{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T14:02:04Z","timestamp":1773928924019,"version":"3.50.1"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"vor","delay-in-days":30,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23K06494"],"award-info":[{"award-number":["23K06494"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K07034"],"award-info":[{"award-number":["22K07034"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21K06978"],"award-info":[{"award-number":["21K06978"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012043","name":"Kindai University","doi-asserted-by":"publisher","award":["KD2502"],"award-info":[{"award-number":["KD2502"]}],"id":[{"id":"10.13039\/100012043","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012043","name":"Kindai University","doi-asserted-by":"publisher","award":["KD2401"],"award-info":[{"award-number":["KD2401"]}],"id":[{"id":"10.13039\/100012043","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP23ym0126809"],"award-info":[{"award-number":["JP23ym0126809"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-026-40526-2","type":"journal-article","created":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T14:55:53Z","timestamp":1771340153000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cell adhesion molecule 1 is upregulated in connective tissue mast cells and potentially contributes in IgE-mediated degranulation"],"prefix":"10.1038","volume":"16","author":[{"given":"Man","family":"Hagiyama","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azusa","family":"Yoneshige","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuka","family":"Takeuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takao","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiko","family":"Ito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,2,17]]},"reference":[{"key":"40526_CR1","doi-asserted-by":"publisher","unstructured":"Tauber, M. et al. Landscape of mast cell populations across organs in mice and humans. J. Exp. Med. 220 https:\/\/doi.org\/10.1084\/jem.20230570 (2023).","DOI":"10.1084\/jem.20230570"},{"key":"40526_CR2","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1159\/000513582","volume":"13","author":"A Paivandy","year":"2021","unstructured":"Paivandy, A. & Pejler, G. Novel strategies to target mast cells in disease. J. Innate Immun. 13, 131\u2013147. https:\/\/doi.org\/10.1159\/000513582 (2021).","journal-title":"J. Innate Immun."},{"key":"40526_CR3","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1038\/s41577-021-00622-y","volume":"22","author":"P Kolkhir","year":"2022","unstructured":"Kolkhir, P., Elieh-Ali-Komi, D., Metz, M., Siebenhaar, F. & Maurer, M. Understanding human mast cells: lesson from therapies for allergic and non-allergic diseases. Nat. Rev. Immunol. 22, 294\u2013308. https:\/\/doi.org\/10.1038\/s41577-021-00622-y (2022).","journal-title":"Nat. Rev. Immunol."},{"key":"40526_CR4","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1038\/nm.2755","volume":"18","author":"SJ Galli","year":"2012","unstructured":"Galli, S. J. & Tsai, M. IgE and mast cells in allergic disease. Nat. Med. 18, 693\u2013704. https:\/\/doi.org\/10.1038\/nm.2755 (2012).","journal-title":"Nat. Med."