. & Tyler, J. K. Epigenetics and aging. Sci. Adv. 2, 1\u201319 (2016).","journal-title":"Sci. Adv."},{"key":"39396_CR7","doi-asserted-by":"publisher","first-page":"6996","DOI":"10.1002\/jcp.26491","volume":"233","author":"T Xia","year":"2018","unstructured":"Xia, T. et al. Effect of substrate stiffness on hepatocyte migration and cellular Young\u2019s modulus. J. Cell Physiol. 233, 6996\u20137006 (2018).","journal-title":"J. Cell Physiol."},{"key":"39396_CR8","doi-asserted-by":"publisher","first-page":"1394","DOI":"10.1002\/hep.22193","volume":"47","author":"RG Wells","year":"2008","unstructured":"Wells, R. G. The role of matrix stiffness in regulating cell behavior. Hepatology. 47, 1394\u2013400 (2008).","journal-title":"Hepatology."},{"key":"39396_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13287-018-0798-0","volume":"9","author":"M Sun","year":"2018","unstructured":"Sun, M. et al. Extracellular matrix stiffness controls osteogenic differentiation of mesenchymal stem cells mediated by integrin \u03b15. Stem Cell Res. Ther. 9, 1\u201313 (2018).","journal-title":"Stem Cell Res. Ther."},{"key":"39396_CR10","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1007\/s10585-019-09966-1","volume":"36","author":"JA Eble","year":"2019","unstructured":"Eble, J. A. & Niland, S. The extracellular matrix in tumor progression and metastasis. Clin. Exp. Metastasis. 36, 171\u2013198 (2019).","journal-title":"Clin. Exp. Metastasis."},{"key":"39396_CR11","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1038\/s41392-021-00544-0","volume":"6","author":"J Huang","year":"2021","unstructured":"Huang, J. et al. Extracellular matrix and its therapeutic potential for cancer treatment. Signal Transduct. Target. Ther. 6, 153 (2021).","journal-title":"Signal Transduct. Target. Ther."},{"key":"39396_CR12","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.devcel.2020.10.011","volume":"56","author":"V Gensbittel","year":"2021","unstructured":"Gensbittel, V. et al. Mechanical adaptability of tumor cells in metastasis. Dev. Cell 56, 164\u2013179 (2021).","journal-title":"Dev. Cell"},{"key":"39396_CR13","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1038\/s41392-023-01501-9","volume":"8","author":"X Di","year":"2023","unstructured":"Di, X. et al. Cellular mechanotransduction in health and diseases: from molecular mechanism to therapeutic targets. Signal Transduct. Target Ther. 8, 282 (2023).","journal-title":"Signal Transduct. Target Ther."},{"key":"39396_CR14","doi-asserted-by":"publisher","first-page":"145","DOI":"10.3389\/fonc.2018.00145","volume":"8","author":"V Gkretsi","year":"2018","unstructured":"Gkretsi, V. & Stylianopoulos, T. Cell adhesion and matrix stiffness: coordinating cancer cell invasion and metastasis. Front. Oncol. 8, 145 (2018).","journal-title":"Front. Oncol."},{"key":"39396_CR15","doi-asserted-by":"publisher","first-page":"15237","DOI":"10.1038\/ncomms15237","volume":"8","author":"S Tavares","year":"2017","unstructured":"Tavares, S. et al. Actin stress fiber organization promotes cell stiffening and proliferation of pre-invasive breast cancer cells. Nat. Commun. 8, 15237 (2017).","journal-title":"Nat. Commun."},{"key":"39396_CR16","doi-asserted-by":"publisher","first-page":"3074","DOI":"10.1093\/humrep\/det341","volume":"28","author":"X Zhang","year":"2013","unstructured":"Zhang, X. et al. Dehydroepiandrosterone induces ovarian and uterine hyperfibrosis in female rats. Hum. Reprod. 28, 3074\u20133085 (2013).","journal-title":"Hum. Reprod."},{"key":"39396_CR17","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1038\/kisup.2014.14","volume":"4","author":"HC Yang","year":"2011","unstructured":"Yang, H. C. & Fogo, A. B. Fibrosis and renal aging. Kidney Int. Suppl. 