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Separation was performed on an Inertsil C18 column (250\u2009\u00d7\u20094.6\u00a0mm, 5\u00a0\u03bcm) using ethanol\/0.025\u00a0M phosphate buffer (pH 3.0) at 70:30 (v\/v) on an Agilent 1200 Infinity II system. The method complied with ICH criteria and showed linearity over 1.20\u2013100.00\u00a0\u00b5g mL\u207b\u00b9 (BBL) and 5.00\u2013100.00\u00a0\u00b5g mL\u207b\u00b9 (MTK). Application to a combined tablet dosage form yielded mean recoveries of 100.92\u2009\u00b1\u20091.08% (BBL) and 99.39\u2009\u00b1\u20091.41% (MTK). Dissolution profiling was performed in 900 mL of 0.5% sodium lauryl sulfate medium. Method greenness and sustainability were benchmarked against a reported procedure using multiple tools, Analytical Eco-Scale, MoGAPI, AGREE, RGB-12, D-CHEMS-1, GEAR, CaFRI, CACI, and BAGI demonstrating a safer solvent profile via ethanol\/buffer. Notably, the separation time is longer (\u2248\u200916\u00a0min), indicating a deliberate trade-off between reduced solvent hazard and throughput; analytical performance was maintained. Overall, the method offers a robust, greener alternative for routine assay and dissolution testing of BBL and MTK in pharmaceuticals.<\/jats:p>","DOI":"10.1038\/s41598-026-41125-x","type":"journal-article","created":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T11:23:45Z","timestamp":1774178625000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Eco-friendly RP-HPLC determination of bambuterol hydrochloride and montelukast sodium in tablet dosage with dissolution analysis"],"prefix":"10.1038","volume":"16","author":[{"given":"Manal","family":"Ibrahim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nesrin K.","family":"Ramadan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magda M.","family":"Ibrahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shereen A.","family":"Boltia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,22]]},"reference":[{"key":"41125_CR1","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/j.trac.2008.05.003","volume":"27","author":"S Armenta","year":"2008","unstructured":"Armenta, S., Garrigues, S. & de la Guardia, M. 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