},{"key":"40526_CR5","doi-asserted-by":"publisher","first-page":"2601","DOI":"10.1182\/blood-2002-07-2265","volume":"101","author":"A Ito","year":"2003","unstructured":"Ito, A. et al. SgIGSF: a new mast-cell adhesion molecule used for attachment to fibroblasts and transcriptionally regulated by MITF. Blood 101, 2601\u20132608. https:\/\/doi.org\/10.1182\/blood-2002-07-2265 (2003).","journal-title":"Blood"},{"key":"40526_CR6","doi-asserted-by":"publisher","unstructured":"Yoneshige, A., Hagiyama, M., Fujita, M. & Ito, A. Pathogenic actions of cell adhesion molecule 1 in pulmonary emphysema and atopic dermatitis. Front. Cell. Dev. Biol. 3 https:\/\/doi.org\/10.3389\/fcell.2015.00075 (2015).","DOI":"10.3389\/fcell.2015.00075"},{"key":"40526_CR7","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1016\/j.bbrc.2004.09.117","volume":"324","author":"K Watabe","year":"2004","unstructured":"Watabe, K. et al. Distinct roles for the SgIGSF adhesion molecule and c-kit receptor tyrosine kinase in the interaction between mast cells and the mesentery. Biochem. Biophys. Res. Commun. 324, 782\u2013788. https:\/\/doi.org\/10.1016\/j.bbrc.2004.09.117 (2004).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"40526_CR8","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1038\/labinvest.3700231","volume":"85","author":"Y Koma","year":"2005","unstructured":"Koma, Y. et al. Distinct role for c-kit receptor tyrosine kinase and SgIGSF adhesion molecule in attachment of mast cells to fibroblasts. Lab. Invest. 85, 426\u2013435. https:\/\/doi.org\/10.1038\/labinvest.3700231 (2005).","journal-title":"Lab. Invest."},{"key":"40526_CR9","doi-asserted-by":"publisher","first-page":"6934","DOI":"10.4049\/jimmunol.174.11.6934","volume":"174","author":"T Furuno","year":"2005","unstructured":"Furuno, T. et al. The spermatogenic Ig superfamily\/synaptic cell adhesion molecule mast-cell adhesion molecule promotes interaction with nerves. J. Immunol. 174, 6934\u20136942. https:\/\/doi.org\/10.4049\/jimmunol.174.11.6934 (2005).","journal-title":"J. Immunol."},{"key":"40526_CR10","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.jneuroim.2012.05.016","volume":"250","author":"T Furuno","year":"2012","unstructured":"Furuno, T. et al. Cell adhesion molecule 1 (CADM1) on mast cells promotes interaction with dorsal root ganglion neurites by heterophilic binding to nectin-3. J. Neuroimmunol. 250, 50\u201358. https:\/\/doi.org\/10.1016\/j.jneuroim.2012.05.016 (2012).","journal-title":"J. Neuroimmunol."},{"key":"40526_CR11","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.jneuroim.2006.12.008","volume":"184","author":"A Ito","year":"2007","unstructured":"Ito, A. et al. Involvement of the SgIGSF\/Necl-2 adhesion molecule in degranulation of mesenteric mast cells. J. Neuroimmunol. 184, 209\u2013213. https:\/\/doi.org\/10.1016\/j.jneuroim.2006.12.008 (2007).","journal-title":"J. Neuroimmunol."},{"key":"40526_CR12","doi-asserted-by":"publisher","first-page":"5983","DOI":"10.4049\/jimmunol.1002244","volume":"186","author":"M Hagiyama","year":"2011","unstructured":"Hagiyama, M. et al. Enhanced nerve-mast cell interaction by a neuronal short isoform of cell adhesion molecule-1. J. Immunol. 186, 5983\u20135992. https:\/\/doi.org\/10.4049\/jimmunol.1002244 (2011).","journal-title":"J. Immunol."},{"key":"40526_CR13","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1111\/bjd.12108","volume":"168","author":"M Hagiyama","year":"2013","unstructured":"Hagiyama, M. et al. Increased expression of cell adhesion molecule 1 by mast cells as a cause of enhanced nerve-mast cell interaction in a hapten-induced mouse model of atopic dermatitis. Br. J. Dermatol. 168, 771\u2013778. https:\/\/doi.org\/10.1111\/bjd.12108 (2013).","journal-title":"Br. J. Dermatol."