{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T03:52:53Z","timestamp":1793332373956,"version":"4.5.0"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T00:00:00Z","timestamp":1771632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"vor","delay-in-days":33,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Scientific Research Project of Guangdong Provincial Bureau of Traditional Chinese Medicine","award":["20251448"],"award-info":[{"award-number":["20251448"]}]},{"name":"Jiangmen Science and Technology Bureau Project","award":["2024YL02001"],"award-info":[{"award-number":["2024YL02001"]}]},{"name":"Jiangsu Association of Chinese Medicine Eaglet Soaring Project","award":["CYTF2024015"],"award-info":[{"award-number":["CYTF2024015"]}]},{"name":"Intra-hospital Young and Middle-aged Science and Technology Elites Project","award":["SEZ2023001"],"award-info":[{"award-number":["SEZ2023001"]}]},{"name":"Science and Technology Projects in Guangzhou","award":["2023A04J1926"],"award-info":[{"award-number":["2023A04J1926"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-026-41351-3","type":"journal-article","created":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T19:33:18Z","timestamp":1771702398000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Sinensetin attenuates post-stroke depression via dual modulation of TLR4\/NF-\u03baB\u2013NRF2\/GPX4 pathways"],"prefix":"10.1038","volume":"16","author":[{"given":"Qiqi","family":"Fan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renfeng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunling","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuanying","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erjuan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyue","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwu","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,21]]},"reference":[{"issue":"2","key":"41351_CR1","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1038\/s41418-024-01389-0","volume":"32","author":"D Shi","year":"2025","unstructured":"Shi, D. et al. Neuronal LAMP2A-mediated reduction of adenylyl cyclases induces acute neurodegenerative responses and neuroinflammation after ischemic stroke. Cell. Death Differ. 32 (2), 337\u2013352 (2025).","journal-title":"Cell. Death Differ."},{"key":"41351_CR2","doi-asserted-by":"publisher","first-page":"6661620","DOI":"10.1155\/2021\/6661620","volume":"2021","author":"D Fu","year":"2021","unstructured":"Fu, D., Liu, H., Zhu, J., Xu, H. & Yao, J. [D-Ala(2), D-Leu(5)] Enkephalin Inhibits TLR4\/NF-\u03baB Signaling Pathway and Protects Rat Brains against Focal Ischemia-Reperfusion Injury. Mediat. Inflamm. 2021, 6661620 (2021).","journal-title":"Mediat. Inflamm."},{"key":"41351_CR3","doi-asserted-by":"publisher","first-page":"119700","DOI":"10.1016\/j.jep.2025.119700","volume":"347","author":"Q Wu","year":"2025","unstructured":"Wu, Q. et al. Chaihu-Shugan-San alleviates post-stroke depression in mice: Mechanistic insights into exosome-mediated neuroprotection. J. Ethnopharmacol. 347, 119700 (2025).","journal-title":"J. Ethnopharmacol."},{"issue":"9","key":"41351_CR4","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1038\/s41419-024-06935-9","volume":"15","author":"A Mohamud Yusuf","year":"2024","unstructured":"Mohamud Yusuf, A. et al. Acid sphingomyelinase inhibition induces cerebral angiogenesis post-ischemia\/reperfusion in an oxidative stress-dependent way and promotes endothelial survival by regulating mitochondrial metabolism. Cell Death Dis. 15 (9), 650 (2024).","journal-title":"Cell Death Dis."},{"key":"41351_CR5","doi-asserted-by":"publisher","first-page":"6643382","DOI":"10.1155\/2021\/6643382","volume":"2021","author":"JX Ren","year":"2021","unstructured":"Ren, J. X. et al. Crosstalk between Oxidative Stress and Ferroptosis\/Oxytosis in Ischemic Stroke: Possible Targets and Molecular Mechanisms. Oxid. Med. Cell. Longev. 