{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T16:00:03Z","timestamp":1783699203945,"version":"3.55.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:00:00Z","timestamp":1771977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"vor","delay-in-days":30,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82302026"],"award-info":[{"award-number":["82302026"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-026-40762-6","type":"journal-article","created":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T09:04:28Z","timestamp":1772010268000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Integrated transcriptomic analysis of the temporal cortex identifies CRH and GAD2 as neuropathological markers and reveals altered immune microenvironment in Alzheimer\u2019s disease"],"prefix":"10.1038","volume":"16","author":[{"given":"Pan","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ChengLong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi Lin","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ZhaoYang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,25]]},"reference":[{"key":"40762_CR1","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.ibneur.2023.11.003","volume":"16","author":"RP Bhole","year":"2024","unstructured":"Bhole, R. P., Chikhale, R. V. & Rathi, K. M. Current biomarkers and treatment strategies in Alzheimer disease: An overview and future perspectives. IBRO Neurosci. Rep. 16, 8\u201342. https:\/\/doi.org\/10.1016\/j.ibneur.2023.11.003 (2024).","journal-title":"IBRO Neurosci. Rep."},{"issue":"3","key":"40762_CR2","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1212\/con.0000000000001131","volume":"28","author":"EM McDade","year":"2022","unstructured":"McDade, E. M. Alzheimer disease. Continuum 28(3), 648\u2013675. https:\/\/doi.org\/10.1212\/con.0000000000001131 (2022).","journal-title":"Continuum"},{"issue":"6","key":"40762_CR3","doi-asserted-by":"publisher","first-page":"1584","DOI":"10.1212\/con.0000000000001507","volume":"30","author":"GS Day","year":"2024","unstructured":"Day, G. S. Diagnosing Alzheimer disease. Continuum 30(6), 1584\u20131613. https:\/\/doi.org\/10.1212\/con.0000000000001507 (2024).","journal-title":"Continuum"},{"issue":"3","key":"40762_CR4","first-page":"281","volume":"110","author":"EE Jaqua","year":"2024","unstructured":"Jaqua, E. E., Tran, M. N. & Hanna, M. Alzheimer disease: Treatment of cognitive and functional symptoms. Am. Fam. Physician 110(3), 281\u2013293 (2024).","journal-title":"Am. Fam. Physician"},{"issue":"4","key":"40762_CR5","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1038\/s41582-024-00942-2","volume":"20","author":"J Therriault","year":"2024","unstructured":"Therriault, J. et al. Biomarker-based staging of Alzheimer disease: Rationale and clinical applications. Nat. Rev. Neurol. 20(4), 232\u2013244. https:\/\/doi.org\/10.1038\/s41582-024-00942-2 (2024).","journal-title":"Nat. Rev. Neurol."},{"issue":"1","key":"40762_CR6","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1146\/annurev-immunol-101921-035222","volume":"42","author":"A Mary","year":"2024","unstructured":"Mary, A., Mancuso, R. & Heneka, M. T. Immune activation in Alzheimer disease. Annu. Rev. Immunol. 42(1), 585\u2013613. https:\/\/doi.org\/10.1146\/annurev-immunol-101921-035222 (2024).","journal-title":"Annu. Rev. Immunol."},{"issue":"4","key":"40762_CR7","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/s1474-4422(15)70016-5","volume":"14","author":"MT Heneka","year":"2015","unstructured":"Heneka, M. T. et al. Neuroinflammation in Alzheimer\u2019s disease. Lancet Neurol. 14(4), 388\u2013405. https:\/\/doi.org\/10.1016\/s1474-4422(15)70016-5 (2015).","journal-title":"Lancet Neurol."