},{"key":"40526_CR14","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1016\/j.jaci.2024.02.005","volume":"153","author":"C Bao","year":"2024","unstructured":"Bao, C. & Abraham, S. N. Mast cell-sensory neuron crosstalk in allergic diseases. J. Allergy Clin. Immunol. 153, 939\u2013953. https:\/\/doi.org\/10.1016\/j.jaci.2024.02.005 (2024).","journal-title":"J. Allergy Clin. Immunol."},{"key":"40526_CR15","doi-asserted-by":"publisher","first-page":"1544","DOI":"10.1053\/j.gastro.2008.01.081","volume":"134","author":"Y Koma","year":"2008","unstructured":"Koma, Y. et al. Cell adhesion molecule 1 is a novel pancreatic-islet cell adhesion molecule that mediates nerve-islet cell interactions. Gastroenterology 134, 1544\u20131554. https:\/\/doi.org\/10.1053\/j.gastro.2008.01.081 (2008).","journal-title":"Gastroenterology"},{"key":"40526_CR16","doi-asserted-by":"publisher","first-page":"e61579","DOI":"10.1371\/journal.pone.0061579","volume":"8","author":"EP Moiseeva","year":"2013","unstructured":"Moiseeva, E. P., Roach, K. M., Leyland, M. L. & Bradding, P. CADM1 is a key receptor mediating human mast cell adhesion to human lung fibroblasts and airway smooth muscle cells. PLoS One. 8, e61579. https:\/\/doi.org\/10.1371\/journal.pone.0061579 (2013).","journal-title":"PLoS One"},{"key":"40526_CR17","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.4049\/jimmunol.176.2.1238","volume":"176","author":"W Yang","year":"2006","unstructured":"Yang, W. et al. Human lung mast cells adhere to human airway smooth muscle, in part, via tumor suppressor in lung cancer-1. J. Immunol. 176, 1238\u20131243. https:\/\/doi.org\/10.4049\/jimmunol.176.2.1238 (2006).","journal-title":"J. Immunol."},{"key":"40526_CR18","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1016\/j.jconrel.2024.05.035","volume":"371","author":"M Hagiyama","year":"2024","unstructured":"Hagiyama, M. et al. Efficient intracellular drug delivery by co-administration of two antibodies against cell adhesion molecule 1. J. Control Release. 371, 603\u2013618. https:\/\/doi.org\/10.1016\/j.jconrel.2024.05.035 (2024).","journal-title":"J. Control Release"},{"key":"40526_CR19","doi-asserted-by":"publisher","first-page":"122997","DOI":"10.1016\/j.lfs.2024.122997","volume":"357","author":"F Takeuchi","year":"2024","unstructured":"Takeuchi, F. et al. Relief of pain in mice by an antibody with high affinity for cell adhesion molecule 1 on nerves. Life Sci. 357, 122997. https:\/\/doi.org\/10.1016\/j.lfs.2024.122997 (2024).","journal-title":"Life Sci."},{"key":"40526_CR20","doi-asserted-by":"publisher","first-page":"1444","DOI":"10.1016\/j.febslet.2008.03.033","volume":"582","author":"H Takano","year":"2008","unstructured":"Takano, H. et al. Establishment of the culture model system that reflects the process of terminal differentiation of connective tissue-type mast cells. FEBS Lett. 582, 1444\u20131450. https:\/\/doi.org\/10.1016\/j.febslet.2008.03.033 (2008).","journal-title":"FEBS Lett."},{"key":"40526_CR21","doi-asserted-by":"publisher","first-page":"268","DOI":"10.4168\/aair.2018.10.3.268","volume":"10","author":"S Benede","year":"2018","unstructured":"Benede, S., Cody, E., Agashe, C. & Berin, M. C. Immune characterization of bone Marrow-Derived models of mucosal and connective tissue mast cells. Allergy Asthma Immunol. Res. 10, 268\u2013277. https:\/\/doi.org\/10.4168\/aair.2018.10.3.268 (2018).","journal-title":"Allergy Asthma Immunol. Res."