2021, 6643382 (2021).","journal-title":"Oxid. Med. Cell. Longev."},{"key":"41351_CR6","doi-asserted-by":"publisher","first-page":"1047550","DOI":"10.3389\/fimmu.2022.1047550","volume":"13","author":"J Zeng","year":"2022","unstructured":"Zeng, J. et al. The mechanism of microglia-mediated immune inflammation in ischemic stroke and the role of natural botanical components in regulating microglia: A review. Front. Immunol. 13, 1047550 (2022).","journal-title":"Front. Immunol."},{"key":"41351_CR7","doi-asserted-by":"publisher","first-page":"146777","DOI":"10.1016\/j.brainres.2020.146777","volume":"1736","author":"C Li","year":"2020","unstructured":"Li, C. et al. Exercise ameliorates post-stroke depression by inhibiting PTEN elevation-mediated upregulation of TLR4\/NF-\u03baB\/NLRP3 signaling in mice. Brain Res. 1736, 146777 (2020).","journal-title":"Brain Res."},{"key":"41351_CR8","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.neuroscience.2021.11.015","volume":"480","author":"W Wang","year":"2022","unstructured":"Wang, W. et al. Effects of High-fat Diet and Chronic Mild Stress on Depression-like Behaviors and Levels of Inflammatory Cytokines in the Hippocampus and Prefrontal Cortex of Rats. Neuroscience 480, 178\u2013193 (2022).","journal-title":"Neuroscience"},{"key":"41351_CR9","doi-asserted-by":"publisher","first-page":"7924199","DOI":"10.1155\/2022\/7924199","volume":"2022","author":"L Wu","year":"2022","unstructured":"Wu, L. et al. Toll-Like Receptor 4: A Promising Therapeutic Target for Alzheimer\u2019s Disease. Mediat. Inflamm. 2022, 7924199 (2022).","journal-title":"Mediat. Inflamm."},{"key":"41351_CR10","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.jad.2023.05.016","volume":"336","author":"Y Fan","year":"2023","unstructured":"Fan, Y. et al. Depression circuit adaptation in post-stroke depression. J. Affect. Disord. 336, 52\u201363 (2023).","journal-title":"J. Affect. Disord"},{"issue":"4","key":"41351_CR11","doi-asserted-by":"publisher","first-page":"2961","DOI":"10.1111\/ejn.16093","volume":"58","author":"N Sun","year":"2023","unstructured":"Sun, N. et al. A new perspective on hippocampal synaptic plasticity and post-stroke depression. Eur. J. Neurosci. 58 (4), 2961\u20132984 (2023).","journal-title":"Eur. J. Neurosci."},{"key":"41351_CR12","doi-asserted-by":"publisher","first-page":"111065","DOI":"10.1016\/j.brainresbull.2024.111065","volume":"217","author":"C Wei","year":"2024","unstructured":"Wei, C. The role of glutathione peroxidase 4 in neuronal ferroptosis and its therapeutic potential in ischemic and hemorrhagic stroke. Brain Res. Bull. 217, 111065 (2024).","journal-title":"Brain Res. Bull."},{"key":"41351_CR13","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.neures.2022.04.003","volume":"181","author":"H Wei","year":"2022","unstructured":"Wei, H. et al. cPKC\u03b3 ameliorates ischemic injury in cultured neurons exposed to oxygen glucose deprivation\/reoxygenation by inhibiting ferroptosis. Neurosci. Res. 181, 95\u2013104 (2022).","journal-title":"Neurosci. Res."},{"key":"41351_CR14","doi-asserted-by":"publisher","first-page":"1525456","DOI":"10.3389\/fphar.2024.1525456","volume":"15","author":"Y Ye","year":"2024","unstructured":"Ye, Y. et al. Naoqing formula alleviates acute ischaemic stroke-induced ferroptosis via activating Nrf2\/xCT\/GPX4 pathway. Front. Pharmacol. 15, 1525456 (2024).","journal-title":"Front. Pharmacol."