},{"key":"40762_CR8","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1016\/j.trci.2018.06.014","volume":"4","author":"JW Kinney","year":"2018","unstructured":"Kinney, J. W. et al. Inflammation as a central mechanism in Alzheimer\u2019s disease. Alzheimer\u2019s Dement. Transl. Res. Clin. Interv. 4, 575\u2013590. https:\/\/doi.org\/10.1016\/j.trci.2018.06.014 (2018).","journal-title":"Alzheimer\u2019s Dement. Transl. Res. Clin. Interv."},{"issue":"9","key":"40762_CR9","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.1038\/s41593-023-01415-3","volume":"26","author":"M Jorfi","year":"2023","unstructured":"Jorfi, M. et al. Infiltrating CD8(+) T cells exacerbate Alzheimer\u2019s disease pathology in a 3D human neuroimmune axis model. Nat. Neurosci. 26(9), 1489\u20131504. https:\/\/doi.org\/10.1038\/s41593-023-01415-3 (2023).","journal-title":"Nat. Neurosci."},{"issue":"7953","key":"40762_CR10","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1038\/s41586-023-05788-0","volume":"615","author":"X Chen","year":"2023","unstructured":"Chen, X. et al. Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy. Nature 615(7953), 668\u2013677. https:\/\/doi.org\/10.1038\/s41586-023-05788-0 (2023).","journal-title":"Nature"},{"key":"40762_CR11","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.768966","volume":"12","author":"Y Lu","year":"2021","unstructured":"Lu, Y., Li, K., Hu, Y. & Wang, X. Expression of immune related genes and possible regulatory mechanisms in Alzheimer\u2019s disease. Front. Immunol. 12, 768966. https:\/\/doi.org\/10.3389\/fimmu.2021.768966 (2021).","journal-title":"Front. Immunol."},{"issue":"7","key":"40762_CR12","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1038\/s41587-019-0114-2","volume":"37","author":"AM Newman","year":"2019","unstructured":"Newman, A. M. et al. Determining cell type abundance and expression from bulk tissues with digital cytometry. Nat. Biotechnol. 37(7), 773\u2013782. https:\/\/doi.org\/10.1038\/s41587-019-0114-2 (2019).","journal-title":"Nat. Biotechnol."},{"key":"40762_CR13","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2022.913535","volume":"13","author":"F Jin","year":"2022","unstructured":"Jin, F., Xi, Y., Xie, D. & Wang, Q. Comprehensive analysis reveals a 5-gene signature and immune cell infiltration in Alzheimer\u2019s disease with qPCR validation. Front. Genet. 13, 913535. https:\/\/doi.org\/10.3389\/fgene.2022.913535 (2022).","journal-title":"Front. Genet."},{"key":"40762_CR14","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1046410","volume":"13","author":"Y Lai","year":"2022","unstructured":"Lai, Y. et al. Identification of immune microenvironment subtypes and signature genes for Alzheimer\u2019s disease diagnosis and risk prediction based on explainable machine learning. Front. Immunol. 13, 1046410. https:\/\/doi.org\/10.3389\/fimmu.2022.1046410 (2022).","journal-title":"Front. Immunol."},{"key":"40762_CR15","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1147501","volume":"14","author":"X Zhuang","year":"2023","unstructured":"Zhuang, X. et al. Development of a novel immune infiltration-related diagnostic model for Alzheimer\u2019s disease using bioinformatic strategies. Front. Immunol. 14, 1147501. https:\/\/doi.org\/10.3389\/fimmu.2023.1147501 (2023).","journal-title":"Front. Immunol."},{"key":"40762_CR16","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.919614","volume":"14","author":"Y Tian","year":"2022","unstructured":"Tian, Y. et al. Identification of diagnostic signatures associated with immune infiltration in Alzheimer\u2019s disease by integrating bioinformatic analysis and machine-learning strategies. Front. Aging Neurosci. 14, 919614. https:\/\/doi.org\/10.3389\/fnagi.2022.919614 (2022).","journal-title":"Front. Aging Neurosci."