4, 75\u201378 (2011).","journal-title":"Kidney Int. Suppl."},{"key":"39396_CR18","doi-asserted-by":"publisher","first-page":"4004","DOI":"10.3390\/ijms24044004","volume":"24","author":"SA Antar","year":"2023","unstructured":"Antar, S. A., Ashour, N. A., Marawan, M. E. & Al-Karmalawy, A. A. Fibrosis: types, effects, markers, mechanisms for disease progression, and its relation with oxidative stress, immunity, and inflammation. Int. J. Mol. Sci. 24, 4004 (2023).","journal-title":"Int. J. Mol. Sci."},{"key":"39396_CR19","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1016\/j.ajpath.2014.11.009","volume":"185","author":"NL Rosin","year":"2015","unstructured":"Rosin, N. L., Sopel, M. J., Falkenham, A., Lee, T. D. G. & L\u00e9gar\u00e9, J. F. Disruption of collagen homeostasis can reverse established age-related myocardial fibrosis. Am. J. Pathol. 185, 631\u2013642 (2015).","journal-title":"Am. J. Pathol."},{"key":"39396_CR20","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1530\/REP-16-0129","volume":"152","author":"SM Briley","year":"2016","unstructured":"Briley, S. M. et al. Reproductive age-associated fibrosis in the stroma of the mammalian ovary. Reproduction 152, 245\u2013260 (2016).","journal-title":"Reproduction"},{"key":"39396_CR21","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1016\/j.stemcr.2020.07.022","volume":"15","author":"S Kurotsu","year":"2020","unstructured":"Kurotsu, S. et al. Soft matrix promotes cardiac Reprogramming via Inhibition of YAP\/TAZ and Suppression of Fibroblast Signatures. Stem Cell Rep. 15, 612\u2013628 (2020).","journal-title":"Stem Cell Rep."},{"key":"39396_CR22","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1097\/00006254-198202000-00001","volume":"37","author":"PE Hughesdon","year":"1982","unstructured":"Hughesdon, P. E. Morphology and morphogenesis of the Stein-Leventhal ovary and of so-called \u201chyperthecosis\u201d. Obstet. Gynecol. Surv. 37, 59\u201377 (1982).","journal-title":"Obstet. Gynecol. Surv."},{"key":"39396_CR23","doi-asserted-by":"publisher","first-page":"4418","DOI":"10.1210\/jc.2007-0729","volume":"92","author":"SA Stubbs","year":"2007","unstructured":"Stubbs, S. A., Stark, J., Dilworth, S. M., Franks, S. & Hardy, K. Abnormal preantral folliculogenesis in polycystic ovaries is associated with increased granulosa cell division. J. Clin. Endocrinol. Metab. 92, 4418\u20134426 (2007).","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"39396_CR24","doi-asserted-by":"publisher","first-page":"e277","DOI":"10.15557\/JoU.2021.0047","volume":"21","author":"T Gursu","year":"2021","unstructured":"Gursu, T. et al. Diagnostic value of shear wave velocity in polycystic ovarian syndrome. J. Ultrason. 21, e277\u2013e281 (2021).","journal-title":"J. Ultrason."},{"key":"39396_CR25","doi-asserted-by":"publisher","first-page":"1288","DOI":"10.1111\/acel.12662","volume":"16","author":"T Umehara","year":"2017","unstructured":"Umehara, T. et al. The acceleration of reproductive aging in Nrg1flox\/flox; Cyp19-Cre female mice. Aging Cell 16, 1288\u20131299 (2017).","journal-title":"Aging Cell"},{"key":"39396_CR26","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13259","volume":"19","author":"F Amargant","year":"2020","unstructured":"Amargant, F. et al. Ovarian stiffness increases with age in the mammalian ovary and depends on collagen and hyaluronan matrices. Aging Cell 19, e13259 (2020).","journal-title":"Aging Cell"},{"key":"39396_CR27","doi-asserted-by":"publisher","first-page":"6841","DOI":"10.1038\/s41598-020-63948-y","volume":"10","author":"T Kawai","year":"2020","unstructured":"Kawai, T. & Shimada, M. Pretreatment of ovaries with collagenase before vitrification keeps the ovarian reserve by maintaining cell-cell adhesion integrity in ovarian follicles. Sci. Rep. 10, 6841 (2020).","journal-title":"Sci. Rep."