},{"key":"40526_CR22","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1182\/blood.V85.1.57.bloodjournal85157","volume":"85","author":"D Rennick","year":"1995","unstructured":"Rennick, D., Hunte, B., Holland, G. & Thompson-Snipes, L. Cofactors are essential for stem cell factor-dependent growth and maturation of mast cell progenitors: comparative effects of interleukin-3 (IL-3), IL-4, IL-10, and fibroblasts. Blood 85, 57\u201365 (1995).","journal-title":"Blood"},{"key":"40526_CR23","doi-asserted-by":"publisher","first-page":"652077","DOI":"10.3389\/fcell.2021.652077","volume":"9","author":"G Menasche","year":"2021","unstructured":"Menasche, G., Longe, C., Bratti, M. & Blank, U. Cytoskeletal Transport, Reorganization, and fusion regulation in mast Cell-Stimulus secretion coupling. Front. Cell. Dev. Biol. 9, 652077. https:\/\/doi.org\/10.3389\/fcell.2021.652077 (2021).","journal-title":"Front. Cell. Dev. Biol."},{"key":"40526_CR24","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.coi.2021.03.002","volume":"72","author":"P Lazki-Hagenbach","year":"2021","unstructured":"Lazki-Hagenbach, P., Klein, O. & Sagi-Eisenberg, R. The actin cytoskeleton and mast cell function. Curr. Opin. Immunol. 72, 27\u201333. https:\/\/doi.org\/10.1016\/j.coi.2021.03.002 (2021).","journal-title":"Curr. Opin. Immunol."},{"key":"40526_CR25","doi-asserted-by":"publisher","first-page":"1845","DOI":"10.1016\/j.jaci.2022.04.012","volume":"149","author":"M Tsai","year":"2022","unstructured":"Tsai, M., Valent, P. & Galli, S. J. KIT as a master regulator of the mast cell lineage. J. Allergy Clin. Immunol. 149, 1845\u20131854. https:\/\/doi.org\/10.1016\/j.jaci.2022.04.012 (2022).","journal-title":"J. Allergy Clin. Immunol."},{"key":"40526_CR26","doi-asserted-by":"publisher","first-page":"6485","DOI":"10.1073\/pnas.83.17.6485","volume":"83","author":"F Levi-Schaffer","year":"1986","unstructured":"Levi-Schaffer, F., Austen, K. F., Gravallese, P. M. & Stevens, R. L. Coculture of Interleukin 3-dependent mouse mast cells with fibroblasts results in a phenotypic change of the mast cells. Proc. Natl. Acad. Sci. U S A. 83, 6485\u20136488. https:\/\/doi.org\/10.1073\/pnas.83.17.6485 (1986).","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"40526_CR27","doi-asserted-by":"publisher","unstructured":"Taketomi, Y. et al. Lipid-orchestrated paracrine circuit coordinates mast cell maturation and anaphylaxis through functional interaction with fibroblasts. Immunity 57, 1828\u20131847 e1811, (2024). https:\/\/doi.org\/10.1016\/j.immuni.2024.06.012","DOI":"10.1016\/j.immuni.2024.06.012"},{"key":"40526_CR28","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.1182\/blood.V88.4.1225.bloodjournal8841225","volume":"88","author":"T Tsujimura","year":"1996","unstructured":"Tsujimura, T. et al. Involvement of transcription factor encoded by the Mi locus in the expression of c-kit receptor tyrosine kinase in cultured mast cells of Mice. Blood 88, 1225\u20131233 (1996).","journal-title":"Blood"},{"key":"40526_CR29","doi-asserted-by":"publisher","first-page":"3629","DOI":"10.1182\/blood-2010-07-293548","volume":"117","author":"YN Lee","year":"2011","unstructured":"Lee, Y. N. et al. KIT signaling regulates MITF expression through MiRNAs in normal and malignant mast cell proliferation. Blood 117, 3629\u20133640. https:\/\/doi.org\/10.1182\/blood-2010-07-293548 (2011).","journal-title":"Blood"},{"key":"40526_CR30","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1038\/s41467-020-20766-0","volume":"12","author":"Y Li","year":"2021","unstructured":"Li, Y. et al. GATA2 regulates mast cell identity and responsiveness to antigenic stimulation by promoting chromatin remodeling at super-enhancers. Nat. Commun. 