},{"key":"40762_CR17","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.947781","volume":"13","author":"K Duan","year":"2022","unstructured":"Duan, K., Ma, Y., Tan, J., Miao, Y. & Zhang, Q. Identification of genetic molecular markers and immune infiltration characteristics of Alzheimer\u2019s disease through weighted gene co-expression network analysis. Front. Neurol. 13, 947781. https:\/\/doi.org\/10.3389\/fneur.2022.947781 (2022).","journal-title":"Front. Neurol."},{"issue":"9","key":"40762_CR18","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1007\/s00115-019-0772-9","volume":"90","author":"J Vogelgsang","year":"2019","unstructured":"Vogelgsang, J. & Wiltfang, J. New biomarkers for Alzheimer\u2019s disease in cerebrospinal fluid and blood. Nervenarzt 90(9), 907\u2013913. https:\/\/doi.org\/10.1007\/s00115-019-0772-9 (2019).","journal-title":"Nervenarzt"},{"issue":"10","key":"40762_CR19","doi-asserted-by":"publisher","first-page":"4899","DOI":"10.1038\/s41380-025-03081-2","volume":"30","author":"Y Wang","year":"2025","unstructured":"Wang, Y. et al. Advance and prospect of positron emission tomography in Alzheimer\u2019s disease research. Mol. Psychiatry 30(10), 4899\u20134909. https:\/\/doi.org\/10.1038\/s41380-025-03081-2 (2025).","journal-title":"Mol. Psychiatry"},{"issue":"8","key":"40762_CR20","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1002\/kjm2.12870","volume":"40","author":"AD Assfaw","year":"2024","unstructured":"Assfaw, A. D., Schindler, S. E. & Morris, J. C. Advances in blood biomarkers for Alzheimer disease (AD): A review. Kaohsiung J. Med. Sci. 40(8), 692\u2013698. https:\/\/doi.org\/10.1002\/kjm2.12870 (2024).","journal-title":"Kaohsiung J. Med. Sci."},{"issue":"9","key":"40762_CR21","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1016\/s1474-4422(21)00214-3","volume":"20","author":"EH Thijssen","year":"2021","unstructured":"Thijssen, E. H. et al. Plasma phosphorylated tau 217 and phosphorylated tau 181 as biomarkers in Alzheimer\u2019s disease and frontotemporal lobar degeneration: A retrospective diagnostic performance study. Lancet Neurol. 20(9), 739\u2013752. https:\/\/doi.org\/10.1016\/s1474-4422(21)00214-3 (2021).","journal-title":"Lancet Neurol."},{"issue":"2","key":"40762_CR22","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1093\/brain\/awac128","volume":"146","author":"J Stevenson-Hoare","year":"2023","unstructured":"Stevenson-Hoare, J. et al. Plasma biomarkers and genetics in the diagnosis and prediction of Alzheimer\u2019s disease. Brain 146(2), 690\u2013699. https:\/\/doi.org\/10.1093\/brain\/awac128 (2023).","journal-title":"Brain"},{"key":"40762_CR23","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1146\/annurev-pathmechdis-030421-112756","volume":"17","author":"N Koutsodendris","year":"2022","unstructured":"Koutsodendris, N., Nelson, M. R., Rao, A. & Huang, Y. Apolipoprotein E and Alzheimer\u2019s disease: Findings, hypotheses, and potential mechanisms. Annu. Rev. Pathol. Mech. Dis. 17, 73\u201399. https:\/\/doi.org\/10.1146\/annurev-pathmechdis-030421-112756 (2022).","journal-title":"Annu. Rev. Pathol. Mech. Dis."},{"issue":"8","key":"40762_CR24","doi-asserted-by":"publisher","first-page":"3406","DOI":"10.1002\/alz.12990","volume":"19","author":"Y Deming","year":"2023","unstructured":"Deming, Y. et al. Neuropathology-based APOE genetic risk score better quantifies Alzheimer\u2019s risk. Alzheimers Dement. 19(8), 3406\u20133416. https:\/\/doi.org\/10.1002\/alz.12990 (2023).","journal-title":"Alzheimers Dement."},{"key":"40762_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2024.119857","volume":"562","author":"K Rajendran","year":"2024","unstructured":"Rajendran, K. & Krishnan, U. M. Biomarkers in Alzheimer\u2019s disease. Clin. Chim. Acta 562, 119857. https:\/\/doi.org\/10.1016\/j.cca.2024.119857 (2024).","journal-title":"Clin. Chim. Acta"},{"key":"40762_CR26","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2023.1169620","volume":"15","author":"B Jin","year":"2023","unstructured":"Jin, B., Cheng, X., Fei, G., Sang, S. & Zhong, C. Identification of diagnostic biomarkers in Alzheimer\u2019s disease by integrated bioinformatic analysis and machine learning strategies. Front. Aging Neurosci. 