},{"key":"39396_CR28","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0192458","volume":"13","author":"H Kitasaka","year":"2018","unstructured":"Kitasaka, H. et al. Inductions of granulosa cell luteinization and cumulus expansion are dependent on the fibronectin-integrin pathway during ovulation process in mice. PLoS One 13, e0192458 (2018).","journal-title":"PLoS One"},{"key":"39396_CR29","doi-asserted-by":"publisher","first-page":"2115","DOI":"10.4049\/jimmunol.1701325","volume":"200","author":"JR Grunwell","year":"2018","unstructured":"Grunwell, J. R. et al. TGF-\u03b21 Suppresses the Type I IFN response and induces mitochondrial dysfunction in alveolar macrophages. J Immunol. 200, 2115\u20132128 (2018).","journal-title":"J Immunol."},{"key":"39396_CR30","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1038\/384470a0","volume":"384","author":"P Sicinski","year":"1996","unstructured":"Sicinski, P. et al. Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis. Nature. 384, 470\u2013474 (1996).","journal-title":"Nature."},{"key":"39396_CR31","doi-asserted-by":"publisher","first-page":"2174","DOI":"10.1210\/en.2012-2256","volume":"154","author":"AK Binder","year":"2013","unstructured":"Binder, A. K. et al. The absence of ER-\u03b2 results in altered gene expression in ovarian granulosa cells isolated from in vivo preovulatory follicles. Endocrinology. 154, 2174\u20132187 (2013).","journal-title":"Endocrinology."},{"key":"39396_CR32","doi-asserted-by":"publisher","first-page":"1741","DOI":"10.1007\/s10815-018-1268-4","volume":"35","author":"A Sanfins","year":"2018","unstructured":"Sanfins, A., Rodrigues, P. & Albertini, D. F. GDF-9 and BMP-15 direct the follicle symphony. J. Assist Reprod. Genet. 35, 1741\u20131750 (2018).","journal-title":"J. Assist Reprod. Genet."},{"key":"39396_CR33","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1172\/JCI41350","volume":"120","author":"JS Richards","year":"2010","unstructured":"Richards, J. S. & Pangas, S. A. The ovary: basic biology and clinical implications. J. Clin. Invest. 120, 963\u2013972 (2010).","journal-title":"J. Clin. Invest."},{"key":"39396_CR34","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.tem.2018.02.012","volume":"29","author":"JS Richards","year":"2018","unstructured":"Richards, J. S. & Ascoli, M. Endocrine, paracrine, and autocrine signaling pathways that regulate ovulation. Trends Endocrinol. Metab. 29, 313\u2013325 (2018).","journal-title":"Trends Endocrinol. Metab."},{"key":"39396_CR35","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1530\/REP-09-0247","volume":"138","author":"HN Jabbour","year":"2009","unstructured":"Jabbour, H. N., Sales, K. J., Catalano, R. D. & Norman, J. E. Inflammatory pathways in female reproductive health and disease. Reproduction 138, 903\u2013919 (2009).","journal-title":"Reproduction"},{"key":"39396_CR36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/15476278.2015.1019687","volume":"11","author":"AM Handorf","year":"2015","unstructured":"Handorf, A. M., Zhou, Y., Halanski, M. A. & Li, W. J. Tissue stiffness dictates development, homeostasis, and disease progression. Organogenesis 11, 1\u201315 (2015).","journal-title":"Organogenesis"},{"key":"39396_CR37","doi-asserted-by":"publisher","first-page":"832","DOI":"10.3389\/fendo.2019.00832","volume":"10","author":"MA Abedel-Majed","year":"2019","unstructured":"Abedel-Majed, M. A., Romereim, S. M., Davis, J. S. & Cupp, A. S. Perturbations in lineage specification of granulosa and theca cells may alter corpus luteum formation and function. Front. Endocrinol. 