{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T13:17:00Z","timestamp":1773839820740,"version":"3.50.1"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T00:00:00Z","timestamp":1771200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:00:00Z","timestamp":1773792000000},"content-version":"vor","delay-in-days":30,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-026-39805-9","type":"journal-article","created":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T12:04:44Z","timestamp":1771243484000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Candidate biomarkers to identify mesothelioma patients at risk of developing venous thromboembolism post-surgery"],"prefix":"10.1038","volume":"16","author":[{"given":"Adnan","family":"Shami-shah","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shira","family":"Roth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shad R.","family":"Morton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bogdan","family":"Budnik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William G.","family":"Richards","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raphael","family":"Bueno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rushdy","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David R.","family":"Walt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,2,16]]},"reference":[{"key":"39805_CR1","doi-asserted-by":"publisher","first-page":"1638","DOI":"10.1016\/j.jtho.2018.08.001","volume":"13","author":"R Bueno","year":"2018","unstructured":"Bueno, R., Opitz, I. & Taskforce, I. M. Surgery in malignant pleural mesothelioma. J. Thorac. Oncol. 13, 1638\u20131654. https:\/\/doi.org\/10.1016\/j.jtho.2018.08.001 (2018).","journal-title":"J. Thorac. Oncol."},{"key":"39805_CR2","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1111\/jth.12611","volume":"12","author":"HY Yhim","year":"2014","unstructured":"Yhim, H. Y. et al. Incidence of venous thromboembolism following major surgery in korea: from the health insurance review and assessment service database. J. Thromb. Haemost. 12, 1035\u20131043. https:\/\/doi.org\/10.1111\/jth.12611 (2014).","journal-title":"J. Thromb. Haemost"},{"key":"39805_CR3","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1016\/j.jtcvs.2019.12.115","volume":"160","author":"LE De Le\u00f3n","year":"2020","unstructured":"De Le\u00f3n, L. E. et al. Routine surveillance for diagnosis of venous thromboembolism after pleurectomy for malignant pleural mesothelioma. J. Thorac. Cardiovasc. Surg. 160, 1064\u20131073. https:\/\/doi.org\/10.1016\/j.jtcvs.2019.12.115 (2020).","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"39805_CR4","first-page":"449","volume":"1","author":"HI Pass","year":"2012","unstructured":"Pass, H. I. Biomarkers and prognostic factors for mesothelioma. Annals Cardiothorac. Surg. 1, 449\u2013456 (2012).","journal-title":"Annals Cardiothorac. Surg."},{"key":"39805_CR5","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/j.ejcts.2010.12.024","volume":"40","author":"DJ Sugarbaker","year":"2011","unstructured":"Sugarbaker, D. J. et al. Clinical and pathological features of three-year survivors of malignant pleural mesothelioma following extrapleural pneumonectomy. Eur. J. Cardiothorac. Surg. 40, 298\u2013303. https:\/\/doi.org\/10.1016\/j.ejcts.2010.12.024 (2011).","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"39805_CR6","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1016\/j.hoc.2005.09.009","volume":"19","author":"JPC Steele","year":"2005","unstructured":"Steele, J. P. C. Prognostic factors for mesothelioma. Hematol. Oncol. Clin. N. Am. 19, 1041\u20131052. https:\/\/doi.org\/10.1016\/j.hoc.2005.09.009 (2005).","journal-title":"Hematol. Oncol. Clin. N. Am."