15, 1169620. https:\/\/doi.org\/10.3389\/fnagi.2023.1169620 (2023).","journal-title":"Front. Aging Neurosci."},{"issue":"2","key":"40762_CR27","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.arr.2005.03.003","volume":"4","author":"DF Swaab","year":"2005","unstructured":"Swaab, D. F., Bao, A. M. & Lucassen, P. J. The stress system in the human brain in depression and neurodegeneration. Ageing Res. Rev. 4(2), 141\u2013194. https:\/\/doi.org\/10.1016\/j.arr.2005.03.003 (2005).","journal-title":"Ageing Res. Rev."},{"issue":"4","key":"40762_CR28","doi-asserted-by":"publisher","first-page":"259","DOI":"10.2174\/1874467210666170109165219","volume":"10","author":"GP Chrousos","year":"2017","unstructured":"Chrousos, G. P. & Zoumakis, E. Milestones in CRH research. Curr. Mol. Pharmacol. 10(4), 259\u2013263. https:\/\/doi.org\/10.2174\/1874467210666170109165219 (2017).","journal-title":"Curr. Mol. Pharmacol."},{"issue":"1","key":"40762_CR29","doi-asserted-by":"publisher","DOI":"10.1038\/s41522-024-00571-z","volume":"10","author":"Y Zhang","year":"2024","unstructured":"Zhang, Y. et al. Stress triggers gut dysbiosis via CRH-CRHR1-mitochondria pathway. NPJ Biofilms Microbiomes 10(1), 93. https:\/\/doi.org\/10.1038\/s41522-024-00571-z (2024).","journal-title":"NPJ Biofilms Microbiomes"},{"issue":"3","key":"40762_CR30","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1006\/nbdi.2001.0395","volume":"8","author":"WA Pedersen","year":"2001","unstructured":"Pedersen, W. A. et al. Corticotropin-releasing hormone protects neurons against insults relevant to the pathogenesis of Alzheimer\u2019s disease. Neurobiol. Dis. 8(3), 492\u2013503. https:\/\/doi.org\/10.1006\/nbdi.2001.0395 (2001).","journal-title":"Neurobiol. Dis."},{"issue":"2","key":"40762_CR31","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/s0165-5728(96)00178-6","volume":"72","author":"K Karalis","year":"1997","unstructured":"Karalis, K., Muglia, L. J., Bae, D., Hilderbrand, H. & Majzoub, J. A. CRH and the immune system. J. Neuroimmunol. 72(2), 131\u2013136. https:\/\/doi.org\/10.1016\/s0165-5728(96)00178-6 (1997).","journal-title":"J. Neuroimmunol."},{"issue":"3","key":"40762_CR32","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1212\/wnl.37.3.535","volume":"37","author":"C May","year":"1987","unstructured":"May, C., Rapoport, S. I., Tomai, T. P., Chrousos, G. P. & Gold, P. W. Cerebrospinal fluid concentrations of corticotropin-releasing hormone (CRH) and corticotropin (ACTH) are reduced in patients with Alzheimer\u2019s disease. Neurology 37(3), 535\u2013538. https:\/\/doi.org\/10.1212\/wnl.37.3.535 (1987).","journal-title":"Neurology"},{"issue":"9","key":"40762_CR33","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1111\/j.1753-4887.2005.tb00147.x","volume":"63","author":"HK Tiwari","year":"2005","unstructured":"Tiwari, H. K., Bouchard, L., P\u00e9russe, L. & Allison, D. B. Is GAD2 on chromosome 10p12 a potential candidate gene for morbid obesity?. Nutr. Rev. 63(9), 315\u2013319. https:\/\/doi.org\/10.1111\/j.1753-4887.2005.tb00147.x (2005).","journal-title":"Nutr. Rev."},{"issue":"2","key":"40762_CR34","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0148558","volume":"11","author":"KN Davis","year":"2016","unstructured":"Davis, K. N. et al. GAD2 alternative transcripts in the human prefrontal cortex, and in schizophrenia and affective disorders. PLoS ONE 11(2), e0148558. https:\/\/doi.org\/10.1371\/journal.pone.0148558 (2016).","journal-title":"PLoS ONE"},{"issue":"4","key":"40762_CR35","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1097\/pas.0000000000002186","volume":"48","author":"M Lennartz","year":"2024","unstructured":"Lennartz, M. et al. GAD2 is a highly specific marker for neuroendocrine neoplasms of the pancreas. Am. J. Surg. Pathol. 