},{"key":"41351_CR15","doi-asserted-by":"publisher","first-page":"154790","DOI":"10.1016\/j.phymed.2023.154790","volume":"114","author":"C Wu","year":"2023","unstructured":"Wu, C. et al. 15, 16-Dihydrotanshinone I protects against ischemic stroke by inhibiting ferroptosis via the activation of nuclear factor erythroid 2-related factor 2. Phytomedicine 114, 154790 (2023).","journal-title":"Phytomedicine"},{"key":"41351_CR16","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.brainresbull.2021.05.008","volume":"173","author":"X Hou","year":"2021","unstructured":"Hou, X. et al. CDDO-Im exerts antidepressant-like effects via the Nrf2\/ARE pathway in a rat model of post-stroke depression. Brain Res. Bull. 173, 74\u201381 (2021).","journal-title":"Brain Res. Bull."},{"key":"41351_CR17","doi-asserted-by":"publisher","first-page":"155433","DOI":"10.1016\/j.phymed.2024.155433","volume":"128","author":"Z Yang","year":"2024","unstructured":"Yang, Z. et al. Echinacoside ameliorates post-stroke depression by activating BDNF signaling through modulation of Nrf2 acetylation. Phytomedicine 128, 155433 (2024).","journal-title":"Phytomedicine"},{"key":"41351_CR18","doi-asserted-by":"publisher","first-page":"114117","DOI":"10.1016\/j.bbr.2022.114117","volume":"437","author":"X Wang","year":"2023","unstructured":"Wang, X. et al. Cranial electrotherapy stimulation alleviates depression-like behavior of post-stroke depression rats by upregulating GPX4-mediated BDNF expression. Behav. Brain Res. 437, 114117 (2023).","journal-title":"Behav. Brain Res."},{"key":"41351_CR19","doi-asserted-by":"publisher","first-page":"1342226","DOI":"10.3389\/fphar.2024.1342226","volume":"15","author":"K Zhu","year":"2024","unstructured":"Zhu, K. et al. Edaravone dexborneol attenuates oxidative stress in experimental subarachnoid hemorrhage via Keap1\/Nrf2 signaling pathway. Front. Pharmacol. 15, 1342226 (2024).","journal-title":"Front. Pharmacol."},{"key":"41351_CR20","doi-asserted-by":"publisher","first-page":"987293","DOI":"10.3389\/fphar.2022.987293","volume":"13","author":"H Zhang","year":"2022","unstructured":"Zhang, H. et al. DL-3-n-butylphthalide (NBP) alleviates poststroke cognitive impairment (PSCI) by suppressing neuroinflammation and oxidative stress. Front. Pharmacol. 13, 987293 (2022).","journal-title":"Front. Pharmacol."},{"key":"41351_CR21","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.foodchem.2016.09.016","volume":"218","author":"XM Chen","year":"2017","unstructured":"Chen, X. M., Tait, A. R. & Kitts, D. D. Flavonoid composition of orange peel and its association with antioxidant and anti-inflammatory activities. Food Chem. 218, 15\u201321 (2017).","journal-title":"Food Chem."},{"issue":"10","key":"41351_CR22","doi-asserted-by":"publisher","first-page":"6069","DOI":"10.1021\/jf904608h","volume":"58","author":"W Stuetz","year":"2010","unstructured":"Stuetz, W., Prapamontol, T., Hongsibsong, S. & Biesalski, H. K. Polymethoxylated flavones, flavanone glycosides, carotenoids, and antioxidants in different cultivation types of tangerines (Citrus reticulata Blanco cv. Sainampueng) from Northern Thailand. J. Agric. Food Chem. 58 (10), 6069\u20136074 (2010).","journal-title":"J. Agric. Food Chem."},{"issue":"37","key":"41351_CR23","doi-asserted-by":"publisher","first-page":"33514","DOI":"10.1021\/acsomega.3c03319","volume":"8","author":"L Lin","year":"2023","unstructured":"Lin, L. et al. Sinensetin Attenuated Macrophagic NLRP3 Inflammasomes Formation via SIRT1-NRF2 Signaling. ACS omega. 8 (37), 33514\u201333525 (2023).","journal-title":"ACS omega"},{"key":"41351_CR24","doi-asserted-by":"publisher","first-page":"114101","DOI":"10.1016\/j.intimp.2025.114101","volume":"148","author":"Z Xu","year":"2025","unstructured":"Xu, Z. et al. Sinensetin attenuates LPS-induced acute pulmonary inflammation in mice and RAW264.7 cells by modulating NF-\u03baB p65-mediated immune resistance and STAT3-mediated tissue resilience. Int. Immunopharmacol. 148, 114101 (2025).","journal-title":"Int. Immunopharmacol."