},{"key":"39805_CR7","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1136\/thorax.55.9.731","volume":"55","author":"JG Edwards","year":"2000","unstructured":"Edwards, J. G. et al. Prognostic factors for malignant mesothelioma in 142 patients: validation of CALGB and EORTC prognostic scoring systems. Thorax 55, 731\u2013735. https:\/\/doi.org\/10.1136\/thorax.55.9.731 (2000).","journal-title":"Thorax"},{"key":"39805_CR8","doi-asserted-by":"publisher","first-page":"e544","DOI":"10.1371\/journal.pone.0000544","volume":"2","author":"SK Ganesh","year":"2007","unstructured":"Ganesh, S. K. et al. Detection of venous thromboembolism by proteomic serum biomarkers. PLoS ONE. 2, e544. https:\/\/doi.org\/10.1371\/journal.pone.0000544 (2007).","journal-title":"PLoS ONE"},{"key":"39805_CR9","doi-asserted-by":"publisher","first-page":"195","DOI":"10.46747\/cfp.6803195","volume":"68","author":"JF Gilens","year":"2022","unstructured":"Gilens, J. F. & Khodaee, M. Does a negative d-dimer test result rule out deep-vein thrombosis? Can. Fam Physician. 68, 195. https:\/\/doi.org\/10.46747\/cfp.6803195 (2022).","journal-title":"Can. Fam Physician"},{"key":"39805_CR10","doi-asserted-by":"publisher","first-page":"7772","DOI":"10.1245\/s10434-021-09941-9","volume":"28","author":"P Dranichnikov","year":"2021","unstructured":"Dranichnikov, P., Mahteme, H., Cashin, P. H. & Graf, W. Coagulopathy and venous thromboembolic events following cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. Ann. Surg. Oncol. 28, 7772\u20137782. https:\/\/doi.org\/10.1245\/s10434-021-09941-9 (2021).","journal-title":"Ann. Surg. Oncol."},{"key":"39805_CR11","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1007\/s11239-010-0460-x","volume":"30","author":"G Lippi","year":"2010","unstructured":"Lippi, G., Cervellin, G., Franchini, M. & Favaloro, E. J. Biochemical markers for the diagnosis of venous thromboembolism: the past, present and future. J. Thromb. Thrombolysis. 30, 459\u2013471. https:\/\/doi.org\/10.1007\/s11239-010-0460-x (2010).","journal-title":"J. Thromb. Thrombolysis"},{"key":"39805_CR12","doi-asserted-by":"publisher","DOI":"10.1186\/s12959-022-00431-w","author":"S Matilainen","year":"2022","unstructured":"Matilainen, S., Kask, G., Nieminen, J., Lassila, R. & Laitinen, M. Preoperative coagulation biomarkers associate with survival and pulmonary embolism after surgical treatment of non-spinal skeletal metastases. Thromb. J. https:\/\/doi.org\/10.1186\/s12959-022-00431-w (2022).","journal-title":"Thromb. J."},{"key":"39805_CR13","unstructured":"Lewandowski, M. et al. In in Mass Spectrometry Based Single Cell Proteomics (eds Vegvari, A., Teppo, J., Roman, A., Zubarev et al.) 157\u2013175 (Springer US, 2024)."},{"key":"39805_CR14","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btad547","author":"B Muzellec","year":"2023","unstructured":"Muzellec, B., Tele\u0144czuk, M., Cabeli, V. & Andreux, M. PyDESeq2: a python package for bulk RNA-seq differential expression analysis. Bioinformatics https:\/\/doi.org\/10.1093\/bioinformatics\/btad547 (2023).","journal-title":"Bioinformatics"},{"key":"39805_CR15","doi-asserted-by":"publisher","first-page":"2535","DOI":"10.1021\/acs.jproteome.9b00078","volume":"18","author":"M Iwasaki","year":"2019","unstructured":"Iwasaki, M., Tabata, T., Kawahara, Y., Ishihama, Y. & Nakagawa, M. Removal of interference MS\/MS spectra for accurate quantification in isobaric Tag-Based proteomics. J. Proteome Res. 18, 2535\u20132544. https:\/\/doi.org\/10.1021\/acs.jproteome.9b00078 (2019).","journal-title":"J. Proteome Res."},{"key":"39805_CR16","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1002\/pro.4218","volume":"31","author":"PD Thomas","year":"2022","unstructured":"Thomas, P. D. et al. Making genome-scale phylogenetics accessible to all. Protein Sci. 31, 8\u201322. https:\/\/doi.org\/10.1002\/pro.4218 (2022).","journal-title":"Protein Sci."},{"key":"39805_CR17","doi-asserted-by":"publisher","first-page":"D638","DOI":"10.1093\/nar\/gkac1000","volume":"51","author":"D Szklarczyk","year":"2023","unstructured":"Szklarczyk, D. et al. The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest. Nucleic Acids Res. 51, D638\u2013d646. https:\/\/doi.org\/10.1093\/nar\/gkac1000 (2023).","journal-title":"Nucleic Acids Res."},{"key":"39805_CR18","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/nar\/28.1.27","volume":"28","author":"M Kanehisa","year":"2000","unstructured":"Kanehisa, M. & Goto, S. KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 28, 27\u201330. https:\/\/doi.org\/10.1093\/nar\/28.1.27 (2000).","journal-title":"Nucleic Acids Res."