10, 832 (2019).","journal-title":"Front. Endocrinol."},{"key":"39396_CR38","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1038\/s42003-021-02662-5","volume":"4","author":"CJ Chan","year":"2021","unstructured":"Chan, C. J., Bevilacqua, C. & Prevedel, R. Mechanical mapping of mammalian follicle development using Brillouin microscopy. Commun. Biol. 4, 1133 (2021).","journal-title":"Commun. Biol."},{"key":"39396_CR39","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1038\/nmat3339","volume":"11","author":"B Trappmann","year":"2012","unstructured":"Trappmann, B. et al. Extracellular-matrix tethering regulates stem-cell fate. Nat. Mater. 11, 642\u2013649 (2012).","journal-title":"Nat. Mater."},{"key":"39396_CR40","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1089\/wound.2019.1021","volume":"9","author":"MJ Blair","year":"2020","unstructured":"Blair, M. J., Jones, J. D., Woessner, A. E. & Quinn, K. P. Skin structure-function relationships and the wound healing response to intrinsic aging. Adv. Wound Care 9, 127\u2013143 (2020).","journal-title":"Adv. Wound Care"},{"key":"39396_CR41","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aav9960","volume":"5","author":"G Nagamatsu","year":"2019","unstructured":"Nagamatsu, G., Shimamoto, S., Hamazaki, N., Nishimura, Y. & Hayashi, K. Mechanical stress accompanied with nuclear rotation is involved in the dormant state of mouse oocytes. Sci. Adv. 5, eaav9960 (2019).","journal-title":"Sci. Adv."},{"key":"39396_CR42","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1530\/REP-16-0129","volume":"152","author":"SM Briley","year":"2016","unstructured":"Briley, S. M. et al. Reproductive age-associated fibrosis in the stroma of the mammalian ovary. Reproduction. 152, 245\u2013260 (2016).","journal-title":"Reproduction."},{"key":"39396_CR43","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1007\/s00418-006-0194-1","volume":"126","author":"CB Berkholtz","year":"2006","unstructured":"Berkholtz, C. B., Lai, B. E., Woodruff, T. K. & Shea, L. D. Distribution of extracellular matrix proteins type I collagen, type IV collagen, fibronectin, and laminin in mouse folliculogenesis. Histochem. Cell Biol. 126, 583\u2013592 (2006).","journal-title":"Histochem. Cell Biol."},{"key":"39396_CR44","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.744257","volume":"11","author":"C Sun","year":"2022","unstructured":"Sun, C., Yang, X., Wang, T., Cheng, M. & Han, Y. Ovarian biomechanics: from health to disease. Front. Oncol. 11, 744257 (2022).","journal-title":"Front. Oncol."},{"key":"39396_CR45","doi-asserted-by":"publisher","first-page":"2423","DOI":"10.1096\/fj.14-267856","volume":"29","author":"Y Cheng","year":"2015","unstructured":"Cheng, Y. et al. Actin polymerization-enhancing drugs promote ovarian follicle growth mediated by the Hippo signaling effector YAP. Faseb J. 29, 2423\u20132430 (2015).","journal-title":"Faseb J."},{"key":"39396_CR46","doi-asserted-by":"publisher","first-page":"53","DOI":"10.3390\/jcm6050053","volume":"6","author":"KM Herum","year":"2017","unstructured":"Herum, K. M., Lunde, I. G., McCulloch, A. D. & Christensen, G. The soft- and hard- heartedness of cardiac fibroblasts: mechanotransduction signaling pathways in fibrosis of the heart. J. Clin. Med. 6, 53 (2017).","journal-title":"J. Clin. Med."},{"key":"39396_CR47","doi-asserted-by":"publisher","first-page":"158","DOI":"10.3802\/jgo.2009.20.3.158","volume":"20","author":"A Ayhan","year":"2009","unstructured":"Ayhan, A., Salman, M. C., Velipasaoglu, M., Sakinci, M. & Yuce, K. Prognostic factors in adult granulosa cell tumors of the ovary: a retrospective analysis of 80 cases. J. Gynecol. Oncol. 