},{"issue":"14","key":"41351_CR25","doi-asserted-by":"publisher","first-page":"7592","DOI":"10.1039\/D4FO01704H","volume":"15","author":"Z Xu","year":"2024","unstructured":"Xu, Z. et al. Sinensetin, a polymethoxyflavone from citrus fruits, ameliorates LPS-induced acute lung injury by suppressing Txnip\/NLRP3\/Caspase-1\/GSDMD signaling-mediated inflammatory responses and pyroptosis. Food Funct. 15 (14), 7592\u20137604 (2024).","journal-title":"Food Funct."},{"issue":"8","key":"41351_CR26","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1055\/s-0031-1298458","volume":"78","author":"M Laavola","year":"2012","unstructured":"Laavola, M. et al. Flavonoids eupatorin and sinensetin present in Orthosiphon stamineus leaves inhibit inflammatory gene expression and STAT1 activation. Planta Med. 78 (8), 779\u2013786 (2012).","journal-title":"Planta Med."},{"issue":"11","key":"41351_CR27","doi-asserted-by":"publisher","first-page":"3012","DOI":"10.1007\/s11064-021-03406-x","volume":"46","author":"Z Zhi","year":"2021","unstructured":"Zhi, Z., Tang, X., Wang, Y., Chen, R. & Ji, H. Sinensetin Attenuates Amyloid Beta(25\u201335)-Induced Oxidative Stress, Inflammation, and Apoptosis in SH-SY5Y Cells Through the TLR4\/NF-\u03baB Signaling Pathway. Neurochem Res. 46 (11), 3012\u20133024 (2021).","journal-title":"Neurochem Res."},{"issue":"1","key":"41351_CR28","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/s12974-021-02091-5","volume":"18","author":"W Li","year":"2021","unstructured":"Li, W. et al. Fluoxetine regulates eEF2 activity (phosphorylation) via HDAC1 inhibitory mechanism in an LPS-induced mouse model of depression. J. Neuroinflammation. 18 (1), 38 (2021).","journal-title":"J. Neuroinflammation"},{"issue":"4","key":"41351_CR29","first-page":"387","volume":"8","author":"NA Weaver","year":"2023","unstructured":"Weaver, N. A. et al. Strategic Infarct Locations for Poststroke Depressive Symptoms: A Lesion- and Disconnection-Symptom Mapping Study. Biol. psychiatry Cogn. Neurosci. neuroimaging. 8 (4), 387\u2013396 (2023).","journal-title":"Biol. psychiatry Cogn. Neurosci. neuroimaging"},{"key":"41351_CR30","doi-asserted-by":"publisher","first-page":"1547551","DOI":"10.3389\/fnins.2025.1547551","volume":"19","author":"T Tuersunjiang","year":"2025","unstructured":"Tuersunjiang, T., Wang, Q., Wang, Z., Gao, F. & Wang, Z. Photochemically induced thrombosis combined with chronic restraint stress for modeling post-stroke depression in mice. Front. Neurosci. 19, 1547551 (2025).","journal-title":"Front. Neurosci."},{"issue":"20","key":"41351_CR31","doi-asserted-by":"publisher","first-page":"6183","DOI":"10.1021\/acs.jcim.3c01153","volume":"63","author":"DA Case","year":"2023","unstructured":"Case, D. A. et al. AmberTools J. Chem. Inf. Model. ;63(20):6183\u20136191. (2023).","journal-title":"AmberTools J. Chem. Inf. Model."},{"issue":"1","key":"41351_CR32","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1021\/acs.jctc.9b00591","volume":"16","author":"C Tian","year":"2020","unstructured":"Tian, C. et al. ff19SB: Amino-Acid-Specific Protein Backbone Parameters Trained against Quantum Mechanics Energy Surfaces in Solution. J. Chem. Theory Comput. 16 (1), 528\u2013552 (2020).","journal-title":"J. Chem. Theory Comput."},{"issue":"7","key":"41351_CR33","doi-asserted-by":"publisher","first-page":"3084","DOI":"10.1021\/ct400341p","volume":"9","author":"DR Roe","year":"2013","unstructured":"Roe, D. R. & Cheatham, T. E. 3 PTRAJ and CPPTRAJ: Software for Processing and Analysis of Molecular Dynamics Trajectory Data. J. Chem. Theory Comput. 9 (7), 3084\u20133095 (2013).","journal-title":"J. Chem. Theory Comput."},{"issue":"3","key":"41351_CR34","first-page":"34","volume":"12","author":"X Luo","year":"2023","unstructured":"Luo, X. et al. Association of lesion location with post-stroke depression in China: a systematic review and meta-analysis. EC Psychol. Psychiatr. 