},{"key":"39805_CR19","doi-asserted-by":"publisher","first-page":"1947","DOI":"10.1002\/pro.3715","volume":"28","author":"M Kanehisa","year":"2019","unstructured":"Kanehisa, M. Toward Understanding the origin and evolution of cellular organisms. Protein Sci. 28, 1947\u20131951. https:\/\/doi.org\/10.1002\/pro.3715 (2019).","journal-title":"Protein Sci."},{"key":"39805_CR20","doi-asserted-by":"publisher","first-page":"D672","DOI":"10.1093\/nar\/gkae909","volume":"53","author":"M Kanehisa","year":"2025","unstructured":"Kanehisa, M., Furumichi, M., Sato, Y., Matsuura, Y. & Ishiguro-Watanabe, M. KEGG: biological systems database as a model of the real world. Nucleic Acids Res. 53, D672\u2013D677. https:\/\/doi.org\/10.1093\/nar\/gkae909 (2025).","journal-title":"Nucleic Acids Res."},{"key":"39805_CR21","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/j.neo.2017.05.002","volume":"19","author":"DS Chandrashekar","year":"2017","unstructured":"Chandrashekar, D. S. et al. A portal for facilitating tumor subgroup gene expression and survival analyses. Neoplasia 19, 649\u2013658. https:\/\/doi.org\/10.1016\/j.neo.2017.05.002 (2017).","journal-title":"Neoplasia"},{"key":"39805_CR22","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1007\/s00281-011-0280-x","volume":"34","author":"K Oikonomopoulou","year":"2012","unstructured":"Oikonomopoulou, K., Ricklin, D., Ward, P. A. & Lambris, J. D. Interactions between coagulation and complement\u2013their role in inflammation. Semin Immunopathol. 34, 151\u2013165. https:\/\/doi.org\/10.1007\/s00281-011-0280-x (2012).","journal-title":"Semin Immunopathol."},{"key":"39805_CR23","first-page":"347","volume":"152","author":"T Nilsson","year":"1986","unstructured":"Nilsson, T., Mellbring, G. & Hedner, U. Relationship between factor XII, von Willebrand factor and postoperative deep vein thrombosis. Acta Chir. Scand. 152, 347\u2013349 (1986).","journal-title":"Acta Chir. Scand."},{"key":"39805_CR24","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1161\/atvbaha.116.308595","volume":"37","author":"KF Nickel","year":"2017","unstructured":"Nickel, K. F., Long, A. T., Fuchs, T. A., Butler, L. M. & Renn\u00e9, T. Factor XII as a therapeutic target in thromboembolic and inflammatory diseases. Arterioscler. Thromb. Vasc Biol. 37, 13\u201320. https:\/\/doi.org\/10.1161\/atvbaha.116.308595 (2017).","journal-title":"Arterioscler. Thromb. Vasc Biol."},{"key":"39805_CR25","doi-asserted-by":"publisher","first-page":"1903","DOI":"10.1182\/blood-2017-04-569111","volume":"131","author":"C Maas","year":"2018","unstructured":"Maas, C. & Renn\u00e9, T. Coagulation factor XII in thrombosis and inflammation. Blood 131, 1903\u20131909. https:\/\/doi.org\/10.1182\/blood-2017-04-569111 (2018).","journal-title":"Blood"},{"key":"39805_CR26","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1111\/joim.12430","volume":"278","author":"E Kenne","year":"2015","unstructured":"Kenne, E. et al. Factor XII: a novel target for safe prevention of thrombosis and inflammation. J. Intern. Med. 278, 571\u2013585. https:\/\/doi.org\/10.1111\/joim.12430 (2015).","journal-title":"J. Intern. Med."},{"key":"39805_CR27","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1007\/s11239-021-02598-x","volume":"54","author":"S Park","year":"2022","unstructured":"Park, S., Gu, J. Y. & Kim, H. K. Contact system activation in disseminated intravascular coagulation: activities of prekallikrein and high-molecular-weight kininogen are significant risk factors. J. Thromb. Thrombolysis. 54, 11\u201314. https:\/\/doi.org\/10.1007\/s11239-021-02598-x (2022).","journal-title":"J. Thromb. Thrombolysis"},{"key":"39805_CR28","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1111\/jth.13194","volume":"14","author":"AH Schmaier","year":"2016","unstructured":"Schmaier, A. H. The contact activation and kallikrein\/kinin systems: pathophysiologic and physiologic activities. J. Thromb. Haemost. 14, 28\u201339. https:\/\/doi.org\/10.1111\/jth.13194 (2016).","journal-title":"J. Thromb. Haemost."