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However, the absence of model animals has limited our understanding of such pregnancy-associated physiological changes. Here, we examined pregnancy-associated metabolic and behavioral changes in common marmosets and mice. Marmosets exhibited a transient weight decrease during the period of placental development in approximately 22% of pregnancies. Some marmosets repeatedly showed transient weight loss across multiple pregnancies, suggesting individual variations in the likelihood of pregnancy-associated weight loss. Although mice did not show apparent alteration in body weight, they exhibited a slowdown in food intake and alterations in locomotor activity during the corresponding phase. The observed transient changes in pregnant marmosets and mice may provide a basis for generating hypotheses regarding physiological changes associated with placentation.<\/jats:p>","DOI":"10.1038\/s41598-026-41314-8","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T10:03:52Z","timestamp":1774433032000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Transient changes in body weight and behavior during the placentation period in non-human primates and rodents"],"prefix":"10.1038","volume":"16","author":[{"given":"Saori","family":"Yano-Nashimoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazutaka","family":"Shinozuka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuma","family":"Kurachi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsura","family":"Kagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kentaro Q.","family":"Sakamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Shigeno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimie","family":"Niimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumi O.","family":"Kuroda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soichiro","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,25]]},"reference":[{"key":"41314_CR1","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1016\/j.molmed.2024.04.006","volume":"30","author":"MS Fejzo","year":"2024","unstructured":"Fejzo, M. S. Hyperemesis gravidarum theories dispelled by recent research: A paradigm change for better care and outcomes. Trends Mol. Med. 30, 530\u2013540 (2024).","journal-title":"Trends Mol. Med."},{"key":"41314_CR2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.809270","volume":"8","author":"C Liu","year":"2021","unstructured":"Liu, C. et al. Emerging progress in nausea and vomiting of pregnancy and hyperemesis gravidarum: Challenges and opportunities. Front. Med. 8, 809270 (2021).","journal-title":"Front. Med."},{"key":"41314_CR3","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-018-1911-1","volume":"18","author":"N Mitsuda","year":"2018","unstructured":"Mitsuda, N. et al. Nausea and vomiting during pregnancy associated with lower incidence of preterm births: The Japan Environment and Children\u2019s Study (JECS). BMC Pregnancy Childbirth 18, 268 (2018).","journal-title":"BMC Pregnancy Childbirth"},{"key":"41314_CR4","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1093\/emph\/eoae012","volume":"12","author":"EH Emmott","year":"2024","unstructured":"Emmott, E. H. Re-examining the adaptive function of nausea and vomiting in pregnancy. Evol. Med. Public Health 12, 97\u2013104 (2024).","journal-title":"Evol. Med. Public Health"},{"key":"41314_CR5","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22115797","author":"W Zhong","year":"2021","unstructured":"Zhong, W. et al. Mechanisms of nausea and vomiting: Current knowledge and recent advances in intracellular emetic signaling systems. Int. J. Mol. Sci. https:\/\/doi.org\/10.3390\/ijms22115797 (2021).","journal-title":"Int. J. Mol. 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After using these services, the authors reviewed and edited the content as needed and take full responsibility for the content of the publication.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"8162"}}