12, 494. https:\/\/doi.org\/10.1038\/s41467-020-20766-0 (2021).","journal-title":"Nat. Commun."},{"key":"40526_CR31","doi-asserted-by":"publisher","unstructured":"Nagata, Y., Suzuki, R. & FcepsilonRI A Master Regulator of Mast Cell Functions. Cells 11, (2022). https:\/\/doi.org\/10.3390\/cells11040622","DOI":"10.3390\/cells11040622"},{"key":"40526_CR32","doi-asserted-by":"publisher","first-page":"3981","DOI":"10.1172\/JCI85538","volume":"126","author":"N Gaudenzio","year":"2016","unstructured":"Gaudenzio, N. et al. Different activation signals induce distinct mast cell degranulation strategies. J. Clin. Invest. 126, 3981\u20133998. https:\/\/doi.org\/10.1172\/JCI85538 (2016).","journal-title":"J. Clin. Invest."},{"key":"40526_CR33","first-page":"5129","volume":"62","author":"M Yageta","year":"2002","unstructured":"Yageta, M. et al. Direct association of TSLC1 and DAL-1, two distinct tumor suppressor proteins in lung cancer. Cancer Res. 62, 5129\u20135133 (2002).","journal-title":"Cancer Res."},{"key":"40526_CR34","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1016\/j.bbrc.2009.10.088","volume":"390","author":"M Sakurai-Yageta","year":"2009","unstructured":"Sakurai-Yageta, M., Masuda, M., Tsuboi, Y., Ito, A. & Murakami, Y. Tumor suppressor CADM1 is involved in epithelial cell structure. Biochem. Biophys. Res. Commun. 390, 977\u2013982. https:\/\/doi.org\/10.1016\/j.bbrc.2009.10.088 (2009).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"40526_CR35","doi-asserted-by":"publisher","first-page":"e85980","DOI":"10.1371\/journal.pone.0085980","volume":"9","author":"EP Moiseeva","year":"2014","unstructured":"Moiseeva, E. P., Straatman, K. R., Leyland, M. L. & Bradding, P. CADM1 controls actin cytoskeleton assembly and regulates extracellular matrix adhesion in human mast cells. PLoS One. 9, e85980. https:\/\/doi.org\/10.1371\/journal.pone.0085980 (2014).","journal-title":"PLoS One"},{"key":"40526_CR36","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1007\/s12013-016-0737-6","volume":"74","author":"S Yokawa","year":"2016","unstructured":"Yokawa, S. et al. Effect of cell adhesion molecule 1 expression on intracellular granule movement in pancreatic alpha cells. Cell. Biochem. Biophys. 74, 391\u2013398. https:\/\/doi.org\/10.1007\/s12013-016-0737-6 (2016).","journal-title":"Cell. Biochem. Biophys."},{"key":"40526_CR37","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1038\/cmi.2008.31","volume":"5","author":"M Nakanishi","year":"2008","unstructured":"Nakanishi, M. & Furuno, T. Molecular basis of neuroimmune interaction in an in vitro coculture approach. Cell. Mol. Immunol. 5, 249\u2013259. https:\/\/doi.org\/10.1038\/cmi.2008.31 (2008).","journal-title":"Cell. Mol. Immunol."},{"key":"40526_CR38","doi-asserted-by":"publisher","first-page":"262","DOI":"10.3389\/fncel.2019.00262","volume":"13","author":"R Magadmi","year":"2019","unstructured":"Magadmi, R., Meszaros, J., Damanhouri, Z. A. & Seward, E. P. Secretion of mast cell inflammatory mediators is enhanced by CADM1-Dependent adhesion to sensory neurons. Front. Cell. Neurosci. 13, 262. https:\/\/doi.org\/10.3389\/fncel.2019.00262 (2019).","journal-title":"Front. Cell. Neurosci."},{"key":"40526_CR39","doi-asserted-by":"publisher","first-page":"714298","DOI":"10.3389\/fcell.2021.714298","volume":"9","author":"H Li","year":"2021","unstructured":"Li, H., Gao, J. & Zhang, S. Functional and clinical characteristics of cell adhesion molecule CADM1 in cancer. Front. Cell. Dev. Biol. 9, 714298. https:\/\/doi.org\/10.3389\/fcell.2021.714298 (2021).","journal-title":"Front. Cell. Dev. Biol."