},{"key":"39805_CR29","doi-asserted-by":"publisher","first-page":"2008","DOI":"10.1161\/ATVBAHA.112.248492","volume":"32","author":"M Sabater-Lleal","year":"2012","unstructured":"Sabater-Lleal, M. et al. A Genome-Wide association study Identifies\u2009<\u2009i>KNG1\u2009as a genetic determinant of plasma factor XI level and activated partial thromboplastin time. Arterioscler. Thromb. Vasc. Biol. 32, 2008\u20132016. https:\/\/doi.org\/10.1161\/ATVBAHA.112.248492 (2012).","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"39805_CR30","doi-asserted-by":"publisher","first-page":"1422","DOI":"10.1182\/blood.2024025322","volume":"146","author":"J Emsley","year":"2025","unstructured":"Emsley, J., Ma, Y. & Meijers, J. C. M. Structure and interactions of the proteins from the contact system. Blood 146, 1422\u20131430. https:\/\/doi.org\/10.1182\/blood.2024025322 (2025).","journal-title":"Blood"},{"key":"39805_CR31","doi-asserted-by":"publisher","first-page":"2605","DOI":"10.1158\/1055-9965.Epi-10-0178","volume":"19","author":"KE Poruk","year":"2010","unstructured":"Poruk, K. E. et al. Serum platelet factor 4 is an independent predictor of survival and venous thromboembolism in patients with pancreatic adenocarcinoma. Cancer Epidemiol. Biomarkers Prev. 19, 2605\u20132610. https:\/\/doi.org\/10.1158\/1055-9965.Epi-10-0178 (2010).","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"39805_CR32","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1160\/TH07-05-0324","volume":"98","author":"R Blindt","year":"2007","unstructured":"Blindt, R. et al. The significance of vasodilator-stimulated phosphoprotein for risk stratification of stent thrombosis. Thromb. Haemost. 98, 1329\u20131334 (2007).","journal-title":"Thromb. Haemost"},{"key":"39805_CR33","doi-asserted-by":"publisher","first-page":"1658","DOI":"10.1182\/blood.2020007140","volume":"137","author":"MK Nayak","year":"2021","unstructured":"Nayak, M. K. et al. The metabolic enzyme pyruvate kinase M2 regulates platelet function and arterial thrombosis. Blood 137, 1658\u20131668. https:\/\/doi.org\/10.1182\/blood.2020007140 (2021).","journal-title":"Blood"},{"key":"39805_CR34","doi-asserted-by":"publisher","first-page":"7385","DOI":"10.1074\/jbc.M807820200","volume":"284","author":"Z Pamuklar","year":"2009","unstructured":"Pamuklar, Z. et al. Autotaxin\/lysopholipase D and lysophosphatidic acid regulate murine hemostasis and thrombosis. J. Biol. Chem. 284, 7385\u20137394. https:\/\/doi.org\/10.1074\/jbc.M807820200 (2009).","journal-title":"J. Biol. Chem."},{"key":"39805_CR35","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1182\/bloodadvances.2021004572","volume":"6","author":"L Han","year":"2022","unstructured":"Han, L. et al. The binding of autotaxin to integrins mediates hyperhomocysteinemia-potentiated platelet activation and thrombosis in mice and humans. Blood Adv. 6, 46\u201361. https:\/\/doi.org\/10.1182\/bloodadvances.2021004572 (2022).","journal-title":"Blood Adv."},{"key":"39805_CR36","doi-asserted-by":"publisher","unstructured":"Wang, H., Ricklin, D. & Lambris, J. D. Complement-activation fragment C4a mediates effector functions by binding as untethered agonist to protease-activated receptors 1 and 4. Proceedings of the National Academy of Sciences 114, 10948\u201310953, doi: (2017). https:\/\/doi.org\/10.1073\/pnas.1707364114","DOI":"10.1073\/pnas.1707364114"},{"key":"39805_CR37","doi-asserted-by":"publisher","first-page":"3280","DOI":"10.1038\/s41467-023-38383-y","volume":"14","author":"MJ Iglesias","year":"2023","unstructured":"Iglesias, M. J. et al. Elevated plasma complement factor H related 5 protein is associated with venous thromboembolism. Nat. Commun. 14, 3280. https:\/\/doi.org\/10.1038\/s41467-023-38383-y (2023).","journal-title":"Nat. Commun."},{"key":"39805_CR38","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.1161\/circulationaha.122.059675","volume":"146","author":"F Thibord","year":"2022","unstructured":"Thibord, F. et al. Cross-Ancestry investigation of venous thromboembolism genomic predictors. Circulation 146, 1225\u20131242. https:\/\/doi.org\/10.1161\/circulationaha.122.059675 (2022).","journal-title":"Circulation"},{"key":"39805_CR39","doi-asserted-by":"publisher","first-page":"2019","DOI":"10.1111\/jth.15345","volume":"19","author":"F Thibord","year":"2021","unstructured":"Thibord, F. et al. FGL1 as a modulator of plasma D-dimer levels: Exome-wide marker analysis of plasma tPA, PAI-1, and D-dimer. J. Thromb. Haemost. 