48(4), 377\u2013386. https:\/\/doi.org\/10.1097\/pas.0000000000002186 (2024).","journal-title":"Am. J. Surg. Pathol."},{"issue":"1","key":"40762_CR36","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-024-05289-3","volume":"24","author":"MP Mosharaf","year":"2024","unstructured":"Mosharaf, M. P., Alam, K., Gow, J., Mahumud, R. A. & Mollah, M. N. H. Common molecular and pathophysiological underpinnings of delirium and Alzheimer\u2019s disease: Molecular signatures and therapeutic indications. BMC Geriatr. 24(1), 716. https:\/\/doi.org\/10.1186\/s12877-024-05289-3 (2024).","journal-title":"BMC Geriatr."},{"key":"40762_CR37","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2025.119994","volume":"350","author":"H Wang","year":"2025","unstructured":"Wang, H. et al. Exploring the pharmacological mechanism of Bu-Wang San on Alzheimer\u2019s disease through multiple GEO datasets of the human hippocampus, network pharmacology, and metabolomics based on GC-MS and UPLC-Q\/TOF-MS. J. Ethnopharmacol. 350, 119994. https:\/\/doi.org\/10.1016\/j.jep.2025.119994 (2025).","journal-title":"J. Ethnopharmacol."},{"issue":"4","key":"40762_CR38","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.3233\/jad-2012-121330","volume":"33","author":"C Schwab","year":"2013","unstructured":"Schwab, C., Yu, S., Wong, W., McGeer, E. G. & McGeer, P. L. GAD65, GAD67, and GABAT immunostaining in human brain and apparent GAD65 loss in Alzheimer\u2019s disease. J. Alzheimers Dis. 33(4), 1073\u20131088. https:\/\/doi.org\/10.3233\/jad-2012-121330 (2013).","journal-title":"J. Alzheimers Dis."},{"issue":"4","key":"40762_CR39","first-page":"68","volume":"114","author":"G Burbaeva","year":"2014","unstructured":"Burbaeva, G. et al. A role of glutamate decarboxylase in Alzheimer\u2019s disease. Zh. Nevrol. Psikhiatr. Im. S S Korsakova 114(4), 68\u201372 (2014).","journal-title":"Zh. Nevrol. Psikhiatr. Im. S S Korsakova"},{"issue":"10","key":"40762_CR40","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1080\/00207454.2020.1860966","volume":"132","author":"X Tian","year":"2022","unstructured":"Tian, X. et al. Identification of vascular dementia and Alzheimer\u2019s disease hub genes expressed in the frontal lobe and temporal cortex by weighted co-expression network analysis and construction of a protein-protein interaction. Int. J. Neurosci. 132(10), 1049\u20131060. https:\/\/doi.org\/10.1080\/00207454.2020.1860966 (2022).","journal-title":"Int. J. Neurosci."},{"key":"40762_CR41","doi-asserted-by":"publisher","DOI":"10.3390\/genes15081027","author":"W Xu","year":"2024","unstructured":"Xu, W. et al. Identification of autophagy-related biomarkers and diagnostic model in Alzheimer\u2019s disease. Genes https:\/\/doi.org\/10.3390\/genes15081027 (2024).","journal-title":"Genes"},{"issue":"1","key":"40762_CR42","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-89980-4","volume":"15","author":"J Liu","year":"2025","unstructured":"Liu, J., Yan, M., Chen, L., Yu, W. & L\u00fc, Y. Construction and evaluation of a diagnostic model for Alzheimer\u2019s disease based on mitophagy-related genes. Sci. Rep. 15(1), 10632. https:\/\/doi.org\/10.1038\/s41598-025-89980-4 (2025).","journal-title":"Sci. Rep."},{"key":"40762_CR43","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiolchem.2025.108475","volume":"118","author":"Y Fan","year":"2025","unstructured":"Fan, Y. et al. Identification and validation of biomarkers in Alzheimer\u2019s disease based on machine learning algorithms and single-cell sequencing analysis. Comput. Biol. Chem. 118, 108475. https:\/\/doi.org\/10.1016\/j.compbiolchem.2025.108475 (2025).","journal-title":"Comput. Biol. Chem."