},{"key":"40526_CR40","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1272\/jnms.JNMS.2025_92-205","volume":"92","author":"Y Murakami","year":"2025","unstructured":"Murakami, Y., Kasai, Y., Masuda, T., Ichihara, H. & Ito, T. Multiple functions of cell adhesion molecule 1 (CADM1) and its role in the pathogenesis of cancer and other diseases. J. Nippon Med. Sch. 92, 122\u2013131. https:\/\/doi.org\/10.1272\/jnms.JNMS.2025_92-205 (2025).","journal-title":"J. Nippon Med. Sch."},{"key":"40526_CR41","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1016\/j.jaci.2016.01.049","volume":"138","author":"PJ Bryce","year":"2016","unstructured":"Bryce, P. J. et al. Humanized mouse model of mast cell-mediated passive cutaneous anaphylaxis and passive systemic anaphylaxis. J. Allergy Clin. Immunol. 138, 769\u2013779. https:\/\/doi.org\/10.1016\/j.jaci.2016.01.049 (2016).","journal-title":"J. Allergy Clin. Immunol."},{"key":"40526_CR42","doi-asserted-by":"publisher","first-page":"945007","DOI":"10.3389\/fcell.2022.945007","volume":"10","author":"M Hagiyama","year":"2022","unstructured":"Hagiyama, M. et al. Possible therapeutic utility of anti-Cell adhesion molecule 1 antibodies for malignant pleural mesothelioma. Front. Cell. Dev. Biol. 10, 945007. https:\/\/doi.org\/10.3389\/fcell.2022.945007 (2022).","journal-title":"Front. Cell. Dev. Biol."},{"key":"40526_CR43","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s13568-022-01355-4","volume":"12","author":"S Ge","year":"2022","unstructured":"Ge, S. et al. Specific anti-SARS-CoV-2 S1 IgY-scFv is a promising tool for recognition of the virus. AMB Express. 12, 18. https:\/\/doi.org\/10.1186\/s13568-022-01355-4 (2022).","journal-title":"AMB Express"},{"key":"40526_CR44","doi-asserted-by":"publisher","first-page":"111","DOI":"10.3389\/fcell.2019.00111","volume":"7","author":"M Hagiyama","year":"2019","unstructured":"Hagiyama, M. et al. Urinary cell adhesion molecule 1 is a novel biomarker that links tubulointerstitial damage to glomerular filtration rates in chronic kidney disease. Front. Cell. Dev. Biol. 7, 111. https:\/\/doi.org\/10.3389\/fcell.2019.00111 (2019).","journal-title":"Front. Cell. Dev. Biol."},{"key":"40526_CR45","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1084\/jem.20131926","volume":"211","author":"K Ogawa","year":"2014","unstructured":"Ogawa, K. et al. DOCK5 functions as a key signaling adaptor that links FcepsilonRI signals to microtubule dynamics during mast cell degranulation. J. Exp. Med. 211, 1407\u20131419. https:\/\/doi.org\/10.1084\/jem.20131926 (2014).","journal-title":"J. Exp. Med."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-40526-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-40526-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-40526-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T10:48:07Z","timestamp":1773917287000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-40526-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,17]]},"references-count":45,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["40526"],"URL":"https:\/\/doi.org\/10.1038\/s41598-026-40526-2","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,17]]},"assertion":[{"value":"8 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"A.I. has received research funding from Pharma Foods International, Co., Ltd.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"9432"}}