19, 2019\u20132028. https:\/\/doi.org\/10.1111\/jth.15345 (2021).","journal-title":"J. Thromb. Haemost"},{"key":"39805_CR40","unstructured":"Leland McInnes, J. H. & Melville, J. UMAP: Uniform manifold approximation and projection for dimension reduction. doi:arXiv:1802.03426 (2020)."},{"key":"39805_CR41","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1093\/jnci\/djp334","volume":"101","author":"SE Taube","year":"2009","unstructured":"Taube, S. E. et al. A perspective on challenges and issues in biomarker development and drug and biomarker codevelopment. J. Natl. Cancer Inst. 101, 1453\u20131463. https:\/\/doi.org\/10.1093\/jnci\/djp334 (2009).","journal-title":"J. Natl. Cancer Inst."},{"key":"39805_CR42","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1517\/17530059.2012.718329","volume":"7","author":"JE McDermott","year":"2013","unstructured":"McDermott, J. E. et al. Challenges in biomarker discovery: combining expert insights with statistical analysis of complex omics data. Expert Opin. Med. Diagn. 7, 37\u201351. https:\/\/doi.org\/10.1517\/17530059.2012.718329 (2013).","journal-title":"Expert Opin. Med. Diagn."},{"key":"39805_CR43","doi-asserted-by":"publisher","first-page":"17332","DOI":"10.1038\/s41598-018-34868-9","volume":"8","author":"Q Wang","year":"2018","unstructured":"Wang, Q. et al. Genetic effects of BDKRB2 and KNG1 on deep venous thrombosis after orthopedic surgery and the potential mediator. Sci. Rep. 8, 17332. https:\/\/doi.org\/10.1038\/s41598-018-34868-9 (2018).","journal-title":"Sci. Rep."},{"key":"39805_CR44","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1093\/emboj\/18.1.37","volume":"18","author":"A Asz\u00f3di","year":"1999","unstructured":"Asz\u00f3di, A. et al. The vasodilator-stimulated phosphoprotein (VASP) is involved in cGMP- and cAMP-mediated Inhibition of agonist-induced platelet aggregation, but is dispensable for smooth muscle function. Embo j. 18, 37\u201348. https:\/\/doi.org\/10.1093\/emboj\/18.1.37 (1999).","journal-title":"Embo j."},{"key":"39805_CR45","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1161\/01.Res.0000146674.38319.07","volume":"95","author":"S Struyf","year":"2004","unstructured":"Struyf, S., Burdick, M. D., Proost, P., Van Damme, J. & Strieter, R. M. Platelets release CXCL4L1, a nonallelic variant of the chemokine platelet factor-4\/CXCL4 and potent inhibitor of angiogenesis. Circ. Res. 95, 855\u2013857. https:\/\/doi.org\/10.1161\/01.Res.0000146674.38319.07 (2004).","journal-title":"Circ. Res."},{"key":"39805_CR46","doi-asserted-by":"publisher","first-page":"491","DOI":"10.4103\/1947-2714.143278","volume":"6","author":"S Pulivarthi","year":"2014","unstructured":"Pulivarthi, S. & Gurram, M. K. Effectiveness of d-dimer as a screening test for venous thromboembolism: an update. N Am. J. Med. Sci. 6, 491\u2013499. https:\/\/doi.org\/10.4103\/1947-2714.143278 (2014).","journal-title":"N Am. J. Med. Sci."},{"key":"39805_CR47","doi-asserted-by":"publisher","DOI":"10.21203\/rs.3.rs-155640\/v1","author":"S Han","year":"2021","unstructured":"Han, S., Luo, Q., Ren, Y., Ma, X. & Fang, J. Identification of critical genes and pathways related to venous thromboembolism in non-small cell lung cancer patients using integrated bioinformatics analysis. Res. Square. https:\/\/doi.org\/10.21203\/rs.3.rs-155640\/v1 (2021).","journal-title":"Res. Square"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-39805-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-39805-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-39805-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T09:39:00Z","timestamp":1773826740000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-39805-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,16]]},"references-count":47,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["39805"],"URL":"https:\/\/doi.org\/10.1038\/s41598-026-39805-9","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,16]]},"assertion":[{"value":"23 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"9313"}}