12 (3), 34\u201345 (2023).","journal-title":"EC Psychol. Psychiatr"},{"issue":"1","key":"41351_CR35","doi-asserted-by":"publisher","first-page":"7598","DOI":"10.1038\/s41598-022-11793-6","volume":"12","author":"A Knezic","year":"2022","unstructured":"Knezic, A., Broughton, B. R. S., Widdop, R. E. & McCarthy, C. A. Optimising the photothrombotic model of stroke in the C57BI\/6 and FVB\/N strains of mouse. Sci. Rep. 12 (1), 7598 (2022).","journal-title":"Sci. Rep."},{"issue":"24","key":"41351_CR36","doi-asserted-by":"publisher","first-page":"1350","DOI":"10.21037\/atm-22-5443","volume":"10","author":"XQ Tang","year":"2022","unstructured":"Tang, X. Q. et al. Aerobic exercise reverses the NF-\u03baB\/NLRP3 inflammasome\/5-HT pathway by upregulating irisin to alleviate post-stroke depression. Ann. Transl Med. 10 (24), 1350 (2022).","journal-title":"Ann. Transl Med."},{"issue":"1","key":"41351_CR37","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1186\/s12964-024-01796-3","volume":"22","author":"Q Gong","year":"2024","unstructured":"Gong, Q. et al. RIPK1 inhibition mitigates neuroinflammation and rescues depressive-like behaviors in a mouse model of LPS-induced depression. Cell. Commun. Signal. 22 (1), 427 (2024).","journal-title":"Cell. Commun. Signal."},{"issue":"21","key":"41351_CR38","first-page":"e2414559","volume":"12","author":"F Gao","year":"2025","unstructured":"Gao, F. et al. Therapeutic Delivery of circDYM by Perillyl Alcohol Nanoemulsion Alleviates LPS-Induced Depressive-Like Behaviors. Adv. Sci. (Weinheim Baden-Wurttemberg Germany). 12 (21), e2414559 (2025).","journal-title":"Adv. Sci. (Weinheim Baden-Wurttemberg Germany)"},{"key":"41351_CR39","doi-asserted-by":"publisher","first-page":"155530","DOI":"10.1016\/j.phymed.2024.155530","volume":"128","author":"S Zhang","year":"2024","unstructured":"Zhang, S. et al. Notoginsenoside R1 alleviates cerebral ischemia\/reperfusion injury by inhibiting the TLR4\/MyD88\/NF-\u03baB signaling pathway through microbiota-gut-brain axis. Phytomedicine 128, 155530 (2024).","journal-title":"Phytomedicine"},{"issue":"8","key":"41351_CR40","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1007\/s11655-013-1539-y","volume":"19","author":"HY Tian","year":"2013","unstructured":"Tian, H. Y. et al. Effects of 14 single herbs on the induction of caspase-3 in tumor cells: a brief review. Chin. J. Integr. Med. 19 (8), 636\u2013640 (2013).","journal-title":"Chin. J. Integr. Med."},{"issue":"10","key":"41351_CR41","first-page":"772","volume":"19","author":"XJ Xu","year":"2021","unstructured":"Xu, X. J. et al. Danshen-Chuanxiongqin Injection attenuates cerebral ischemic stroke by inhibiting neuroinflammation via the TLR2\/ TLR4-MyD88-NF-\u03baB Pathway in tMCAO mice. Chin. J. Nat. Med. 19 (10), 772\u2013783 (2021).","journal-title":"Chin. J. Nat. Med."},{"key":"41351_CR42","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.neuroscience.2024.01.017","volume":"541","author":"Y Bai","year":"2024","unstructured":"Bai, Y. et al. Resveratrol Improves Cognitive Function in Post-stroke Depression Rats by Repressing Inflammatory Reactions and Oxidative Stress via the Nrf2\/HO-1 Pathway. Neuroscience 541, 50\u201363 (2024).","journal-title":"Neuroscience"},{"key":"41351_CR43","doi-asserted-by":"publisher","first-page":"114541","DOI":"10.1016\/j.expneurol.2023.114541","volume":"369","author":"H Liu","year":"2023","unstructured":"Liu, H. et al. Rhein attenuates cerebral ischemia-reperfusion injury via inhibition of ferroptosis through NRF2\/SLC7A11\/GPX4 pathway. Exp. Neurol. 369, 114541 (2023).","journal-title":"Exp. Neurol."