},{"key":"40762_CR44","doi-asserted-by":"publisher","DOI":"10.3389\/fragi.2023.1231706","volume":"4","author":"SF Darwish","year":"2023","unstructured":"Darwish, S. F., Elbadry, A. M. M., Elbokhomy, A. S., Salama, G. A. & Salama, R. M. The dual face of microglia (M1\/M2) as a potential target in the protective effect of nutraceuticals against neurodegenerative diseases. Front. Aging 4, 1231706. https:\/\/doi.org\/10.3389\/fragi.2023.1231706 (2023).","journal-title":"Front. Aging"},{"key":"40762_CR45","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.neurobiolaging.2017.08.022","volume":"60","author":"V Sackmann","year":"2017","unstructured":"Sackmann, V. et al. Anti-inflammatory (M2) macrophage media reduce transmission of oligomeric amyloid beta in differentiated SH-SY5Y cells. Neurobiol. Aging 60, 173\u2013182. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2017.08.022 (2017).","journal-title":"Neurobiol. Aging"},{"issue":"1","key":"40762_CR46","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/s0952-7915(00)00180-1","volume":"13","author":"C Th\u00e9ry","year":"2001","unstructured":"Th\u00e9ry, C. & Amigorena, S. The cell biology of antigen presentation in dendritic cells. Curr. Opin. Immunol. 13(1), 45\u201351. https:\/\/doi.org\/10.1016\/s0952-7915(00)00180-1 (2001).","journal-title":"Curr. Opin. Immunol."},{"issue":"6","key":"40762_CR47","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1007\/s10571-018-0598-1","volume":"38","author":"V Brezovakova","year":"2018","unstructured":"Brezovakova, V., Valachova, B., Hanes, J., Novak, M. & Jadhav, S. Dendritic cells as an alternate approach for treatment of neurodegenerative disorders. Cell. Mol. Neurobiol. 38(6), 1207\u20131214. https:\/\/doi.org\/10.1007\/s10571-018-0598-1 (2018).","journal-title":"Cell. Mol. Neurobiol."},{"issue":"18","key":"40762_CR48","doi-asserted-by":"publisher","first-page":"7668","DOI":"10.7150\/thno.75965","volume":"12","author":"H Yang","year":"2022","unstructured":"Yang, H. et al. Adoptive therapy with amyloid-\u03b2 specific regulatory T cells alleviates Alzheimer\u2019s disease. Theranostics 12(18), 7668\u20137680. https:\/\/doi.org\/10.7150\/thno.75965 (2022).","journal-title":"Theranostics"},{"issue":"2","key":"40762_CR49","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1111\/j.1471-4159.2006.03741.x","volume":"97","author":"AB Patel","year":"2006","unstructured":"Patel, A. B., de Graaf, R. A., Martin, D. L., Battaglioli, G. & Behar, K. L. Evidence that GAD65 mediates increased GABA synthesis during intense neuronal activity in vivo. J. Neurochem. 97(2), 385\u2013396. https:\/\/doi.org\/10.1111\/j.1471-4159.2006.03741.x (2006).","journal-title":"J. Neurochem."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-40762-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-40762-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-40762-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T23:01:56Z","timestamp":1774652516000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-40762-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,25]]},"references-count":49,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["40762"],"URL":"https:\/\/doi.org\/10.1038\/s41598-026-40762-6","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,25]]},"assertion":[{"value":"23 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The Institutional Review Board of the Institutional Ethics Committee at Renmin Hospital of Wuhan University, granted approval for this study (approval No.2025K-K290). The research was conducted in compliance with the principles outlined in the Declaration of Helsinki. Informed consent for participation in this study was obtained from the next of kin or legal guardians of the postmortem tissue donors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}}],"article-number":"10438"}}