20, 158 (2009).","journal-title":"J. Gynecol. Oncol."},{"key":"39396_CR48","doi-asserted-by":"publisher","first-page":"2776","DOI":"10.1093\/humrep\/dem240","volume":"22","author":"L De Santis","year":"2007","unstructured":"De Santis, L. et al. Permeability of human oocytes to ethylene glycol and their survival and spindle configurations after slow cooling cryopreservation. Hum. Reprod. 22, 2776\u20132783 (2007).","journal-title":"Hum. Reprod."},{"key":"39396_CR49","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abb8471","volume":"6","author":"VS Meli","year":"2020","unstructured":"Meli, V. S. et al. YAP-mediated mechanotransduction tunes the macrophage inflammatory response. Sci. Adv. 6, eabb8471 (2020).","journal-title":"Sci. Adv."},{"key":"39396_CR50","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1038\/nature10137","volume":"474","author":"S Dupont","year":"2011","unstructured":"Dupont, S. et al. Role of YAP\/TAZ in mechanotransduction. Nature 474, 179\u2013183 (2011).","journal-title":"Nature"},{"key":"39396_CR51","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1053\/j.gastro.2016.10.047","volume":"152","author":"SH Patel","year":"2017","unstructured":"Patel, S. H., Camargo, F. D. & Yimlamai, D. Hippo signaling in the liver regulates organ size, cell fate, and carcinogenesis. Gastroenterology 152, 533\u2013545 (2017).","journal-title":"Gastroenterology"},{"key":"39396_CR52","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1146\/annurev-pathol-030420-105050","volume":"16","author":"JH Driskill","year":"2020","unstructured":"Driskill, J. H. & Pan, D. The hippo pathway in liver homeostasis and pathophysiology. Annu. Rev. Pathol. 16, 299\u2013322 (2020).","journal-title":"Annu. Rev. Pathol."},{"key":"39396_CR53","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1530\/jrf.0.0170555","volume":"17","author":"T Pedersen","year":"1968","unstructured":"Pedersen, T. & Peters, H. Proposal for a classification of oocytes and follicles in the mouse ovary. J. Reprod. Fertil. 17, 555\u2013557 (1968).","journal-title":"J. Reprod. Fertil."},{"key":"39396_CR54","doi-asserted-by":"publisher","first-page":"3228","DOI":"10.1210\/me.2006-0194","volume":"20","author":"M Shimada","year":"2006","unstructured":"Shimada, M., Hernandez-Gonzalez, I., Gonzalez-Robanya, I. & Richards, J. S. Induced expression of pattern recognition receptors in cumulus oocyte complexes: novel evidence for innate immune-like functions during ovulation. Mol. Endocrinol. 20, 3228\u20133239 (2006).","journal-title":"Mol. Endocrinol."},{"key":"39396_CR55","doi-asserted-by":"publisher","first-page":"2001","DOI":"10.1242\/dev.020461","volume":"135","author":"M Shimada","year":"2008","unstructured":"Shimada, M. Hyaluronan fragments generated by sperm-secreted hyaluronidase stimulate cytokine\/chemokine production via the TLR2 and TLR4 pathway in cumulus cells of ovulated COCs, which may enhance fertilization. Development 135, 2001\u20132011 (2008).","journal-title":"Development"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-39396-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-39396-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-39396-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T11:02:15Z","timestamp":1773313335000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-39396-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,13]]},"references-count":55,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["39396"],"URL":"https:\/\/doi.org\/10.1038\/s41598-026-39396-5","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,13]]},"assertion":[{"value":"13 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"8837"}}