},{"key":"41351_CR44","doi-asserted-by":"publisher","first-page":"176264","DOI":"10.1016\/j.ejphar.2023.176264","volume":"963","author":"C Peng","year":"2024","unstructured":"Peng, C. et al. Quercetin attenuates cerebral ischemic injury by inhibiting ferroptosis via Nrf2\/HO-1 signaling pathway. Eur. J. Pharmacol. 963, 176264 (2024).","journal-title":"Eur. J. Pharmacol."},{"key":"41351_CR45","doi-asserted-by":"publisher","first-page":"102387","DOI":"10.1016\/j.jchemneu.2023.102387","volume":"136","author":"F Zhu","year":"2024","unstructured":"Zhu, F., Ding, S., Liu, Y., Wang, X. & Wu, Z. Ozone-mediated cerebral protection: Unraveling the mechanism through ferroptosis and the NRF2\/SLC7A11\/GPX4 signaling pathway. J. Chem. Neuroanat. 136, 102387 (2024).","journal-title":"J. Chem. Neuroanat."},{"key":"41351_CR46","doi-asserted-by":"publisher","first-page":"116833","DOI":"10.1016\/j.ecoenv.2024.116833","volume":"283","author":"X Yang","year":"2024","unstructured":"Yang, X. et al. Ellagic acid ameliorates arsenic-induced neuronal ferroptosis and cognitive impairment via Nrf2\/GPX4 signaling pathway. Ecotoxicol. Environ. Saf. 283, 116833 (2024).","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"41351_CR47","doi-asserted-by":"publisher","first-page":"107844","DOI":"10.1016\/j.intimp.2021.107844","volume":"98","author":"N Yan","year":"2021","unstructured":"Yan, N., Xu, Z., Qu, C. & Zhang, J. Dimethyl fumarate improves cognitive deficits in chronic cerebral hypoperfusion rats by alleviating inflammation, oxidative stress, and ferroptosis via NRF2\/ARE\/NF-\u03baB signal pathway. Int. Immunopharmacol. 98, 107844 (2021).","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"41351_CR48","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/s12943-016-0550-2","volume":"15","author":"R Arora","year":"2016","unstructured":"Arora, R. et al. Esculetin induces antiproliferative and apoptotic response in pancreatic cancer cells by directly binding to KEAP1. Mol. Cancer. 15 (1), 64 (2016).","journal-title":"Mol. Cancer"},{"key":"41351_CR49","doi-asserted-by":"publisher","first-page":"113764","DOI":"10.1016\/j.intimp.2024.113764","volume":"146","author":"IA Abdelmawgood","year":"2025","unstructured":"Abdelmawgood, I. A. et al. Gentisic acid attenuates ovalbumin-induced airway inflammation, oxidative stress, and ferroptosis through the modulation of Nrf2\/HO-1 and NF-\u03baB signaling pathways. Int. Immunopharmacol. 146, 113764 (2025).","journal-title":"Int. Immunopharmacol."},{"issue":"8","key":"41351_CR50","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1038\/s41419-022-05192-y","volume":"13","author":"Y Han","year":"2022","unstructured":"Han, Y. et al. Long noncoding RNA LINC00239 inhibits ferroptosis in colorectal cancer by binding to Keap1 to stabilize Nrf2. Cell. Death Dis. 13 (8), 742 (2022).","journal-title":"Cell. Death Dis."},{"key":"41351_CR51","doi-asserted-by":"crossref","unstructured":"Wang, X. et al. Identification and therapeutic potential of polymethoxylated flavones in citri reticulatae pericarpium for Alzheimer\u2019s disease: Targeting neuroinflammation. Molecules 30(4) (2025).","DOI":"10.3390\/molecules30040771"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-41351-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-41351-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-41351-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T14:02:41Z","timestamp":1774533761000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-41351-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,21]]},"references-count":51,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["41351"],"URL":"https:\/\/doi.org\/10.1038\/s41598-026-41351-3","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,21]]},"assertion":[{"value":"18 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"10141"}}